期刊
PSYCHOLOGICAL MEDICINE
卷 45, 期 5, 页码 985-999出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291714001998
关键词
Anxiety disorders; gestational age; longitudinal cohort study; mental disorders; mood disorders; personality disorders; psychotic disorders; SGA and LGA birth; substance use disorders; suicides
资金
- Academy of Finland [261661, 140278, 135132, 132614, 129911, 129457]
- University of Helsinki
- Finnish Foundation of Cardiovascular Research
- Finnish Diabetes Research Foundation
- Finnish Medical Society
- Finska Lakaresallskapet
- National Doctoral Programme of Psychology
- Paivikki and Sakari Sohlberg Foundation
- Juho Vainio Foundation
- Yrjo Jahnsson Foundation
- Samfundet Folkhalsan
- Signe and Ane Gyllenberg Foundation
- Jalmari and Rauha Ahokas Foundation
- Emil Aaltonen Foundation
- Finnish Ministry of Education
- Finnish Foundation for Paediatric Research
- Medical Research Council [MC_UP_A620_1017] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC1016374] Funding Source: researchfish
- MRC [MC_UP_A620_1017] Funding Source: UKRI
- Academy of Finland (AKA) [135132, 132614, 129457, 129911, 140278, 132614, 261661, 129911, 140278, 135132, 261661, 129457] Funding Source: Academy of Finland (AKA)
Background. Late preterm births constitute the majority of preterm births. However, most evidence suggesting that preterm birth predicts the risk of mental disorders comes from studies on earlier preterm births. We examined if late preterm birth predicts the risks of severe mental disorders from early to late adulthood. We also studied whether adulthood mental disorders are associated with post-term birth or with being born small (SGA) or large (LGA) for gestational age, which have been previously associated with psychopathology risk in younger ages. Method. Of 12597 Helsinki Birth Cohort Study participants, born 1934-1944, 664 were born late preterm, 1221 post-term, 287 SGA, and 301 LGA. The diagnoses of mental disorders were identified from national hospital discharge and cause of death registers from 1969 to 2010. In total, 1660 (13.2%) participants had severe mental disorders. Results. Individuals born late preterm did not differ from term-born individuals in their risk of any severe mental disorder. However, men born late preterm had a significantly increased risk of suicide. Post-term birth predicted significantly increased risks of any mental disorder in general and particularly of substance use and anxiety disorders. Individuals born SGA had significantly increased risks of any mental and substance use disorders. Women born LGA had an increased risk of psychotic disorders. Conclusions. Although men born late preterm had an increased suicide risk, late preterm birth did not exert widespread effects on adult psychopathology. In contrast, the risks of severe mental disorders across adulthood were increased among individuals born SGA and individuals born post-term.
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