Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Summary: The bidirectional interaction between adipocytes and adipose tissue immune cells is crucial for regulating adipose function, inflammation, and insulin responsiveness. Obesity reduces cAMP-driven IL-6 secretion from adipocytes, but restoring their catecholamine sensitivity can stimulate IL-6 secretion and activate macrophages to promote an anti-inflammatory gene expression pattern.
Article
Medicine, Research & Experimental
Luana Heimfarth, Marilia Matos Rezende, Erik Willyame Menezes Pereira, Fabiolla Rocha Santos Passos, Brenda Souza Monteiro, Tiffany Karoline Barroso Santos, Natalia Teles Lima, Isana Carla Leal Souza, Ricardo Luiz Cavalcanti de Albuquerque Junior, Pollyana de Souza Siqueira Lima, Adriano Antunes de Souza Araujo, Lucindo Jose Quintans Junior, Bonglee Kim, Henrique D. M. Coutinho, Jullyana de Souza Siqueira Quintans
Summary: Inflammatory arthritis is a common chronic inflammatory disease, and oral administration of BIS and β CD/BIS can significantly alleviate its symptoms, with the cyclodextrin inclusion complex also improving the pharmacological profile of the drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Lihua Zhang, Zhongliang Li, Changcheng Xing, Ning Gao, Rui Xu
Summary: This study found that HHcy synergistically aggravated arterial damage in hypertensive rats through immune/inflammatory response, while folate demonstrated anti-inflammatory properties and reversed the NF-kappa B p65/Rela/IL-6 levels induced by HHcy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Fuqing Hu, Da Song, Yumeng Yan, Changsheng Huang, Chentao Shen, Jingqin Lan, Yaqi Chen, Anyi Liu, Qi Wu, Li Sun, Feng Xu, Fayong Hu, Lisheng Chen, Xuelai Luo, Yongdong Feng, Shengyou Huang, Junbo Hu, Guihua Wang
Summary: IL-6 activates autophagy in colorectal cancer through the interaction between JAK2 and autophagy regulator BECN1, leading to chemotherapeutic resistance. BECN1 Y333 phosphorylation is crucial for BECN1 activation and IL-6-induced autophagy by regulating PI3KC3 complex formation. Combination treatment targeting the IL-6/JAK2/BECN1 signaling pathway may be a potential strategy for CRC therapy.
NATURE COMMUNICATIONS
(2021)
Article
Peripheral Vascular Disease
Yusuke Kobayashi, Chiemi Sakai, Takafumi Ishida, Minako Nagata, Yukiko Nakano, Mari Ishida
Summary: Smoking is a risk factor for atherosclerosis due to inflammation caused by accumulation of nuclear and mitochondrial DNA in human umbilical vein endothelial cells. The chemical constituents of cigarette smoke extract, including acrolein, methyl vinyl ketone, and 2-cyclopenten-1-one, contribute to DNA damage, reduced mitochondrial membrane potential, and induction of inflammatory cytokines. Cytosolic free mitochondrial DNA plays a crucial role in IL-6 expression, a key mediator of inflammation.
HYPERTENSION RESEARCH
(2023)
Article
Immunology
Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang
Summary: This study suggests that Saikosaponin C (SSc), a traditional Chinese medicine compound, has potential therapeutic effects on depressive symptoms by reducing inflammatory cytokines levels, enhancing synaptic plasticity, and alleviating chronic social defeat stress-induced depression-like behavior in mice. The mechanism of action may involve the inhibition of DNMT1 protein expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Psychology, Developmental
Elena Raffetti, Anton Jonatan Landgren, Filip Andersson, Francesco Donato, Catharina Lavebratt, Yvonne Forsell, Maria Rosaria Galanti
Summary: The study found that higher levels of morning cortisol and cortisol area under the curve were associated with an increased risk of tobacco use initiation in adolescents, while there were no significant associations with afternoon cortisol concentration.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Chemistry, Multidisciplinary
Asma B. Omer, Obaid Afzal, Abdulmalik S. A. Altamimi, Shaktipal Patil, Shareefa A. AlGhamdi, Amira M. Alghamdi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi
Summary: Streptozotocin (STZ) impairs memory in rats through various mechanisms including cholinergic dysfunction, oxidative stress, hyperglycemia, and alterations in glucagon-like peptide (GLP). Barbaloin has been shown to have pharmacological effects but its effectiveness in improving STZ-induced memory dysfunction is not clear. In this study, barbaloin treatment significantly improved memory and cognitive functions, as measured by Y-maze and Morris water maze tests. The levels of oxidative stress markers, cholinergic dysfunction indicators, and inflammatory cytokines were also regulated by barbaloin treatment. These findings suggest that barbaloin has a protective impact against cognitive dysfunction caused by STZ.
