Article
Multidisciplinary Sciences
Zilong Gao, Hanqing Wang, Chen Lu, Tiezhan Lu, Sean Froudist-Walsh, Ming Chen, Xiao-Jing Wang, Ji Hu, Wenzhi Sun
Summary: Our study found that the activity of dopaminergic neurons in the ventral tegmental area steadily increases during the waiting period, and optical manipulation of these neurons can extend or reduce waiting time. The reinforcement learning model we developed can explain our experimental observations, supporting the hypothesis that delayed gratification involves real-time deliberation.
Article
Psychology, Multidisciplinary
Afework Tsegaye, Cuiling Guo, Renata Cserjesi, Leon Kenemans, Gijsbert Stoet, Gyongyi Kokonyei, Alexander Logemann
Summary: The study found that smokers showed reduced inhibitory control in contexts of reward, leading to faster response times, indicating an enhanced approach bias to reward-related stimuli. This suggests that smokers may have difficulty in controlling their impulses in rewarding situations, possibly due to heightened sensitivity to rewards.
BEHAVIORAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sarah D. Lichenstein, Dustin Scheinost, Marc N. Potenza, Kathleen M. Carroll, Sarah W. Yip
Summary: The study identified an opioid abstinence network characterized by specific brain connections associated with substance use treatment response. These findings could lead to the development of personalized treatment approaches and predicting treatment outcomes. The anatomical substrates of opioid vs. cocaine abstinence were found to be distinct, suggesting the potential for novel opioid-specific treatment approaches in combating the opioid epidemic.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Qian Lv, Miao Zhang, Haifeng Jiang, Yilin Liu, Shaoling Zhao, Xiaomin Xu, Wenlei Zhang, Tianzhen Chen, Hang Su, Jiangtao Zhang, Heqiu Wang, Jianmin Zhang, Yuanjing Feng, Yongqiang Li, Biao Li, Min Zhao, Zheng Wang
Summary: Elevated impulsivity is commonly observed in individuals receiving methadone maintenance therapy (MMT) for opioid addiction. This study aimed to understand the underlying neural mechanisms and cognitive subprocesses associated with this impulsivity. The results showed that individuals receiving MMT exhibited higher self-reported impulsivity and had a tendency for impulsive decision-making without available evidence. The impulsive decision bias was associated with the dose and duration of methadone use, rather than the duration of heroin use. Furthermore, the hypoactivation in the left rostral middle frontal gyrus during a decision-making task was correlated with the impulsive decision bias. The findings suggest that elevated impulsivity in individuals receiving MMT is driven by deficits in top-down cognitive control, rather than reward sensitivity.
Article
Biochemistry & Molecular Biology
Michelle Ren, Shahrdad Lotfipour
Summary: Communication between the brain and gut bacteria affects drug and addiction behaviors. Researchers investigated the impact of gut microbiota on fentanyl reinforcement and reward by depleting gut bacteria in adult male and female rats using antibiotics and allowing them to self-administer fentanyl. The results showed that antibiotic treatment increased fentanyl self-administration in males, but not females, at the lowest reinforcement schedule. Both males and females treated with antibiotics self-administered higher amounts of fentanyl at higher reinforcement schedules. Replenishing microbial metabolites restored normal fentanyl self-administration levels, indicating a significant relationship between gut microbiome and opioid use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Substance Abuse
Wenhan Yang, Shicong Wang, Ziqiang Shao, Ru Yang, Fei Tang, Jing Luo, Cui Yan, Jun Zhang, Jiyuan Chen, Jun Liu, Kai Yuan
Summary: The study found that heroin-dependent individuals (HDIs) exhibited decreased structural connectivity of the striatum-medial orbitofrontal cortex circuit and higher impulsivity. These findings suggest that the striatal circuit tract strengths might be a novel potential biomarker in heroin and, potentially, general opioid addiction.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Biochemistry & Molecular Biology
Brianna E. George, Monica H. Dawes, Emily G. Peck, Sara R. Jones
Summary: Chronic heroin exposure leads to low dopamine levels in the nucleus accumbens and alterations in dopamine release dynamics, which may contribute to increased heroin seeking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
David De Sa Nogueira, Romain Bourdy, Rafael Alcala-Vida, Dominique Filliol, Virginie Andry, Yannick Goumon, Jean Zwiller, Pascal Romieu, Karine Merienne, Mary C. Olmstead, Katia Befort
