Article
Multidisciplinary Sciences
Davidson Sypre, Geraldine Pignot, Rajae Touzani, Patricia Marino, Jochen Walz, Stanislas Rybikowski, Thomas Maubon, Nicolas Branger, Naji Salem, Julien Mancini, Gwenaelle Gravis, Marc-Karim Bendiane, Anne-Deborah Bouhnik
Summary: Active surveillance is a standard treatment option for low risk localized prostate cancer. This study found that patients managed with active surveillance do not report more anxiety or depressive symptoms compared to patients managed with curative treatment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sanaz Eyni, Seyede Elham Mousavi
Summary: This study investigated the relationship between intolerance of uncertainty, cognitive fusion, and self-perception as burdens in cancer patients, as well as the mediating role of coping self-efficacy. The results showed that intolerance of uncertainty, cognitive fusion, and coping self-efficacy had a direct and significant relationship with self-perceived burden in cancer patients, and intolerance of uncertainty and cognitive fusion indirectly affected self-perceived burden through coping self-efficacy. Therefore, targeting these three components through psychological therapies can reduce the perception of self-perception as burden in cancer patients.
Article
Oncology
Yesol Yang, Stephanie M. Gorka, Michael L. Pennell, Kellie Weinhold, Tonya Orchard
Summary: Approximately 30% of breast cancer survivors experience cancer-related cognitive impairment (CRCI) after cancer treatments. Individual differences in intolerance of uncertainty (IU) and anxiety may be potential risk factors for CRCI. This study suggests that assessing IU and anxiety could help identify those at higher risk for CRCI and may be potential targets for intervention studies.
Article
Oncology
Kamil Wolyniec, Jessica Sharp, Krista Fisher, Richard W. Tothill, David Bowtell, Linda Mileshkin, Penelope Schofield
Summary: Patients diagnosed with Cancer of Unknown Primary (CUP) experience high levels of psychological distress and poor understanding of their cancer. The relationship between patients' understanding of their cancer and psychological distress is mediated by illness uncertainty. Younger age and more physical symptoms are predictive of higher levels of psychological distress. Improving patients' understanding of their illness is important for reducing illness uncertainty and alleviating psychological distress.
Article
Oncology
Mariska Blom, Onno R. Guicherit, Madelein T. Hoogwegt
Summary: This study examined the relationship between perfectionism and fear of cancer recurrence (FCR), and the mediating role of intolerance of uncertainty (IU) and coping strategies in this relationship. The results showed that IU mediated the relationship between perfectionism and FCR.
Article
Oncology
Berta Obispo, Patricia Cruz-Castellanos, Ana Fernandez-Montes, Sara Coca-Membribes, Jacobo Rogado, Monica Antonanzas, Oscar A. Castillo-Trujillo, Helena Lopez-Ceballos, Adan Rodriguez-Gonzalez, Paula Jimenez-Fonseca, Caterina Calderon
Summary: The diagnosis of advanced cancer often leads to significant psychological distress due to uncertainty. This study evaluated the incidence of psychological distress in patients with unresectable advanced cancer and explored whether coping strategies mediated the relationship between illness uncertainty and distress. The findings showed that a high percentage of patients experienced clinically significant psychological distress. The use of cognitive avoidance as a coping strategy was associated with less distress, while anxious preoccupation was linked to more distress.
