Article
Psychiatry
Sidney Zisook, Beata Planeta, Paul B. Hicks, Peijun Chen, Lori L. Davis, Gerardo Villarreal, Mamta Sapra, Gary R. Johnson, Somaia Mohamed
Summary: The study explores the association between specific types of childhood adversity and clinical features and treatment outcomes in adults with Major Depressive Disorder (MDD). It shows that childhood adversities are linked to demographic characteristics, severity of depression and anxiety, treatment response, and long-term outcomes, emphasizing the importance of considering childhood maltreatment histories in treating individuals with MDD.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Family Studies
Jordan P. Davis, Eric R. Pedersen, Joan Tucker, Michael Dunbar, Anthony Rodriguez, Rachana Seelam, Elizabeth J. D'Amico
Summary: This study used data from a longitudinal cohort to examine the effects of early childhood adversity on transitions into alcohol and cannabis co-use trajectories among young adults. The study found that individuals who experienced high levels of childhood adversity were more likely to transition into chronic and rapidly increasing co-use trajectories. Male individuals who experienced high levels of childhood adversity were also more likely to meet clinical cutoff for depression.
CHILD ABUSE & NEGLECT
(2023)
Article
Clinical Neurology
Wooyoung Kang, Youbin Kang, Aram Kim, Hyeyoung Kim, Kyu-Man Han, Byung-Joo Ham
Summary: This study aimed to identify gray and white matter abnormalities in MDD patients who experienced childhood adversity. The results showed decreased gray matter in the left rectus and reduced white matter connectivity in various regions including the corpus callosum and superior longitudinal fasciculus. Childhood adversity was found to be negatively correlated with white matter connectivity. These findings suggest that MDD is associated with gray matter atrophy and white matter connectivity changes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Nan Zhao, Dianhong Shi, Juan Huang, Qiuying Chen, Qiang Wang
Summary: The study revealed a strong relationship between childhood traumatic experience and personality disorder traits, with variations in PD traits and CTE observed in patients with SZ and MDD. These factors may serve as premorbid risk factors for disease development and could be targeted for preventive interventions.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Jingyu Lin, Yunai Su, Xiaozhen Lv, Qi Liu, Gang Wang, Jing Wei, Gang Zhu, Qiaoling Chen, Hongjun Tian, Kerang Zhang, Xueyi Wang, Nan Zhang, Hong Yan, Ying Wang, Xin Yu, Tianmei Si
Summary: The stress sensitization model suggests that early adversity increases vulnerability to psychiatric disorders by sensitizing individuals to subsequent proximal stress. This study confirms the hypothesis that stress sensitization influences suicidal ideation in patients with major depressive disorder (MDD). Focusing on stress sensitization can improve early identification and timely intervention for MDD patients at risk of suicide.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Anders Hjern, Jesus Palacios, Bo Vinnerljung
Summary: The study found that international adoptees and former child refugees have a higher risk of non-affective psychotic disorders compared to the Swedish-born population. The risk of NAPD in international adoptees is influenced by the age at adoption, while the age at residency does not affect the risk of NAPD in refugees.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Yann Quide, Oliver J. Watkeys, Emiliana Tonini, Dominik Grotegerd, Udo Dannlowski, Igor Nenadic, Tilo Kircher, Axel Krug, Tim Hahn, Susanne Meinert, Janik Goltermann, Marius Gruber, Frederike Stein, Katharina Brosch, Adrian Wroblewski, Florian Thomas-Odenthal, Paula Usemann, Benjamin Straube, Nina Alexander, Elisabeth J. Leehr, Jochen Bauer, Nils R. Winter, Lukas Fisch, Katharina Dohm, Wulf Roessler, Lukasz Smigielski, Pamela DeRosse, Ashley Moyett, Josselin Houenou, Marion Leboyer, James Gilleen, Sophia I. Thomopoulos, Paul M. Thompson, Andre Aleman, Gemma Modinos, Melissa J. Green
Summary: The present study investigated the relationship between schizotypy and childhood trauma exposure on brain morphological differences. The results showed that higher levels of schizotypy were associated with thicker or thinner cortical regions in individuals exposed to higher levels of childhood trauma. This suggests that the effects of schizotypy on brain regions critical for higher cognitive processes may be enhanced in those with a history of significant trauma.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Kai Yao, Tracey van der Veen, Johan Thygesen, Nick Bass, Andrew Mcquillin
Summary: This study explores the interaction between adverse childhood experiences and genetic risk for bipolar disorder and its impact on symptom outcomes. The findings emphasize the importance of considering multiple psychiatric polygenic risk scores in predicting symptom outcomes among bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Developmental
Koen Bolhuis, Lisa R. Steenkamp, Laura M. E. Blanken, Alexander Neumann, Philip R. Jansen, Manon H. J. Hillegers, Charlotte A. M. Cecil, Henning Tiemeier, Steven A. Kushner
