Article
Clinical Neurology
Joshua Chiappelli, Mark Kvarta, Heather Bruce, Shuo Chen, Peter Kochunov, L. Elliot Hong
Summary: This study found a significant association between stressful life events and openness to experience, with participants with a history of depression exhibiting higher levels of openness. Furthermore, openness to experience was related to overall intelligence but not processing speed or working memory. The findings suggest that openness to experience may partially mediate the relationship between stressful life events and depression in rural populations with high social and environmental homogeneity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Date C. van der Veen, Bernice Gulpers, Willeke van Zelst, Sebastian Kohler, Hannie C. Comijs, Robert A. Schoevers, Richard C. Oude Voshaar
Summary: Comorbid anxiety disorders have a negative impact on complete remission in depressed patients at the 2-year follow-up. The course of anxiety severity appears to be dependent on the interaction of personality traits and life events.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Daria A. Pawlak, Arash Sahraie
Summary: The accurate placement of events on a timeline is often a challenge, particularly for distant past events. In a study conducted with 277 participants in May 2022, it was found that participants made more errors in recalling the timeline of distant events compared to more recent ones. Surprisingly, there was also a significant error in estimating the timing of events that occurred in 2021, similar to events that happened 3 to 4 years earlier. This error in perception of event timeline was associated with levels of depression, anxiety, resilience, and the demands of the COVID pandemic.
Article
Clinical Neurology
Elena Scumaci, Enrica Marzola, Giovanni Abbate-Daga, Marianna Pellegrini, Valentina Ponzo, Ilaria Goitre, Andrea Benso, Fabio Broglio, Sara Belcastro, Chiara Crespi, Chiara D'Eusebio, Franco De Michieli, Ezio Ghigo, Simona Bo
Summary: The study found that many outpatient with obesity reported symptoms of anxiety and depression even without a formal psychiatric diagnosis. Cyclothymic temperament was positively associated with binge eating, while hyperthymic temperament showed a protective effect on both binge eating and multiple weight cycling.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Lindsey M. Filiatreau, Peter Vanes Ebasone, Anastase Dzudie, Rogers Ajeh, Brian W. Pence, Milton Wainberg, Denis Nash, Marcel Yotebieng, Kathryn Anastos, Eric Pefura-Yone, Denis Nsame, Angela M. Parcesepe
Summary: Stressful life events are common among people living with HIV in Cameroon and are associated with poor mental health outcomes, particularly in the case of work-related difficulties and PTSD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Julia S. S. Yarrington, Allison V. V. Metts, Richard E. E. Zinbarg, Robin Nusslock, Kate Wolitzky-Taylor, Constance L. L. Hammen, Nicholas J. J. Kelley, Susan Bookheimer, Michelle G. G. Craske
Summary: Negative or stressful life events are strong risk factors for depression and anxiety. This study investigated the role of positivity in buffering against negativity and predicting anxiety and depressive symptoms. The findings demonstrated that positivity protected against high levels of negativity in noninterpersonal events, while interpersonal negativity predicted higher levels of anhedonia-apprehension. The results suggest that the positivity of life events may play a buffering role in predicting symptoms shared between anxiety and depression.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Clinical Neurology
Becky Mars, Jo Gibson, Barnaby D. Dunn, Christopher Gordon, Jon Heron, David Kessler, Nicola Wiles, Paul Moran
Summary: The study found that personality difficulties may result in less favorable treatment outcomes for individuals with depression and anxiety disorders. The more personality difficulties a person has, the lower the likelihood of recovery and improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Xueru Duan, Murui Zheng, Wenjing Zhao, Jun Huang, Lixian Lao, Haiyi Li, Jiahai Lu, Weiqing Chen, Xudong Liu, Hai Deng
Summary: Depression and anxiety, especially their co-occurrence, are associated with an increased risk of obstructive sleep apnea (OSA) in the Chinese population. However, life events are not related to the risk of OSA.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Shaoyun Yang, Pengfei Huang, Biqin Li, Ting Gan, Wenzheng Lin, Yinhua Liu
Summary: This study examined the mediating effect of trait anxiety and the moderating effect of self-esteem in the relationship between negative life events and depression among Chinese college students. The results showed that negative life events had an indirect effect on depression through trait anxiety, and this mediation was moderated by self-esteem. Limitations of the study included self-reported measures and a cross-sectional design.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Maital Neta, Rebecca L. Brock
