Review
Immunology
Syed Faizan Mehdi, Suma Pusapati, Raja Ram Khenhrani, Muhammad Saad Farooqi, Sobia Sarwar, Ahmad Alnasarat, Nimisha Mathur, Christine Noel Metz, Derek LeRoith, Kevin J. Tracey, Huan Yang, Michael J. Brownstein, Jesse Roth
Summary: Sepsis is a life-threatening inflammatory syndrome caused by dysregulated immune responses to infection. Human chorionic gonadotropin (hCG) and oxytocin, among other hormones, have anti-inflammatory properties and may play a role in limiting organ damage associated with sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Gholam Reza Nikrahan
Summary: This article attempts to explain the complexities of marital behaviors based on the science of complexity and neuroscience. It proposes a new theoretical framework that views marital behaviors as the product of the brain's complex adaptive system. Therefore, understanding the complexities of marital behaviors requires familiarity with the brain's complex adaptive system involved in such behaviors.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Krzysztof M. Wilczynski, Aleksandra Stasik, Lena Cichon, Aleksandra Augusciak-Duma, Malgorzata Janas-Kozik
Summary: Autism spectrum disorders (ASD) are a heterogeneous group of disorders that affect every population. Its pathogenesis involves the interaction of genetic and environmental factors. Social communication deficits are the main symptom of ASD, which lead to difficulties in everyday functioning.
Review
Biochemistry & Molecular Biology
Ewa Szczepanska-Sadowska
Summary: The automatism of cardiac pacemaker cells is regulated by the autonomic nervous system and multiple endocrine and paracrine factors, including cardiovascular peptides. Vasopressin and other cardiovascular peptides play important roles in the regulation of the cardiovascular system, especially in cardiovascular diseases. The interactions between vasopressin and other regulatory factors may have a significant impact on the responsiveness of the cardiovascular system in specific cardiovascular disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Sara Bubber, Jigisha Gala
Summary: Indian psychology views a person holistically and emphasizes the desire to know oneself, as well as the role of spirituality and meditation in marital wellbeing.
CURRENT PSYCHOLOGY
(2023)
Article
Reproductive Biology
Ricardo Mondragon-Ceballos, Genesis Chantal Hernandez-Vazquez, Susana Rojas-Maya, Monica Dafne Garcia-Granados, Jaqueline Lugo-Ferrer, Leonor Estela Hernandez-Lopez
Summary: In stump-tailed macaques, male-female friendships promote higher post-copulatory oxytocin concentrations and better physiological conditions for males. As closeness between males and females increases, sperm concentration, immotile and motile sperm decrease gradually.
Article
Endocrinology & Metabolism
Soledad Barez-Lopez, Agnieszka Konopacka, Stephen J. Cross, Mingkwan Greenwood, Marina Skarveli, David Murphy, Michael P. Greenwood
Summary: This study explores the expression of two genes, Caprin2 and Creb3l1, in magnocellular neurones (MCNs) and their changes during dehydration. The findings suggest that both genes are expressed in MCNs and their expression increases in response to dehydration. Protein levels mirror the increase in transcript levels for both CREB3L1 and CAPRIN2. In addition, CREB3L1 may be a transcription factor regulating Oxt gene expression, while CAPRIN2 binds to Oxt mRNA and regulates its poly(A) tail length.
NEUROENDOCRINOLOGY
(2022)
Article
Psychology, Multidisciplinary
Reza Fallahchai, Maryam Fallahi, Manijeh Badiee
Summary: The research on Iranian adults' intentions, attitudes, and expectations regarding marriage revealed that 96% of participants intended to marry, with significant differences based on gender, age, and education. The main purposes of marriage were found to be emotional, religious, and sexual, respectively, highlighting the importance of these factors in shaping marital decisions.
CURRENT PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
G. Wirobski, F. S. Schaebs, F. Range, S. Marshall-Pescini, T. Deschner
Summary: The study validated a commercial Enzyme Immunoassay for measuring oxytocin metabolite concentrations in dog, wolf, and human urine samples, with improved performance compared to a previously validated assay.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ewa Szczepanska-Sadowska, Agnieszka Wsol, Agnieszka Cudnoch-Jedrzejewska, Tymoteusz Zera
Summary: Oxytocin and vasopressin play important roles in the brain and peripheral organs, and their secretion is influenced by various factors. Inappropriate regulation may contribute to the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Monika Baryla-Matejczuk, Wieslaw Poleszak, Kamil Filipek, Andrzej Cwynar, Tomasz Zoltak
Summary: The aim of the study was to investigate the factors affecting life satisfaction in heterosexual couples. The study used actor-partner interdependence models (APIM) to analyze the relationships between male and female partners. The results showed that women's credit management behavior patterns predict their own well-being and also impact their male partners' well-being. Shared goals and values were found to be significant in assessing the quality of life for both men and women.
