期刊
PSYCHOLOGICAL MEDICINE
卷 43, 期 5, 页码 911-920出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712001870
关键词
Alzheimer's disease; anxiety; apathy; biomarkers; cerebrospinal fluid; depression; mild cognitive impairment; neuropsychiatric symptoms
资金
- Center for Translational Molecular Medicine, project Leiden - Alzheimer Research Nederland (LeARN) [02N-101]
- European Commission [QLT-6-CT-2002-02455]
- ADNI [National Institutes of Health (NIH)] [U01 AG024904]
- NIA
- NIBIB
- NIH [P30 AG010129, K01 AG030514]
- Dana Foundation
- Center for Translational Molecular Medicine, project LeARN [02N-01]
- VUmc Fonds
- American Alzheimer Association
- Alzheimer Drug Discovery Foundation
- Stichting International Parkinson Fonds
- Internationale Stichting Alzheimer Onderzoek
- Hersentichting Nederland
- NIA for ADNI 1
- NIA for ADNI GO
- NIA for ADNI 2
- Bristol-Myers Squibb
- European Commission 6th Framework programme
- European Commission 7th Framework programme
- Life Sciences, Genomics and Biotechnology for Health, Diagenic, Norway
- Life Sciences, Genomics and Biotechnology for Health, Innogenetics, Belgium
- [AG10124]
Background. Anxiety, apathy and depression are common in subjects with mild cognitive impairment (MCI) and may herald Alzheimer's disease (AD). We investigated whether these symptoms correlated with cerebrospinal fluid (CSF) markers for AD in subjects with MCI. Method. Subjects with MCI (n = 268) were selected from the 'Development of screening guidelines and criteria for pre-dementia Alzheimer's disease' (DESCRIPA) and Alzheimer's Disease Neuroimaging Initiative (ADNI) studies. We measured amyloid beta((1-42)) protein (A beta 42) and total tau (t-tau) in CSF. Neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory. Results. Depressive symptoms were reported by 55 subjects (21%), anxiety by 35 subjects (13%) and apathy by 49 subjects (18 %). The presence of anxiety was associated with abnormal CSF A beta 42 [odds ratio (OR) 2.3, 95% confidence interval (CI) 1.6-3.3] and t-tau (OR 2.6, 95% CI 1.9-3.6) concentrations and with the combination of abnormal concentrations of both A beta 42 and t-tau (OR 3.1, 95% CI 2.0-4.7). The presence of agitation and irritability was associated with abnormal concentrations of A beta 42 (agitation: OR 1.6, 95% CI 1.1-2.3; irritability: OR 2.2, 95% CI 1.5-3.3). Symptoms of depression and apathy were not related to any of the CSF markers. Conclusions. In subjects with MCI, symptoms of anxiety, agitation and irritability may reflect underlying AD pathology, whereas symptoms of depression and apathy do not.
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