Article
Rehabilitation
Kathryn Moran, Linda Barclay, Natasha A. Lannin
Summary: This study explores the experiences of individuals with non-traumatic spinal cord injuries transitioning from rehabilitation to home. The findings indicate that a positive adjustment experience is facilitated by adequate preparation and support from rehabilitation services. Challenges include loss of identity and the importance of maintaining hope for physical recovery.
DISABILITY AND REHABILITATION
(2022)
Article
Medicine, General & Internal
Ashley Craig, Yvonne Tran, Mohit Arora, Ilaria Pozzato, James W. Middleton
Summary: This paper presents the Spinal Cord Injury Adjustment Model (SCIAM), which explains how individuals adjust to spinal cord injury and proposes that the adjustment process is multifactorial and nonlinear over time. Mediation analyses supported the role of self-efficacy and quality of life appraisal in enhancing self-care and buffering the negative impact of health challenges.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychology, Clinical
Danielle Sandalic, Mohit Arora, Ilaria Pozzato, Grahame Simpson, James Middleton, Ashley Craig
Summary: Spinal cord injury can affect mental health, but existing guidelines tend to focus on diagnosable mental disorders and neglect the importance of adjustment, coping, grief, and resilience. Research on positive processes is limited and needs consensus on key processes and a shift in focus from outcomes.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Review
Pharmacology & Pharmacy
Amina T. Mneimneh, Mohammed M. Mehanna
Summary: Collagen-based scaffolds play a significant role in promoting regeneration, repair, and recovery of spinal cord injuries by providing a suitable environment for tissue repair, axonal regeneration, and vascularization. They are biocompatible, biodegradable, and widely used in pharmaceutical, cosmetic, food industries, and tissue engineering. Functionalized with different ligands and factors, collagen in scaffolds enhances its binding specificity and activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Immunology
Fan Jiang, Mingjie Xia, Yanan Zhang, Jie Chang, Jiang Cao, Zhongkai Zhang, Zhanyang Qian, Lei Yang
Summary: Activation of CB2R attenuates neuroinflammation by promoting NLRP3 clearance, thus facilitating microglial polarization and functional recovery post-SCI.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jie Qin, Jian Mo, Yi Chen, Jie Han, Xinjian Feng, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Linxuan Han, Rongyu Lan, Haixuan Deng, Huihui Yao, Zhongquan Qi, Hongjun Gao, Lishan Wei, Shuai Ren
Summary: This study tested spinal cord fusion (SCF) using the neuroprotective agent polyethylene glycol (PEG) in different animal models and developed a new clinical procedure called vascular pedicle hemisected spinal cord transplantation (vSCT) for the treatment of paraplegic patients. The results demonstrated the feasibility and efficacy of vSCT in re-establishing the continuity of spinal nerve fibers, potentially restoring motor, sensory, and autonomic nervous functions in paraplegic patients. Further clinical trials are needed to validate these findings.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Elnaz Nakhjiri, Shaqayeq Roqanian, Hamid Soltani Zangbar, Manuchehr Seyedi Vafaee, Daryoush Mohammadnejad, Shahin Ahmadian, Selva Zamanzadeh, Ehsan Ehsani, Parviz Shahabi, Koorosh Shahpasand
Summary: Spinal cord injury (SCI) leads to the development of brain tau pathology and brain dysfunction. Our study on severe SCI mouse models revealed a progressive increase in tau pathology in the spinal cord and brain areas, resulting in motor dysfunction, memory impairment, and abnormal risk-taking behavior. Immunotherapy with an anti-cis P-tau antibody successfully restored the pathological and functional consequences of SCI.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nashid Islam, A. K. M. Motiur Rahman Bhuiyan, Afroja Alam, Mostofa Kamal Chowdhury, Jheelam Biswas, Palash Chandra Banik, Md. Maruf Ahmed Molla, Mostofa Monwar Kowshik, Mridul Sarker, Nezamuddin Ahmed
Summary: This study aims to explore the different coping strategies adopted by women with metastatic breast cancer and their relationship with mental health issues. The findings indicate that positive coping helps patients adapt to the disease and routine screening and assessment should be conducted to address psychological distress and improve quality of life.