Summary: Previous studies have shown that schizophrenia polygenic risk predicts various mental health problems in the general population, and this association partly arises from childhood adversity. The genetic liability to schizophrenia increases the risk for mental health problems in children, with childhood adversities playing a role in mediating this association.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Maya Kuperberg, Douglas Katz, Sophie L. A. Greenebaum, Nevita George, Louisa G. Sylvia, Gustavo Kinrys, Astrid Desrosiers, Andrew A. Nierenberg
Summary: This study examined the relationship between psychotic symptoms during bipolar depressive episodes and suicidal ideation among outpatients with bipolar disorder. The results indicated that patients with psychotic symptoms were more likely to report active suicidal thoughts, including specific plans and methods.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Aki Yazawa, Koichiro Shiba, Yosuke Inoue, Sakurako S. Okuzono, Kosuke Inoue, Naoki Kondo, Katsunori Kondo, Ichiro Kawachi
Summary: This study found a link between adverse childhood experiences (ACEs) and late-life depression, with adult socioeconomic status (SES) playing a role as a mediator and an effect modifier. The controlled direct effect had the greatest contribution to the association between ACEs and late-life depression.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Immunology
Clare McCormack, Vincenzo Lauriola, Tianshu Feng, Seonjoo Lee, Marisa Spann, Anika Mitchell, Frances Champagne, Catherine Monk
Summary: Inflammatory processes may be a mechanism through which early adversity is biologically embedded and leads to poorer health outcomes, with pregnancy being a pathway for intergenerational transmission of adversity. Research indicates that factors such as mood, diet, BMI, and social support may moderate the association between childhood trauma history and inflammation in adulthood, with limited studies examining these associations among pregnant women.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychiatry
Aino Saarinen, Liisa Keltikangas-Jarvinen, Henrik Dobewall, Elina Sormunen, Terho Lehtimaki, Mika Kahonen, Olli Raitakari, Jarmo Hietala
Summary: This study examined the influence of childhood family environment on the risk of developing mental disorders in adulthood. It found that frequent stress-prone life events increased the risk of non-affective psychotic disorders, while disadvantageous emotional family atmosphere slightly increased the risk of affective disorders. These results highlight the importance of individual and public health preventive measures, including family support interventions.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Franz Veru, Kathleen MacDonald, Ashok Malla, Marita Pruessner, Suzanne King, Ridha Joober, Jai Shah, Srividya N. Iyer
Summary: Childhood trauma is associated with prolonged treatment delays in psychosis patients, with higher CTQ scores predicting longer DUP. Patients with schizophrenia-spectrum psychosis have longer help-seeking and total DUPs compared to those with affective psychosis. Increased positive symptoms predict longer help-seeking DUPs, while more severe negative symptoms predict longer referral DUPs. Social disadvantage indicators do not impact DUP.
PSYCHIATRY RESEARCH
(2022)
Review
Psychology, Multidisciplinary
Dorota Frydecka, Eid Abo Hamza, Ahmed Helal, Ahmed A. Moustafa
Summary: This review examines the relationship between childhood adversity and the onset of psychosis, focusing on the impact of specific genetic variants that affect dopamine levels. The review highlights the significant role of COMT, DRD2, and AKT1 genes in mediating the association between childhood adversity and the development of psychosis. Conflicting findings on the impact of dopamine genes suggest the need to consider other genetic and environmental factors.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Aki Rintala, Martien Wampers, Ginette Lafit, Inez Myin-Germeys, Wolfgang Viechtbauer
Summary: This study investigated the level of disturbance and its predictors in participants using experience sampling method (ESM) through a pooled dataset analysis. The findings suggest that high-frequency ESM protocols can be used in mental health research, but researchers should be aware of the possible disturbance caused by their research design.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Clinical
Anita Schick, Ruud van Winkel, Bochao D. Lin, Jurjen J. Luykx, Sonja M. C. de Zwarte, Kristel R. van Eijk, Group Investigators, Inez Myin-Germeys, Ulrich Reininghaus
Summary: This study aimed to investigate the impact of polygenic risk on stress reactivity in individuals with psychosis, their relatives, and controls. The results showed that polygenic risk score modified the associations between momentary stress and psychotic experiences, suggesting that it may amplify reactivity to stress in unaffected individuals but attenuate stress reactivity in relatives. These findings suggest that polygenic risk operates differently than previously assumed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Karlijn S. F. M. Hermans, Olivia J. Kirtley, Zuzana Kasanova, Robin Achterhof, Noemi Hagemann, Anu P. Hiekkaranta, Aleksandra Lecei, Leonardo Zapata-Fonseca, Ginette Lafit, Ruben Fossion, Tom Froese, Inez Myin-Germeys
Summary: The study examined the ecological and convergent validity of the Perceptual Crossing Experiment (PCE) in a sample of 208 adolescents, finding that only self-reported social skills were positively associated with daily social experiences, failing to support the ecological and convergent validity of the PCE.
