Article
Biochemistry & Molecular Biology
Lena Machetanz, Moritz Philipp Guenther, Steffen Lau, Johannes Kirchebner
Summary: Compared to acute or community settings, forensic psychiatric settings are more likely to use antipsychotic polypharmacy and/or high dose pharmacotherapy, including overdosing. This study evaluated prescription patterns in offender patients compared to non-offender patients with schizophrenia spectrum disorders (SSD). The results showed that offender patients received higher doses of antipsychotics, while non-offender patients were more likely to receive polypharmacologic treatment as well as additional antidepressants and benzodiazepines.
Article
Clinical Neurology
Xinying Chen, Ce Chen, Feng Ji, Yong Xu, Wenqiang Wang, Xiaodong Lin, Deguo Jiang, Xueqin Song, Xiangyang Gao, Hongjun Tian, Chuanjun Zhuo, Jingliang Zhang
Summary: This study focused on investigating the pathological changes of the primary visual cortex in a prenatal mouse model of MK801-induced high-risk schizophrenia. The results showed that both groups of HRMMS mice, with or without antipsychotic treatment, had decreased neuronal calcium activity in the primary visual cortex, which was not improved by the treatment. This suggests the presence of independent regulatory pathways for visual perception disturbance in schizophrenia.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Psychiatry
Brian O'Donoghue, Nathan Mifsud, Emily Castagnini, Alison Langstone, Andrew Thompson, Eoin Killackey, Patrick McGorry
Summary: Background factors such as obesity, smoking, and sedentary behavior contribute to early mortality in psychotic disorders. However, adding a physical health nurse to the care of young people with first-episode psychosis did not prevent clinically significant weight gain, smoking, metabolic syndrome, or sedentary behavior. This suggests that more intensive interventions are needed.
Article
Psychiatry
Markku Laehteenvuo, Jurjen J. Luykx, Heidi Taipale, Ellenor Mittendorfer-Rutz, Antti Tanskanen, Albert Batalla, Jari Tiihonen
Summary: This study compared the effects of different antipsychotic medications on the risk of developing substance use disorder (SUD) and hospital admissions in patients with schizophrenia. The results showed that clozapine and antipsychotic polytherapy were most strongly associated with a reduced risk of developing SUD and lower relapse rates.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Georgi Panov Panov
Summary: This study evaluated the effect of the first antipsychotic medication on the prognosis of patients with schizophrenia. The results showed that the effectiveness of the first antipsychotic was found in 46.7% of patients. Patients with resistant schizophrenia were more likely to have ineffective initial medication, suggesting the need for more aggressive measures to prevent future resistance and disability.
Article
Neurosciences
Yi Yin, Shuangshuang Li, Jinghui Tong, Junchao Huang, Baopeng Tian, Song Chen, Yimin Cui, Shuping Tan, Zhiren Wang, Fude Yang, Yongsheng Tong, L. Elliot Hong, Yunlong Tan
Summary: This study aimed to compare pre-treatment neurocognitive profiles among individuals with early-onset schizophrenia (EOS), typical-onset schizophrenia (TOS), and late-onset schizophrenia (LOS). The results showed that TOS patients had lower scores in verbal learning compared to LOS patients, while there were no differences in other cognitive domains. The association between age of onset and verbal memory showed a U-shaped curve.
COGNITIVE NEURODYNAMICS
(2023)
Article
Psychiatry
Emanuele F. Osimo, Jonathan Lewis, Rudolf N. Cardinal, Golam M. Khandaker
Summary: Patients receiving clozapine were more likely to be tested for COVID-19, but not to test positive. Increased testing in patients receiving clozapine suggests prudent judgement by clinicians, considering the overall health vulnerabilities of this group.
