期刊
PSYCHONEUROENDOCRINOLOGY
卷 35, 期 8, 页码 1167-1177出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2010.02.002
关键词
Children; Depression; Anxiety; Internalizing; HPA axis; Stress reactivity
资金
- NIMH [1 K23 MH067947, MH56557]
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been observed in association with internalizing symptoms and is thought to be involved in the pathogenesis of depression and some anxiety disorders. This study examined basal and stress-induced cortisol concentrations in relation to internalizing and externalizing symptoms in a racially mixed community sample of 102 8-11-year-old boys. Afternoon basal cortisol concentrations were positively correlated with measures of internalizing behavior problems, social problems, and emotionality. Greater change in cortisol across a home-visit challenge task was also significantly associated with internalizing behaviors and social problems, as well as attention and thought problems. The implications of these findings and how they may relate to the pathogenesis of emotional and behavioral problems are discussed. (C) 2010 Elsevier Ltd. All rights reserved.
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