Review
Biochemistry & Molecular Biology
Maria Rosaria Melis, Antonio Argiolas
Summary: Oxytocin is involved in central functions such as social and sexual behaviors, with a key role in erectile function and sexual behavior. While animal studies support its facilitatory role in male and female sexual behavior, human studies using intranasal oxytocin do not confirm this effect. Possible explanations for this discrepancy and strategies to address it are being considered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychology, Biological
Adriano Winterton, Lars T. Westlye, Nils Eiel Steen, Ole A. Andreassen, Daniel S. Quintana
Summary: Research on intranasal oxytocin highlights the importance of improving delivery methods and combining methodology, theory, and replicability for successful and meaningful outcomes. Despite promising preclinical results, there is a need for robust theory and reproducible methodology to bridge the gap between animal models and human research for oxytocin's role in behavior and psychiatric illnesses.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Multidisciplinary Sciences
Nanna Louise Junker Udesen, Ole Kristian Lerche Helgestad, Jakob Josiassen, Christian Hassager, Henrik Frederiksen Hojgaard, Louise Linde, Jesper Kjaergaard, Lene Holmvang, Lisette Okkels Jensen, Henrik Schmidt, Hanne Berg Ravn, Jacob Eifer Moller
Summary: Vasoactive treatment strategies in patients with AMICS stratified by SCAI shock classification are associated with treatment target achievement and outcomes. Despite increased vasoactive load and use of epinephrine, treatment targets can still be reached in most patients. Only in SCAI class C, the use of epinephrine is significantly associated with higher mortality.
Article
Nutrition & Dietetics
Chi-Ying Chen, Yu-Chen Chiang, Tai-Chih Kuo, Ka-Wai Tam, El-Wui Loh
Summary: In non-psychiatric subjects, single-dose INOT significantly reduces food intake, but no significant effects were found in patients with anorexia nervosa, bulimia nervosa, and schizophrenia. Further studies are needed to assess the long-term effects and safety of INOT in obese patients and whether it could be a treatment option for patients with eating disorders.
CLINICAL NUTRITION
(2021)
Article
Neurosciences
Luanne H. Hale, Maria C. Tickerhoof, Adam S. Smith
Summary: This study investigated the effects of chronic oxytocin (OXT) and selective serotonin reuptake inhibitor (SSRI) treatment on social defeat stress in male and female socially monogamous prairie voles. Results showed that chronic intranasal OXT treatment had a negative impact on sociability in non-defeated females but promoted social engagement in defeated females. Moreover, SSRI treatment had only modest effects on social behaviors compared to OXT.
Review
Biochemistry & Molecular Biology
Daniel S. Quintana, Alexander Lischke, Sally Grace, Dirk Scheele, Yina Ma, Benjamin Becker
Summary: Recent advances in human and animal research provide converging evidence for functionally relevant effects of intranasal oxytocin administration, supporting the idea that direct nose-to-brain delivery underlies the behavioral effects of oxytocin on social cognition and behavior. Furthermore, discussions on previously debated methodological issues, such as pre-registration, reproducibility, statistical power, interpretation of non-significant results, dosage, and sex differences, are integrated with suggestions for the next steps in translating intranasal oxytocin into psychiatric applications.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Physical
O. A. Mostovaya, P. L. Padnya, D. N. Shurpik, I. E. Shiabiev, I. I. Stoikov
Summary: The study focuses on utilizing p-tert-butylthiacalix[4]arene as a macrocyclic scaffold to design and synthesize dendrimer-like compounds. By modifying the macrocycle with fragments containing amide and lactide groups, original analogs of dendrimers with symmetric and asymmetric structures can be obtained. The 1,3-alternate conformation is found to be most favorable for binding catechol-amines, while the cone conformation shows selectivity in binding epinephrine and norepinephrine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Multidisciplinary Sciences
Yan-Fen Chen, Qi Song, Paola Colucci, Federica Maltese, Cristina Siller-Perez, Karina Prins, James L. McGaugh, Erno J. Hermans, Patrizia Campolongo, Nael Nadif Kasri, Benno Roozendaal
Summary: Noradrenergic activation of the basolateral amygdala influences recognition memory by suppressing activity in the anterior insular cortex. This finding sheds light on the broader dynamics of the brain network involved in emotional regulation of memory.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Environmental
Jia An, Yuxia Shi, Junan Fang, Yongqin Hu, Yufei Liu
Summary: This study successfully developed a fluorescence turn-on strategy to distinguish catecholamines (CAs) molecules, such as dopamine, epinephrine, and norepinephrine, as well as their precursor levodopa, with high sensitivity and selectivity. The ratiometric fluorescent probes were validated for quantitative detection in real human serum and urine samples, opening up a novel avenue for the rapid identification and clinical diagnosis of CAs.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Analytical
Zina Fredj, Mohamad Sawan
Summary: Catecholamines are crucial neurotransmitters in the central nervous system and play key roles in neurological disorders. Optical and electrochemical biosensors have been widely adopted for the real-time monitoring of catecholamine neurotransmitters and their development has been greatly accelerated in the last decade. This review provides a comprehensive overview on the recent advances and main challenges in catecholamines biosensors, with emphasis on electrochemical biosensors and the unique characteristics brought by nanotechnology. It also summarizes the therapeutic use of nanomaterials for catecholamine analysis and future development trends based on specific biosensors' performance metrics.
