Article
Oncology
Meagan S. Whisenant, Loretta A. Williams, Tito Mendoza, Charles Cleeland, Tsun-Hsuan Chen, Michael J. Fisch, Quiling Shi
Summary: This study identified two subgroups of women with distinct symptom severity, with older and employed women less likely to be in the high symptom severity subgroup and women with poorer performance status more likely to be in the high subgroup. Women in the high subgroup reported lower quality of life and greater interference with functioning.
Article
Psychology, Multidisciplinary
Megan E. Renna, Annelise A. Madison, Juan Peng, Marcella Rosie Shrout, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew Cherian, William B. Malarkey, Rebecca Andridge, Janice K. Kiecolt-Glaser
Summary: This study examined the impact of emotion regulation strategies on breast cancer survivors. It found that higher levels of worry and lower levels of mindfulness were associated with memory problems, focus problems, and pain sensitivity.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Review
Oncology
Alix G. Sleight, Sylvia L. Crowder, Jacek Skarbinski, Paul Coen, Nathan H. Parker, Aasha Hoogland, Brian D. Gonzalez, Mary C. Playdon, Steven Cole, Jennifer Ose, Yuichi Murayama, Erin M. Siegel, Jane C. Figueiredo, Heather S. L. Jim
Summary: Fatigue presents a major challenge for cancer survivors, and our current understanding of its causes and treatment options is limited. This paper proposes a comprehensive model, the 3P factors model, which combines metabolomics, the microbiome, inflammation, and behavioral science to better understand the pathophysiology of cancer-related fatigue. The complex biological, clinical, demographic, and lifestyle mechanisms underlying fatigue hinder the development of new treatments. The application of the 3P model may provide a more in-depth analysis of the etiology of cancer-related fatigue and improve personalized approaches to its clinical treatment.
Article
Oncology
Freja Ejlebaek Ebbestad, Gunn Ammitzboll, Trine Allerslev Horsboll, Ingelise Andersen, Christoffer Johansen, Bo Zehran, Susanne Oksbjerg Dalton
Summary: Fatigue, insomnia and pain are common and distressing symptoms in breast cancer treatment and survivorship. These symptoms form a symptom cluster and may negatively impact physical and emotional functioning. In this study, we aimed to examine the burden of the fatigue-pain-insomnia symptom cluster and its prognostic value for long-term symptom severity and functioning.
Article
Oncology
Ying Sheng, Janet S. Carpenter, Steven M. Paul, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: Patients with breast cancer commonly report symptoms such as anxiety, depression, sleep disturbance, fatigue, cognitive dysfunction, pain, and palpitations. This study compared the severity and occurrence rates of these symptoms, as well as quality of life outcomes, between patients with and without palpitations. The results showed significant differences and decrements in psychological symptoms and quality of life for patients with palpitations.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2023)
Article
Oncology
Ellen Krueger, Ekin Secinti, Catherine E. Mosher, Patrick Stutz, Andrea A. Cohee, Shelley A. Johns
Summary: This study investigated cancer survivors' interest in learning skills to manage CRF and associated symptoms, finding that many survivors, especially those with high levels of fatigue, expressed strong interest in this. They were more likely to be interested in learning skills to manage various symptoms, including self-compassion training and programs offered individually.
Article
Oncology
Eva Kimpe, Amber Werbrouck, Mark De Ridder, Koen Putman
Summary: Radiation-induced cardiotoxicity can cause additional costs and disutility in breast cancer survivors, but these effects are relatively minor. The past investments in achieving current mean heart dose (MHD) seem justified considering the reduction in costs and disutility resulting from radiation-induced cardiovascular events.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Julienne E. Bower, Patricia A. Ganz, Michael R. Irwin, Steve W. Cole, Deborah Garet, Laura Petersen, Arash Asher, Sara A. Hurvitz, Catherine M. Crespi
Summary: This study aimed to explore distinct trajectories of fatigue in women with early-stage breast cancer during treatment and identified five different trajectories: Stable Low, Stable High, Decreasing, Increasing, and Reactive. Psychological and treatment-related factors were found to be associated with fatigue trajectories, with psychological factors most strongly linked to high fatigue levels.