Summary: Negativity bias plays a central role in mood and anxiety disorders and decision-making, and this project examines negativity bias using dual-valence ambiguity. The study reveals that one's propensity toward negativity is predictive of valence bias especially in older adulthood, and social connectedness can also influence an individual's valence bias.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Marcantonio M. Spada, Ana Niksevic, Daniel C. Kolubinski, Alessia Offredi, Simona Giuri, Antonella Gemelli, Alessandra Brugnoni, Andrea Ferrari, Gabriele Caselli
Summary: Research on metacognitions and repetitive negative thinking in patients with Personality Disorder is limited, but findings suggest that these factors differ between patients with PD and those without PD, with metacognitions playing a role in predicting repetitive negative thinking in patients with PD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Gabriel Martin-Gagnon, Lina Normandin, Peter Fonagy, Karin Ensink
Summary: This study found that childhood emotional abuse is associated with adolescent borderline personality features, depression, and anxiety symptoms. Uncertainty/confusion about mental states mediates the relationships between childhood emotional abuse and these outcomes.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Dermatology
Manuel Sanchez-Diaz, Trinidad Montero-Vilchez, Maria I. Quinones-Vico, Alvaro Sierra-Sanchez, Ana Ubago-Rodriguez, Raquel Senabria-De La Torre, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: Type D personality, characterized by social inhibition and negative affectivity, has been associated with poorer outcomes and quality of life in patients with non-dermatological diseases. However, research on the relationship between type D personality and skin diseases is limited. This review aims to summarize the current evidence regarding type D personality and skin diseases.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Public, Environmental & Occupational Health
Tianqi Yang, Zhihua Guo, Xia Zhu, Xufeng Liu, Yaning Guo
Summary: This study aimed to determine the fine-grained connections between different personality traits and symptoms of anxiety and depression, and identify the detrimental or protective effects of personality traits. The findings revealed that neuroticism was the most crucial risk trait for depression and anxiety symptoms, while agreeableness was the most central protective trait.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Pentagiotissa Stefanatou, Lida Alkisti Xenaki, George Konstantakopoulos, Anthoula Papaiakovou, Irene Ralli, Aristea D. Berk, Diamantina S. Katopodi, Aphrodite D. Pantagoutsou, Aimilia Charitaki, Maria Ginieri-Coccossis, Eleni Giannouli, Ioannis A. Malogiannis
Summary: This study investigated the psychopathological determinants of subjective quality of life in individuals with borderline personality disorder. The results showed that depression was the strongest determinant, while the number of diagnostic criteria for BPD and self-harming behavior were not significantly associated with quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Behavioral Sciences
Margot P. van de Weijer, Dirk H. M. Pelt, Lianne P. de Vries, Floris Huider, Matthijs D. van der Zee, Quinta Helmer, Lannie Ligthart, Gonneke Willemsen, Dorret Boomsma, Eco de Geus, Meike Bartels
Summary: By treating the COVID-19 pandemic as a natural experiment, researchers in the Netherlands examined the impact of lockdown measures on quality of life. They found a significant decrease in mean QoL during the pandemic, as well as a reduction in heritability estimates.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Veronika V. Odintsova, Matthew Suderman, Fiona A. Hagenbeek, Doretta Caramaschi, Jouke-Jan Hottenga, Rene Pool, Conor V. Dolan, Lannie Ligthart, Catharina E. M. van Beijsterveldt, Gonneke Willemsen, Eco J. C. de Geus, Jeffrey J. Beck, Erik A. Ehli, Gabriel Cuellar-Partida, David M. Evans, Sarah E. Medland, Caroline L. Relton, Dorret I. Boomsma, Jenny van Dongen
Summary: This study investigated the epigenetic mechanisms of handedness and found that CpG sites located near handedness-associated genetic variants were more strongly associated with left-handedness. However, no differentially methylated positions were identified. Longitudinal analyses demonstrated moderately stable associations across age but inconsistency across tissues.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Amy M. Tedja, Meenakshi S. Shanmugam, Stephen Stathis, Christel M. Middeldorp
Summary: This study explored the changes in demand for child and youth mental health services in Brisbane, Australia, following the COVID-19 pandemic. The results showed a significant increase in referrals to both the emergency department and community CYMHS. The most vulnerable families, including Indigenous children and those from lower socio-economic areas, were the most affected.
