Article
Medicine, Research & Experimental
Man Ki Kwok, Gabriel Matthew Leung, Lin Xu, Hung Fat Tse, Tai Hing Lam, C. Mary Schooling
Summary: The study found that short-term puerarin supplementation did not significantly improve lipid profile in young-to-middle-aged Chinese men, but was beneficial in reducing fasting glucose.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Dante Xing, Choongsung Yoo, Drew Gonzalez, Victoria Jenkins, Kay Nottingham, Broderick Dickerson, Megan Leonard, Joungbo Ko, Mark Faries, Wesley Kephart, Martin Purpura, Ralf Jaeger, Shawn D. Wells, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider
Summary: The study investigated the effects of varying doses of PXN on cognitive function and side effects, finding that acute ingestion of 100 mg and 200 mg of PXN may affect measures of cognition, memory, reasoning, and response time. Additionally, daily ingestion of PXN for 7 days was not associated with any clinically significant side effects, suggesting PXN may serve as an effective nootropic agent at doses as low as 50 mg.
Article
Food Science & Technology
Masanobu Hibi, Yuji Matsui, Sachiko Niwa, Sachiko Oishi, Aya Yanagimoto, Takahiro Ono, Tohru Yamaguchi
Summary: Corosolic acid has been found to improve glucose tolerance in both healthy individuals and prediabetic subjects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Max L. Eckstein, Antonia Brockfeld, Sandra Haupt, Janis R. Schierbauer, Rebecca T. Zimmer, Nadine Wachsmuth, Beate Zunner, Paul Zimmermann, Barbara Obermayer-Pietsch, Othmar Moser
Summary: The study found that fructose led to lower peak blood glucose levels compared to glucose and glucose and fructose supplementation, with no significant difference between glucose and glucose and fructose supplementation in terms of peak values. Additionally, all conditions resulted in significantly higher peak blood glucose values compared to sucralose.
Article
Microbiology
Vipul K. Gupta, Gary Maier, Paul Eckburg, Lisa Morelli, Yang Lei, Akash Jain, Erika Manyak, David Melnick
Summary: Tebipenem pivoxil hydrobromide (TBP-PI-HBr) was found to have no clinically significant adverse effects on heart rate or ECG parameters, supporting the use of QT interval corrected by Fridericia's method as an appropriate correction. The study evaluated the effects of single therapeutic and supratherapeutic doses of TBP-PI-HBr on the heart rate-corrected QT interval using exposure-response modeling.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Food Science & Technology
Yoichi Sunagawa, Yusuke Miyazaki, Masafumi Funamoto, Kana Shimizu, Satoshi Shimizu, Sari Nurmila, Yasufumi Katanasaka, Masashi Ito, Tatsuya Ogawa, Hitomi Ozawa-Umeta, Koji Hasegawa, Tatsuya Morimoto
Summary: The amorphous formulation curcuRougeTM of curcumin demonstrated significantly higher bioavailability compared to Theracurmin(R) in both rat and human studies. Furthermore, curcuRougeTM reached Cmax faster than Theracurmin(R) in both experiments.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Endocrinology & Metabolism
Casper K. Nielsen, Caroline C. Ohrstrom, Urd L. Kielgast, Dorte L. Hansen, Bolette Hartmann, Jens J. Holst, Asger Lund, Tina Vilsboll, Filip K. Knop
Summary: This study investigated the efficacy and safety of a novel stable glucagon analog, dasiglucagon, in individuals who had undergone Roux-en-Y gastric bypass (RYGB) and suffered from postbariatric hypoglycemia (PBH). The results demonstrated that a single-dose administration of dasiglucagon effectively mitigated postprandial hypoglycemia.
Article
Endocrinology & Metabolism
Soumita Mandal, Pradip Mukhopadhyay, Sujoy Ghosh
Summary: This study aimed to investigate the use of DHEA supplementation in patients with Sheehan syndrome (SS). The results showed that DHEA supplementation significantly improved the Female Sexual Functioning Index (FSFI) score, with significant improvements in both FSFI score and individual domains of female sexual dysfunction (FSD). Furthermore, DHEA treatment did not result in any metabolic side effects.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Jemima S. A. Dzator, Peter R. C. Howe, Kirsten G. Coupland, Rachel H. X. Wong
Summary: This study aimed to investigate the effects of resveratrol on hormonal migraineurs. After three months of supplementation, it was found that resveratrol did not improve the burden index, migraine-related disability, or quality of life in this cohort of hormonal migraineurs.