Article
Psychiatry
Shaoling Zhong, Jun Wang, Huijuan Guo, Jiansong Zhou, Xiaoping Wang
Summary: This study developed an easy-to-use predictive tool to assist clinicians in identifying the risk of violent offending in patients with severe mental illness in China.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Kristyna Vochoskova, Sean R. McWhinney, Marketa Fialova, Marian Kolenic, Filip Spaniel, Patrik Svancer, Petra Boron, Yurai Okaji, Pavel Trancik, Tomas Hajek
Summary: The study found that patients with first-episode psychosis experienced rapid weight gain during their first psychiatric hospitalization, which was associated with the use of antipsychotic medication. These patients also showed metabolic changes consistent with metabolic syndrome. Therefore, close monitoring of weight and caution in prescribing metabolically problematic antipsychotics is necessary, especially for patients with lower BMI.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Banny Silva Barbosa Correia, Joao Victor Nani, Raniery Waladares Ricardo, Danijela Stanisic, Tassia Brena Barroso Carneiro Costa, Mirian A. F. Hayashi, Ljubica Tasic
Summary: This study evaluated the effects of antipsychotic drugs on blood serum lipids in an SCZ animal model and normal control rats, revealing similar lipid alterations to those seen in SCZ patients. The use of psychostimulants in normal rats resulted in decreased ω-3 fatty acids, similar to the first episode of psychosis in SCZ. CLZ was found to reverse lipid metabolism changes in SHR.
Article
Pharmacology & Pharmacy
Jiajun Weng, Lei Zhang, Wenjuan Yu, Nan Zhao, Binggen Zhu, Chengyu Ye, Zhanxing Zhang, Changlin Ma, Yan Li, Yiming Yu, Huafang Li
Summary: This study aimed to explore the risk factors, clinical correlates, and social functions of drug-induced parkinsonism (DIP) in Chinese schizophrenia patients. It found that age, high D2 receptor antagonist antipsychotic dose, and valproate dose were risk factors for DIP. DIP was significantly correlated with psychiatric symptoms and social performance. Rational application or discontinuation of valproate is necessary, and early intervention and treatment of DIP can improve schizophrenia patients' prognosis and social performance.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Matthew Harlin, Craig Chepke, Frank Larsen, Karimah S. Bell Lynum, Sanjeda R. Chumki, Heather Fitzgerald, Pedro Such, Jessica Madera-McDonough, Murat Yildirim, Moeen Panni, Stephen R. Saklad
Summary: Aripiprazole 2-month ready-to-use 960 mg and Aripiprazole lauroxil 1064 mg are both long-acting injectable formulations used for the treatment of schizophrenia. Comparing the drug concentrations, both formulations maintain therapeutic levels over the 2-month dosing interval.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Psychiatry
Chao-Hsiun Tang, Darmendra Ramcharran, Ching-Wen Wendy Yang, Chi-Chun Chang, Po-Ya Chuang, Hong Qiu, Kuo-Hsuan Chung
Summary: This study found that patients with schizophrenia had varying risks of mortality based on different types of antipsychotic treatments, with oral medications posing the highest risk and long-acting injections having the lowest risk.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Behavioral Sciences
Gary Remington, Margaret K. Hahn, Sri Mahavir Agarwal, Araba Chintoh, Ofer Agid
Summary: The introduction of chlorpromazine led to schizophrenia being repositioned as a biological illness. The evolution of antipsychotics, from 'typical' to 'atypical', and drug development that aligns with the illness' heterogeneity and complexity are explored. It may be time to reconsider the notion of developing drugs that specifically treat 'schizophrenia'.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Norio Sugawara, Norio Yasui-Furukori, Kazutaka Shimoda
Summary: This study aimed to analyze the association between antipsychotic medication and DKA in patients with schizophrenia. The results revealed that treatment with olanzapine was associated with the development of DKA. Male patients were found to be at higher risk for DKA when treated with olanzapine.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Chemistry, Applied
Camila de Souza Paglarini, Vitor Andre Silva Vidal, Maristela Midori Ozaki, Ana Paula Badan Ribeiro, Oigres Daniel Bernardinelli, Ana Karoline Ferreira Ignacio Camara, Ana M. Herrero, Claudia Ruiz-Capillas, Edvaldo Sabadini, Marise Aparecida Rodrigues Pollonio
Summary: Gelled emulsions (GE) used as animal fat replacers in Bologna sausages resulted in reduced fat content, increased hardness, and higher lipid oxidation rates. Consumer tests indicated that the reformulated sausages were acceptable, but CATA tests revealed issues with the sensory properties of sausages with partial or total pork fat replaced with GE.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2022)
Article
Substance Abuse
Delyse Hutchinson, Elizabeth A. Spry, Hanafi Mohamad Husin, Melissa Middleton, Stephen Hearps, Margarita Moreno-Betancur, Elizabeth J. Elliott, Joanne Ryan, Craig A. Olsson, George C. Patton
Summary: The study found that there is a high degree of continuity between binge drinking behaviors in adolescence and young adulthood and periconception alcohol use, indicating that women with a history of frequent or binge drinking are more likely to engage in risky drinking behaviors in early pregnancy.
