期刊
PSYCHONEUROENDOCRINOLOGY
卷 38, 期 8, 页码 1251-1258出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2012.11.008
关键词
FKBP5; GR; Gene expression; Protein expression; Suicide; HPA-axis; Amygdala
资金
- Ministry of Science and Innovation [SAF 2008-01106, RETICS RD06/0001/1004]
- Ministry of Health [PNSD 2007/061]
- Red Tematica de Investigacion Cooperativa en Salud (RETICS, Institut de Salud Carlos III, MICINN and FEDER, Madrid, Spain, Red de Trastornos Adictivos [RD06/0001/1004]
- FISCAM (Fundacion para la investigacion sanitaria en Castilla La Mancha)
Recent reports suggest that FKBP5 gene and its corresponding FKBP5 protein play a relevant role in the regulation of anxiety and depression in animal models and human stress-related disorders. In the present study, FKBP5 and glucocorticoid receptor (GR) gene and protein expression were analyzed in the amygdala (AMY) of suicide victims (n = 13 males, without clinical psychiatric history and non-treated with anxiolytic or antidepressant drugs) and its corresponding controls (n = 13 males) by real-time PCR and Western blotting. The results revealed that FKBP5 and GR gene expression were significantly reduced in the AMY (-38% and -48%, respectively) of suicide victims compared with controls. Interestingly, FKBP5 and GR protein expression were also significantly decreased (-41% and -42%, respectively) in the AMY of suicide victims compared with controls. These results suggest that the FKBP5 plays a relevant role in human emotional responses and suggest this receptor as a new promising target in the treatment of suicide behavior. (C) 2012 Elsevier Ltd. All rights reserved.
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