Review
Biochemistry & Molecular Biology
Chen Wang, Yumeng Shen, Jiaping Ni, Weiwei Hu, Yong Yang
Summary: Chronic stress affects tumor occurrence and development, but the exact molecular mechanisms are still not fully understood. This review summarizes the effects of chronic stress on various stages of tumor and provides an overview of the underlying molecular mechanisms. Additionally, available treatments and potential therapies for stressed patients with tumor are highlighted.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Peiwei Liu, Tian Lin, David Feifel, Natalie C. Ebner
Summary: Growing evidence suggests that the neuropeptide oxytocin plays a role in promoting social cognition and prosocial behavior by modulating the salience of social information. This study found that self-administered intranasal oxytocin reduced resting-state functional connectivity within the salience network, with a stronger effect observed in older participants.
Article
Chemistry, Analytical
Sivasankar Kulandaivel, Chia-Her Lin, Yi-Chun Yeh
Summary: In this study, copper-based coordination polymer (Cu-CP) nanozymes were successfully synthesized to accelerate the oxidation of epinephrine (Epi) with high specificity. The Cu-CP nanozymes showed a wide linear range for Epi detection and excellent stability and recyclability. Moreover, colorimetric and fluorescence signals were used for sequential detection of the coexistence of Epi and norepinephrine (NE), making it possible to track the treatment outcomes of patients with pheochromocytoma. Experiments using artificial urine confirmed the efficacy of the proposed system.
Article
Pharmacology & Pharmacy
Heidi N. Boyda, Michelle Pham, Joyce Huang, Amanzo A. Ho, Ric M. Procyshyn, Jessica W. Y. Yuen, William G. Honer, Alasdair M. Barr
Summary: This study examined the role of peripheral catecholamines in antipsychotic-induced glucose intolerance and found a significant association between increased peripheral catecholamines and glucose intolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Kosuke Inoue, Tamara Horwich, Roshni Bhatnagar, Karan Bhatt, Deena Goldwater, Teresa Seeman, Karol E. Watson
Summary: Higher levels of urinary stress hormones were associated with an increased risk of incident hypertension in this multiethnic population study. Urinary cortisol levels were also found to be associated with an increased risk of incident cardiovascular events. These findings suggest a potential important role of stress hormones in the prevention and treatment of hypertension and cardiovascular diseases.
Article
Behavioral Sciences
Chung-Ying Lin, Sonia Oveisi, Andrea Burri, Amir H. Pakpour
EPILEPSY & BEHAVIOR
(2017)
Article
Cardiac & Cardiovascular Systems
Mohsen Saffari, Chung-Ying Lin, Anders Brostrom, Jan Martensson, Dan Malm, Andrea Burri, Bengt Fridlund, Amir H. Pakpour
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2017)
Article
Anesthesiology
A. Burri, S. Ogata, F. Williams
EUROPEAN JOURNAL OF PAIN
(2017)
Article
Anesthesiology
A. Burri, S. Ogata, D. Rice, F. M. K. Williams
EUROPEAN JOURNAL OF PAIN
(2018)
Article
Urology & Nephrology
Andrea Burri, Hartmut Porst
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2018)
Editorial Material
Urology & Nephrology
Andrea Burri
JOURNAL OF SEXUAL MEDICINE
(2018)
Article
Urology & Nephrology
Andrea Burri, Soshiro Ogata
JOURNAL OF SEXUAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Andrea Burri, Soshiro Ogata, David Rice, Frances Williams
Article
Medicine, General & Internal
Andrea Burri, Hartmut Porst
Article
Urology & Nephrology
Andrea Burri, Joceline Buchmeier, Hartmut Porst
JOURNAL OF SEXUAL MEDICINE
(2018)
Review
Urology & Nephrology
Hartmut Porst, Andrea Burri
SEXUAL MEDICINE REVIEWS
(2019)
Article
Psychology, Clinical
Annette Bischof-Campbell, Peter Hilpert, Andrea Burri, Karoline Bischof
JOURNAL OF SEX RESEARCH
(2019)
Article
Psychology, Clinical
Sandy Krammer, Martin Grosse Holtforth, Andrea Burri, Michael Soyka, Alex Gamma, Michael Liebrenz
JOURNAL OF SEX & MARITAL THERAPY
(2018)
Letter
Urology & Nephrology
Giacomo Ciocca, Erika Limoncin, Vittorio Lingiardi, Andrea Burri, Emmanuele A. Jannini
SEXUAL MEDICINE REVIEWS
(2018)
Article
Medicine, General & Internal
Andrea Burri, David Rice, Nicola Kluger, Michal Kluger
NEW ZEALAND MEDICAL JOURNAL
(2018)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)