Article
Biochemistry & Molecular Biology
Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura
Summary: This study investigated the effects of cocaine on cardiac Cx43 and found a negative correlation between CBN and dephosphorylated cardiac Cx43. Additionally, increased levels of apoptosis, necroptosis, and adiponectin were observed in the myocardium after cocaine exposure. These findings provide insights into the cardiotoxicity of cocaine and the potential protective role of adiponectin in the heart.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Danuta Kowalczyk-Pachel, Malgorzata Iciek, Anna Bilska-Wilkosz, Magdalena Gorny, Joanna Jastrzebska, Kinga Kaminska, Paulina Dudzik, Malgorzata Filip, Elzbieta Lorenc-Koci
Summary: This study evaluated the impact of cocaine on thiols and reactive sulfur species in the liver and kidney of rats, finding that cocaine leads to a decrease in reactive sulfur species in the liver and an increase in the kidney, with these changes being maintained during drug abstinence. Additionally, cocaine alters cysteine metabolism towards an anaerobic pathway in the kidney.
Article
Neurosciences
David De Sa Nogueira, Romain Bourdy, Dominique Filliol, Pascal Romieu, Katia Befort
Summary: This study investigated transcriptional and functional changes of the mu opioid receptor in reward-related brain regions induced by intravenous cocaine self-administration in rats. The findings revealed increased mu opioid receptor gene expression and enhanced functionality in the hippocampus of cocaine self-administering animals. The study highlights the hippocampus as an important target for further investigation of neuroadaptive processes leading to cocaine addiction.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Psychology, Educational
Jessica E. Kilday, Allison M. Ryan
Summary: This article examines the importance of peer relationships and teacher practices for students' academic motivation. It discusses how the quality of peer relationships and interactions provide social support, and how peer interactions influence students' achievement beliefs, values, and goals. The article also explores the role of classroom contextual factors and the link between teacher practices and the classroom peer ecology in shaping students' motivation.
EDUCATIONAL PSYCHOLOGY REVIEW
(2022)
Article
Neurosciences
W. S. Doyle, K. B. Freeman, J. Woods, S. L. Huskinson
Summary: Through an experiment on drug choice, it was found that the efficacy of drugs is related to the availability of food, with variable ratio (VR) schedules having a greater effect than fixed ratio (FR) schedules. This has important implications for the development of interventions or policies regarding drug addiction.
PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lais F. Berro, C. Austin Zamarripa, James K. Rowlett
Summary: This study evaluated the reinforcing effects of fentanyl, alone or in combination with alprazolam, in rhesus monkeys. The results showed that the combination of fentanyl and alprazolam generally resulted in proportion-dependent additive or supra-additive enhancements, providing an explanation for the prevalence of opioid-benzodiazepine polydrug abuse.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Behavioral Sciences
Kathleen M. Kantak, Carissa Stots, Elon Mathieson, Camron D. Bryant
Summary: Research using reduced complexity cross (RCC) strategy has accelerated the discovery of genes related to cocaine addiction traits in rat substrains. By validating differences in compulsive-like behavior and cocaine self-administration traits between two substrains, the effectiveness of using RCC approach has been confirmed.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Vladimir L. Tsibulsky, Andrew B. Norman
Summary: Progressive ratio (PR) schedules of drug delivery are used to determine the 'motivational' state of an animal and drug 'reinforcing efficacy'. The compulsion zone theory of cocaine self-administration explains the lever-pressing behavior and cocaine injections under the PR schedule in rats.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dawid Gawlinski, Kinga Gawlinska, Malgorzata Frankowska, Malgorzata Filip
Summary: Recent studies have shown that Wnt/beta-catenin signaling plays an important role in the pathophysiology of mental illnesses, including cocaine use disorder. Chronic cocaine self-administration affects the expression of Wnt signaling elements in the brain, and early abstinence periods show different patterns of gene expression changes. Additionally, exposure to cocaine reduces the expression of miR-374 and miR-544, which can regulate Wnt5a levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Developmental
Julia D. McQuade, Rosanna Breaux, Arianna E. Mordy, Daria Taubin
Summary: This study investigates the impact of parent reactions to children's negative emotions on adolescent emotion regulation and peer problems, finding that even for youth with clinical elevations in ADHD symptoms, parent reactions play an important role.
JOURNAL OF YOUTH AND ADOLESCENCE
(2021)
Review
Psychology, Developmental
Angela K. Henneberger, Dawnsha R. Mushonga, Alison M. Preston
Summary: Peer influence plays a significant role in adolescent substance use, with peer selection and socialization being key processes. Studies show that adolescent alcohol and tobacco use are influenced by peer selection, while alcohol use is more impacted by peer socialization. Future research should further explore the specific mechanisms of peer selection and socialization.
ADOLESCENT RESEARCH REVIEW
(2021)
Article
Neurosciences
David De Sa Nogueira, Romain Bourdy, Dominique Filliol, Cyril Quessada, Isabelle McCort-Tranchepain, Francine Acher, Jean Zwiller, Pascal Romieu, Katia Befort
Summary: Studies indicate that mGlu group III receptors are new targets for reducing the motivation to self-administer cocaine.
NEUROSCIENCE LETTERS
(2021)
Article
Multidisciplinary Sciences
Valeria Ivaniushina, Vera Titkova
Summary: The advancement in social network analysis methodologies has enabled accurate estimation of peer influence effects free from peer selection effects. Further research is needed to clarify the roles of age, gender, and individual susceptibility in the changing behavior of adolescents under the influence of their peers. Understanding the effects of peer influence can help inform practitioners and policymakers in designing and delivering more effective prevention programs.