Summary: This study investigated the long-term adaptations induced by cocaine self-administration, including transcriptional modifications and associated epigenetic processes. The results suggest that the endogenous cannabinoid system may play a role in this process, and highlight the key role of the hippocampus in cocaine-induced plasticity.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Psychiatry
Diana Mejia Cruz, Laurent Avila Chauvet, Luis Villalobos-Gallegos, Christian Gabriel Toledo-Lozano
Summary: Sexual addiction is associated with serious health problems. This study conducted a cross-cultural adaptation of the Sex Addiction Screening Test (SAST-R) on the Mexican population. The Mexican Spanish version of the SAST-R was found to have good psychometric properties and can be used in future research.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Yachao Rong, Ningxuan Chen, Jiarui Dong, Qi Li, Xiaodong Yue, Li Hu, Ping Wei
Summary: The current study used a modified task to investigate the neural mechanisms involved in anticipating and receiving immediate or delayed rewards, as well as how pursuing these rewards affects cognitive task performance. The findings suggest that immediate rewards are associated with the fastest behavioral responses and the strongest neural activity, followed by delayed rewards, while no rewards are associated with the slowest behavioral responses and the weakest neural activity. Additionally, expectations related to specific neural activities predicted behavioral performance, particularly in the context of immediate rewards.
Article
Multidisciplinary Sciences
Xiaohui Bai, Kun Zhang, Chaopeng Ou, Yanyu Mu, Dongmei Chi, Jianxing Zhang, Jingxiu Huang, Xile Li, Yingjun Zhang, Wan Huang, Handong Ouyang
Summary: This study found that the expression of AKAP150 in the NAc is upregulated during morphine withdrawal, and inhibiting AKAP150 has a positive effect on alleviating withdrawal symptoms and improving test performance. AKAP150 in NAc D1R-MSNs is related to the performance of morphine withdrawal tests, while AKAP150 in NAc D2R-MSNs is relevant to the severity of physical responses.
Article
Neurosciences
Dillon J. McGovern, Abigail M. Polter, Emily D. Prevost, Annie Ly, Connor J. McNulty, Bodhi Rubinstein, David H. Root
Summary: A three-neuron model of VTA opioid function has been discovered, involving a mu-opioid receptor gated VTA glutamate neuron pathway to VTA dopamine neurons. These glutamate-Mu opioid receptor neurons are distributed in the anterior VTA, while the majority of VTA mu-opioid receptor neurons are GABAergic neurons in the posterior VTA. Optogenetic stimulation of VTA glutamate neurons can induce excitatory currents in VTA dopamine neurons, regulated by the mu-opioid receptor.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemical Research Methods
Leslie A. A. Ramsey, Fernanda M. M. Holloman, Samantha S. S. Lee, Marco Venniro
Summary: Little is known about the contribution of social factors to neurobiology or neuropsychiatric disorders. This study compares the social self-administration and choice behavior of female adolescent and adult C57BL/6 mice and outbred CD1 mice, finding that CD1 mice show stronger social self-administration and social seeking compared to C57BL/6J mice. The study introduces a new method for studying operant social reward in mice.
Review
Clinical Neurology
Chloe Kidd, Natalie J. Loxton
Summary: Adolescence is characterized by heightened reward drive and weaker inhibitory control, which may increase vulnerability to compulsive overconsumption of highly-palatable foods and food addiction. Impulsivity traits (reward sensitivity and rash impulsivity) were found to be associated with food addiction in adolescents, with mixed relationships between reward sensitivity and food addiction. Longitudinal and prospective research is recommended to further confirm these findings and investigate potential interactive effects of reward sensitivity and rash impulsivity.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Wenhui Li, Jin Huang, Nan Zhang, Kathrin Weidacker, Jun Li, Valerie Voon, Chuansheng Wang, Chencheng Zhang
Summary: The present study investigates whether patients with opioid use disorder on chronic methadone maintenance therapy exhibit abnormal attentional bias to drug and negative-affective cues. The results show that these patients have normalized attentional bias to both types of cues. Furthermore, the duration of methadone treatment and impulsivity level were found to affect the attentional avoidance of negative-affective cues in patients.
