Article
Chemistry, Analytical
Xiangtang Li, Hang Hu, Julia Laskin
Summary: In this study, a new integrated microfluidic probe (iMFP) was developed for high spatial resolution imaging of biological samples. The new probe design increased the robustness and throughput of imaging, making it suitable for high-resolution imaging of large tissue sections. This technology is important for understanding biological systems.
ANALYTICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Junyu Chen, Unnikrishnan Sivan, Sin Lih Tan, Luciana Lippo, Jessica De Angelis, Rossella Labella, Amit Singh, Alexandros Chatzis, Stanley Cheuk, Mino Medhghalchi, Jesus Gil, Georg Hollander, Brian D. Marsden, Richard Williams, Saravana K. Ramasamy, Anjali P. Kusumbe
Summary: Blood vessels play a crucial role in supporting tissue functions, but age-associated vascular changes and their connection to tissue aging remains poorly understood. Vessel density and pericyte numbers decline with age in multiple organs, except highly remodeling tissues like the skin which preserve their vasculature. Molecular changes in the endothelium drive vascular loss and influence pericyte to fibroblast differentiation.
Article
Engineering, Electrical & Electronic
Dan Yi, Hon Ki Tsang
Summary: In this paper, a fully integrated high-resolution and broadband two-stage spectrometer based on a multimode waveguide (MMW) is proposed and experimentally tested. The spectrometer utilizes MMW to enhance resolution and integrated photodiodes for a fully integrated solution. Experimental results show that the spectrometer has high spectral resolution and a large optical bandwidth, and can successfully reconstruct both sparse and continuous spectra.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2022)
Article
Optics
Siyuan Shen, Suning Li, Yuan Yuan, Heping Tan
Summary: Polarization-imaging technology based on metalenses has important applications in various fields. However, currently designed metalens arrays for full-Stokes polarization imaging can only be used for monochromatic detection, limiting the amount of measured information. To achieve broad-spectrum polarization imaging, we propose and design a metalens array that can achieve full-Stokes polarization imaging in the broadband visible range. Evaluation: 8/10
Article
Engineering, Electrical & Electronic
Zhile Han, Ninghao Wang, Xinle Zhu, Zhangjian Li, Yaoyao Cui, Xiaohua Jian
Summary: A high-frequency rotary ultrasonic encoder with cylinder gratings was developed to fix NURD and obtain high quality restored image dynamically. The miniature encoder with a diameter of 3 mm and resolutions up to 64 pulses per revolution is demonstrated as the smallest and highest frequency rotary ultrasonic encoder reported, showing great potential for ultrasonic endoscopy, OCT, and other mechanical scanning imaging.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Analytical
Yen-Lung Chen, Huihua Kenny Chiang
Summary: Handheld ultrasound has the potential to improve healthcare in resource-limited areas. This study developed a dual-element ultrasound transducer combined with an optical position tracker, which improved signal contrast and reduced noise. The custom-made device enables continuous scanning without limitations and could popularize medical care in remote villages.
Article
Optics
Qinghua Yang
Summary: The B-2HSR-FIS is a flexible imaging spectrometer that combines high spatial and spectral resolution, broadband spectral range, and moderate field angle, making it a powerful tool for applications like vision intelligence in robotics.
Article
Optics
Xiaoxue Chen, Shangyuan Li, Luhang Xing, Jinghan Yu, Xiaoxiao Xue, Xiaoping Zheng
Summary: This paper presents a broadband photonic beam processor for the all-optical multifunction integrated receiver. By implementing echo signals with optical beam multi-domain processing based on space-to-time mapping and time-to-frequency mapping, the non-mechanical control of expected beam pointing is enabled while the target within the beam can be imaged simultaneously.
Article
Optics
Jiaying Xiao, Jinsheng Jiang, Jiaxi Zhang, Yongjun Wang, Bo Wang
Summary: The study of molecular photoacoustic endoscopic imaging in deep tissues is limited due to technical difficulties. In this work, a multimodal acoustic-resolution-based PAE system was set up to image the rabbit rectum and explore the potential of molecular PAE for deep-seated targets. The results show that the system has achieved high resolution and signal-to-noise ratio at an imaging depth of 1.4 cm, and can distinguish the rectum wall and indocyanine green.
Article
Optics
Qi Zhang, Chaoneng Wu, Kai Long, Cheng Huang, Xiaoxuan Zhong, Xue Bai, Linghao Cheng, Long Jin, Yizhi Liang, Bai-Ou Guan
Summary: All-optical ultrasound enables ultrasound imaging using laser and photonics technologies. A rotational-scanning probe with a small laser sensor is used for in vivo endoscopic imaging. This approach provides stable ultrasound responses and is immune to low-frequency disturbances.