Article
Oncology
Bryan A. Johnson, Bruce R. Lindgren, Anne H. Blaes, Helen M. Parsons, Christopher J. LaRocca, Ronda Farah, Jane Yuet Ching Hui
Summary: This study measured patient satisfaction and telemedicine usability in breast cancer care at an academic institution. Results showed that breast cancer patients were satisfied with telemedicine and found it usable. Satisfaction and usability scores did not vary significantly according to patient characteristics.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Psychology, Multidisciplinary
Yongjuan Yu
Summary: This study examines the relationship between anxiety, depression, and impulse buying, as well as the mediating role of cognitive characteristics. The results show positive associations between anxiety, depression, and intolerance of uncertainty with impulse buying, while cognitive flexibility is negatively associated. Cognitive flexibility fully mediates the effects of anxiety and depression on cognitive facet of impulse buying, while intolerance of uncertainty fully mediates the effects on affective facet of impulse buying.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Isabelle Hardy-Leger, Cecile Charles, Marie Lange, Florence Joly, Pauline Roux, Aurelie Capel, Jean Petrucci, Olivier Rigal, Johan Le Fel, Laurence Vanlemmens, Sibille Everhard, Anne-Laure Martin, Ines Vaz Luis, Charles Coutant, Paul Cottu, Christelle Levy, Florence Lerebours, Fabrice Andre, Idlir Licaj, Sarah Dauchy
Summary: Cognitive complaints are more common in women with breast cancer than in healthy controls, with four distinct groups identified based on cognitive assessments before treatment. The groups with higher proportions of complaints showed more impairment in executive function, higher levels of anxiety, depression, fatigue, and lower quality of life.
Article
Psychology, Developmental
Gioia Bottesi
Summary: Sivertsen et al. (2023) found that adolescents endorsing high levels of internalizing and externalizing symptoms are at risk of increased mental health problems during emerging adulthood, and both homotypic and heterotypic continuities of mental disorders exist. This perspective contextualizes their findings in relation to the literature on intolerance of uncertainty and the Uncertainty Distress Model, and calls for further research on how adolescents and emerging adults process and deal with uncertainty.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Ramona Adriana Schenker, Michael Schenker, Puiu Olivian Stovicek, Laura Mazilu, Serban Mircea Negru, Georgeta Burov, Marius Eugen Ciurea
Summary: In the context of trauma experienced by patients following a cancer diagnosis and the expectation of surgical intervention, it is important to assess the psychological status using a unified and multidimensional approach. This assessment can help psycho-oncologists adapt their therapeutic interventions to alleviate stress caused by the cancer diagnosis and treatment. A study involving breast cancer patients and patients with breast lumps awaiting diagnosis found significant differences in self-esteem, depression, and cognitive schemas between the two groups. These differences were associated with personality traits and specific psychological changes.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Oncology
Megan Best, Christine Napier, Timothy Schlub, Nicci Bartley, Barbara Biesecker, Mandy Ballinger, Phyllis Butow
Summary: The study aimed to adapt an existing cancer risk assessment scale for cancer patients waiting for germline genome sequencing results. The results showed that the adapted scale successfully measured anxiety and uncertainty associated with waiting for results.
Article
Oncology
Elisabeth Wang Areklett, Elisabeth Fagereng, Kjersti Bruheim, Stein Andersson, Kristina Lindemann
Summary: This study found that cervical cancer survivors treated with combined chemo-radiotherapy had significant cognitive impairment, which was associated with indicators of poor quality of life such as anxiety, depression, and fatigue.
Article
Oncology
Cristiane D. Bergerot, Marianne Razavi, Errol J. Philip, Paulo G. Bergerot, Marco M. Buso, Karen L. Clark, Matthew Loscalzo, Sumanta K. Pal, William Dale
Summary: The study evaluated the association between emotional symptoms and problem-related distress in cancer patients undergoing chemotherapy. Results showed that emotional symptoms improved over time but remained associated with problem-related distress.
Article
Oncology
Joerg Haier, Johannes Beller, Kristina Adorjan, Stefan Bleich, Moritz de Greck, Frank Griesinger, Markus Heppt, Rene Hurlemann, Soeren Torge Mees, Alexandra Philipsen, Gernot Rohde, Georgia Schilling, Karolin Trautmann, Stephanie E. Combs, Siegfried Geyer, Juergen Schaefers
Summary: This study assessed the different perceptions of patients, nurses, and physicians regarding the impact of the pandemic on clinical management, decision-making processes, and burden. The results showed that the extent and perception of the pandemic's impact varied among different stakeholder groups, and there was a dissociated perception towards other stakeholders. Therefore, specific awareness should be raised to avoid the dissociation of impact perception between patients and professionals, which may result in impaired shared decision-making.
