期刊
PSYCHONEUROENDOCRINOLOGY
卷 38, 期 10, 页码 2051-2064出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2013.03.014
关键词
Aged; Novelty; Food intake; 5-HT2cR; Rikkunshito
资金
- National Center for Geriatrics and Gerontology (NCGG), Japan [23-25]
- Japanese Ministry of Education, Culture, Sports, Science, and Technology [22590676]
- Hokkaido University
- Tsumura Et Co (Ibaraki, Japan)
- Grants-in-Aid for Scientific Research [22590676] Funding Source: KAKEN
This study was conducted to clarify the role of serotonin (5-hydroxytryptamine, 5-HT) 2C receptor (5-HT2cR) signaling during novelty-induced hypophagia in aged mice. Male C57BL/6J mice [6-week-old (young) and 79-80-week-old (aged) mice] were exposed to a novel environment, and its effects on feeding behavior, stress hormones, and appetite-related factors were examined. Exposure of aged mice to a novel environment suppressed food intake and increased corticosterone secretion. These responses were marked compared with those in young mice. The expression in hypothalamic corticotropin-releasing factor (CRF), pituitary CRF1R and proopiomelanocortin mRNA in aged mice exposed to a novel environment was increased or tended to increase, compared to control mice. 5-HT2cR antagonist, SB242084 or rikkunshito administration attenuated the decrease in food intake and increased stress hormone levels in aged mice exposed to the environmental change. The 5-HT2cR mRNA expression in paraventricular nucleus was significantly enhanced, when aged mice was exposure to the novel environment. Thus, novelty-induced hypophagia in aged mice resulted, at least in part, from up-regulated hypothalamic 5-HT2cR function. In conclusion, 5-HT2cR signaling enhancement and the subsequent activation of the CRF neuron were involved in novelty-induced hypophagia in aged mice, and the 5-HT2cR antagonists offer a promising therapeutic option for depression. (C) 2013 Elsevier Ltd. All rights reserved.
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