Article
Neurosciences
Masaya Harada, Vincent Pascoli, Agnes Hiver, Jerome Flakowski, Christian Luescher
Summary: The study reveals that compulsive individuals exhibit stronger neuronal activity in the DS during the cue predicting reward availability, even at the risk of punishment. An increased AMPA/NMDA ratio was observed selectively at orbitofrontal cortex to DS synapses, and spiny projection neurons in the DS showed an activity peak at the moment of signaled reward availability.
BIOLOGICAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thomas Lissek, Andry Andrianarivelo, Estefani Saint-Jour, Marie-Charlotte Allichon, Hanke Gwendolyn Bauersachs, Merie Nassar, Charlotte Piette, Priit Pruunsild, Yan-Wei Tan, Benoit Forget, Nicolas Heck, Jocelyne Caboche, Laurent Venance, Peter Vanhoutte, Hilmar Bading
Summary: Npas4 is a crucial regulator of medium spiny neuron function, affecting spine density and electrophysiological parameters, as well as cocaine-induced locomotion magnitude. Its induction is calcium-dependent and independent of common kinase pathways, controlling a regulon that includes synaptic molecules.
Article
Neurosciences
Agustin Zapata, Carl R. Lupica
Summary: Animal and human studies suggest that cannabis can increase cocaine seeking and is associated with impulse control deficits, possibly through involvement of the CB1 receptors. The CB1 receptors in the Lateral Habenula (LHb) play a role in impulsivity deficits, highlighting a potential therapeutic target for substance use disorders.
Article
Neurosciences
Eric Y. Choi, Daniela Franco, Catherine A. Stapf, Madeleine Gordin, Amanda Chow, Kara K. Cover, Ramesh Chandra, Mary Kay Lobo
Summary: Substance use disorder is a chronic disease with significant impact on global disability. This study investigates the molecular and functional changes in the NAc associated with cocaine exposure, specifically in D1-MSNs and D2-MSNs. Using CRISPR tools, the researchers mimic the expression patterns of Nab2 and Egr3 in these neurons and shed light on their role in cocaine action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Lauren E. Mueller, Melissa J. Sharpe, Thomas A. Stalnaker, Andrew M. Wikenheiser, Geoffrey Schoenbaump
Summary: Substance use disorders are associated with maladaptive behavior due to drug-induced neural alterations affecting the encoding of state-specific information in the dorsomedial striatum. Prior cocaine experience can lead to enhanced encoding of specific rules in the DMS, resulting in slower decision-making behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Lidia E. W. Spelta, Yuli Y. S. Torres, Sarah C. W. S. E. F. de Oliveira, Mauricio Yonamine, Alexis Bailey, Rosana Camarini, Raphael C. T. Garcia, Tania Marcourakis
Summary: This study demonstrates that cocaine use induces plastic changes in the hippocampal cholinergic muscarinic system, while withdrawal leads to a resetting of the system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Clinical Neurology
Chenyuan Qin, Jiawei Hu, Yiming Wan, Mengyao Cai, Zhenting Wang, Zhao Peng, Yuxiao Liao, Dan Li, Ping Yao, Liegang Liu, Shuang Rong, Wei Bao, Guifeng Xu, Wei Yang
Summary: This review primarily focuses on the relationships between alcohol, cocaine, and methamphetamine addiction and gut microbiota, as well as possible treatment methods. By establishing a bridge between substance addiction and gut microbiota based on existing evidence, the review aims to explore the potential bidirectional function of the microbiota-gut-brain axis in substance addiction for the development of therapeutic strategies in the future.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Giorgia Caspani, Viktoria Sebok, Nowshin Sultana, Jonathan R. Swann, Alexis Bailey
Summary: Metabolomics can elucidate the biochemical impact of substance abuse, understand the addiction cycle, and predict prognosis for recovery or relapse.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Kevin R. Coffey, Vaishnavi Venkat, Mark O. West, David J. Barker
Summary: Neurons in the lateral preoptic area show varied responses to different components of drug self-administration. The majority of these neurons signal the operant response with increases in spiking activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Julian Guarque-Chabrera, Aitor Sanchez-Hernandez, Patricia Ibanez-Marin, Ignasi Melchor-Eixea, Marta Miquel
Summary: This study investigates the role of perineuronal nets (PNNs) in cocaine-induced conditioned preference. The results show that digestion of PNNs disrupts short-term memory of conditioned preference but facilitates extinction formation. Moreover, PNN degradation also encourages the reinstatement of cocaine-induced conditioned preference. Therefore, degradation of PNNs may be a promising tool to manipulate drug-induced memory.
Review
Behavioral Sciences
Shradhha Kaushik, Faraz Ahmad, Sunita Choudhary, Darin Mansor Mathkor, Bhartendu Nath Mishra, Vineeta Singh, Shafiul Haque
Summary: Recent lifestyle changes have led to increased peer pressure and mental stress, resulting in higher incidences of addiction, depression, and anxiety (ADA). Genetic factors play a significant role in individuals' stress tolerance levels, with vulnerable individuals often turning to drug addiction as a coping mechanism. This systematic review examines the relationship between various genetic factors and the development of ADA, specifically focusing on cocaine abuse. The study identifies 51 genes linked to ADA development, with BDNF, PERIOD2, and SLC6A4 being common to all three aspects of ADA. The findings suggest potential for identifying diagnostic biomarkers and drug targets, as well as developing more effective therapeutic approaches against ADA.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Neurosciences
Brooke N. Bender, Mary M. Torregrossa
Summary: The study found that habitual drug seeking leads to plasticity in the DLS and behavior that is resistant to cue extinction, but the effects of cue extinction are restored when glutamatergic signaling in the DLS is blocked.
Article
Substance Abuse
Violaine Mongeau-Perusse, Suzanne Brissette, Julie Bruneau, Patricia Conrod, Simon Dubreucq, Guillaume Gazil, Emmanuel Stip, Didier Jutras-Aswad
Summary: This study tested the efficacy of CBD for reducing craving and preventing relapse in people with CUD. However, the findings showed that CBD treatment did not reduce cocaine craving or relapse among participants being treated for CUD.
Article
Psychiatry
Daniela Benzano, Felipe Ornell, Jaqueline Bohrer Schuch, Flavio Pechansky, Anne Orgler Sordi, Lisia von Diemen, Felix Henrique Paim Kessler
Summary: Individuals with substance use disorder are at higher risk of COVID-19 severity due to various risk factors such as smoking, hypertension, respiratory issues, and homelessness. Multiple risk factors were observed in the sample, indicating a potentially worse prognosis for COVID-19 in this population.
PSYCHIATRY RESEARCH
(2021)