4.5 Article

Sleep and biomarkers in the English Longitudinal Study of Ageing: Associations with C-reactive protein, fibrinogen, dehydroepiandrosterone sulfate and hemoglobin

期刊

PSYCHONEUROENDOCRINOLOGY
卷 38, 期 9, 页码 1484-1493

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2012.12.015

关键词

Sleep disturbance; Sleep duration; Inflammation; CRP; Fibrinogen; DHEAS; Hemoglobin; Anemia

资金

  1. National Institute on Aging [2R01AG7644-01A1, 2R01AG017644]
  2. Office for National Statistics
  3. Biotechnology and Biological Sciences Research Council
  4. Unilever Discover
  5. Economic and Social Research Council [RES-596-28-0001]
  6. Medical Research Council
  7. British Heart Foundation
  8. ESRC [ES/J019119/1, ES/G002452/1, ES/K005774/1] Funding Source: UKRI
  9. Economic and Social Research Council [ES/K005774/1, ES/G002452/1, ES/J019119/1] Funding Source: researchfish

向作者/读者索取更多资源

Sleep duration and quality are associated with adverse physical health outcomes. The mechanisms are not well understood, and little is known about associations with biomarkers in older population cohorts. This study assessed cross-sectional associations between self-reported sleep measures and biomarkers in a representative sample of British people aged 50 years and above. Participants were 6465 men and women aged 50-99 years from the English Longitudinal Study of Ageing (ELSA). Associations of sleep duration and sleep disturbance with C-reactive protein (CRP), fibrinogen, dehydroepiandrosterone sulfate (DHEAS) and hemoglobin were analyzed, adjusting for age, wealth, body mass index (BMI), smoking, physical activity, limiting long-standing illness and depressive symptoms. In men, long sleep duration (OR: 1.50, 1.05-2.14) and greater sleep disturbance (OR: 1.29, C. I. 1.05-1.59) were associated with raised CRP levels, while long sleep was also related to raised plasma fibrinogen (P = 0.001). DHEAS levels were lower among men reporting more sleep disturbances (P = 0.016), but were not related to sleep duration. Sleep duration (P = 0.015) and sleep disturbance (P = 0.039) were associated with lower hemoglobin levels, and anemia was more prevalent among men with disturbed sleep (OR: 1.73, C.I. 1.13-2.65). In women more disturbed steep was associated with greater likelihood of anemia (OR: 1.59, C.I. 1.02-2.46), but there was no relationship between sleep disturbance or duration with other biomarkers. This study suggests that self-reported sleep duration and disturbance are related to biological risk factors in community-dwelling older adults, with different associations being present in men and women. A better understanding of these relationships using longitudinal cohort studies will broaden our understanding of the mechanisms relating sleep indices and ill health in advancing age. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

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