期刊
PSYCHOLOGICAL MEDICINE
卷 39, 期 7, 页码 1153-1161出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S003329170800487X
关键词
Decision making; generalized anxiety disorder; generalized social phobia
资金
- Intramural Research Program of the National Institutes of Health
- National Institute of Mental Health
Background. Generalized social phobia (GSP) involves the fear/avoidance Of Social Situations whereas generalized anxiety disorder (GAD) involves an intrusive worry about everyday life circumstances. It remains unclear whether these, highly co-morbid, conditions represent distinct disorders or alternative presentations of a single underlying pathology. In this study, we examined stimulus-reinforcement-based decision making in GSP and GAD. Method. Twenty unmedicated patients with GSP, 16 unmedicated patients with GAD and 19 age-, IQ- and gender-matched healthy comparison (HQ individuals completed the Differential Reward/Punishment Learning Task (DRPLT). In this task, the subject chooses between two objects associated with different levels of reward or punishment. Thus, response choice indexes not only reward/punishment sensitivity but also sensitivity to reward/punishment level according to between-object reinforcement distance. Results. We found that patients with GAD committed a significantly greater number of errors than both the patients with GSP and the HC individuals. By contrast, the patients with GSP and the HC individuals did not differ in performance on this task. Conclusions. These results link GAD with anomalous non-affective-based decision making. They also indicate that CSP and GAD are associated with distinct pathophysiologies.
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