Article
Psychiatry
Livia Graumann, Moritz Duesenberg, Sophie Metz, Lars Schulze, Oliver T. Wolf, Stefan Roepke, Christian Otte, Katja Wingenfeld
Summary: BPD patients exhibit lower emotional empathy scores but unchanged cognitive empathy scores under stress; The study showed no effect of psychosocial stress induced by TSST on emotion recognition performance in BPD patients, and no difference was found between the BPD group and the healthy control group.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Behavioral Sciences
L. F. Saccaro, Z. Schilliger, A. Dayer, N. Perroud, C. Piguet
Summary: Bipolar disorder (BD) and borderline personality disorder (BPD) share common characteristics such as symptoms, risk factors, and comorbidities. While some studies have focused on the link between stress and peripheral inflammation in other affective disorders, fewer have explored this relationship in BD and BPD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Sarah Herzog, Hanga Galfalvy, John G. Keilp, J. John Mann, M. Elizabeth Sublette, Ainsley Burke, Maria A. Oquendo, Barbara H. Stanley
Summary: Higher intent suicide attempts are associated with an increased risk of future suicidal behavior. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is linked to both nonfatal suicidal behavior and suicide deaths in major depressive disorder. However, few studies have identified biological markers for a high-intent suicidal subgroup.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Irene Messina, Pietro Spataro, Sara Sorella, Alessandro Grecucci
Summary: This study aimed to test a model in which the influence of attachment on borderline personality features in a subclinical population is mediated by anger regulation. The results indicated that anger suppression played a significant mediating role in the associations between both anxious and avoidant attachment and borderline personality traits, while anger control had a marginal mediating effect in the association between attachment avoidance and borderline personality.
Article
Psychiatry
Olivia Plett, Vera Flasbeck, Martin Bruene
Summary: This study examined the effects of animal-assisted and human-guided skills training on neurobiological correlates of affiliation and stress regulation. The results showed that both interventions had significant short-term effects on affiliative and stress hormones, with no difference between the two approaches in this regard.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Julia Kroener, Caroline Schaitz, Alexander Karabatsiakis, Anna Maier, Bernhard Connemann, Elisa Schmied, Zrinka Sosic-Vasic
Summary: Relationship dysfunction is a significant feature of borderline personality disorder (BPD), characterized by frequent conflicts. This study investigated the hormonal, personality, and relationship factors in couples where one partner is diagnosed with BPD. The results showed that females with BPD have higher scores in childhood maltreatment, dysfunctional attachment styles, and neuroticism, while their male partners showed lower testosterone levels and higher levels of childhood maltreatment and neuroticism. Traumatic childhood experiences, insecure attachment styles, and neurotic personality characteristics contribute to relationship disruptions in couples. These findings emphasize the importance of considering hormonal and psychosocial parameters in the treatment of females with BPD.
BEHAVIORAL SCIENCES
(2023)
Article
Behavioral Sciences
Aikaterini Fotopoulou, Mariana von Mohr, Charlotte Krahe
Summary: Social touch plays an important role in affective regulation, contributing to embodied predictions, homeostatic control, and emotional regulation in social interactions.
CURRENT OPINION IN BEHAVIORAL SCIENCES
(2022)
Article
Psychiatry
Jose Manuel Lopez-Villatoro, Karina S. MacDowell, Marina Diaz-Marsa, Alejandro De La Torre-luque, Clara Prittwitz, Alejandra Galvez-Merlin, Juan C. Leza, Jose L. Carrasco
Summary: This study investigates the abnormalities of cortisol response in borderline personality disorder (BPD) by examining the cellular expression of glucocorticoid receptors (GR) in BPD patients. The results show a significant decrease in the nuclear expression of GR in BPD patients compared to healthy controls, which is associated with clinical levels of anxiety and depression but not with previous traumatic experiences. This suggests that reduced GR expression may be linked to other aspects of BPD, such as emotional instability.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Sylwia Hyniewska, Joanna Dabrowska, Iwona Makowska, Kamila Jankowiak-Siuda, Krystyna Rymarczyk
Summary: People with borderline personality disorder (iBPD) tend to interpret negative emotions related to social rejection more accurately and negatively compared to healthy controls, with contempt being recognized better by iBPD than controls.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Cathy Davies, Elizabeth Appiah-Kusi, Robin Wilson, Grace Blest-Hopley, Matthijs G. Bossong, Lucia Valmaggia, Michael Brammer, Jesus Perez, Paul Allen, Robin M. Murray, Philip McGuire, Sagnik Bhattacharyya
Summary: Evidence suggests that the cortisol response to social stress and mediotemporal function during fear processing are associated in individuals at Clinical High Risk for Psychosis (CHR), and this relationship may be affected by cannabidiol treatment.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Katherine L. Dixon-Gordon, Skye Fitzpatrick, Lauren A. Haliczer
Summary: The study suggests that individuals with elevated BPD features may have less functional emotion regulation in social contexts compared to non-social contexts.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Rachael H. Moss, Mark Conner, Daryl B. O'Connor
Summary: The study found that daily hassles and uplifts have significant effects on healthy snack intake, with daily cortisol levels playing a moderating role in these relationships.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Psychology, Clinical
Wanrong Peng, Zhaoxia Liu, Qian Liu, Jun Chu, Kaili Zheng, Jingwei Wang, Hao Wei, Mingtian Zhong, Yu Ling, Jinyao Yi
Summary: Childhood trauma is a significant factor in the development of borderline personality disorder (BPD), and insecure attachment and maladaptive emotion regulation may play a role in the relationship between childhood trauma and BPD. The study found that childhood trauma influences BPD features mainly through insecure attachment and maladaptive emotion regulation.