CHILD AND ADOLESCENT MENTAL HEALTH
(2023)
Article
Food Science & Technology
Joshua M. Tybur, Laura W. Wesseldijk, Dorret I. Boomsma, Gonneke Willemsen, Jacqueline M. Vink
Summary: Genetic factors have a significant influence on individuals' food preferences, as well as their decision to abstain from eating meat and fish. In a study conducted on a Dutch twin sample, it was found that genetic factors accounted for a large proportion of variation in pescetarianism and vegetarianism. Different meats and fish were abstained from for different reasons, with health concerns being the main reason for abstaining from pork, dislike for poultry, fish, and shellfish, and beliefs for abstaining from beef.
FOOD QUALITY AND PREFERENCE
(2023)
Article
Clinical Neurology
Sarah R. Vreijling, Marije van Haeringen, Yuri Milaneschi, Floris Huider, Mariska Bot, Najaf Bot, Joline W. Beulens, Marijke A. Bremmer, Petra J. Elders, Tessel E. Galesloot, Lambertus A. Kiemeney, Hanna M. van Loo, H. Susan J. Picavet, Femke Rutters, Ashley van der Spek, Anne M. van de Wiel, Cornelia van Duijn, Edith J. M. Feskens, Catharina A. Hartman, Albertine J. Oldehinkel, Jan H. Smit, W. M. Monique Verschuren, Gonneke Willemsen, Eco J. C. de Geus, Dorret I. Boomsma, Brenda W. J. H. Penninx, Femke Lamers, Rick Jansen
Summary: In a subgroup of depressed patients, energy-related symptoms are associated with immuno-metabolic dysregulations. This study examines the associations between energy-related symptoms and sociodemographic, lifestyle, and clinical characteristics.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychology, Developmental
Matthew Bisset, Louise E. E. Brown, Sampada Bhide, Pooja Patel, Nardia Zendarski, David Coghill, Leanne Payne, Mark A. A. Bellgrove, Christel M. Middeldorp, Emma Sciberras
Summary: Understanding the unmet needs of healthcare consumers with ADHD is crucial for improving services, education, and research. This review examined consumer-identified needs related to ADHD clinical care or research priorities. The results revealed significant gaps in treatment beyond medication, ADHD education/training, access to clinical services and support, school accommodations, and ongoing research on treatment efficacy.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Mark K. Bakker, Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stephanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K. Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J. E. HUNT All In Stroke, Jan H. CADISP Grp, Ynte M. Int Consortium Blood Pressure, Int Headache Genetics Consortium, ISGC, Intracranial Aneurysm Working Grp, Gabriel J. E. Rinkel, Jan Veldink, Ynte Ruigrok
Summary: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to have potential for genetic risk prediction. However, a genetic risk score incorporating these factors only showed limited predictive value for IA presence and ASAH incidence, suggesting that it may not be suitable for daily clinical use.
