Article
Pharmacology & Pharmacy
Tzu-Hua Wu, Chieh-Hsin Lin, Kah Kheng Goh, Cynthia Yi-An Chen, Chun-Hsin Chen, Hsien-Yuan Lane, Mong-Liang Lu
Summary: The study assessed the relationship between prolactin levels and sexual dysfunction in schizophrenia patients using olanzapine. Hyperprolactinemia, sexual dysfunction, and metabolic syndrome were prevalent, with factors such as gender, age, and insulin levels being associated with these conditions. Female patients had higher levels of sexual dysfunction, while male patients had lower prolactin levels.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Claudia Aymerich, Borja Pedruzo, Malein Pacho, Marta Laborda, Jon Herrero, Toby Pillinger, Robert A. McCutcheon, Daniel Alonso-Alconada, Marta Bordenave, Maria Martinez-Querol, Ainara Arnaiz, Javier Labad, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres, Ana Catalan
Summary: Alterations in prolactin and cortisol levels have been found in antipsychotic naive patients with first episode psychosis. This study aims to provide estimates for the standardized mean differences and inter-group variability of these hormone levels in this patient group compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xiaofang Chen, Yong Fan, Wenchao Ren, Maodi Sun, Xiaoni Guan, Meihong Xiu, Shuyun Li
Summary: This study found a close relationship between baseline BMI and improvement in negative symptoms in first-episode and medication-naive SZ patients after treatment with risperidone. Linear regression analysis showed that baseline BMI was an independent predictor of response to risperidone in the early stage of SZ.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychology, Clinical
Brian O'Donoghue, John Lyne, Eric Roche, Nathan Mifsud, Laoise Renwick, Caragh Behan, Mary Clarke
Summary: This study found that migrants from Africa have a nearly twofold increased risk of developing a psychotic disorder compared to those born in the Republic of Ireland, while migrants from certain Asian countries have a reduced risk. Further research into the factors behind this increased risk in specific migrant groups could provide insights into the cause of psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Maria Hidalgo-Figueroa, Alejandro Salazar, Cristina Romero-Lopez-Alberca, Karina S. MacDowell, Borja Garcia-Bueno, Miquel Bioque, Miquel Bernardo, Mara Parellada, Ana Gonzalez-Pinto, Maria Paz Garcia Portilla, Antonio Lobo, Roberto Rodriguez-Jimenez, Esther Berrocoso, Juan C. Leza
Summary: This study analyzed the plasma oxytocin and prolactin levels in FEP patients and found that low oxytocin, high prolactin, poor premorbid IQ, and sustained attention deficits are associated with FEP, indicating potential therapeutic targets. Further research in these biological and cognitive domains could lead to improved outcomes for FEP patients, possibly with gender-specific strategies.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Franck Schurhoff, Cecile Corfdir, Baptiste Pignon, Mohamed Lajnef, Jean-Romain Richard, Elisabeth Marcos, Antoine Pelissolo, Marion Leboyer, Serge Adnot, Stephane Jamain, Andrei Szoke
Summary: This study compared telomere length between first-episode schizophrenia patients and controls, finding no significant association after adjusting for confounders. The results suggest that psycho-social stress may impact telomere length in individuals with schizophrenia, rather than telomere erosion contributing to the development of the disorder.
PSYCHIATRY RESEARCH
(2021)
Review
Endocrinology & Metabolism
Daniele Cavaleri, Chiara Alessandra Capogrosso, Pierluca Guzzi, Gianna Bernasconi, Martina Re, Blazej Misiak, Cristina Crocamo, Francesco Bartoli, Giuseppe Carra
Summary: This study investigated the differences in blood concentrations of anterior pituitary hormones between drug-naive individuals with first-episode psychosis and healthy controls. The results showed that drug-naive individuals with first-episode psychosis had higher levels of ACTH and PRL, and lower levels of TSH compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Alba Toll, Emilio Pechuan, Daniel Berge, Teresa Legido, Laura Martinez-Sadurni, Khadija El-Abidi, Victor Perez-Sola, Anna Mane
Summary: The risk of suicide is high in individuals experiencing first-episode psychosis (FEP), but the factors associated with this risk are not well-understood. This study aimed to identify the sociodemographic and clinical factors that contribute to suicide attempts in FEP patients over a two-year period. The findings revealed that prior suicide attempts, low functionality, depression, and feelings of guilt were significantly associated with suicide attempts. These findings highlight the importance of targeted interventions, particularly during the prodromal stage, in identifying and treating FEP patients with a high suicide risk.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xiaoe Lang, Mei Xue, Xiaocui Zang, Fengchun Wu, Meihong Xiu, Xiangyang Zhang
Summary: This study aimed to examine the efficacy, safety, and tolerability of low-dose risperidone combined with sertraline in reducing serious adverse effects in first-episode and medication-naive schizophrenia patients. The results showed that the combination of low-dose risperidone and sertraline was more effective in reducing psychotic symptoms and improving psychosocial functioning, with significantly fewer adverse effects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Esther Setien-Suero, Victor Ortiz-Garcia de la Foz, Paula Suarez-Pinilla, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola
Summary: The study compared the effects of risperidone and aripiprazole on cognition in patients with first-episode psychosis and found slight differences in their impact on cognitive function. This suggests the need for further research to determine the specific efficacy patterns of these drugs on cognition.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
Toby Pillinger, Robert A. McCutcheon, Oliver D. Howes
Summary: Patients with first-episode psychosis (FEP) show greater variability in metabolic parameters compared to controls, indicating potential subgroups of patients with more susceptibility to metabolic dysregulation. Female sex and higher symptom severity are associated with poorer metabolic outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Nan Chen, Haixia Liu, Jing Yao, Song Chen, Meihong Xiu, Fengchun Wu, Xiangyang Zhang
Summary: This study found that smoking had a greater improvement in negative symptoms in drug-naive first-episode schizophrenia patients after medication treatment. The study also found that there was a difference in antioxidant enzyme activity changes and symptom improvement, which was unrelated to smoking for smokers and related to nonsmokers.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
R. Segarra, M. Recio-Barbero, M. Saenz-Herrero, O. Mentxaka, J. Cabezas-Garduno, J. Eguiluz, L. F. Callado
Summary: This retrospective cohort analysis compared the efficacy, tolerability, and pattern of use of long-acting injectable palmitate paliperidone formulations to oral paliperidone/risperidone in patients with a nonaffective first episode of psychosis. Patients receiving the long-acting injectable formulations showed greater improvements in the main assessed domains compared to the oral group. There were no significant differences in hospitalizations between the groups, and some patients were able to reduce antipsychotic doses to avoid side effects.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Natalie Martos, William Hall, Alicia Marhefka, Thomas W. Sedlak, Frederick C. Nucifora
Summary: Neutropenia is a potential adverse effect of antipsychotic medications, with clozapine receiving most of the attention. However, paliperidone can also cause neutropenia, as demonstrated in a case report of a 23-year-old African American male. Clinicians should be aware of the risk of neutropenia when initiating paliperidone and consider comparative risks across antipsychotics for treatment decisions.
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