Review
Food Science & Technology
Mayara de Souza Queiros, Rodolfo Lazaro Soares Viriato, Ana Paula Badan Ribeiro, Mirna Lucia Gigante
Summary: This review investigates modification strategies and demonstrates the potential of application of milk fat on a macro, micro, and nanoscale. Milk fat is a complex fat and modification techniques, including biological, physical, and chemical modifications, can be used to change its physicochemical properties for various applications in the food industry.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Julia Cristina Zuin, Renata Luana de Padua Gandra, Ana Paula Badan Ribeiro, Juliana Neves Rodrigues Ract, Juliana Alves Macedo, Gabriela Alves Macedo
Summary: One of the challenges in the food industry is to develop lipid bases with desired technological performance and lower caloric value. This research compares chemical and enzymatic interesterification as methods for obtaining structured low-calorie lipids and finds that interesterification improves the physical properties of the lipids, making them a potential alternative to fats in low-calorie foods.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Nadia Morin-Crini, Eric Lichtfouse, Marc Fourmentin, Ana Rita Lado Ribeiro, Constantinos Noutsopoulos, Francesca Mapelli, Eva Fenyvesi, Melissa Gurgel Adeodato Vieira, Lorenzo A. Picos-Corrales, Juan Carlos Moreno-Pirajan, Liliana Giraldo, Tamas Sohajda, Mohammad Mahmudul Huq, Jafar Soltan, Giangiacomo Torri, Monica Magureanu, Corina Bradu, Gregorio Crini
Summary: The rise of emerging contaminants presents challenges for the scientific community and water treatment stakeholders to develop remediation techniques that are simple, practical, inexpensive, effective, and environmentally friendly. Adsorption-oriented processes and advanced oxidation processes are the most promising strategies for removing emerging contaminants in wastewater.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
C. I. A. V. Santos, M. C. F. Barros, A. C. F. Ribeiro, M. M. Bou-Ali, A. Mialdun, V. Shevtsova
Summary: The Soret effect and diffusion in TEG-water mixtures were investigated using optical digital interferometry. The results showed that all coefficients, including diffusion, thermal diffusion, and Soret coefficients, decreased with increasing concentrations of TEG and n-EG. The change of sign in the Soret coefficient was directly related to the hydrogen bonding ability of the n-EG molecule with water. The diffusion and thermal diffusion coefficients exhibited a plateau behavior, indicating changes in preferential interactions in aqueous solutions with concentration.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Applied
Maria Lucimar da Silva Medeiros, J. P. Cruz-Tirado, Adriano Freitas Lima, Jose Marcelino de Souza Netto, Ana Paula Badan Ribeiro, Doglas Bassegio, Helena Teixeira Godoy, Douglas Fernandes Barbin
Summary: The study aimed to analyze the oil content and fatty acids of Brassica seeds using portable Near Infrared spectroscopy (NIRS) and NIR-Hyperspectral Imaging (NIR-HSI), as well as classify seed species. Results showed that prediction models based on NIR-HSI spectra were superior and could effectively differentiate between different varieties of Brassica seeds.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agricultural Economics & Policy
Felipe Furtini Haddad, Ana Paula Lima Ribeiro, Kelly Carvalho Vieira, Rafaela Correa Pereira, Joao de Deus Souza Carneiro
Summary: By surveying producers and consumers of specialty beers, this study identified an important convergence between producer perceptions and actual consumer behavior, and segmented consumers into different groups. The study also highlighted the practical and social implications, such as new product development and creating precise labels and packaging, in the specialty brewing industry.