Article
Psychiatry
Lena de Thurah, Glenn Kiekens, Rob Sips, Ana Teixeira, Zuzana Kasanova, Inez Myin-Germeys
Summary: The Experience sampling method (ESM) has the potential to support person-centered care of psychotic disorders, but the lack of user involvement in the design of ESM tools hampers clinical implementation. This qualitative study explored the perspective of nine people with lived experiences of psychosis. Participants reported a need to monitor a diverse range of daily-life experiences and indicated that ESM should allow for personalization to be clinically useful. Although participants recognized the potential of ESM to increase awareness and control over their mental health, concerns were voiced about the validity and burden of monitoring one's own mental health.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Bochao Danae Lin, Jentien M. Vermeulen, K. Bolhuis, Xiao Chang, Frederike Schirmbeck, Kristel R. van Eijk, Sinan Guloksuz, Matthijs Blankers, W. van den Brink, Lieuwe de Haan, Jurjen J. Luykx
Summary: In this six-year prospective cohort study, researchers investigated the relationship between smoking behavior polygenic scores (PRS) and psychosis. They found that smoking initiation and age at regular smoking initiation were associated with various symptom dimensions of schizophrenia. However, these associations were only observed in unaffected siblings and healthy controls, not in patients. The findings suggest that other genetic risk factors may play a dominant role in patients.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Psychology, Clinical
S. Siddi, R. Bailon, I. Gine-Vazquez, F. Matcham, F. Lamers, S. Kontaxis, E. Laporta, E. Garcia, F. Lombardini, P. Annas, M. Hotopf, B. W. J. H. Penninx, A. Ivan, K. M. White, S. Difrancesco, P. Locatelli, J. Aguilo, M. T. Penarrubia-Maria, V. A. Narayan, A. Folarin, D. Leightley, N. Cummins, S. Vairavan, Y. Ranjan, A. Rintala, G. de Girolamo, S. K. Simblett, T. Wykes, I. Myin-Germeys, R. Dobson, J. M. Haro
Summary: This 2-year study examined the intra-individual variations in heart rate (HR) parameters and their relationship with depression severity in individuals with recurrent major depressive disorder. The results showed that decreased HR variation during resting periods during the day was associated with increased depression severity, and higher mean HR during resting at night was observed in participants with more severe depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Eva Velthorst, Adam Socrates, Behrooz Z. Alizadeh, Therese van Amelsvoort, Agna A. Bartels-Velthuis, Richard Bruggeman, Wiepke Cahn, Lieuwe de Haan, Frederike Schirmbeck, Claudia J. P. Simons, Jim van Os, Anne-Kathrin Fett
Summary: This study found age-related differences in social cognitive impairment among individuals with psychotic disorders, unaffected siblings, and non-psychotic controls. Older participants had worse performance in emotion perception and processing (EPP) but better theory of mind (ToM) performance, particularly among patients. The timing of social cognitive training is crucial for patients with psychotic disorders.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Zhiling Qiao, Ginette Lafit, Aleksandra Lecei, Robin Achterhof, Olivia J. Kirtley, Anu P. Hiekkaranta, Noemi Hagemann, Karlijn S. F. M. Hermans, Bart Boets, Ulrich Reininghaus, Inez Myin-Germeys, Ruud van Winkel
Summary: This study used a network approach to examine the complex interactions between childhood adversity, psychotic experiences (PEs), other psychiatric symptoms, and multiple psychological mediators. The results revealed the pivotal role of depression, anxiety, negative affect, and loneliness within the network, and the bridging role of threat anticipation between childhood adversity and maladaptive cognitive emotion regulation. Multiple pathways were found between childhood adversity and PEs, with symptoms of general psychopathology as the main connective component. Variables with higher centrality better predicted follow-up PEs.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Natalia Tiles-Sar, Tesfa Dejenie Habtewold, Edith J. Liemburg, Lisette van der Meer, Richard Bruggeman, Behrooz Z. Alizadeh