DEPRESSION AND ANXIETY
(2021)
Article
Endocrinology & Metabolism
Li Lin, Lars Schwabe, Lei Zhan, Xiaoyu Wang, Xianghong Sun, Liang Zhang
Summary: This study found that neural emotion regulation processes can predict cortisol response to stress, while cognitive control and its neural underpinning cannot predict individual stress responses.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biology
Edina Torok, Oguz Kelemen, Szabolcs Keri
Summary: While the role of oxytocin and cortisol in social cognition and emotion regulation is supported by evidence, their peripheral levels' relationship with social perception and mentalization in the general population is less understood. In this study, 150 healthy individuals were assessed on mentalization abilities, intensity of positive and negative emotions, and levels of oxytocin and cortisol in saliva. Results showed that oxytocin, but not cortisol, predicted mentalization abilities and there was a positive correlation between mentalization, positive emotions, and biological motion detection. These findings suggest the importance of oxytocin in low-level perceptual and self-reflective aspects of social cognition.
Editorial Material
Psychology, Biological
Gregory A. Miller, Brigitte S. Rockstroh, Holly K. Hamilton, Cindy M. Yee
Article
Psychiatry
Holly K. Hamilton, Veronica B. Perez, Judith M. Ford, Brian J. Roach, Judith Jaeger, Daniel H. Mathalon
SCHIZOPHRENIA BULLETIN
(2018)
Article
Psychiatry
Holly K. Hamilton, Terrance J. Williams, Joseph Ventura, Leland J. Jasperse, Emily M. Owens, Gregory A. Miller, Kenneth L. Subotnik, Keith H. Nuechterlein, Cindy M. Yee
AMERICAN JOURNAL OF PSYCHIATRY
(2018)
Article
Behavioral Sciences
Kim E. Goldstein, Erin A. Hazlett, Kimberley R. Savage, Heather A. Berlin, Holly K. Hamilton, Yuliya Zelmanova, Amy E. Look, Harold W. Koenigsberg, Effie M. Mitsis, Cheuk Y. Tang, Margaret McNamara, Larry J. Siever, Barry H. Cohen, Antonia S. New
BEHAVIOURAL BRAIN RESEARCH
(2011)
Review
Medicine, General & Internal
Heather A. Berlin, Holly Hamilton, Eric Hollander
MOUNT SINAI JOURNAL OF MEDICINE
(2008)
Article
Clinical Neurology
Sarah Ketay, Holly K. Hamilton, Brian W. Haas, Daphne Simeon
PSYCHIATRY RESEARCH-NEUROIMAGING
(2014)
Article
Psychiatry
Holly K. Hamilton, Deepak C. D'Souza, Judith M. Ford, Brian J. Roach, Naomi S. Kort, Kyung-Heup Ahn, Savita Bhakta, Mohini Ranganathan, Daniel H. Mathalon
SCHIZOPHRENIA RESEARCH
(2018)
Article
Neurosciences
Jennifer Bartz, Daphne Simeon, Holly Hamilton, Suah Kim, Sarah Crystal, Ashley Braun, Victor Vicens, Eric Hollander
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2011)
Article
Psychology, Clinical
Holly K. Hamilton, Jane C. Sun, Michael F. Green, Kimmy S. Kee, Junghee Lee, Mark Sergi, Gretchen L. Sholty, Kristopher I. Mathis, Christopher Jetton, Terrance J. Williams, Robert Kern, William Horan, Alan Fiske, Kenneth L. Subotnik, Joseph Ventura, Gerhard Hellemann, Keith H. Nuechterlein, Cindy M. Yee
JOURNAL OF ABNORMAL PSYCHOLOGY
(2014)
Article
Psychology, Experimental
David M. Amodio, Holly K. Hamilton
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)