期刊
BIOMEDICAL OPTICS EXPRESS
卷 7, 期 1, 页码 57-65出版社
Optica Publishing Group
DOI: 10.1364/BOE.7.000057
关键词
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资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2014-049289, NRF-2014R1A2A1A11052300]
- Basic Research Projects in High-tech Industrial Technology Project through grant by GIST
- National Research Foundation of Korea [2010-0029187] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Laser-induced breakdown spectroscopy (LIBS) has the potential to be used as a surgical tool for simultaneous tissue ablation and elemental analysis of the ablated tissue. LIBS may be used to distinguish melanoma lesions from the surrounding dermis based on the quantitative difference of elements within melanoma lesions. Here, we measured the elements in homogenized pellets and real tissues from excised skin samples of melanoma-implanted mice. In addition, statistical analysis of LIBS spectra using principal component analysis and linear discriminant analysis was performed. Our results showed that this method had high detection sensitivity, highlighting the potential of this tool in clinical applications. (C)2015 Optical Society of America
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