Article
Psychiatry
Leanne Payne, Hedwig J. Goijen, Vanessa Cobham, William Bor, Stephen S. Stathis, David C. Coghill, Christel M. Middeldorp
Summary: This explorative study investigates the impact of the COVID-19 pandemic and restrictions on the mental health of children, adolescents, and their parents. An online survey was conducted among parents of 110 children receiving treatment at a Child and Youth Mental Health Services in Brisbane, Australia. The results show that most children experienced symptoms such as sadness, anxiety, lack of focus, lack of joy in usual activities, and reduced sleep. Parental emotions were significantly correlated with their child's emotions, and remote schooling was found to be a significant risk factor for more reported symptoms. Mental health continued to deteriorate even as restrictions eased.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Psychiatry
Jackson G. Thorp, Zachary F. Gerring, Lucia Colodro-Conde, Enda M. Byrne, Sarah E. Medland, Christel M. Middeldorp, Eske M. Derks
Summary: This study analyzed data from the large-scale UK Biobank population cohort to investigate the association between trauma exposure, depression polygenic risk scores (PRS), and their interaction with major depressive disorder (MDD) and individual depression symptoms. The results showed significant associations between trauma, depression PRS, and both current depression and lifetime MDD. Trauma exposure and depression PRS were also associated with specific patterns of depression symptoms.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Eshim S. Jami, Anke R. Hammerschlag, Hannah M. Sallis, Zhen Qiao, Ole A. Andreassen, Per M. Magnus, Pal R. Njolstad, Alexandra Havdahl, Jean-Baptiste Pingault, David M. Evans, Marcus R. Munafo, Eivind Ystrom, Meike Bartels, Christel Middeldorp
Summary: Parental genes can influence offspring psychiatric outcomes indirectly through the environment they create. This study aimed to estimate the contribution of parental genetic nurture effects on childhood psychiatric symptoms using advanced statistical genetic methods. The results suggest that parental genetic nurture effects may play a role in explaining individual differences in childhood psychiatric symptoms, but further research with larger samples is needed.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Biological
Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Ahmad Vaez, Natalie van Zuydam, Barbara D. Bitarello, Eugene J. Gardner, Evelina T. Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Boomsma, Kristina Bosak, Marco Brumat, Julie E. Buring, David Cesarini, Daniel Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tonu Esko, Jessica D. Faul, Oscar Franco, Andrea Ganna, Audrey J. Gaskins, Andrea Gelemanovic, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Joergen Grabe, Erica P. Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W. David Hill, Eva R. Hoffmann, Georg Homuth, Jouke Jan Hottenga, Hongyang Huang, Elina Hyppoenen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Sharon L. R. Kardia, Maryam Kavousi, Annette Kifley, Tuomo Kiiskinen, Peter Kraft, Brigitte Kuehnel, Claudia Langenberg, Gerald Liew, Penelope A. Lind, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark McCarthy, George McMahon, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Paul Mitchell, Stine Mollegaard, Dennis O. Mook-Kanamori, Anna Morgan, Peter van der Most, Renee de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W. J. H. Penninx, Annette Peters, Patricia A. Peyser, Ozren Polasek, Chris Power, Ajka Pribisalic, Paul Redmond, Janet W. Rich-Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Vallari Shukla, Jennifer A. Smith, Stasa Stankovic, Kari Stefansson, Doris Stoeckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Gudmar Thorleifsson, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Constance Turman, Andre G. Uitterlinden, Melanie Waldenberger, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Jing Hau Zhao, Wei Zhao, Yajie Zhao, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R. B. Perry
Summary: Identifying genetic determinants of reproductive success can reveal the mechanisms underlying fertility and identify genes that are currently under natural selection. A genome-wide association study on individuals of European ancestry identified 43 genomic loci associated with the number of children ever born or childlessness. These loci are involved in various aspects of reproductive biology, such as puberty timing, age at first birth, sex hormone regulation, endometriosis, and age at menopause. Additionally, missense variants in ARHGAP27 were found to be associated with higher number of children ever born but shorter reproductive lifespan, suggesting a trade-off at this locus. Other genes, including PIK3IP1, ZFP82, and LRP4, were also implicated by coding variants, and a new role for the melanocortin 1 receptor (MC1R) in reproductive biology was suggested. Furthermore, integration with data from historical selection scans revealed an allele in the FADS1/2 gene locus that has been undergoing selection for thousands of years. These findings highlight the diverse biological mechanisms contributing to reproductive success.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Psychiatry
Gayani Tennakoon, Enda M. Byrne, Rhema Vaithianathan, Christel M. Middeldorp
Summary: The utility of routinely collected data in developing a tool to aid early identification of young people at risk of self-harm or suicidal ideation (SHoSI) was explored. The prediction model showed fair overall predictive power for currently non-SHoSI children but was more difficult for those currently rated SHoSI.