Review
Oncology
Tracy D. Vannorsdall, Ermiece Straub, Christina Saba, Mallory Blackwood, Jingyi Zhang, Keren Stearns, Karen Lisa Smith
Summary: This meta-analysis assessed the effects of exercise, psychological interventions, and alternative forms of interventions on cognitive, physical, and general dimensions of cancer-related fatigue in women with a history of breast cancer. Exercise showed moderate benefits for cognitive and physical aspects of cancer-related fatigue, while psychotherapy and other interventions were not as effective. Further research is needed to determine the most effective forms of exercise and explore acupressure as a potential intervention for cancer-related fatigue.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Caroline S. Dorfman, Hannah M. Fisher, Samantha Thomas, Sarah A. Kelleher, Joseph G. Winger, Nia S. Mitchell, Shannon N. Miller, Tamara J. Somers
Summary: Overweight and obesity are common issues for breast cancer survivors and are associated with high symptom burden. Physical activity may help reduce symptoms in breast cancer survivors with higher BMI, but the role of physical activity in buffering the relationship between higher BMI and symptoms is unclear.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Edward Christopher Dee, Ryan D. Nipp, Vinayak Muralidhar, Zizi Yu, Santino S. Butler, Brandon A. Mahal, Paul L. Nguyen, Nina N. Sanford
Summary: A majority of cancer survivors reported financial worry, with female sex, younger age, and Asian American race associated with increased odds of financial worry. Participants endorsing financial worry were more likely to have psychological distress.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nutrition & Dietetics
Christian A. Maino Vieytes, Alison M. Mondul, Sylvia L. Crowder, Katie R. Zarins, Caitlyn G. Edwards, Erin C. Davis, Gregory T. Wolf, Laura S. Rozek, Anna E. Arthur
Summary: This study evaluated the impact of four a priori-defined diet quality indices on nutrition impact symptoms (NIS) in patients with head and neck squamous cell carcinoma (HNSCC) 1 year postdiagnosis. It was found that higher adherence to the aMED and DASH diet quality indices before treatment may help reduce NIS burden at 1-year postdiagnosis.
Article
Oncology
Yu-Yin Allemann-Su, Marcus Vetter, Helen Koechlin, Yvette Conley, Steven M. Paul, Bruce A. Cooper, Kord M. Kober, Jon D. Levine, Christine Miaskowski, Maria C. Katapodi
Summary: In our previous study, we found three distinct groups of breast cancer patients with different profiles of cancer-related cognitive impairment (CRCI). In this study, we further evaluated the differences in psychological and physical symptoms among these groups before surgery and found that the low-moderate class had higher levels of pain interference.
Article
Oncology
Sylvia van Deuren, Adriaan Penson, Eline van Dulmen-den Broeder, Martha A. Grootenhuis, Margriet van der Heiden-van der Loo, Ewald Bronkhorst, Nicole M. A. Blijlevens, Nina Streefkerk, Jop C. Teepen, Wim J. E. Tissing, Helena J. H. van der Pal, Marry M. van den Heuvel-Eibrink, Birgitta A. B. Versluys, Dorine Bresters, Flora E. van Leeuwen, Cecile M. Ronckers, Leontien C. M. Kremer, Hans Knoop, Jacqueline J. Loonen
Summary: This study demonstrates that CCSs report fatigue more frequently than sibling controls, regardless of their cancer diagnosis. It provides new evidence on the prevalence of fatigue in CCSs.
Article
Health Care Sciences & Services
Kathrin Sommer, Marco Vignetti, Francesco Cottone, Massimo Breccia, Ombretta Annibali, Mario Luppi, Tamara Intermesoli, Erika Borlenghi, Paola Carluccio, Francesco Rodeghiero, Francesco Fabbiano, Claudio Romani, Marco Sborgia, Bruno Martino, Monica Crugnola, Fabio Efficace
Summary: This study aimed to investigate the association between fatigue and severity of other key cancer symptoms, as well as the interference with daily activities and outlook on life in long-term survivors of acute promyelocytic leukaemia (APL). The results showed a higher fatigue burden was associated with increased affective symptoms, memory problems, sleep disturbances, and pain. Fatigue also had a significant impact on the overall interference with daily activities and enjoyment of life among APL survivors.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Medicine, General & Internal
Krupal B. Patel, Kea Turner, Amir Alishahi Tabriz, Brian D. Gonzalez, Laura B. Oswald, Oliver T. Nguyen, Young-Rock Hong, Heather S. L. Jim, Anthony C. Nichols, Xuefeng Wang, Edmondo Robinson, Cristina Naso, Philippe E. Spiess
Summary: Patients with cancer often face greater financial hardships and time costs. The COVID-19 pandemic has exacerbated this issue and posed challenges to cancer care. This study evaluated the cost savings in patient travel, time, and expenses associated with telehealth for cancer care delivery. The findings suggest that telehealth can reduce the financial burden on patients with cancer.