Article
Chemistry, Multidisciplinary
Asma B. Omer, Obaid Afzal, Abdulmalik S. A. Altamimi, Shaktipal Patil, Shareefa A. AlGhamdi, Amira M. Alghamdi, Sami I. Alzarea, Waleed Hassan Almalki, Imran Kazmi
Summary: Streptozotocin (STZ) impairs memory in rats through various mechanisms, but it can be improved by cholinergic agonist, antioxidant, and antihyperglycemic treatment. Barbaloin, a compound with multiple pharmacological effects, was found to significantly improve cognitive dysfunction caused by STZ in rats. Barbaloin treatment decreased body weight and improved learning and memory capacities in behavioral tests. It also regulated oxidative stress markers and indicators of cholinergic dysfunction. The findings suggest that barbaloin has a protective impact against cognitive dysfunction caused by STZ.
Review
Biochemistry & Molecular Biology
Anna Lucia Fedullo, Antonio Schiattarella, Maddalena Morlando, Anna Raguzzini, Elisabetta Toti, Pasquale De Franciscis, Ilaria Peluso
Summary: This review emphasizes the impact of the Mediterranean Diet on GDM and GWG during the COVID-19 era, as well as the role of IL-6 in diabesity. The Mediterranean Diet, rich in beneficial nutrients, improves the immune system, lowers IL-6 levels, and helps prevent the development of diabesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Rita Haldar, Lee Shaashua Berger, Ella Rossenne, Arielle Radin, Anabel Eckerling, Elad Sandbank, Erica K. Sloan, Steve W. Cole, Shamgar Ben-Eliyahu
Summary: We demonstrated that minimally-invasive removal of primary tumors (PTs) and elimination of secreted factors can induce regression of micro-metastases in breast cancer. However, laparotomy during the procedure leads to an outbreak of micro-metastases. Administration of propranolol and etodolac can maintain metastatic dormancy following laparotomy.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Chemistry, Medicinal
Yoo-Hun Noh, Junkee Hong, Ji-Won Lee, Sung-Su Kim, Il-Jun Kang, Wan Kyunn Whang, Soon-Chul Myung, Myung-Hee Chung, Moo-Ho Won
Summary: The mixture of Clematis mandshurica Rupr. and Erigeron annuus Pers., YES-10, has anti-inflammatory properties and can improve mental health by reducing depression and anxiety.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Pharmacology & Pharmacy
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Summary: PGK1 plays a role in immunometabolism by influencing metabolic status. The inhibitor DC-PGKI can suppress the activity of PGK1 and alleviate symptoms of inflammatory bowel disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Immunology
Erik L. Knight, Yanping Jiang, Jacqueline Rodriguez-Stanley, David M. Almeida, Christopher G. Engeland, Samuele Zilioli
Summary: Exposure to and perceptions of stress are associated with altered systemic inflammation, with diurnal cortisol slopes playing a role in linking self-reported psychological stress to inflammation. The results support an allostatic load model of psychosomatic health, highlighting the importance of cortisol in understanding the relationship between stress exposure, perceived stress, and immune functioning.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Social Sciences, Mathematical Methods
Rebecca Roberts Andridge, Katherine Jenny Thompson
Summary: The U.S. Census Bureau historically used nearest neighbor or random hot deck imputation to handle missing survey data. Nearest neighbor imputation is preferred for its precision and robustness against misspecified response mechanisms, while random hot deck imputation ignores auxiliary information. K-nearest neighbor imputation is a compromise between the two methods. However, using the Approximate Bayesian Bootstrap method for nearest neighbor imputation leads to variance underestimation.
