Article
Biochemistry & Molecular Biology
Yu-Lung Lin, Chin-Wen Wei, Thomas A. Lerdall, Jennifer Nhieu, Li-Na Wei
Summary: This study demonstrates that Crabp1 regulates feedback inhibition of the HPA axis by modulating FKBP5 expression. Furthermore, RA and stress can increase Crabp1 levels, which in turn up-regulates FKBP5 thereby decreasing GR signaling sensitivity and increasing the risk of stress-related disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
P. Sampedro-Piquero, R. D. Moreno-Fernandez
Summary: Both preclinical and clinical studies suggest that moderate doses of aerobic exercise can promote physiological and neuroplastic adaptations that reduce anxiety responses. Aerobic exercise has been shown to positively regulate neuroplasticity and neurogenesis-related genes, as well as improve control of the HPA axis function. It is proposed that aerobic exercise may modulate FKBP5 activity, offering a potential therapeutic approach for mood disorders.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Pediatrics
Tonny Jimmy Owalla, Wilber Joseph Ssebajjwe, Dennis Muhanguzi, Jacqueline Samantha Womersley, Eugene Kinyanda, Allan Kalungi
Summary: Children and adolescents living with human immunodeficiency virus (CA-HIV) suffer from a considerable burden of internalizing disorders, with severe recent stress increasing vulnerability to IDs among CA-HIV. However, no gene-environment effect on vulnerability to IDs was observed in this African population, supporting the view that single genetic loci only have a small effect on genetic vulnerability to IDs.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, Research & Experimental
Lin Zhou, Tian Wang, Yawen Yu, Mingan Li, Xiaohui Sun, Wenhao Song, Yunjie Wang, Ce Zhang, Fenghua Fu
Summary: Approximately one in three ischemic stroke survivors suffer from post-stroke depression (PSD), which affects functional rehabilitation and quality of life. This study focuses on the stroke-induced hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its role in PSD. The review summarizes possible etiologies of PSD, including stress and proinflammatory cytokines release, and discusses the effects of HPA axis hyperactivity on specific brain structures, enzymes expression, excitotoxicity, intestinal permeability, microglial activation, neuroendocrine regulation, inflammation, and therapy options.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Chaselyn Ruffaner-Hanson, Shahani Noor, Melody S. Sun, Elizabeth Solomon, Lidia Enriquez Marquez, Dominique E. Rodriguez, Andrea M. Allan, Kevin K. Caldwell, Ludmila N. Bakhireva, Erin D. Milligan
Summary: This review explores the physiological, cellular, and molecular factors that are involved in the alteration of the developing fetal brain stress circuits and responses of the hypothalamic-pituitary-adrenal (HPA) axis caused by maternal stress and prenatal alcohol exposure (PAE). The role of the placenta in these processes is emphasized. Alterations in the fetal HPA axis can lead to long-term dysregulation of the brain stress-response system. The review also addresses the reciprocal interactions between the neuroimmune and neuroendocrine systems during fetal development, as well as the impact of maternal stress and PAE on later-life stress responses and mood dysregulation.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sebastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P. Guiard
Summary: The study found that 5d-RFSS mice exhibited strong depressive characteristics in the FST, but the model has limitations in replicating the broad spectrum of depressive symptoms observed in other chronic models. However, it showed a significant impact on the hypothalamic-pituitary-adrenal axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jakob Hartmann, Thomas Bajaj, Claudia Klengel, Chris Chatzinakos, Tim Ebert, Nina Dedic, Kenneth M. McCullough, Roy Lardenoije, Marian Joels, Onno C. Meijer, Katharine E. McCann, Serena M. Dudek, R. Angela Sarabdjitsingh, Nikolaos P. Daskalakis, Torsten Klengel, Nils C. Gassen, Mathias Schmidt, Kerry J. Ressler
Summary: The study highlights the critical role of FK506-binding protein 51 (FKBP5) in fine-tuning mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) balance in the hippocampus. Lack of MR decreases hippocampal Fkbp5 levels and dampens the stress-induced increase in glucocorticoid levels, providing insight into mechanisms of stress homeostasis.
Article
Endocrinology & Metabolism
Alex Ferrer, Virginia Soria, Neus Salvat-Pujol, Lourdes Martorell, Antonio Armario, Mikel Urretavizcaya, Alfonso Gutierrez-Zotes, Jose Antonio Monreal, Jose Manuel Crespo, Clara Massaneda, Elisabet Vilella, Diego Palao, Jose Manuel Menchon, Javier Labad
Summary: Cognitive impairment is linked to childhood adversity and HPA axis abnormalities. The interaction between FKBP5 rs1360780 polymorphism and childhood maltreatment influences clinical outcomes. Physical neglect impacts neurocognition, while DSTR interacts with physical and emotional neglect. Social cognition is associated with sexual and physical abuse, as well as rs1360780 risk-allele carriers. An interaction between rs1360780 genotype and physical abuse significantly impacts social cognition.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Juan Zhu, Shanrui Ma, Ru Chen, Shuanghua Xie, Zhengkui Liu, Xinqing Li, Wenqiang Wei
Summary: This study evaluated the biological correlates of EC screening and diagnosis in high-risk regions in China, finding no significant differences in cortisol and immunoglobulin levels before and after screening. Repeated measures ANOVA showed that IgA levels had significant main effects between pre-screening and post-diagnosis.