Article
Biochemistry & Molecular Biology
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Summary: The expression of SIRT1 in spinal cord endothelial cells is decreased after spinal cord injury (SCI). SIRT1 has the ability to reduce endothelial reactive oxygen species production and protect endothelial barrier function, indicating its potential as a therapeutic target for promoting functional recovery against blood-spinal cord barrier (BSCB) disruption following SCI.
Article
Engineering, Environmental
Zengjie Zhang, Xiaolei Zhang, Chenggui Wang, Wangsiyuan Teng, Hongyuan Xing, Fangqian Wang, Eloy Yinwang, Hangxiang Sun, Yan Wu, Chengcheng Yu, Xupeng Chai, Zhiyong Qian, Xiaohua Yu, Zhaoming Ye, Xiangyang Wang
Summary: Persistent inflammation during the secondary injury of spinal cord injury is identified as the main cause of poor regenerative capability of spinal cord. Extracellular vesicles derived from M2 microglia have shown therapeutic potential for inflammation alleviation and neural regeneration. However, their applications in spinal cord injury treatment are limited due to issues such as poor accumulation, short retention, and lack of controlled release. Therefore, a novel thermosensitive hydrogel system was developed to deliver M2 derived extracellular vesicles for spinal cord injury treatment. The hydrogel enabled effective retention and controlled release of the vesicles, resulting in improved motor nerve functional recovery. Mechanistic study revealed that the sustained release of the vesicles attenuated local inflammation and inhibited neuron apoptosis, thus protecting the spinal cord. This approach provides a microenvironment-responsive and noninvasive method to improve spinal cord injury therapy through both anti-inflammatory and neural protective mechanisms.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Critical Care Medicine
Margot Kelly-Hedrick, Beatrice Ugiliweneza, Elizabeth G. Toups, George Jimsheleishvili, Shekar N. Kurpad, Bizhan Aarabi, James S. Harrop, Norah Foster, Rory C. Goodwin, Christopher I. Shaffrey, Michael G. Fehlings, Charles H. Tator, James D. Guest, Chris J. Neal, Muhammad M. Abd-El-Barr, Theresa Williamson
Summary: The North America Clinical Trials Network for Spinal Cord Injury (NACTN) has maintained a prospective registry since 2004 and supports early surgical intervention for improved outcomes. This study examined the association between interhospital transfer (IHT), early surgery, and outcome using data from the NACTN SCI Registry. The findings suggest barriers in timely recognition and management of spinal cord injury, with IHT patients less likely to receive surgery within 24 hours of injury. Rating: 8/10.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Psychology, Clinical
Joy McLeod, Christopher G. Davis
Summary: Peer support is assumed to help individuals with spinal cord injury (SCI) adjust, but the evidence is mixed. This study found that peer support is most effective when there is a lack of informal support from family and friends. Individuals who reported higher satisfaction with peer support showed better adjustment, but the relationship between satisfaction with peer support and depressive symptoms depended on the level of family/friend support.
JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Rehabilitation
Chungyi Chiu, Jessica Brooks, Alicia Jones, Kortney Wilcher, Sa Shen, Simon Driver, James Krause
Summary: This study validated the existence of different types of resilient coping among individuals with spinal cord injuries and identified three types: goal-pursuing, bouncing-back, and persevering; uncertainty about coping with setbacks; and loss of resilient coping. The three types showed significant differences in resilience, depression, and life satisfaction, providing insights for future psychosocial interventions.
