4.4 Article

Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment

期刊

PSYCHOPHARMACOLOGY
卷 222, 期 1, 页码 17-26

出版社

SPRINGER
DOI: 10.1007/s00213-011-2618-4

关键词

Alcohol dependence; Attentional bias; Cue-reactivity; Heart rate variability; Relapse

资金

  1. National Institute of Drug Abuse [R03DA032517-01]
  2. National Center for Complementary and Alternative Medicine [T32AT003378]
  3. Mind and Life Institute
  4. Florida State University Council on Research and Creativity

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Identification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services. Given that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency heart rate variability (HFHRV) and alcohol attentional bias (AB) as potential relapse risk indices. Alcohol-dependent patients in long-term residential treatment who had participated in mindfulness-oriented therapy or an addiction support group completed a spatial cueing task as a measure of alcohol AB and an affect-modulated alcohol cue-reactivity protocol while HFHRV was assessed. Post-treatment HFHRV cue-reactivity and alcohol AB significantly predicted the occurrence and timing of relapse by 6-month follow-up, independent of treatment condition and after controlling for alcohol dependence severity. Alcohol-dependent patients who relapsed exhibited a significantly greater HFHRV reactivity to stress-primed alcohol cues than patients who did not relapse. Cue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings.

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