SCIENTIFIC REPORTS
(2021)
Review
Geriatrics & Gerontology
Jayaditya Devpal Patil, Manar Abdulkarim Alrashid, Ayah Eltabbakh, Salim Fredericks
Summary: Extensive literature supports the impact of tinnitus induced stress in patients, while limited evidence focuses on whether stress actually causes tinnitus. Disruptions in the hypothalamus pituitary adrenal axis, a key neuroendocrine system involved in stress response, have been observed in tinnitus patients. Psycho-social stress and chronic hyperactivity in the sympathetic branch of the autonomic nervous system contribute to the development and worsening of tinnitus. Despite limited research, stress seems to play a significant role in the development and severity of tinnitus.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Jun Ho Seo, Shin Tae Kim, Sumoa Jeon, Jee In Kang, Se Joo Kim
Summary: This study found that DNA methylation levels at the FKBP5 intron 7 were significantly lower in male OCD patients, suggesting that epigenetic regulation of FKBP5 may be involved in the pathogenesis of OCD. However, there was no significant mediation effect of DNA methylation levels between early-life trauma and OCD status.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Filip Stramecki, Blazej Misiak, Lukasz Gaweda, Katarzyna Prochwicz, Joanna Klosowska, Jerzy Samochowiec, Agnieszka Samochowiec, Edyta Pawlak, Elzbieta Szmida, Pawel Skiba, Andrzej Cechnicki, Dorota Frydecka
Summary: Stressful life experiences increase the risk of psychosis, and the FKBP5 gene moderates this risk by interacting with environmental factors. Anxious and avoidant attachment styles also increase the risk of psychosis by affecting perceived stress levels. This study investigates how FKBP5 gene variants moderate the effects of attachment styles and perceived stress on the development of psychotic-like experiences (PLEs).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Joanna Mikulska, Gabriela Juszczyk, Monika Gawronska-Grzywacz, Mariola Herbet
Summary: The HPA axis is implicated in the pathophysiology of neuropsychiatric disorders like depression and schizophrenia. Increased HPA axis activity is associated with chronic stress and depression, with a correlation to gut microbiota. New therapeutic strategies for depression and schizophrenia involve targeting the HPA axis.
Article
Psychiatry
Mariana S. Mendonca, Paula M. Mangiavacchi, Alvaro F. L. Rios
Summary: The FKBP5 gene is involved in the modulation of glucocorticoid receptor interaction and plays a role in adaptive stress response. The presence of glucocorticoid response elements (GREs) in its introns affects gene expression. Research has shown that low DNA methylation levels in intron 7 of FKBP5 are associated with psychiatric disorders, but there are no reports on DNA methylation in introns 2 and 5 in relation to psychiatric disease diagnosis. Further exploration is needed to better understand the role of DNA methylation in psychiatric disease susceptibility.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Biology
Zhiqiang Liu, Yongzhou Zou, Min He, Ping Yang, Xinhui Qu, Lijun Xu
Summary: Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine with anti-oxidative and anti-inflammatory properties, can improve depressive behavior by inhibiting HPA signaling, repressing hippocampal inflammation, and oxidative stress.
JOURNAL OF BIOSCIENCES
(2022)
Review
Psychology, Clinical
San Lee, Keum Hwa Lee, Kyung Mee Park, Sung Jong Park, Won Jae Kim, Jinhee Lee, Andreas Kronbichler, Lee Smith, Marco Solmi, Brendon Stubbs, Ai Koyanagi, Louis Jacob, Andrew Stickley, Trevor Thompson, Elena Dragioti, Hans Oh, Andre R. Brunoni, Andre F. Carvalho, Joaquim Radua, Suk Kyoon An, Kee Namkoong, Eun Lee, Jae Il Shin, Paolo Fusar-Poli
Summary: Errors in data extraction may account for discrepancies in previous meta-analyses on the association between depression and inflammatory biomarkers.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Shin Tae Kim, Jun Ho Seo, Sangmin Lee, Sumoa Jeon, Chun Il Park, Se Joo Kim, Jee In Kang
Summary: This study examined dysfunctional coronavirus anxiety in nonpsychotic psychiatric outpatients during the pandemic and found that health worry may be an important bridge symptom that connects coronavirus anxiety and other clinical psychopathology.
DEPRESSION AND ANXIETY
(2022)
Article
Oncology
Ji Hyun Lee, Su-Jin Shin, Eun-Ah Choe, Jungyoun Kim, Woo Jin Hyung, Hyo Song Kim, Minkyu Jung, Seung-Hoon Beom, Tae Il Kim, Joong Bae Ahn, Hyun Cheol Chung, Sang Joon Shin
Summary: This study analyzed the incidence of NTRK fusion in KIT/PDGFRA wild-type GISTs and found that 16% of cases in the Yonsei Cancer Center had NTRK fusion. The confirmation of NTRK fusion in KIT/PDGFRA wild-type GISTs provides important information for improving therapeutic outcomes and suggests further research to improve methods for identifying this disease subtype.