REHABILITATION COUNSELING BULLETIN
(2022)
Review
Infectious Diseases
Julie A. Chambers, Margaret Crumlish, David A. Comerford, Ronan E. O'Carroll
Article
Medicine, General & Internal
Jayne Digby, Ronan E. O'Carroll, Julie A. Chambers, Robert J. C. Steele
Review
Cardiac & Cardiovascular Systems
Alice Pearsons, Coral L. Hanson, Robyn Gallagher, Ronan E. O'Carroll, Sahar Khonsari, Janet Hanley, Fiona E. Strachan, Nicholas L. Mills, Terence J. Quinn, Brian McKinstry, Sheona McHale, Stacey Stewart, Mengying Zhang, Siobhan O'Connor, Lis Neubeck
Summary: This review aimed to assess commercially available atrial fibrillation (AF) self-management apps, finding that these apps had limited functions, lacked intuitive operations, and had difficult-to-read privacy policies, failing to meet the standards for use in healthcare settings.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Medicine, General & Internal
Chloe Fawns-Ritchie, Christopher B. Miller, Marjon van der Pol, Elaine Douglas, David Bell, Ronan E. O'Carroll, Ian J. Deary
Summary: The study found that risk aversion and present orientation were associated with reduced odds of participating in CRC screening, while higher scores in health literacy, cognitive ability, and the intellect personality trait were associated with increased odds of screening. Risk aversion and cognitive ability were identified as correlates of CRC screening in the model.
Article
Medicine, General & Internal
Marie Kotzur, Sara Macdonald, Ronan E. O'Carroll, Rory C. O'Connor, Audrey Irvine, Robert J. C. Steele, Kathryn A. Robb
Summary: This study identified barriers and solutions to colorectal screening using faecal immunochemical tests (FITs) through a questionnaire survey. Participants who had not completed a FIT reported more barriers, while those who had completed a FIT provided more solutions. However, participants agreed on the most common barriers and solutions regardless of their screening history.
Article
Public, Environmental & Occupational Health
Lee Shepherd, Ronan E. O'Carroll, Eamonn Ferguson
Summary: Family and friends have a significant influence on organ donation, and their approval or disapproval can affect the donation decision. This study examines how next-of-kin approval varies under opt-out legislation. The study found that next-of-kin approval is influenced by the deceased's registration status and their own beliefs about organ donation.
SOCIAL SCIENCE & MEDICINE
(2023)
Editorial Material
Psychology, Clinical
Ronan E. O'Carroll
HEALTH PSYCHOLOGY REVIEW
(2020)
Article
Psychology, Clinical
Jordan Miller, Sinead Currie, Lesley M. McGregor, Ronan E. O'Carroll
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2020)
Article
Psychology, Clinical
Daryl B. O'Connor, Dawn Branley-Bell, Jessica A. Green, Eamonn Ferguson, Ronan E. O'Carroll, Rory C. O'Connor
JOURNAL OF ABNORMAL PSYCHOLOGY
(2020)
Article
Psychology, Clinical
D. De Beurs, R. I. Fried, K. Wetherall, S. Cleare, D. B. O'Connor, E. Ferguson, R. E. O'Carroll, R. C. O'Connor
BEHAVIOUR RESEARCH AND THERAPY
(2019)
Article
Public, Environmental & Occupational Health
Eamonn Ferguson, Catherine Murray, Ronan E. O'Carroll
PSYCHOLOGY & HEALTH
(2019)
Article
Psychology, Clinical
Andy P. Siddaway, Alex M. Wood, Ronan E. O'Carroll, Rory C. O'Connor
PSYCHOLOGICAL ASSESSMENT
(2019)
Article
Psychology, Social
Eamonn Ferguson, Kun Zhao, Ronan E. O'Carroll, Luke D. Smillie
SOCIAL PSYCHOLOGICAL AND PERSONALITY SCIENCE
(2019)
Article
Psychology, Clinical
Jordan Miller, Sinead Currie, Ronan E. O'Carroll
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2019)
Article
Psychology, Multidisciplinary
Louise Wood, Michael Smith, Christopher B. Miller, Ronan E. O'Carroll
ANNALS OF BEHAVIORAL MEDICINE
(2019)