FRONTIERS IN PSYCHIATRY
(2022)
Correction
Multidisciplinary Sciences
Joshua Obermayer, Antonio Luchicchi, Tim S. Heistek, Sybren F. de Kloet, Huub Terra, Bastiaan Bruinsma, Ouissame Mnie-Filali, Christian Kortleven, Anna A. Galakhova, Ayoub J. Khalil, Tim Kroon, Allert J. Jonker, Roel de Haan, Wilma D. J. van de Berg, Natalia A. Goriounova, Christiaan P. J. de Kock, Tommy Pattij, Huibert D. Mansvelder
NATURE COMMUNICATIONS
(2020)
Article
Medicine, Research & Experimental
Jasper A. Heinsbroek, Taco J. De Vries, Jamie Peters
Summary: This review discusses the mechanisms by which glutamate, dopamine, and opioid signaling interact to mediate the primary rewarding effects of opioids, and covers the glutamatergic systems and circuits that mediate the expression, extinction, and reinstatement of opioid seeking over the course of opioid addiction.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Esther Visser, Mariana R. Matos, Rolinka J. van der Loo, Nathan J. Marchant, Taco J. de Vries, August B. Smit, Michel C. van den Oever
Article
Substance Abuse
Tommy Pattij, Yvar van Mourik, Leontien Diergaarde, Taco J. de Vries
DRUG AND ALCOHOL DEPENDENCE
(2020)
Correction
Medicine, Research & Experimental
Jasper A. Heinsbroek, Taco J. De Vries, Jamie Peters
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2020)
Review
Behavioral Sciences
Maria Nalberczak Skora, Tommy Pattij, Anna Beroun, Georgios Kogias, Dirk Mielenz, Taco de Vries, Kasia Radwanska, Christian P. Mueller
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Biochemical Research Methods
Antonio Luchicchi, Tommy Pattij, John Noel M. Viana, Sybren de Kloet, Nathan Marchant
Summary: There has been significant progress in understanding brain function over the last century, with the use of viral vectors playing a crucial role in the development of techniques like optogenetics and chemogenetics. The introduction of adeno-associated virus and the retrograde tracer canine-associated-2 Cre virus have been pivotal in achieving optimal visualization and interrogation of chemically-specific neuronal populations and projections.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Review
Nutrition & Dietetics
Janette de Goede, Kerstin G. van der Mark-Reeuwijk, Kees P. Braun, Saskia le Cessie, Sarah Durston, Rutger C. M. E. Engels, Anna E. Goudriaan, Karel G. M. Moons, Wilma A. M. Vollebergh, Taco J. de Vries, Reinout W. Wiers, Jaap Oosterlaan
Summary: Alcohol consumption in young people may negatively affect brain function and development, including abnormal gray matter development and increased risk of alcohol use disorder. Current evidence on white matter, brain activity, cognitive function, and educational achievement remains limited or unclear.
ADVANCES IN NUTRITION
(2021)
Article
Multidisciplinary Sciences
Sybren F. de Kloet, Bastiaan Bruinsma, Huub Terra, Tim S. Heistek, Emma M. J. Passchier, Alexandra R. van den Berg, Antonio Luchicchi, Rogier Min, Tommy Pattij, Huibert D. Mansvelder
Summary: The study identifies four distinct populations of prefrontal neurons projecting to different sub-regions of the striatum and thalamus, each playing a discrete role in the regulation of cognitive control. Dorsal and ventral mPFC circuits exhibit differential synaptic inputs to postsynaptic striatal and thalamic neurons, potentially amplifying distinct pathways underlying cognitive control. Chemogenetic silencing of specific mPFC projections to thalamic subregions oppositely regulate cognitive control, highlighting the complex mechanisms involved in behavior regulation.
NATURE COMMUNICATIONS
(2021)
Article
Neuroimaging
Antonia Kaiser, Liesbeth Reneman, Paul J. Lucassen, Taco J. de Vries, Anouk Schrantee, Anne Marije Kaag
Summary: The study examined the neural mechanisms underlying the interaction between working memory (WM) and emotional reactivity (ER) in adult ADHD participants, finding that taxing WM reduced reactivity to emotional stimuli in heavy drinkers but did not affect neural correlates of ER in ADHD participants. No impairments in WM or ER were found in the ADHD group, possibly due to the relatively unimpaired ADHD population and well-matched control group. Further investigation is needed to determine if targeting WM may be effective in participants with severe ER impairments in ADHD.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Elham Alaee, Parisa Moazen, Tommy Pattij, Saeed Semnanian, Hossein Azizi
Summary: Prenatal exposure to morphine has lasting effects on cognitive abilities and inhibitory control in offspring, leading to deficits in task learning and attention in adult life.
