Article
Biochemistry & Molecular Biology
Khian Giap Lim, Rajavel Varatharajan, Arunachalam Muthuraman
Summary: This study investigated the beneficial effects of beta-carotene on diabetes-associated vascular dementia and its antioxidative actions. Beta-carotene treatment improved cognitive function and reduced oxidative stress markers in rats with diabetic vascular dementia.
Article
Pharmacology & Pharmacy
Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komaki
Summary: This study investigated the effects of minocycline on cognitive abilities, antioxidant enzyme activities, neuronal loss, and plaque number in rats with Alzheimer's disease induced by Aβ. The results showed that minocycline improved anxiety behavior, restored learning and memory deficits, and had antioxidant and anti-apoptotic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jagadeesh Dhamodharan, Ganthimathy Sekhar, Arunachalam Muthuraman
Summary: This study aimed to explore the ameliorative potential of gefitinib (GE) in Alzheimer's disease (AD) mice. The results showed that GE significantly improved AD-associated behavioral, biochemical, and histopathological changes by inhibiting EGFR kinase activation and having antioxidant and antilipid peroxidative effects against A beta(1-42) oligomer-induced neurotoxicity.
Article
Pharmacology & Pharmacy
Atinderpal Kaur, Kuldeep Nigam, Amit Tyagi, Shweta Dang
Summary: Memantine-encapsulated polymeric nanoparticles were prepared and studied for their potential in treating Alzheimer's disease. The nanoparticles exhibited sustained release, no cytotoxicity, and high drug uptake, demonstrating their efficacy in inhibiting spatial memory impairment.
Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Pharmacology & Pharmacy
Rodolfo Baldinotti, Mariana G. Fronza, Jenifer Fetter, Luana Silva, Camila Bonemann Bender, Diogo Seibert Ludtke, Fabiana K. Seixas, Tiago Collares, Diego Alves, Lucielli Savegnago
Summary: In an AD mouse model, pre-treatment with OSX was found to alleviate cognitive and memory decline induced by STZ, attributed to the prevention of lipid peroxidation and modulation of acetylcholinesterase and monoamine oxidase activities in cerebral cortices and hippocampi. Additionally, OSX treatment demonstrated reduction of amyloidogenic pathway genes expression when compared to the control groups.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Maryam Sajjadi, Ehsan Oskoueian, Ehsan Karimi, Mahdi Ebrahimi
Summary: The root extract of Amygdalus spinosissima plant contains bioactive phenolic and flavonoid compounds with antioxidant and anti-inflammatory properties, improving learning and memory function in mice. This extract shows promising potential in retarding the development of neurodegenerative diseases such as Alzheimer's disease.
METABOLIC BRAIN DISEASE
(2021)
Article
Biology
Debby Van Dam, Femke Valkenburg, Kristof Van Kolen, Isabel Pintelon, Jean-Pierre Timmermans, Peter Paul De Deyn
Summary: The tau protein dysfunction is a core feature of neurodegenerative diseases, and mouse models expressing mutated tau protein associated with FTDP-17 can mimic some aspects of the disease. Our study demonstrates the validity of these models in replicating the pathology and symptoms of FTDP-17.
Article
Engineering, Chemical
Khian Giap Lim, Arunachalam Muthuraman
Summary: This study evaluated the ameliorative effect of beta-carotene in a rat model of diabetic vascular dementia. The results showed that beta-carotene improved cognitive function and normalized neurotransmitter changes, suggesting its potential as a therapeutic agent for the management of vascular dementia.