SUICIDE AND LIFE-THREATENING BEHAVIOR
(2023)
Article
Hematology
Julie Hahn, Jan Bressler, Arce Domingo-Relloso, Ming-Huei Chen, Daniel L. McCartney, Alexander Teumer, Jenny van Dongen, Marcus E. Kleber, Dylan Aissi, Brenton R. Swenson, Jie Yao, Wei Zhao, Jian Huang, Yujing Xia, Michael R. Brown, Ricardo Costeira, Eco J. C. de Geus, Graciela E. Delgado, Dre'Von A. Dobson, Paul Elliott, Hans J. Grabe, Xiuqing Guo, Sarah E. Harris, Jennifer E. Huffman, Sharon L. R. Kardia, Yongmei Liu, Stefan Lorkowski, Riccardo E. Marioni, Matthias Nauck, Scott M. Ratliff, Maria Sabater-Lleal, Tim D. Spector, Pierre Suchon, Kent D. Taylor, Florian Thibord, David-Alexandre Tregouet, Kerri L. Wiggins, Gonneke Willemsen, Jordana T. Bell, Dorret I. Boomsma, Shelley A. Cole, Simon R. Cox, Abbas Dehghan, Andreas Greinacher, Karin Haack, Winfried Marz, Pierre-Emmanuel Morange, Jerome I. Rotter, Nona Sotoodehnia, Maria Tellez-Plaza, Ana Navas-Acien, Jennifer A. Smith, Andrew D. Johnson, Myriam Fornage, Nicholas L. Smith, Alisa S. Wolberg, Alanna C. Morrison, Paul S. de Vries
Summary: This study examined the association between DNA methylation and circulating fibrinogen levels, and identified 83 CpG sites that are associated with fibrinogen levels. These associations are partially driven by inflammatory pathways shared by both fibrinogen and CRP.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Obstetrics & Gynecology
Hamdi Mbarek, Scott D. Gordon, David L. Duffy, Nikki Hubers, Sally Mortlock, Jeffrey J. Beck, Jouke-Jan Hottenga, Rene Pool, Conor Dolan, Ky'Era Actkins, Zachary F. Gerring, Jenny Van Dongen, Erik A. Ehli, William G. Iacono, Matt Mcgue, Daniel Chasman, C. Scott Gallagher, Samantha L. P. Schilit, Cynthia C. Morton, Guillaume Pare, Gonneke Willemsen, David C. Whiteman, Catherine M. Olsen, Catherine Derom, Robert Vlietinck, Daniel Gudbjartsson, Lisa Cannon-Albright, Eva Krapohl, Robert Plomin, Patrik K. E. Magnusson, Nancy L. Pedersen, Pirro Hysi, Massimo Mangino, Timothy D. Spector, Teemu Palviainen, Yuri Milaneschi, Brenda W. Penninnx, Adrian Campos, Ken K. Ong, John R. B. Perry, Cornelis B. Lambalk, Jaakko Kaprio, Isleifur Olafsson, Karine Duroure, Celine Revenu, Miguel E. Renteria, Loic Yengo, Lea Davis, Eske M. Derks, Sarah E. Medland, Hreinn Stefansson, Kari Stefansson, Filippo Del Bene, Bruno Reversade, Grant W. Montgomery, Dorret Boomsma, Nicholas G. Martin
Summary: This study identified four new loci associated with female propensity for giving birth to spontaneous dizygotic twins. The novel loci, GNRH1 and FSHR, have established roles in female reproduction, while ZFPM1 and IPO8 were not previously linked to female fertility. The study also found significant genetic correlations with multiple aspects of female reproduction and body size, suggesting important roles in human evolution.
HUMAN REPRODUCTION
(2023)
Article
Neurosciences
Camiel M. van der Laan, Steve G. A. van de Weijer, Rene Pool, Jouke-Jan Hottenga, Toos C. E. M. van Beijsterveldt, Gonneke Willemsen, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Summary: Family members resemble each other in their propensity for aggression, with approximately 50% of the variance in aggression explained by genetic influences. This study investigated the importance of PGSs and found significant direct effects on aggression for PGSs based on early-life aggression, educational attainment, and ADHD, though the explained variance was low. Further research on other PGSs related to aggression and related phenotypes is needed to determine the generalizability of these findings to overall genetic influences on aggression.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)