Article
Biochemistry & Molecular Biology
Kerstin Wolk, Dagmar Wilsmann-Theis, Katrin Witte, Theresa-Charlotte Brembach, Christian Kromer, Sascha Gerdes, Kamran Ghoreschi, Kristian Reich, Rotraut Moessner, Robert Sabat
Summary: This study found elevated levels of interleukin-19 (IL-19) in the blood of palmoplantar pustulosis (PPP) patients. The results also showed that treatment with apremilast (a PDE4 inhibitor) significantly reduced IL-19 levels and improved the condition of PPP patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ling Yu, Huiqian Yu, Shuai Zhang, Yanzhao Hao, Shoumin Zhang
Summary: Alopecia universalis is an autoimmune disorder characterized by non-scarring hair loss in the body, which negatively impacts patient prognosis. CD8+ T cells are believed to cause autoimmune attacks on hair follicles, leading to the collapse of hair follicle immune privilege. Janus kinase inhibitors have the potential to inhibit IFN-gamma and may be a promising treatment option for AU patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Yinping Guo, Qianqian Kong, Yi Zhang, Jing Zhao, Zhiyuan Yu, Dan He, Hao Huang, Xiang Luo
Summary: This study investigated the relationship between cerebral atherosclerotic stenosis (CAS) and acute ischemic stroke (AIS). The results showed that patients with CAS had higher levels of serum RANTES than non-CAS patients, regardless of stroke status. These findings suggest that RANTES may play an important role in the formation of CAS.
Article
Nutrition & Dietetics
Fabricia Geralda Ferreira, Luiza Kuhnen Reitz, Aline Valmorbida, Mariana Papini Gabiatti, Fernanda Hansen, Patricia Faria Di Pietro, Leandro Licursi de Oliveira, Erasmo Benicio Santos de Moraes Trindade, Giana Zarbato Longo
Summary: The study aimed to investigate the association between cytokine levels and metabolic phenotypes, and the results showed that an unhealthy metabolic profile is associated with higher levels of proinflammatory cytokines. Excess weight and metabolic dysregulation are related to inflammation, especially when both conditions are present, possibly due to visceral adiposity.
Article
Physiology
Elizabeth G. Damato, Seth J. Fillioe, Seunghee P. Margevicius, Ryan S. Mayes, Jonathan E. Somogyi, Ian S. Vannix, Alireza Abdollahifar, Anthony M. Turner, Lidia S. Ilcus, Michael J. Decker
Summary: Tactical aviation presents unprecedented physical challenges to aviators, including hypergravity, hyperoxia, increased work of breathing, and profound cognitive workloads. This study found a potential relationship between serum levels of proinflammatory cytokines and the onset of fatigue in aviators.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Michael Maes, Joao Victor Nani, Cristiano Noto, Lucas Rizzo, Mirian A. F. Hayashi, Elisa Brietzke
Summary: The study found that bipolar disorder is associated with simultaneous activation of the immune-inflammatory response system and the compensatory immune-regulatory system, which may be related to the staging of the illness. Immune injuries and HCMV infection in BD patients contribute to dysfunctional CIRS and exaggerated IRS responses, playing a key role in inflammation and neuroaffective toxicity.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Li Wu, Dongyan Liu, Xuhui Fang, Yu Zhang, Nan Guo, Fangting Lu, Joanne Kwak-Kim, Yanshi Wang
Summary: This study aimed to determine whether a high serum level of IL-12 was associated with adverse in vitro fertilization (IVF) outcomes. The results showed that women with high serum IL-12 levels had lower numbers of retrieved oocytes and embryos, lower rates of embryo development, and higher levels of Th1, Th2, and Th17-related cytokines than the control group. Additionally, the follicular fluid IL-12 levels were positively correlated with serum IL-12 levels, and IL-12 promoted apoptosis of granulosa cells in vitro. Therefore, early screening for IL-12 and appropriate consultation for couples receiving IVF-ET should be considered.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Anna Gard, Fredrik Vedung, Fredrik Piehl, Mohsen Khademi, Maria Portonova Wernersson, Ia Rorsman, Yelverton Tegner, Helene Pessah-Rasmussen, Karsten Ruscher, Niklas Marklund
Summary: A sports-related concussion (SRC) often leads to shearing and stretching of axons in the white matter, causing secondary inflammatory processes and persistent post-concussive symptoms (PPCS). In this study, athletes with PPCS showed signs of ongoing neuroinflammation, as indicated by altered profiles of cerebrospinal fluid (CSF) biomarkers. The findings suggest the importance of studying treatments targeting the post-injury inflammatory response in sports-related concussion.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Nutrition & Dietetics
Guiqian Huang, Jiahao Chen, Luqian Zhan, Jingfang Long, Yisi Lin, Beilei Zhu, Jincai He
Summary: This study evaluated the association between vitamin D and sleep quality in patients with acute ischemic stroke (AIS). The results showed that reduced serum levels of vitamin D at admission were independently and significantly associated with poor sleep quality at 1 month after stroke. The combination of vitamin D and depression status could provide important predictive information for post-stroke sleep quality.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Valter Almeida, Isadora Lima, Deborah Fraga, Eugenia Carrillo, Javier Moreno, Washington L. C. dos-Santos
Summary: The study correlated hematological changes in dogs infected with Leishmania infantum with cell lineages and cytokine gene expression patterns in the bone marrow. Dogs with positive splenic cultures had lower red blood cell counts and leukocytosis in peripheral blood, along with increased neutrophils and monocytes. Inflammatory and cytokine gene expression changes in the bone marrow may contribute to the observed hematological changes in visceral leishmaniasis.