Summary: This study aimed to identify lifelong predictors of social functioning (SF) after psychosis onset and build prediction models. The results showed that premorbid adjustment trajectories, cognitive deficits, positive and negative symptom trajectories, as well as demographic, clinical, and environmental factors were significantly associated with SF. The final prediction models explained a variance of 27% and 26% at 3-year and 6-year follow-ups, respectively.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Thomas Vaessen, Ulrich Reininghaus, Evelyne van Aubel, Annelie Beijer-Klippel, Henrietta Steinhart, Inez Myin-Germeys, James Waltz
Summary: Affective reactivity to daily stressors is increased in individuals in the early stages of psychosis. Studies have shown altered neural reactivity to stress in limbic, prelimbic, and salience areas in psychosis patients and individuals at increased psychosis risk. This study investigates if a similar pattern of neural reactivity is present in early psychosis individuals and if brain activity in these regions is associated with daily-life stress reactivity.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Vivian Shi Cheng Fung, Joseph Ching Yui Chan, Sandra Chi Yiu Wong, Corine Sau Man Wong, Olivia Kirtley, Inez Myin-Germeys, Gregory P. Strauss, Wing Chung Chang
Summary: Negative symptoms in early psychosis are not associated with blunted affective experiences, anhedonia or asociality, according to a study using an experience-sampling methodology. The study found higher intensity and variability of negative affect in patients compared to controls, but no group differences in affect instability or positive affect. Patients also had a preference for company when alone and a preference for being alone when with others. Future research combining experience-sampling methodology with other measures will provide a more refined assessment of negative symptoms in daily life.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Victoria Bell, Eva Velthorst, Jorge Almansa, Inez Myin-Germeys, Sukhi Shergill, Anne-Kathrin Fett
Summary: This study investigates the effects of loneliness and social exclusion on the development of paranoia, and finds that negative affect may mediate the relationship between these factors. The study reveals a significant association between loneliness, social exclusion, and paranoia, and that negative affect partially mediates this association.
SCHIZOPHRENIA RESEARCH-COGNITION
(2023)
Article
Psychology, Multidisciplinary
S. A. Bogemann, A. Riepenhausen, L. M. C. Puhlmann, S. Bar, E. J. C. Hermsen, J. Mituniewicz, Z. C. Reppmann, A. Uscilko, J. M. C. van Leeuwen, C. Wackerhagen, K. S. L. Yuen, M. Zerban, J. Weermeijer, M. A. Marciniak, N. Mor, A. van Kraaij, G. Koeber, S. Pooseh, P. Koval, A. Arias-Vasquez, H. Binder, W. De Raedt, B. Kleim, I. Myin-Germeys, K. Roelofs, J. Timmer, O. Tuescher, T. Hendler, D. Kobylinska, I. M. Veer, R. Kalisch, E. J. Hermans, H. Walter
Summary: This study aims to enhance stress resilience through two new mechanistically targeted just-in-time adaptive interventions, and further advance the field of resilience research by identifying predictors for successful intervention response.
Article
Health Care Sciences & Services
Jeroen Dennis Merlijn Weermeijer, Martien Wampers, Lena de Thurah, Rafael Bonnier, Maarten Piot, Peter Kuppens, Inez Myin-Germeys, Glenn Kiekens
Summary: The experience sampling method (ESM) may facilitate bringing contextual information into therapy, but its implementation in clinical practice is limited. This pilot study evaluates the usability of an ESM protocol in a specialized mental health care setting. Results show that practitioners rated the usability of the ESM protocol as reasonable to good, while clients had slightly lower ratings and voiced concerns over the piloted ESM template.
JMIR FORMATIVE RESEARCH
(2023)
Article
Psychology, Applied
Marta Anna Marciniak, Lilly Shanahan, Inez Myin-Germeys, Ilya Milos Veer, Kenneth S. L. Yuen, Harald Binder, Henrik Walter, Erno J. Hermans, Raffael Kalisch, Birgit Kleim
Summary: This study investigated the impact of a mobile health application called Imager on reward sensitivity and mental health symptoms through a two-arm randomized controlled trial. The results showed that participants in the intervention group who used Imager reported fewer mental health symptoms in the follow-up assessment, which may contribute to the clinical preventive practice of affective disorders.
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
(2023)