BRITISH FOOD JOURNAL
(2023)
Article
Computer Science, Artificial Intelligence
Teofilo P. G. Mendes, Leizer Schnitman, Idelfonso Bessa dos Reis Nogueira, Ana Mafalda Almeida Peixoto Ribeiro, Alirio Egidio Rodrigues, Jose Miguel Loureiro, Marcio A. F. Martins
Summary: This manuscript presents a new fuzzy approach applied to Model Predictive Control (MPC). The first contribution of this work is a modification in the Takagi-Sugeno-Kang (TSK) structure that allows modeling IF-THEN rules without approximation. The second contribution is a new MPC formulation that guarantees system stability by combining optimization, state-space model, and terminal constraints. These methods were implemented on a Programmable Logic Controller and applied to control a physical DC motor.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Editorial Material
Engineering, Chemical
Ana C. F. Ribeiro, Pedro M. G. Nicolau, Sonia I. G. Fangaia
Article
Nursing
Ana Cristina Ribeiro, Priscila Poli, Silvia Carla da Silva Andre Uehara
Summary: This observational, retrospective, and analytical study aimed to analyze the risk of mortality from COVID-19 in people with obesity. The results showed that obese individuals with COVID-19 had a 26% higher risk of death compared to those without obesity. The highest mortality risks were found in obese individuals in the 11 to 60 age groups, while obese women aged 31 to 50 years and elderly women over 71 years had the lowest mortality risk compared to obese men.
Review
Medicine, General & Internal
Jessica Heerde, Rohan Borschmann, Jesse Young, Stuart A. Kinner, Susan M. Sawyer, George C. Patton
Summary: This systematic review aims to synthesize international literature on mortality rates and risk and protective factors among people who have experienced homelessness. The study will search for cohort studies examining mortality in this population and assess the quality of included studies. The findings will be disseminated through academic channels.
Article
Health Care Sciences & Services
Shilpa Aggarwal, Kate L. Francis, S. Ghazaleh Dashti, George Patton
Summary: This study investigates the association between child marriage and mental health in girls, finding that poor mental health is both preceding and a consequence of early marriage. The findings highlight the importance of considering mental health in policies and programs aimed at reducing early marriage and protecting the mental health of young brides.
LANCET REGIONAL HEALTH - SOUTHEAST ASIA
(2023)
Review
Nursing
Bianca Chel da Silva, Ana Cristina Ribeiro, Silvia Carla da Silva Andre Uehara
Summary: This study conducted a scoping review to examine the relationship between socioeconomic factors and child mortality from COVID-19. The findings demonstrated that low income and residing in socially vulnerable areas are associated with increased mortality rates.
Article
Nutrition & Dietetics
Carolina Curti, Luciana E. Carvalho Fino, Ana Paula Olivares Lamadrid, Ana Paula Badan Ribeiro, Diogo Timotheo da Cunha, Gabriel Vinderola, Adriane Elisabete Costa Antunes, Adriana Ramon
Summary: Andean lupin concentrate is rich in nutrients, and when added to yoghurts, increases protein content and enhances unsaturated fatty acids, polyphenols, flavonoids, and antioxidant activity. Enriched yoghurts show improved physicochemical properties such as increased lactic acid content and reduced syneresis. This demonstrates that yoghurts enriched with lupin protein concentrate could be a beneficial option in promoting health and preventing chronic diseases.
REVISTA ESPANOLA DE NUTRICION HUMANA Y DIETETICA
(2022)