Article
Clinical Neurology
Wanying Shan, Liang Xu, Zhuoyin Qiu, Jingwen Wang, Jiaxing Shao, Jie Feng, Jie Zhao
Summary: This study aimed to investigate whether high-mobility group box 1 (HMGB1) levels could predict post-stroke depression (PSD) at 3 months after acute ischemic stroke. The results demonstrated that higher HMGB1 levels in the acute phase of ischemic stroke were associated with an increased risk of PSD, with an optimal cutoff point of 8.6 ng/mL showing good sensitivity and specificity for predicting PSD.
NEUROLOGICAL SCIENCES
(2022)
Article
Psychology, Clinical
Anna P. Mclaughlin, Ellen Lambert, Rebecca Milton, Nicole Mariani, Melisa Kose, Naghmeh Nikkheslat, Olivia Patsalos, Luca Ferraro, Ghassan Chamseddine, Spyros Panagiotopoulos, Avril Chang, Sasindran Ramar, Ameet Patel, Francesco Rubino, Valeria Mondelli
Summary: There is a link between depression and inflammation in the cycle between depression and obesity. Preoperative depression diagnosis may affect weight loss outcomes after surgery.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hetal Bhadricha, Vainav Patel, Amit Kumar Singh, Lalita Savardekar, Anushree Patil, Suchitra Surve, Meena Desai
Summary: The study indicates that the increase in Th17 cell frequency and IL-17 levels in postmenopausal women may be associated with decreased bone density, possibly due to estrogen deficiency. Th17 cells and IL-17 could be potential targets for immunotherapy in the treatment of osteoporosis.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Salman Zeb, Huan Ye, Yuan Liu, Hua-Ping Du, Yi Guo, Yong-Ming Zhu, Yong Ni, Hui-Ling Zhang, Yuan Xu
Summary: The decrease in astrocytes in depressive models may be caused by the activation of necroptotic kinases and astrocytic necroptosis. Treatment with fluoxetine inhibits the activation of receptor-interacting protein kinase 1 and improves depressive-like behaviors.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Otorhinolaryngology
Nikita Chapurin, Ping Li, Rakesh K. Chandra, Justin H. Turner, Naweed I. Chowdhury
Summary: The study retrospectively analyzed prospectively collected data from 231 patients undergoing surgical therapy for CRS, finding that IL-17A levels were significantly correlated with the number of prior sinus surgeries. Other cytokine levels, such as RANTES, were inversely related to the number of surgeries.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Correction
Endocrinology & Metabolism
Ehraz Anis, Aoji Xie, Lena Brundin, Patrik Brundin
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Hasan Cagin Lenk, Robert Lovsletten Smith, Kevin S. O'Connell, Marin M. Jukic, Marianne Kristiansen Kringen, Ole A. Andreassen, Magnus Ingelman-Sundberg, Espen Molden
Summary: This study found that genetic variants in CYP1A and NFIB have a significant impact on the dose requirements and clinical response of clozapine, especially in smokers. Smokers carrying these genetic variants may require higher doses to achieve therapeutic effects.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Psychiatry
Nora R. Bakken, Laurie J. Hannigan, Alexey Shadrin, Guy Hindley, Helga Ask, Ted Reichborn-Kjennerud, Martin Tesli, Ole A. Andreassen, Alexandra Havdahl
Summary: This study examines the association between childhood temperamental traits, emotional and behavioral problems, and adolescent mood and anxiety disorders. The findings show a consistent and increasing relationship between negative emotionality, behavioral and emotional problems in early to middle childhood, and mood and anxiety disorders in adolescence.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Multidisciplinary Sciences
Aili R. Lochen, Knut K. Kolskar, Ann-Marie G. de Lange, Markus H. Sneve, Beathe Haatveit, Trine V. Lagerberg, Torill Ueland, Ingrid Melle, Ole A. Andreassen, Lars T. Westlye, Dag Alnaes
Summary: The objective of this study was to compare visual discrimination performance in patients with schizophrenia spectrum disorder or bipolar disorder with healthy controls, and investigate associations with clinical symptoms and IQ. The results showed that patients with schizophrenia spectrum or bipolar disorders exhibited higher visual discrimination thresholds than healthy controls. Furthermore, there were negative associations between IQ and discrimination threshold among healthy controls and bipolar disorder patients.