Review
Endocrinology & Metabolism
Ato O. Aikins, Dianna H. Nguyen, Obed Paundralingga, George E. Farmer, Caroline Gusson Shimoura, Courtney Brock, J. Thomas Cunningham
Summary: AVP and OXY are released by magnocellular neurosecretory cells projecting to the posterior pituitary. While traditionally not believed to contribute to basal cardiovascular function, recent studies suggest potential re-evaluation as evidence indicates their role in cardiovascular pathophysiology.
Article
Neurosciences
Paul J. Marvar, Raul Andero, Rene Hurlemann, Tiffany R. Lago, Moriel Zelikowsky, Joanna Dabrowska
Summary: Post-traumatic stress disorder (PTSD) is associated with dysregulation of limbic neuropeptides, with studies showing that blocking certain pathways can weaken fear memory consolidation, enhance fear extinction, and improve threat discrimination. Novel approaches targeting these pathways offer promising potential for treating core elements of PTSD pathophysiology.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalao, Maria Jose Alves Rocha
Summary: The study findings demonstrate that microglial activation modulates the secretion of several hormones to varying degrees during sepsis, and this process is associated with inflammatory mediators produced both centrally and peripherally.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Meyer, Benjamin Jurek, Mercedes Alfonso-Prieto, Rui Ribeiro, Vladimir M. Milenkovic, Julia Winter, Petra Hoffmann, Christian H. Wetzel, Alejandro Giorgetti, Paolo Carloni, Inga D. Neumann
Summary: This study reveals the cellular mechanism linking the oxytocin receptor gene mutation (OXTR rs4686302 SNP) with genetic dysregulations associated with autism spectrum disorder (ASD). The mutation leads to increased OXTR protein stability, changes in Ca2+ dynamics, and reduced activation of the MAPK pathway. Whole-genome and RNA sequencing analysis showed numerous differentially regulated genes in the mutant cells, including 429 genes associated with ASD. Computational modeling suggested that the OXTR mutation affects downstream events by altering receptor activation and signaling, consistent with the in vitro results.
MOLECULAR PSYCHIATRY
(2022)
Article
Immunology
Rosie Shrout, Annelise A. Madison, Megan E. Renna, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, Doreen M. Agnese, William E. Carson, William B. Malarkey, Michael T. Bailey, Janice K. Kiecolt-Glaser
Summary: Satisfying relationships among breast cancer survivors are associated with lower gut permeability and inflammation levels, leading to improved physiological health. This type of relationship can help reduce disease risks and enhance quality of life.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Emergency Medicine
Romolo J. Gaspari, Timothy Gleeson, Stephen Alerhand, William Caputo, Sara Damewood, Christopher Dicroce, Kristin Dwyer, Ryan Gibbons, Joshua Greenstein, Justin Harvey, Michael Hill, Beatrice Hoffmann, Mary Kate Jordan, Benjamin Karfunkle, Charles Kropf, Robert Lindsay, Shawn Luo, Monika Lusiak, Ari Nalbandian, Leily Naraghi, Bret Nelson, L. Connor Nickels, Laura Nolting, Alexandra Nordberg, Ashley Panicker, Joseph Pare, Mandy Peach, Dorcas Pinto, Powell Graham, Gabe Rose, Frances Russell, Jesse Schafer, Mark Scheatzle, Nikolai Schnittke, Marina Shpilko, Zachary Soucy, Jeffrey R. Stowell, Daniel Vryhof, Michael Gottlieb
Summary: This study aimed to compare the time to image acquisition, image quality, and visualization of cardiac anatomy using subxiphoid and parasternal long views in echocardiography. The results showed that the parasternal long view had shorter image acquisition time, better image quality, and improved identification of cardiac landmarks.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Annelise A. Madison, Rebecca Andridge, M. Rosie Shrout, Megan E. Renna, Jeanette M. Bennett, Lisa M. Jaremka, Christopher P. Fagundes, Martha A. Belury, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: The social-signal-transduction theory of depression suggests that individuals who experience ongoing interpersonal stress and have a greater inflammatory response to social stressors are more likely to develop depression. This was confirmed in two adult samples, where heightened depressive symptoms were observed in those with more frequent interpersonal tension and greater inflammatory reactivity to social stress. Lonelier and less socially supported individuals, particularly those with higher inflammatory response to social-evaluative stressors, showed increased depressive symptoms.