Article
Oncology
Kea Turner, Angela M. Stover, Danielle B. Tometich, Carley Geiss, Arianna Mason, Oliver T. Nguyen, Emma Hume, Rachael McCormick, Sean Powell, Julie Hallanger-Johnson, Krupal B. Patel, Kedar S. Kirtane, Neelima Jammigumpula, Colin Moore, Randa Perkins, Dana E. Rollison, Heather S. L. Jim, Laura B. Oswald, Sylvia Crowder, Brian D. Gonzalez, Edmondo Robinson, Amir Alishahi Tabriz, Jessica Y. Islam, Scott M. Gilbert
Summary: This study assessed the perspectives of oncology providers and professionals on the barriers and facilitators of implementing suicide risk screening for patients with head and neck cancer. Multilevel implementation barriers were identified, such as patient difficulty with using a tablet, limited nursing engagement, limited clinic Wi-Fi connectivity, and low clinician self-efficacy for interpreting and acting upon patient-reported outcome scores. Participants recommended strengthening patient and clinician education and providing alternative data entry modalities for patients.
JCO ONCOLOGY PRACTICE
(2023)
Article
Psychology, Multidisciplinary
Danielle B. Tometich, Catherine E. Mosher, Melissa Cyders, Brenna C. McDonald, Andrew J. Saykin, Brent J. Small, Zhai Wanting, Zhou Xingtao, Heather S. L. Jim, Paul Jacobsen, Tim A. Ahles, James C. Root, Deena Graham, Sunita K. Patel, Jeanne Mandelblatt
Summary: Physical activity may improve cognitive function for older cancer survivors, and cognitive function may also affect the ability to organize oneself to be physically active. However, the expected prospective relationships between cognition and physical activity were not found in this study. The findings indicate that there is cross-sectional association between cognition and physical activity in survivors, but long-term predictive relationships were not observed. The study suggests that future research should consider the impact of cognitive function when older cancer survivors are attempting to increase their physical activity.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Oncology
Kelly E. Rentscher, Traci N. Bethea, Wanting Zhai, Brent J. Small, Xingtao Zhou, Tim A. Ahles, Jaeil Ahn, Elizabeth C. Breen, Harvey Jay Cohen, Martine Extermann, Deena M. A. Graham, Heather S. L. Jim, Brenna C. McDonald, Zev M. Nakamura, Sunita K. Patel, James C. Root, Andrew J. Saykin, Kathleen Van Dyk, Jeanne S. Mandelblatt, Judith E. Carroll
Summary: This study aimed to investigate if older breast cancer survivors had higher levels of epigenetic aging and if it was related to functional outcomes. The study found that breast cancer survivors had higher levels of epigenetic aging compared to non-cancer controls, especially those who had undergone chemotherapy. Additionally, epigenetic aging was associated with worse cognitive and physical function.
Article
Oncology
Jeanne S. Mandelblatt, Brent J. Small, Xingtao Zhou, Zev M. Nakamura, Harvey J. Cohen, Tim A. Ahles, Jaeil Ahn, Traci N. Bethea, Martine Extermann, Deena Graham, Claudine Isaacs, Paul B. Jacobsen, Heather S. L. Jim, Brenna C. McDonald, Sunita K. Patel, Kelly E. Rentscher, James C. Root, Andrew J. Saykin, Danielle B. Tometich, Kathleen Van Dyk, Wanting Zhai, Elizabeth C. Breen, Judith E. Carroll
Summary: Immune activation/inflammation markers were found to explain differences in neurocognition between breast cancer survivors and noncancer controls. Breast cancer survivors had significantly higher IL-6 levels before and after systemic therapy, and IL-6 partially explained the neurocognitive differences between survivors and controls.
Article
Oncology
Xiaoyin Li, Siddhartha Roy, Jennifer Damonte, Hyun Y. Park, Aasha I. Hoogland, Kala Jamison, Khaled R. Komrokji, Chang Dong Yeo, Youngchul Kim, Jasreman Dhillon, Lisa M. Gudenkauf, Laura B. Oswald, Heather S. L. Jim, Kosj Yamoah, Julio M. Pow-Sang, Peter A. Kanetsky, Clement K. Gwede, Jong Y. Park, Brian D. Gonzalez
Summary: This study aimed to establish a state-wide biobank of African American prostate cancer survivors in Florida to identify biological bases for health disparities. African American men diagnosed with prostate cancer between 2013 and 2017 were identified through the State of Florida's cancer registry. Of the eligible and reachable individuals, a low overall consent rate of 10% was observed. Existing challenges limit the consent and participation in biospecimen research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Ambika S. Bhatt, Matthew B. Schabath, Aasha I. Hoogland, Heather S. L. Jim, Renee Brady-Nicholls
Summary: This study analyzed the dynamics of patient-reported outcomes (PROs) to predict tumor volume changes in non-small cell lung cancer patients undergoing immunotherapy. The study found significant correlations between changes in tumor volume over time and dizziness, insomnia, and fatigue. Cumulative changes in insomnia were able to predict progressive disease with 77% accuracy, an average of 45 days prior to the next imaging scan.