Article
Clinical Neurology
Wouter Peelaerts, Gabriela Mercado, Sonia George, Marie Villumsen, Alysa Kasen, Miguel Aguileta, Christian Linstow, Alexandra B. Sutter, Emily Kuhn, Lucas Stetzik, Rachel Sheridan, Liza Bergkvist, Lindsay Meyerdirk, Allison Lindqvist, Martha L. Escobar Gavis, Chris van den Haute, Scott J. Hultgren, Veerle Baekelandt, J. Andrew Pospisilik, Tomasz Brudek, Susana Aznar, Jennifer A. Steiner, Michael X. Henderson, Lena Brundin, Magdalena I. Ivanova, Tom J. Hannan, Patrik Brundin
Summary: Symptoms in the urogenital organs are common in MSA, and our study suggests that infection of the genitourinary tract could trigger alphaSyn aggregation, leading to MSA diagnosis. Urinary tract infections are associated with future MSA diagnosis and impact both men and women. Bacterial infection of the urinary bladder triggers synucleinopathy in mice, indicating a potential link between bacterial infections and MSA.
ACTA NEUROPATHOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Stuart B. Murray, Jaroslav Rokicki, Alina M. Sartorius, Adriano Winterton, Ole A. Andreassen, Lars T. Westlye, Jason M. Nagata, Daniel S. Quintana
Summary: By analyzing the Allen Human Brain Atlas, researchers have found that genes associated with anorexia nervosa are highly expressed in the brain and have specific expression patterns, which are related to brain activity involved in processing appetitive and aversive cues.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Rune Boen, Tobias Kaufmann, Oleksandr Frei, Dennis van der Meer, Srdjan Djurovic, Ole A. Andreassen, Kaja K. Selmer, Dag Alnaes, Ida E. Sonderby
Summary: The study investigates the differences in brain morphology and ageing process between 15q11.2 BP1-BP2 CNV carriers and non-carriers. Despite the alterations in brain structure, there is no apparent effect on ageing in terms of brain structure and motor, lung, and heart function.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pal R. Njolstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafo, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Summary: Parental genes can influence offspring psychiatric outcomes indirectly through the environment they create. This study aimed to estimate the contribution of parental genetic nurture effects on childhood psychiatric symptoms using advanced statistical genetic methods. The results suggest that parental genetic nurture effects may play a role in explaining individual differences in childhood psychiatric symptoms, but further research with larger samples is needed.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Ragna Bugge Askeland, Laurie J. Hannigan, Kevin S. O'Connell, Elizabeth C. Corfield, Oleksandr Frei, Anita Thapar, George Davey Smith, Ted Reichborn-Kjennerud, Ole A. Andreassen, Helga Ask, Alexandra Havdahl
Summary: Knowledge on how genetic risk for bipolar disorder manifests in developmental, emotional or behavioral traits during childhood is lacking. This issue is important to address to inform early detection and intervention efforts. Our study investigated the association between polygenic risk for bipolar disorder and developmental outcomes in children, and found robust evidence for an association with conduct difficulties and oppositional defiant difficulties at 8 years. Other associations were estimated within a range close to zero, except for negative associations with activity levels and benevolence at age 5 and positive associations with motor difficulties, inattention, and hyperactivity at age 3 and 8. These findings suggest that genetic risk for bipolar disorder manifests as disruptive behaviors in childhood.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Neurosciences
MayaN Abou N. Chahla, Mahmoud I. Khalil, Stefano Comai, Lena Brundin, Sophie Erhardt, Gilles J. Guillemin
Summary: Suicide is a global health burden, ranking as the 17th leading cause of death worldwide (1.3%), and the 4th among young people aged 15 to 29. Suicidal behavior is a complex and multifactorial mental health problem, resulting from alterations and dysfunctions in biological pathways and brain mechanisms that are poorly understood and require further investigation. Extensive research has been conducted at various levels to uncover the triggers and develop therapeutic or preventive approaches for suicidal behavior.