PSYCHOPHARMACOLOGY
(2021)
Review
Behavioral Sciences
Marianne Amalric, Tommy Pattij, Ioannis Sotiropoulos, Joana M. Silva, Nuno Sousa, Samira Ztaou, Cristiano Chiamulera, Lars U. Wahlberg, Dwaine F. Emerich, Giovanna Paolone
Summary: Historically, studies on neurodegenerative diseases have largely examined alterations in specific neuronal populations, but it is becoming increasingly clear that the integrity of multiple interconnected neuronal circuits regulates various brain activities in mammals. The dopaminergic and cholinergic systems play crucial roles in orchestrating cognitive and non-cognitive symptoms in PD and AD.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biology
Hussein Ghareh, Isis Alonso-Lozares, Dustin Schetters, Rae J. Herman, Tim S. Heistek, Yvar Van Mourik, Philip Jean-Richard-dit-Bressel, Gerald Zernig, Huibert D. Mansvelder, Taco J. De Vries, Nathan J. Marchant
Summary: This study shows the critical role of environmental contexts in promoting nicotine relapse and the importance of aIC activity in context-induced relapse.
Article
Neurosciences
Ruey-Ming Liao, Tommy Pattij
Summary: This article reviews early and recent experiments using brain lesions and drug infusions to investigate the neural substrates and neuropharmacological basis of differential reinforcement of low-rate response (DRL) behavior. The findings suggest that certain cortical and subcortical areas are involved in DRL behavior and disruption of dopamine or serotonin neurotransmission can alter this behavior.
BRAIN RESEARCH BULLETIN
(2022)
Correction
Biochemistry & Molecular Biology
Lisa Genzel, Roger Adan, Anton Berns, Jeroen J. J. P. van den Beucken, Arjan Blokland, Erik H. W. G. M. Boddeke, Willy M. Bogers, Ronald Bontrop, R. Bulthuis, Teun Bousema, Hans Clevers, Tineke C. J. J. Coenen, Anne-Marie van Dam, Peter M. T. Deen, K. W. van Dijk, Bart J. L. Eggen, Ype Elgersma, Izel Erdogan, Bernhard Englitz, J. Martje Fentener van Vlissingen, Susanne la Fleur, Ron Fouchier, Carlos P. Fitzsimons, Wilbert Frieling, Bart Haagmans, Balthasar A. Heesters, Marloes J. A. G. Henckens, Sander Herfst, Elly Hol, Daniel van den Hove, Marien I. de Jonge, Jos Jonkers, Leo A. B. Joosten, Andries Kalsbeek, Maarten Kamermans, Harm H. Kampinga, Martien J. Kas, Jaap Keijer, Sander Kersten, Amanda J. Kiliaan, Taco W. A. Kooij, Sander Kooijman, Werner J. H. Koopman, Aniko Korosi, Harm J. Krugers, Thijs Kuiken, Steven A. Kushner, Jan A. M. Langermans, Heidi M. B. Lesscher, Paul J. Lucassen, Esther Lutgens, Mihai G. Netea, Lucas P. J. J. Noldus, Jos W. M. van der Meer, Frank J. Meye, Joram D. Mul, Kees van Oers Jocelien D. A. Olivier, R. Jeroen Pasterkamp, Ingrid H. C. H. M. Philippens, Jos Prickaerts, B. J. A. Pollux, Patrick C. N. Rensen, Jacco van Rheenen, Ronald P. van Rij, Laila Ritsma, Barry. H. G. Rockx, Benno Roozendaal, Evert M. van Schothorst, K. Stittelaar, Norbert Stockhofe, Dick F. Swaab, Rik L. de Swart, Louk J. M. J. Vanderschuren, Taco J. de Vries, Femke de Vrij, Richard van Wezel, Corette J. Wierenga, Maximilian Wiesmann, Ingo Willuhn, Chris I. de Zeeuw, Judith R. Homberg