PSYCHOLOGICAL SCIENCE
(2022)
Article
Communication
Stephanie J. Wilson, Lisa M. Jaremka, Christopher P. Fagundes, Rebecca Andridge, Janice K. Kiecolt-Glaser
Summary: Research shows that the use of "we" in couples' discussions can predict better relationship quality and well-being. However, prior studies have not differentiated "we" talk based on its context. Additionally, the consistency of "we" talk during conflicts is high, but its effects may vary depending on the context in which it is used.
JOURNAL OF SOCIAL AND PERSONAL RELATIONSHIPS
(2022)
Article
Immunology
Janice K. Kiecolt-Glaser, Megan Renna, Juan Peng, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Rebecca Andridge
Summary: This study investigated the inflammatory responses of breast cancer survivors to a typhoid vaccine as an indicator of their innate immune response to new pathogens. The results showed that chemotherapy and central obesity were associated with smaller vaccine responses. Women with lower fitness levels also had reduced vaccine responses.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Geriatrics & Gerontology
Stephanie J. Wilson, Janice K. Kiecolt-Glaser
Summary: This study compares the differences in language use and emotional reactions during relationship history discussions between older and younger couples. The study found that compared to younger couples, older couples used more positive words and less immediacy during the discussion, which was associated with less negative mood and more positive appraisals among husbands. However, partners' language use in older couples was more similar but unrelated to mood and appraisals.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Oncology
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Catherine M. Alfano, Stephen P. Povoski, Adele M. Lipari, William E. Carson, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study found that colorectal cancer patients with higher levels of depressive and anxiety symptoms experienced greater pain, fatigue, and inflammation. These results emphasize the negative impact that anxiety and depression can have on the physical and biological side effects of colorectal cancer.
Article
Endocrinology & Metabolism
Annelise A. Madison, Janice K. Kiecolt-Glaser
Summary: This article assesses the relationship between inflammation and impulsivity and presents three challenges: vague definition of impulsivity, reverse causality, and lack of causal evidence. Future research can explore the relationship between inflammation and impulsivity by improving study design.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Ruchika Shaurya Prakash, Stephanie Fountain-Zaragoza, Megan Fisher, Oyetunde Gbadeyan, Rebecca Andridge, Janice Kiecolt-Glaser, Heena R. Manglani, Elizabeth J. Duraney, Anita Shankar, Michael R. McKenna, James Teng, Madhura Phansikar, Rosie Canter
Summary: This study aims to examine the benefits of a manualized mindfulness-based stress reduction program in improving attentional control and reducing mind-wandering in older adults. The study design includes randomized controlled trial with behavioral and neuroimaging assessments, as well as long-term follow-up. The primary outcomes are behavioral measures of attentional control and mind-wandering.
Article
Psychology, Clinical
Megan E. Renna, M. Rosie Shrout, Annelise A. Madison, Maryam Lustberg, Stephen P. Povoski, Doreen M. Agnese, Raquel E. Reinbolt, Robert Wesolowski, Nicole O. Williams, Bhuvaneswari Ramaswamy, Sagar D. Sardesai, Anne M. Noonan, Jeffrey B. VanDeusen, Daniel G. Stover, Mathew Cherian, William B. Malarkey, Michael Di Gregorio, Janice K. Kiecolt-Glaser
Summary: Psychological disorders can worsen physical symptoms associated with breast cancer diagnosis and treatment, and a distress disorder history may increase the risk of pain, fatigue, sleep difficulties, and lower self-rated health in breast cancer survivors both before and after adjuvant treatment.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Immunology
Annelise A. Madison, Baldwin Way, Kyle G. Ratner, Megan Renna, Rebecca Andridge, Juan Peng, M. Rosie Shrout, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study examined whether a typhoid vaccine would increase social disconnection and avoidance behavior, and found that mild inflammatory stimuli did not affect social processes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Meeting Abstract
Psychiatry
Marie Filatov, Annelise Madison, William Malarkey, Janice Kiecolt-Glaser
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychiatry
Annelise A. Madison, Janice K. Kiecolt-Glaser, William Malarkey
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychiatry
Megan E. Renna, Rosie Shrout, Annelise A. Madison, Janice K. Kiecolt-Glaser
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychiatry
M. Rosie Shrout, Annelise Madison, Megan E. Renna, Janice E. Kiecolt-Glaser
PSYCHOSOMATIC MEDICINE
(2022)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)