Article
Biochemistry & Molecular Biology
Olivia Wootton, Alexey A. Shadrin, Christine Mohn, Ezra Susser, Raj Ramesar, Ruben C. Gur, Ole A. Andreassen, Dan J. Stein, Shareefa Dalvie
Summary: This study conducted a large-scale genome-wide association study (GWAS) to identify genetic underpinnings of reaction time variability (RTV). The findings suggest that RTV is associated with genes involved in synaptic function and neural development. Additionally, RTV is genetically correlated with other neuropsychological traits. The study also demonstrated the predictive ability of a polygenic score for RTV.
MOLECULAR PSYCHIATRY
(2023)
Article
Behavioral Sciences
Max Korbmacher, Meng-Yun Wang, Rune Eikeland, Ralph Buchert, Ole A. Andreassen, Thomas Espeseth, Esten Leonardsen, Lars T. Westlye, Ivan I. Maximov, Karsten Specht
Summary: This study shows that there is a small correlation between brain age predictions and actual age, and the prediction can be influenced by factors such as field strength and scan quality. Therefore, the clinical applications of brain age models should be carefully validated and take into account potential biases in the data acquisition process.
BRAIN AND BEHAVIOR
(2023)
Article
Psychiatry
Laura A. Wortinger, Alexey A. Shadrin, Attila Szabo, Stener Nerland, Runar Elle Smelror, Kjetil Nordbo Jorgensen, Claudia Barth, Dimitrios Andreou, Marianne Thoresen, Ole A. Andreassen, Srdjan Djurovic, Gianluca Ursini, Ingrid Agartz
Summary: Placental dysfunction and birth asphyxia have an impact on fetal brain development and may increase the risk of developing schizophrenia. This study found that placental genomic risk factors associated with schizophrenia were more likely to be present in individuals with a history of birth asphyxia. Additionally, the interaction between these risk factors and birth asphyxia affected neonatal head circumference and adult intracranial volume, particularly in males.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Ashlea Segal, Linden Parkes, Kevin Aquino, Seyed Mostafa Kia, Thomas Wolfers, Barbara Franke, Martine Hoogman, Christian F. Beckmann, Lars T. Westlye, Ole A. Andreassen, Andrew Zalesky, Ben J. Harrison, Christopher G. Davey, Carles Soriano-Mas, Narcis Cardoner, Jeggan Tiego, Murat Yucel, Leah Braganza, Chao Suo, Michael Berk, Sue Cotton, Mark A. Bellgrove, Andre F. Marquand, Alex Fornito
Summary: Traditional case-control research often ignores the substantial individual heterogeneity among people with mental illness. This study provides a comprehensive, multiscale characterization of gray matter volume differences in six mental disorders. The results show that individual deviations in regional gray matter volume are highly heterogeneous, but some of these deviations are embedded within common functional circuits and networks.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Claudia Barth, Sinead Kelly, Stener Nerland, Neda Jahanshad, Clara Alloza, Sonia Ambrogi, Ole A. Andreassen, Dimitrios Andreou, Celso Arango, Inmaculada Baeza, Nerisa Banaj, Carrie E. Bearden, Michael Berk, Hannes Bohman, Josefina Castro-Fornieles, Yann Chye, Benedicto Crespo-Facorro, Elena de la Serna, Covadonga M. Diaz-Caneja, Tiril P. Gurholt, Catherine E. Hegarty, Anthony James, Joost Janssen, Cecilie Johannessen, Erik G. Joensson, Katherine H. Karlsgodt, Peter Kochunov, Noemi G. Lois, Mathias Lundberg, Anne M. Myhre, Sauel Pascual-Diaz, Fabrizio Piras, Runar E. Smelror, Gianfranco Spalletta, Therese S. Stokkan, Gisela Sugranyes, Chao Suo, Sophia I. Thomopoulos, Diana Tordesillas-Gutierrez, Daniela Vecchio, Kirsten Wedervang-Resell, Laura A. Wortinger, Paul M. Thompson, Ingrid Agartz
Summary: This study compared white matter microstructure in adolescents with early-onset psychosis (EOP) and healthy controls using diffusion tensor imaging (DTI). The results showed widespread lower fractional anisotropy (FA) and higher radial diffusivity (RD), mean diffusivity (MD), and axial diffusivity (AD) in EOP patients. There were significant effects of diagnostic subgroup, sex, and duration of illness.
MOLECULAR PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)