Article
Psychiatry
Alvaro Cabral Araujo, Nickolas Carui, Alia Garrudo Guirado, Daniela Schiller, Francisco Lotufo Neto, Felipe Corchs
Summary: Delivering ECT after retrieving traumatic memories can enhance the treatment efficacy in PTSD by reducing symptoms and reactivity. Regardless of memory retrieval, the sample as a whole experienced reduction in anxiety, mood symptoms, and physiological reactivity to traumatic memories.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Biological
Lena Jellestad, Thomas Zeffiro, Marco Piccirelli, Jolanda Malamud, Benedikt B. M. Klimke, Katrin Rauen, Michael Rufer, Scott P. Orr, Christoph Mueller-Pfeiffer
Summary: This study examined the efficacy of pursuit eye movements in interfering with the reconsolidation of conditioned fear memories. The results showed that participants who performed pursuit eye movements during the reinstatement phase had significantly reduced fear-conditioned skin conductance responses.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2021)
Article
Neurosciences
Satoshi Kida
Summary: Memory retrieval is a dynamic process that involves reconsolidation, where retrieved memories return to a labile state and are re-stored. This discovery challenges the traditional view of memory consolidation and suggests that memory can be modified through reconsolidation. Extinction, on the other hand, weakens a conditioned fear memory through a new inhibitory learning process. In our research, we investigated the relationship between memory reconsolidation and extinction at behavioral, cellular, and molecular levels, finding that they have opposite effects on fear memory and interact with each other in a memory transition process.
BRAIN RESEARCH BULLETIN
(2023)
Article
Clinical Neurology
Camille Deforges, Deborah Fort, Suzannah Stuijfzand, Emily A. Holmes, Antje Horsch
Summary: This study tested a single-session behavioral intervention for reducing childbirth-related intrusive memories and symptoms of childbirth-related posttraumatic stress disorder (CB-PTSD). The results showed that participants had a significant reduction in the number of intrusive memories and CB-PTSD symptom severity after the intervention. The intervention was highly acceptable to the participants.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Pascal Roullet, Guillaume Vaiva, Etienne Very, Axel Bourcier, Antoine Yrondi, Laetitia Dupuch, Pierre Lamy, Claire Thalamas, Laurence Jasse, Wissam El Hage, Philippe Birmes
Summary: The study demonstrated that using propranolol during traumatic memory reactivation can reduce PTSD symptoms, especially for patients with severe symptoms. However, the post-treatment effect may be influenced by the severity of baseline PTSD symptoms.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Paola Colucci, Alessia Santori, Luca Romanelli, Clemens Zwergel, Antonello Mai, Sergio Scaccianoce, Patrizia Campolongo
Summary: The study found that amphetamine enhances memory consolidation in rats under mild stress conditions, but impairs long-term memory performance in rats exposed to strong stress, depending on the stress-induced activation of the peripheral adrenergic response.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jesus Cudeiro, David Soto, Emilio Gutierrez
Summary: Correlational studies suggest that high temperatures may impair online cognitive performance and learning processes. In this study, it was hypothesized that heat exposure blocks offline memory consolidation. Two studies were conducted, including a pre-registered replication. The results showed that exposure to high temperature impaired recognition memory performance, indicating that heat exposure impairs memory consolidation and might be used for the treatment of clinical mental disorders.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Camille Deforges, Suzannah Stuijfzand, Yvonnick Noel, Moira Robertson, Tone Breines Simonsen, Malin Eberhard-Gran, Susan Garthus-Niegel, Antje Horsch
Summary: The study suggests that N2O administration during childbirth may reduce the severity of subsequent PTSD symptoms, although combining it with severe pain during labor may increase symptoms. A similar trend was observed for morphine. Further investigations are needed to explore the role of severe peritraumatic pain in the context of drug administration.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Vanessa E. Hennessy, Luzia Troebinger, Georges Iskandar, Ravi K. Das, Sunjeev K. Kamboj
Summary: This study provides new insights into the prevention of posttraumatic stress disorder (PTSD). The results indicate that early treatment with hydrocortisone can reduce the frequency of intrusive memories. Sex and sex hormone levels have an impact on the effects of hydrocortisone. These findings provide a basis for incorporating individual endocrinological profiles into the treatment of post-traumatic glucocorticoids to target intrusive memories.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Behavioral Sciences
Tony J. Cunningham, Robert Stickgold, Elizabeth A. Kensinger
Summary: This article reviews the research on the influence of sleep on different stages of emotional memory processing, identifies problematic overlaps in traditional sleep-wake study designs, and highlights areas for future research. It aims to be a valuable resource for hypothesis generation and promote important future research in understanding the relationship between sleep and emotional memory processing.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Claire Mallet, Christina F. Chick, Redwan Maatoug, Philippe Fossati, Alain Brunet, Bruno Millet
Summary: This study investigates the effects of memory reconsolidation therapy with propranolol on the severity of posttraumatic nightmares compared to other symptoms of posttraumatic stress disorder. The results show that the therapy can effectively reduce nightmare severity and is well-tolerated by patients. However, further research is needed to assess the long-term effects of this treatment.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Review
Psychiatry
Amir Assouline, Avi Mendelsohn, Alon Reshef
Summary: Posttraumatic stress disorder (PTSD) is a chronic problem without effective treatment. This paper proposes a model that combines conversation-based technique with acupuncture to improve the clinical condition of PTSD patients. Research shows that acupuncture can have positive effects on neural activity, limbic system activation, and functional connectivity in important brain regions.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Luke J. Ney, Kevin M. Crombie, Leah M. Mayo, Kim L. Felmingham, Tim Bowser, Allison Matthews
Summary: The endocannabinoid system plays an important role in PTSD, and researchers have successfully translated findings from animal studies to human subjects using modern paradigms and methods. This approach offers the potential to gain deeper insights into the impact of endocannabinoid signaling on stress response, emotional and intrusive memories, and fear extinction in PTSD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Livia Maria Bolsoni, Jose Alexandre S. Crippa, Jaime Eduardo Cecilio Hallak, Francisco Silveira Guimaraes, Antonio Waldo Zuardi
Summary: Studies suggest that CBD has anxiolytic properties and may attenuate symptoms induced by recall of traumatic events in individuals with PTSD. This double-blind trial found that CBD in a dosage of 300 mg significantly reduced cognitive impairment associated with trauma recall, with this effect lasting for a week after administration. However, CBD did not significantly affect anxiety, alertness, or discomfort induced by recall, and there were no differences in physiological measures between the CBD and placebo groups.
PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Boyoung Lee, Santosh Pothula, Min Wu, Hyeyeon Kang, Matthew J. Girgenti, Marina R. Picciotto, Ralph J. DiLeone, Jane R. Taylor, Ronald S. Duman
Summary: Researchers tested a novel NMDAR-positive modulator, NYX-783, in rodent models of PTSD and found that it significantly reduced spontaneous recovery and enhanced fear extinction. The study elucidated the cellular targets and molecular mechanisms underlying NYX-783's effects on PTSD symptoms.
MOLECULAR PSYCHIATRY
(2022)