Article
Oncology
Mitchell E. Gross, Tanya B. Dorff, David I. Quinn, Patricia M. Diaz, Olga O. Castellanos, David B. Agus
CLINICAL GENITOURINARY CANCER
(2018)
Meeting Abstract
Oncology
Rishi R. Rawat, Daniel Ruderman, David B. Agus
Article
Endocrinology & Metabolism
Shikha Gaur, Mitchell E. Gross, Chun-Peng Liao, Bin Qian, Jean C. Shih
Article
Oncology
Mitchell E. Gross, David B. Agus, Tanya B. Dorff, Jacek K. Pinski, David Quinn, Olga Castellanos, Patrick Gilmore, Jean C. Shih
Summary: Phenelzine showed efficacy in patients with biochemical recurrent castrate-sensitive prostate cancer, with mild treatment-related toxicities observed in most patients and rare significant and reversible cardiovascular toxicities. Treatment reduced anxiety symptoms significantly, but did not change depressive symptoms. Therapies targeting MAOA may provide a new avenue for treating recurrent prostate cancer patients.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Multidisciplinary Sciences
Rishi R. Rawat, Itzel Ortega, Preeyam Roy, Fei Sha, Darryl Shibata, Daniel Ruderman, David B. Agus
SCIENTIFIC REPORTS
(2020)
Editorial Material
Oncology
David B. Agus, Elizabeth M. Jaffee, Chi Van Dang
Article
Multidisciplinary Sciences
Nikhil Naik, Ali Madani, Andre Esteva, Nitish Shirish Keskar, Michael F. Press, Daniel Ruderman, David B. Agus, Richard Socher
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Katherin Patsch, Chao Liu, Grzegorz Zapotoczny, Yuanye Sun, Harish Sura, Nolan Ung, Ren X. Sun, Bethany Haliday, Chen Yu, Mayada Aljehani, Jerry S. H. Lee, Boris A. Kashemirov, David B. Agus, Charles E. McKenna, Daniel Ruderman
Summary: This study identified a new mechanism of drug resistance in lethal prostate cancer and discovered a structurally contradictory stereoisomer in a drug compound, suggesting new strategies to overcome drug resistance mechanisms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Chun-Te Chiang, Roy Lau, Ahmadreza Ghaffarizadeh, Matthew Brovold, Dipen Vyas, Edwin F. Juarez, Anthony Atala, David B. Agus, Shay Soker, Paul Macklin, Daniel Ruderman, Shannon M. Mumenthaler
Summary: Quantitative imaging dataset of CRC cell growth dynamics influenced by in vivo-mimicking conditions was presented, showing that highly aggressive HCT116 cell growth is affected by oxygen, substrate stiffness, and liver extracellular matrix. Hypoxia has a protective effect against oxaliplatin-induced cytotoxicity on plastic and liver extracellular matrix. Insights provided by this dataset contribute to understanding critical tumor microenvironment features that influence metastatic seeding and tumor growth.
Article
Computer Science, Information Systems
Yongkui Tang, Leng-Ying Chen, Ailin Zhang, Chun-Peng Liao, Mitchell Eric Gross, Eun Sok Kim
Summary: The study evaluated the therapeutic effects of a new pulsed high-frequency medium-intensity focused ultrasound in selective cancer treatment with promising results, demonstrating reduced tumor size without thermal damage for potentially safer cancer treatment.
Meeting Abstract
Oncology
Rishi Rawat, Fei Sha, Darryl Shibata, Daniel Ruderman, David Agus
Article
Biology
Katherin Patsch, Naim Matasci, Anjana Soundararajan, Patricia Diaz, David B. Agus, Daniel Ruderman, Mitchell E. Gross
BMC RESEARCH NOTES
(2019)
Article
Oncology
Rishi R. Rawat, Daniel Ruderman, Paul Macklin, David L. Rimm, David B. Agus
Article
Oncology
Christine J. McPherson, Alanna Devereaux
Summary: This study examines the dyadic effects of patient and caregiver attachment orientations on mutually supportive care in cancer treatment. It highlights the interdependence within the cancer caregiving relationship and emphasizes the importance of considering individual and relational ways of responding in providing support. Attachment theory provides a framework for understanding and therapeutic intervention.