Article
Health Care Sciences & Services
Johanne Eliacin, Scott M. Patterson, Diana M. Mendez, Diana J. Burgess, Morgan H. Traylor, Maria Y. Borden, James E. Slaven, Marianne S. Matthias
Summary: The study aims to assess the feasibility and acceptability of a novel intervention called CONNECTED, which aims to reduce social isolation among veterans. The results suggest that CONNECTED is a feasible and acceptable intervention and may be effective in reducing social isolation among veterans.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Behavioral Sciences
Madison M. Marcus, S. Stevens Negus, Matthew L. Banks
Summary: Cocaine use disorder occurs in an environment where cocaine and other nondrug commodities are concurrently available. Preclinical drug-vs-nondrug choice procedures are one simplified method of modeling this complex clinical environment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Psychology, Biological
Justin C. Strickland, Max A. Feinstein, Ryan T. Lacy, Mark A. Smith
BEHAVIOURAL PROCESSES
(2016)
Article
Behavioral Sciences
Geoffrey W. Peitz, Justin C. Strickland, Elizabeth G. Pitts, Mark Foley, Scott Tonidandel, Mark A. Smith
BEHAVIOURAL PHARMACOLOGY
(2013)
Review
Behavioral Sciences
Wendy J. Lynch, Alexis B. Peterson, Victoria Sanchez, Jean Abel, Mark A. Smith
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2013)
Article
Pharmacology & Pharmacy
Mark A. Smith, Elizabeth G. Pitts
PHARMACOLOGICAL REPORTS
(2012)
Article
Behavioral Sciences
M. A. Smith, K. T. Cole, J. C. Iordanou, D. C. Kerns, P. C. Newsom, G. W. Peitz, K. T. Schmidt
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2013)
Review
Substance Abuse
Mark A. Smith
DRUG AND ALCOHOL DEPENDENCE
(2020)
Article
Psychology, Biological
Mark A. Smith, Sarah B. Ethridge, Abigail N. Gibson, Karl T. Schmidt, Jessica L. Sharp
Summary: This study shows that estradiol reduces heroin intake, especially during the proestrus stage in the menstrual cycle of female rats. Interestingly, only estradiol, but not progesterone, was found to be responsible for this effect, indicating the potential value of estrogen-based pharmacotherapies for women with opioid use disorders.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Mark A. Smith, Sarah B. Ethridge, Tallia Pearson, Huailin Zhang, Madison M. Marcus, Shannon L. Ballard, Alexander T. Casimir, Kenzie M. Potter, Karl T. Schmidt, Jessica L. Sharp, Andrea M. Robinson
Summary: The study found that estradiol, not progesterone, is responsible for the decreased intake of heroin during the proestrus phase, and estradiol-treated rats self-administered less heroin than rats treated with progesterone. These results suggest that estrogen-based pharmacotherapies may be beneficial for women with opioid use disorder.
PSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Karl T. Schmidt, Jessica L. Sharp, Sarah B. Ethridge, Tallia Pearson, Shannon Ballard, Kenzie M. Potter, Mark A. Smith
Summary: The study found that heroin intake significantly decreases during the proestrus phase in female rats, while sugar intake remains unaffected. This suggests that responding maintained by heroin decreases during proestrus, while responding to a nondrug reinforcer remains stable. These effects are consistent across different rat strains.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Mark A. Smith, Karl T. Schmidt, Jessica L. Sharp, Tallia Pearson, Anna L. Davis, Abigail N. Gibson, Kenzie M. Potter
Summary: The study aimed to characterize the positive reinforcing and prosocial effects of MDMA in a translational model of the social environment in rats. Results showed that MDMA failed to produce positive reinforcing effects in rats under all conditions examined.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Jessica L. Sharp, Tallia Pearson, Mark A. Smith
Summary: Research has shown that there are sex differences in endogenous opioid peptides and receptors, resulting in functional differences in sensitivity to opioid receptor mediated behaviors between males and females. This review focuses on the influence of androgens on these effects and suggests that further investigation may lead to new treatment options for conditions like chronic pain and substance use disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Biological
Mark A. A. Smith, Anna L. L. Davis, Justin C. C. Strickland
Summary: This study aimed to investigate whether the physical attractiveness of the opposite-gender influences the likelihood a person will use cannabis. The research found that the relative physical attractiveness of the opposite-gender can affect the likelihood of engaging in drug and non-drug activities, and there are gender differences in attitudes towards cannabis use.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Mark A. Smith, Jacob D. Camp, Alexandra N. Johansen, Justin C. Strickland
Summary: Recent exposure to response-contingent cocaine transiently increases the reinforcing effectiveness of social contact, suggesting that cocaine use may strengthen social cohesion by enhancing the reinforcing effects of social contact with others.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Mark A. Smith, Tallia Pearson, Shannon L. Ballard, Jacob D. Camp, Jessica L. Sharp
Summary: Previous studies have shown that gonadal hormones influence opioid self-administration in female rodents, but very few studies have examined these effects in male rodents. The purpose of this study was to examine the effects of chronic hormone treatment on intravenous heroin self-administration in gonadectomized male rats using both physiological and supraphysiological doses of testosterone, estradiol, or progesterone. Data from the study indicate that exogenous progesterone or a pharmacologically active metabolite selectively decreases heroin intake in male rodents, which may have therapeutic implications for men with opioid use disorder.
PSYCHOPHARMACOLOGY
(2023)