Review
Oncology
Sun Young Rha, Hyun Cheol Chung
Summary: Gastric cancer is heterogeneous and can be characterized by HER2 overexpression and FGFR2 alterations. Combination therapy with fluoropyrimidine/platinum and trastuzumab has been approved as a standard treatment for HER2-positive patients. However, other agents have shown limited efficacy in first- and second-line treatments. Recent trials with HER2-directed treatment and immune checkpoint inhibitors have shown promising results. The management of HER2-positive gastric cancer requires further optimization to achieve precision medicine with a chemotherapeutic backbone.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Multidisciplinary Sciences
Ye Eun Lee, Jun Ho Seo, Shin Tae Kim, Sumoa Jeon, Chun Il Park, Se Joo Kim, Jee In Kang
Summary: This study examined the association between psychological factors such as loneliness, perfectionism, and health anxiety and COVID-19 related anxiety and depression in young Korean adults. The results showed that health anxiety was a risk factor for both COVID-19 related anxiety and depression, and loneliness was the strongest predictor of depressive symptoms during the pandemic.
Article
Psychiatry
Shin Tae Kim, Jun Ho Seo, Chun Il Park, Se Joo Kim, Jee In Kang
Summary: This study examined the changes in the depression and anxiety symptom network during the COVID-19 pandemic in individuals with non-psychotic mental illness. The results showed a significant difference in network structure before and during the pandemic, with somatic anxiety emerging as the most central node during the pandemic. Somatic anxiety, which was highly correlated with suicidal ideation during the pandemic, may serve as a target for psychiatric intervention in the era of the pandemic.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Jhin Goo Chang, Do-Won Kim, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Se Joo Kim, Jin Woo Chang
Summary: Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound (MRgFUS-capsulotomy) is a promising treatment option for treatment-refractory obsessive-compulsive disorder (OCD). This study investigated the effects of MRgFUS-capsulotomy on neural oscillations in OCD patients. The results showed that the high beta band power in certain brain areas decreased at 1 month and remained stable for 6 months after the procedure. The cortical connectivity of the high beta band also gradually decreased over time. Improvement in anxiety and depression symptoms was significantly correlated with changes in high beta band power.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Oncology
Chang Gon Kim, Minkyu Jung, Hyo Song Kim, Choong-kun Lee, Hei-Cheul Jeung, Dong-Hoe Koo, Woo Kyun Bae, Dae Young Zang, Bum Jun Kim, Hyunki Kim, Un-Jung Yun, Jingmin Che, Sejung Park, Tae Soo Kim, Woo Sun Kwon, Juin Park, Sang Woo Cho, Chung Mo Nam, Hyun Cheol Chung, Sun Young Rha
Summary: Trastuzumab combined with ramucirumab and paclitaxel showed appreciable efficacy with manageable safety profiles in patients with previously treated HER2-positive G/GEJ cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Si Won Lee, Jung Hye Kwon, Seung-hoon Beom, Sang Joon Shin, Hyo Song Kim, Sun Young Rha, Minkyu Jung, Joo Hyuk Sohn, Joong-Bae Ahn, Hyun Cheol Chung, Gun Min Kim, Hye Ryun Kim, Beodeul Kang, Youn Jung Hu, Hye Jin Choi
Summary: This study evaluated the first-year outcomes of patients admitted to an acute palliative care unit (APCU) at a tertiary hospital in Korea. The results showed that during their stay in the APCU, the overall symptoms of inpatients were reduced.
PALLIATIVE MEDICINE REPORTS
(2023)
Article
Endocrinology & Metabolism
Jun Ho Seo, Shin Tae Kim, Sumoa Jeon, Jee In Kang, Se Joo Kim
Summary: This study found that DNA methylation levels at the FKBP5 intron 7 were significantly lower in male OCD patients, suggesting that epigenetic regulation of FKBP5 may be involved in the pathogenesis of OCD. However, there was no significant mediation effect of DNA methylation levels between early-life trauma and OCD status.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Shin Tae Kim, Jun Ho Seo, Chun Il Park, Hae Won Kim, Young Jun Boo, Heeyeon Kim, Sumoa Jeon, Jee In Kang, Se Joo Kim
Summary: This study aimed to evaluate the network of core clinical symptoms in patients with obsessive-compulsive disorder (OCD) and understand the factors contributing to suicidal ideation. The findings revealed that the symptoms directly related to suicidal ideation in OCD patients included the degree of control over compulsive behaviors, distress associated with those behaviors, time spent performing compulsions, and unacceptable thoughts. This suggests that in addition to depressive symptoms and alexithymia, compulsions and unacceptable thoughts may contribute to suicidality in OCD patients.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