Article
Ophthalmology
Diogo Cabral, Ana C. Fradinho, Telmo Pereira, Meera S. Ramakrishnan, Tommaso Bacci, Dong An, Sandra Tenreiro, Miguel C. Seabra, Chandrakumar Balaratnasingam, K. Bailey Freund
Summary: The study characterizes macular blood flow connectivity in humans using high-resolution OCT, revealing a hybrid circuitry of blood flow in the parafoveal macula. This has implications for understanding the vascular structure and function in the macula region.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Jun Wan, Shaofu Xu, Weifan Weng, Yang Zhao, Linda Shao, Weiwen Zou
Summary: We propose and demonstrate a high-resolution single-antenna three-dimensional microwave imaging scheme, which combines the spatial decoupling capabilities of Hadamard modulation and the broadband characteristics of optical receivers. It has been experimentally demonstrated that our scheme can achieve high-resolution 3D imaging resolution without scanning, and successfully image an unmanned aerial vehicle-shaped target. The measurement shows that the 3D image can obtain a resolution of better than 4 cm in all dimensions. This method is expected to greatly promote the application of high-resolution microwave 3D imaging in complex and changing scenarios with limited equipment.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2023)
Article
Chemistry, Physical
Fei Wang, Shuming Yang, Shaobo Li, Shuhao Zhao, Biyao Cheng, Chengsheng Xia
Summary: This study successfully obtained high-order near-field optical signals using a platinum-coated optical probe (Pt-Si probe), leading to improved imaging results.
Article
Chemistry, Analytical
Hongyu Chen, Xiangyi Kong, Dongrui Wang, Meiqin Zhang
Summary: This study presents a simple and universal strategy for fabricating flexible platinum disk ultramicroelectrodes. The preparation procedure is highly efficient and allows for adjustable performance parameters. The flexible probe can be reused in multiple experiments and its flexibility and electrochemical properties can be optimized. It shows great potential for various applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Optics
Shulang Lin, Li Gong, Zhiwei Huang
Summary: This article reports a novel two-photon fluorescence tomography (TPFT) technique that enables super-resolution deeper tissue 3D imaging without the need for z-scanning. By using phase-shifted optical beatings of Bessel beams, the lateral and axial resolutions are improved, and the penetration depth is increased. This method allows for depth-resolved imaging without mechanical depth-scanning.
LASER & PHOTONICS REVIEWS
(2023)
Review
Chemistry, Physical
Ioannis Papakonstantinou, Mark Portnoi, Michael G. Debije
Summary: The luminescent solar concentrator (LSC) has evolved into a versatile photovoltaic solution with potential for integration into various applications beyond electricity generation. With unique spectral manipulation and light distribution properties, LSC is being explored in sensing applications, smart windows, horticulture, and optical communication. Encouraging interdisciplinary involvement in LSC research aims to drive the development of novel technologies inspired by LSC capabilities.
ADVANCED ENERGY MATERIALS
(2021)
Correction
Multidisciplinary Sciences
Pierre Lecointre, Sophia Laney, Martyna Michalska, Tao Li, Alexandre Tanguy, Ioannis Papakonstantinou, David Quere
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Semyon Bodian, Richard J. Colchester, Thomas J. Macdonald, Filip Ambroz, Martha Briceno de Gutierrez, Sunish J. Mathews, Yu Man Mandy Fong, Efthymios Maneas, Kathryn A. Welsby, Ross J. Gordon, Paul Collier, Edward Z. Zhang, Paul C. Beard, Ivan P. Parkin, Adrien E. Desjardins, Sacha Noimark
Summary: Dual-modality imaging using complementary modalities, such as all-optical ultrasound and photoacoustic imaging, is well-suited for guiding minimally invasive surgical procedures. Quantum dots, a promising material for these devices, provide wavelength-selective optical absorption for improved imaging capabilities.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Optics
Richard J. Colchester, Callum D. Little, Erwin J. Alles, Adrien E. Desjardins
Summary: All-optical ultrasound transducers are suitable for imaging during minimally invasive surgical procedures, utilizing a polydimethylsiloxane-dye composite material for ultrasound generation. Different configurations of the transmitters show similar ultrasound beam profiles, capable of generating ultrasound pressures exceeding 2 MPa, and are suitable for integration into small medical devices.
Article
Chemistry, Multidisciplinary
Martyna Michalska, Sophia K. Laney, Tao Li, Manish K. Tiwari, Ivan P. Parkin, Ioannis Papakonstantinou
Summary: By utilizing a versatile fabrication process and controlling the height and diameter of a hard mask, tailored silicon nanostructures can be achieved. The method is scalable and highly controllable, enabling uniform patterning of a 6-inch wafer.
Article
Nanoscience & Nanotechnology
Francisco Ramirez-Cuevas, Kargal L. Gurunatha, Ivan P. Parkin, Ioannnis Papakonstantinou
Summary: This article presents a universal theory of averaged light scattering of randomly oriented objects, providing formulas for the absorption cross section, scattering cross section, and asymmetry parameter for objects of arbitrary shape. The proposed modeling framework is validated against optical measurements of polymer composite films. This work is important for understanding light-matter interactions in disordered systems and has applications in various fields.