Article
Behavioral Sciences
Niklas Lonnemann, Martin Korte, Shirin Hosseini
Summary: Alzheimer's disease is a neurodegenerative disease with no successful treatment. In addition to its features, neuroinflammatory processes, genetic factors, and lifestyle also play important roles. Training in a water maze has shown positive effects on memory formation in AD mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Behavioral Sciences
Zhenrong Xiong, Xinming Li, Dejiang Yang, Chongyu Xiong, Qinggang Xu, Qi Zhou
Summary: This systematic review and meta-analysis indicates that cataract may be associated with cognitive impairment in older adults. However, the causal relationship between cataract and cognition remains unclear and requires further investigation.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Zuchen Wei, Yuanji Wang, Zhenxing Shi, Nong Zhou, Guixing Ren, Xiyu Hao, Liang Zou, Yang Yao
Summary: Early undernutrition is associated with neurodevelopmental deficits, but a mung bean protein diet (MBPD) has been shown to reverse these effects by modulating gut microbiota and improving central nervous system functions. MBPD supplementation upregulates key neurotrophic factors and synaptic proteins while downregulating inflammatory pathways, indicating its potential therapeutic value for cognitive dysfunction.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Stephanie Sutoko, Akira Masuda, Akihiko Kandori, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Tsukasa Funane
Summary: Research classified mice with a high risk of AD at a preclinical stage based on their behaviors, using machine learning to identify AD risk early on, with a focus on compulsive and learning behaviors.
Article
Pharmacology & Pharmacy
Virendra Tiwari, Jitendra Singh, Priya Tiwari, Swati Chaturvedi, Shivangi Gupta, Akanksha Mishra, Sonu Singh, Muhammad Wahajuddin, Kashif Hanif, Shubha Shukla
Summary: In this study, the role of the ACE2/Ang-(1-7)/Mas receptor axis in Alzheimer's disease (AD) was investigated using various methods. The results showed that activation of this axis could improve cognitive impairment and amyloid deposition in an AD-like rat model. These findings suggest the potential involvement of the ACE2/Ang-(1-7)/Mas axis in the pathophysiology of AD by regulating inflammation and cognitive functions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Behavioral Sciences
M. Taheri, S. H. Oryan, D. Eslimi Esfahani, H. Mohseni Kouchesfahani, A. Salari
Summary: The hydroalcoholic extract of Artemisia absinthium shows significant improvement in spatial memory and neuronal injury in a rat model of Alzheimer's disease, reducing amyloid-beta plaques and apoptosis.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Neurosciences
Poonam Sharma, G. T. Kulkarni, Bhupesh Sharma
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study found that papaverine can improve behavioral deficits related to autism spectrum disorder in rats with hyperserotonemia, and has significant effects on neuronal function, brain inflammation, and brain oxidative stress.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Clinical Neurology
Prabhat Singh, Bhupesh Sharma
Summary: Stroke is associated with cerebral ischemia/reperfusion injury. Ischemic postconditioning (IPoC) has been shown to reduce cerebral ischemic injury and offer neuroprotection in rats. The research demonstrated that IPoC may provide neuroprotection against cerebral I/R induced brain injury by modulating the histaminergic-H-1-receptor pathway.
CURRENT NEUROVASCULAR RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: This study investigated the effects of a PDE10A inhibitor, papaverine, on core phenotypes of ASD in a Pre-VPA model in rats. Papaverine administration improved social behavior, anxiety, locomotion, and nociception, while also impacting protein markers associated with neuronal function. The findings suggest that targeting PDE10A could be a potential strategy for further understanding ASD phenotypes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Developmental Biology
Niti Sharma, Neerupma Dhiman, Lalit K. Golani, Bhupesh Sharma
Summary: ADHD is a neurodevelopmental disorder with complex etiology, and PDE10A has been implicated as a potential target for further understanding its phenotypes. Administration of the PDE10A inhibitor papaverine improved hyperactivity, inattention, and anxiety in an ADHD model, possibly by altering protein markers associated with neuronal function and brain inflammation.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Neerupma Dhiman, Rajendra Awasthi, Bhupesh Sharma, Harsha Kharkwal, Giriraj T. Kulkarni
Summary: Nanotechnology has significantly impacted industries like pharmaceuticals, biotechnology, food, and cosmetics, especially in improving the solubility and bioavailability of lipophilic drugs. Various nanotechnology-based drug delivery systems, such as solid lipid nanoparticulate drug delivery systems and emulsion-based nanodrug delivery systems, play crucial roles in the targeted delivery of poorly soluble drugs. This review provides a comprehensive overview of lipid nanoparticles as carriers of bioactive molecules, covering aspects like synthesis, characterization, advantages, disadvantages, toxicity, and applications in the medical field. Recent developments in patents and clinical trials related to solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) are also discussed.