Article
Nutrition & Dietetics
Max L. L. Eckstein, Maximilian P. P. Erlmann, Felix Aberer, Sandra Haupt, Paul Zimmermann, Nadine B. B. Wachsmuth, Janis Schierbauer, Rebecca T. T. Zimmer, Daniel Herz, Barbara Obermayer-Pietsch, Othmar Moser
Summary: This study found that individualized amounts of glucose, fructose, and a combination of these did not enhance high-intensity anaerobic endurance performance and moderate resistance exercise in healthy young individuals, compared to a placebo.
Article
Urology & Nephrology
Julie Refardt, Cornelia Imber, Rianne Nobbenhuis, Clara O. Sailer, Aaron Haslbauer, Sophie Monnerat, Cemile Bathelt, Deborah R. Vogt, Manfred Berres, Bettina Winzeler, Stephanie A. Bridenbaugh, Mirjam Christ-Crain
Summary: This study compared the effects of empagliflozin treatment with placebo in outpatients with chronic SIAD-induced hyponatremia. The results showed that empagliflozin treatment significantly increased serum sodium levels and improved neurocognitive function. This suggests that empagliflozin may be a promising treatment option for chronic SIAD-induced hyponatremia.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biology
Max Lennart Eckstein, Antonia Brockfeld, Sandra Haupt, Janis Ramon Schierbauer, Rebecca Tanja Zimmer, Nadine Bianca Wachsmuth, Beate Elisabeth Maria Zunner, Paul Zimmermann, Maximilian Erlmann, Barbara Obermayer-Pietsch, Felix Aberer, Othmar Moser
Summary: This study investigated the cardio-autonomic stress responses to different types of carbohydrates in healthy individuals. The findings showed that ingestion of carbohydrates led to a reduction in heart-rate variability. Blood glucose levels above or below 70-90 mg/dL and rapid glucose changes also decreased heart-rate variability. It is important for healthy individuals to be conscious of their carbohydrate intake and maintain blood glucose levels between 70-90 mg/dL.
Article
Critical Care Medicine
Elisa Perger, Luigi Taranto Montemurro, Debora Rosa, Stefano Vicini, Mariapaola Marconi, Lucia Zanotti, Paolo Meriggi, Ali Azarbarzin, Scott A. Sands, Andrew Wellman, Carolina Lombardi, Gianfranco Parati
Summary: The combination therapy of Reb-Oxy significantly reduces the severity of OSA and improves vigilance. These findings highlight the potential of pharmacologic treatment for OSA.
Article
Biochemistry & Molecular Biology
Belen Murcia Casas, Juan Luis Carrillo Linares, Isabel Baquero Aranda, Jose Rioja Villodres, Vicente Merino Bohorquez, Andres Gonzalez Jimenez, Miguel Angel Rico Corral, Ricardo Bosch, Miguel Angel Sanchez Chaparro, Maria Garcia Fernandez, Pedro Valdivielso
Summary: Pseudoxanthoma elasticum (PXE) is a condition characterized by low levels of inorganic pyrophosphate (PPi) and high activity of tissue-nonspecific alkaline phosphatase (TNAP). This study investigated the effect of lansoprazole, a partial inhibitor of TNAP, on plasma PPi levels in PXE patients. The results showed that 30 mg/day of lansoprazole significantly increased plasma PPi levels in PXE patients, indicating the potential therapeutic role of lansoprazole in PXE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Itziar Olaizola, Martin F. Brodde, Beate E. Kehrel, Stefan Evers
Summary: Valproate intake can lead to decreased platelet aggregation due to decreased fibrinogen binding and increased CD62 expression. This may be one reason for the increased risk of bleeding associated with valproate, which is not observed with levetiracetam.
JOURNAL OF CLINICAL MEDICINE
(2023)