Article
Materials Science, Multidisciplinary
India Lewis-Thompson, Shaoyan Zhang, Sacha Noimark, Adrien E. Desjardins, Richard J. Colchester
Summary: All-optical ultrasound (OpUS) imaging is a suitable imaging method for minimally invasive surgical procedures and can be integrated with other imaging and therapeutic modalities. In this study, a wavelength-selective composite material was developed, which can generate high-pressure ultrasound and has long-term photostability and device performance.
Article
Biochemical Research Methods
Richard J. Colchester, Edward Z. Zhang, Paul C. Beard, Adrien E. Desjardins
Summary: This study presents an all-optical ultrasound transducer for highly miniaturised applications. The transducer utilizes a dual-clad optical fibre for multimode light generation and single mode light reception. It demonstrates high-pressure ultrasound generation and reception, high image quality, and unprecedented miniaturisation, representing a new paradigm for minimally invasive imaging.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Chemistry, Multidisciplinary
Martyna Michalska, Alessandro Rossi, Gasper Kokot, Callum M. M. Macdonald, Silvia Cipiccia, Peter R. T. Munro, Alessandro Olivo, Ioannis Papakonstantinou
Summary: This paper presents a method for fabricating high-aspect ratio nanogratings, which have important applications in X-ray imaging. By combining laser interference and nanoimprint lithography, physical vapor deposition, metal assisted chemical etching, and electroplating, the fabrication challenges are overcome. The results show that the fabricated nanogratings have aspect ratios exceeding 40, and they exhibit excellent diffractive abilities when exposed to a hard X-ray beam, suggesting potential applicability in phase-based X-ray imaging.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Optics
Zhijie Xu, Mark Portnoi, Ioannis Papakonstantinou
Summary: An effective method for improving outcoupling efficiency of luminescent solar concentrators (LSCs) was proposed by patterning protruded and extruded micro-cone arrays on the bottom surface of LSCs. Monte Carlo ray tracing estimated a maximum external quantum efficiency (EQE) of 37.73% for the horticulture LSC (HLSC), representing a 53.78% improvement compared to conventional, planar LSCs. Additionally, structured HLSCs provide diffuse light beneficial for plant growth. The micro-patterned surfaces offer a solution to light trapping in LSCs and lay the foundation for practical applications of HLSCs.
Article
Optics
Esra Aytac Kipergil, Eleanor Martin, Sunish J. Mathews, Ioannis Papakonstinou, Erwin J. Alles, Adrien E. Desjardins
Summary: In order to increase the signal-to-noise ratio of fiber-optic hydrophones, a partially reflective coating was added to the fiber end face. Numerical simulation and experimental results confirmed that the coated hydrophone had a higher signal-to-noise ratio in the frequency range of 1 to 30 MHz, and could withstand a peak positive pressure of 35 MPa.
Article
Biochemical Research Methods
Shaoyan Zhang, Semyon Bodian, Edward Z. Zhang, Paul C. Beard, Sacha Noimark, Adrien E. Desjardins, Richard J. Colchester
Summary: This article presents a fiber optic device capable of simultaneous laser interstitial thermal therapy and real-time all-optical ultrasound imaging, which can guide tumor resection.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
India Lewis-Thompson, Edward Z. Zhang, Paul C. Beard, Adrien E. Desjardins, Richard J. Colchester
Summary: All-optical ultrasound (OpUS) is a promising imaging technique that utilizes light to generate and receive ultrasound waves. In this study, a rapid pullback imaging catheter was developed for side-viewing B-mode ultrasound imaging in the upper gastrointestinal tract. The imaging probe achieved high-resolution imaging with ultrasound pressures exceeding 1 MPa and a signal-to-noise ratio (SNR) of 42 dB. Imaging of an ex vivo swine oesophagus demonstrated the potential of OpUS for rapid diagnostics and guidance in clinical settings alongside conventional endoscopy.
BIOMEDICAL OPTICS EXPRESS
(2023)
Proceedings Paper
Acoustics
India Lewis Thompson, Sunish Mathews, Edward Zhang, Paul Beard, Adrien Desjardins, Richard Colchester
Summary: This study demonstrates B-mode all-optical ultrasound imaging using a cost-effective and simple to manufacture composite. The composite is compared with an established ultrasound-generating composite and their imaging resolution and signal-to-noise ratio are evaluated.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Article
Engineering, Biomedical
George Dwyer, Erwin J. Alles, Richard J. Colchester, Keshav Iyengar, Adrien E. Desjardins, Danail Stoyanov
Summary: This paper presents a robotic-assisted scanning solution for optical ultrasound probes, utilizing a concentric tube robot to manipulate the probe along a consistent trajectory and maintaining axial orientation using a torque coil. The integration of scanning mechanism with fibre-based imaging probe improves trajectory repeatability and expands diagnostic field of view.
IEEE TRANSACTIONS ON MEDICAL ROBOTICS AND BIONICS
(2021)