FRONTIERS IN CHEMISTRY
(2021)
Article
Behavioral Sciences
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: Vinpocetine, a PDE1 inhibitor, ameliorated ASD-associated symptoms in rats prenatally exposed to VPA, possibly by improving neuronal function, brain inflammation, and oxidative stress. This study suggests PDE1 as a potential new pharmacological target for ASD treatment.
Article
Pharmacology & Pharmacy
Kanishk Luhach, Giriraj T. Kulkarni, Vijay P. Singh, Bhupesh Sharma
Summary: The study showed that cilostazol could alleviate prenatal VPA exposure-related hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety, while significantly increasing biochemical markers such as BDNF, pCREB, IL-10, and GSH in the assessed brain regions.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Neurosciences
Poonam Sharma, Prachi Kaushik, Swati Jain, Brij Mohan Sharma, Rajendra Awasthi, Giriraj Thirupathirao Kulkarni, Bhupesh Sharma
Summary: The study found that UTI and SUL, either alone or in combination, significantly alleviated impairments in behavioral, endothelial, and biochemical parameters induced by STZ-diabetes in rats modulating vascular dementia.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Neurosciences
Hariom Kumar, G. T. Kulkarni, Vishal Diwan, Bhupesh Sharma
Summary: Propionic acid may lead to symptoms of autism, and the modulation of intracellular calcium regulation by propionic acid and its interaction with neurodevelopmental pathways are important mechanisms to be explored.
BASIC AND CLINICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Poonam Sharma, Nikita Gaur, Shalini Jayant, B. M. Sharma, Bhagwat Singh, Harsha Kharkwal, Bhupesh Sharma
Summary: The study found that ulinastatin and quercetin alone or in combination can significantly attenuate the damage caused by hypertension-induced endothelial dysfunction and vascular dementia.
PHARMACOLOGICAL REPORTS
(2022)
Article
Substance Abuse
Niti Sharma, Kanishk Luhach, Lalit K. Golani, Bhagwat Singh, Bhupesh Sharma
Summary: The study found that administration of the PDE1 inhibitor vinpocetine to prenatal alcohol exposure (PAE) rat offspring resulted in improved behavioral profiles and increased levels of cerebral health markers, while reducing inflammation and oxidative stress. This suggests that the PDE1 enzyme may be an important pharmacological tool to study ADHD as a result of PAE.
Article
Food Science & Technology
Nouratan Singh, Poonam Rani, Neeraj Tandan, Dinesh Kumar Arya, Ansuman Mahato
Summary: An Ultra-High-Performance Liquid Chromatography (UHPLC) method was developed and validated for the analysis of 16 PAH compounds in soil samples from Manesar, India. The study found that PAH concentrations were highest in the winter season in industrial areas, while the lowest levels were observed during the monsoon season. The PAH levels in Manesar were relatively lower compared to Brazil, UK, Germany, and Korea.
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2022)
Article
Neurosciences
Hariom Kumar, Vishal Diwan, Bhupesh Sharma
Summary: The study investigated the effects of nimodipine on behavior and biochemistry in prenatal valproic acid-induced autism in rats. The results showed that nimodipine attenuated the reduction in social behavior, inflammation, and blood brain barrier permeability induced by prenatal valproic acid administration, suggesting its potential in the treatment of autism.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Mathematical & Computational Biology
Poonam Rani, Nouratan Singh, Monika Bhaskar, Neeraj Tandan
Summary: This study surveyed the microbial community and their antibiotic profiling in the domestic environment of rural and urban areas in Meerut city, India. The results revealed a higher bacterial load compared to fungal load, with kitchens being more contaminated than living rooms. The dominant bacteria were Pseudomonas sps, Citrobacter sps, Bacillus Subtilis, Brevundimonas diminuta, Bacillus megaterium, and Klebsiella pneumoniae. Antibiotic resistance was mainly derived from plasmids.