JOURNAL OF SURVEY STATISTICS AND METHODOLOGY
(2023)
Article
Psychology, Clinical
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Maryam Lustberg, Stephen P. Povoski, Doreen M. Agnese, Raquel E. Reinbolt, Robert Wesolowski, Nicole O. Williams, Bhuvaneswari Ramaswamy, Sagar D. Sardesai, Anne M. Noonan, Jeffrey B. VanDeusen, Daniel G. Stover, Mathew Cherian, William B. Malarkey, Michael Di Gregorio, Janice K. Kiecolt-Glaser
Summary: Psychological disorders can worsen physical symptoms associated with breast cancer diagnosis and treatment, and a distress disorder history may increase the risk of pain, fatigue, sleep difficulties, and lower self-rated health in breast cancer survivors both before and after adjuvant treatment.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Felix Tretter, Eva M. J. Peters, Joachim Sturmberg, Jeanette Bennett, Eberhard Voit, Johannes W. Dietrich, Gary Smith, Wolfram Weckwerth, Zvi Grossman, Olaf Wolkenhauer, James A. Marcum
Summary: This paper argues that data-driven analysis alone is insufficient for understanding the COVID-19 pandemic and for justifying public health regulations. It emphasizes the need for over-arching hypothesis-related and/or theory-based rationales to conduct effective research on SARS-CoV2/COVID-19.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Psychology, Experimental
Lydia G. Roos, Jeanette M. Bennett
Summary: Inadequate emotion regulation can lead to the development of psychopathology and worsened physical health. Cognitive reappraisal is considered an adaptive strategy to manage negative emotions, but its effectiveness depends on contextual and individual differences. The interactive effects of habitual reappraisal, reappraisal ability, and exposure to stressful life events on mental health were examined. Habitual reappraisal may protect against elevated depressive symptoms and worsened physical health for individuals facing more stressful life events.
Article
Immunology
Annelise A. Madison, Baldwin Way, Kyle G. Ratner, Megan Renna, Rebecca Andridge, Juan Peng, M. Rosie Shrout, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study examined whether a typhoid vaccine would increase social disconnection and avoidance behavior, and found that mild inflammatory stimuli did not affect social processes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Nicole L. Stott Bond, Didier Dreau, Ian Marriott, Jeanette. M. M. Bennett, Michael. J. J. Turner, Susan. T. T. Arthur, Joseph. S. S. Marino
Summary: This study discovered that metformin can reduce the proliferation of non-small cell lung cancer cells and downregulate certain genes related to cell cycle regulation and apoptosis. These findings support further research on the use of metformin as an anti-cancer agent or adjunctive therapy.
Article
Anesthesiology
Annelise A. Madison, Megan Renna, Rebecca Andridge, Juan Peng, M. Rosie Shrout, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Nicole O. Williams, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: Individuals respond differently to inflammation. Pain, sadness, and fatigue are common correlates of inflammation among breast cancer survivors. This study found that breast cancer survivors who experienced chronic social stress were more likely to report pain and sadness in response to increases in IL-1Ra.
Article
Communication
Brady T. West, Rebecca R. Andridge
Summary: Among various explanations for recent errors in pre-election polls, selection bias due to non-ignorable partisan nonresponse bias has received relatively less attention. This study introduces a new measure to detect and adjust for this type of bias in estimating the proportion of likely voters for a specific candidate. Using data from 18 pre-election polls conducted in the US and UK, the study rigorously evaluates the effectiveness of the measure by comparing it with official outcomes and alternative data sources.
PUBLIC OPINION QUARTERLY
(2023)
Article
Oncology
Annelise A. Madison, Rebecca Andridge, Anthony H. Kantaras, Megan E. Renna, Jeanette M. Bennett, Catherine M. Alfano, Stephen P. Povoski, Doreen M. Agnese, Maryam Lustberg, Robert Wesolowski, William E. Carson III, Nicole O. Williams, Raquel E. Reinbolt, Sagar D. Sardesai, Anne M. Noonan, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: Depression combined with inflammation or intestinal permeability may contribute to poorer subjective and objective cognitive function in breast cancer survivors. These findings suggest that survivors with depression accompanied by immune dysregulation may be more aware of depression-related cognitive deficits compared to other depressed survivors.
Article
Pediatrics
Bharathi J. Zvara, Sarah A. Keim, Rebecca Andridge, Sarah E. Anderson
Summary: Sensitive and responsive parenting supports optimal growth and development in children across cultures. Self-compassion has been found to be positively related to sensitive parenting. However, there is still limited research on the associations between self-compassion, depressive symptoms, socioeconomic status, and sensitive parenting.
Article
Psychology, Multidisciplinary
Megan E. Renna, Annelise A. Madison, Juan Peng, Marcella Rosie Shrout, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew Cherian, William B. Malarkey, Rebecca Andridge, Janice K. Kiecolt-Glaser
Summary: This study examined the impact of emotion regulation strategies on breast cancer survivors. It found that higher levels of worry and lower levels of mindfulness were associated with memory problems, focus problems, and pain sensitivity.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Meeting Abstract
Psychiatry
Marie Filatov, Annelise Madison, William Malarkey, Janice Kiecolt-Glaser
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychiatry
Annelise A. Madison, Janice K. Kiecolt-Glaser, William Malarkey
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychiatry
Megan E. Renna, Rosie Shrout, Annelise A. Madison, Janice K. Kiecolt-Glaser
PSYCHOSOMATIC MEDICINE
(2022)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
