期刊
PSYCHOLOGICAL MEDICINE
卷 43, 期 2, 页码 391-400出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291712001018
关键词
Inhibition; obsessive-compulsive disorder; punishment; response control; reward
资金
- Wellcome Trust [089589/Z/09/Z, G00001354]
- Medical Research Council
- Gates Cambridge Trust
- Johnson and Johnson
- AstraZeneca
- Cephalon
- European College of Neuropsycho-pharmacology
- GlaxoSmithKline
- Lundbeck
- Servier
- Wellcome
- Bristol-Myers Squibb
- International College of Obsessive-Compulsive Spectrum Disorders
- Wyeth
- Jazz
- Janssen
- Lilly
- Medical Research Council [G0001354, G0001354B, G1000183B] Funding Source: researchfish
Background. Obsessive-compulsive disorder (OCD) has been associated with response inhibition deficits under motivationally neutral contingencies. We examined response inhibition performance in the presence of reward and punishment. We further investigated whether the hypothesized difficulties in flexibly updating behaviour based on external feedback in OCD would also lead to a reduced ability to adjust to changes in the reward and punishment contingencies. Method. Participants completed a go/no-go task that used punishments or rewards to promote response activation or suppression. The task was administered to OCD patients free of current Axis-I co-morbidities including major depression (n=20) and a group of healthy controls (n=32). Results. Compared with controls, patients with OCD had increased commission errors in punishment conditions, and failed to slow down immediately after receiving punishment. The punishment-induced increase in commission errors correlated with self-report measures of OCD symptom severity. Additionally, patients did not differ from controls in adapting their overall response style to the changes in task contingencies. Conclusions. Individuals with OCD showed reduced response control selectively under punishment conditions, manifesting in an impulsive response style that was related to their current symptom severity. This stresses failures of cognitive control in OCD, particularly under negative motivational contingencies.
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