CLINICAL CANCER RESEARCH
(2023)
Article
Otorhinolaryngology
Kedar Kirtane, Aasha I. Hoogland, Xiaoyin Li, Yvelise Rodriguez, Kelsey Scheel, Brent J. Small, Laura B. Oswald, Jameel Muzaffar, Julie A. Kish, Marcelo Bonomi, Priyanka Bhateja, Nabil F. Saba, Conor E. Steuer, Christine H. Chung, Heather S. L. Jim
Summary: This study examined patient-reported outcomes among patients with head and neck squamous cell carcinoma (HNSCC) treated with immune checkpoint inhibitors. The results showed that although toxicity increased over time, overall quality of life improved after 12 weeks of treatment and then remained stable or declined. There were no significant differences in quality of life or toxicity between monotherapy and combination therapy.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Editorial Material
Oncology
Heather S. L. Jim, Renee Brady-Nicholls, Dawn L. Hershman
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Aasha I. Hoogland, Brent J. Small, Laura B. Oswald, Crystal Bryant, Yvelise Rodriguez, Brian D. Gonzalez, Xiaoyin Li, Michelle C. Janelsins, Hailey W. Bulls, Brian W. James, Bianca Arboleda, Claudia Colon-Echevarria, Mary K. Townsend, Shelley S. Tworoger, Paulo C. Rodriguez, Julienne E. Bower, Sachin M. Apte, Robert M. Wenham, Heather S. L. Jim
Summary: Treatment-related symptoms such as fatigue, depression, and disruptions in sleep and physical activity are common in gynecologic cancer patients. Higher levels of inflammation, particularly C-reactive protein, are associated with worse symptomatology, specifically depression and disrupted physical activity. However, inflammation may not be significantly related to fatigue or sleep disturbance.
Article
Oncology
Danielle B. Tometich, Aasha I. Hoogland, Brent J. Small, Michelle C. Janelsins, Crystal Bryant, Yvelise Rodriguez, Brian D. Gonzalez, Xiaoyin Li, Hailey W. Bulls, Brian W. James, Bianca Arboleda, Claudia Colon-Echevarria, Mary K. Townsend, Shelley S. Tworoger, Paulo Rodriguez, Laura B. Oswald, Julienne E. Bower, Sachin M. Apte, Robert M. Wenham, Hye Sook Chon, Mian M. Shahzad, Heather S. L. Jim
Summary: A study found that women with gynecologic cancer have lower levels of physical activity and poorer sleep quality, even a year after completing chemotherapy. Higher levels of inflammation were associated with less physical activity and more sleep problems. Future research should examine whether reducing inflammation can improve physical activity and sleep in cancer patients.
Article
Oncology
Laura B. Oswald, Lisa M. Gudenkauf, Xiaoyin Li, Gabriel De Avila, Lauren C. Peres, Kedar Kirtane, Brian D. Gonzalez, Aasha I. Hoogland, Oanh Nguyen, Yvelise Rodriguez, Rachid C. Baz, Kenneth H. Shain, Melissa Alsina, Frederick L. Locke, Ciara Freeman, Omar Castaneda Puglianini, Taiga Nishihori, Hien Liu, Brandon Blue, Ariel Grajales-Cruz, Heather S. L. Jim, Doris K. Hansen
Summary: This study aimed to evaluate patient-reported outcomes among patients with relapsed/refractory multiple myeloma treated with idecabtagene vicleucel (ide-cel) therapy. The findings showed that most patients reported significant and meaningful improvements in health-related quality of life and physical well-being after CAR T treatment.
Article
Rehabilitation
Janet L. Poole, Susan L. Murphy, Erin R. Foster, Alix G. Sleight, Toni Van Denend, Arash Asher, Kristine Carandang, Marcia Finlayson, Donald Fogelberg, Heather S. L. Jim, Aileen Ledingham, Tanya Packer, Matthew Plow, Katherine Preissner, Stephen Wechsler, Daniel Whibley
Summary: Fatigue is a burdensome symptom that affects various aspects of daily life. Occupational practitioners have historically played vital roles in managing fatigue. A workshop was organized by the American Occupational Therapy Foundation to develop research ideas and proposals for fatigue management. Four main topics were discussed, including implementation science, treatment taxonomy, trial design, and phenotyping.
OTJR-OCCUPATIONAL THERAPY JOURNAL OF RESEARCH
(2023)
Article
Hematology
Rajshekhar Chakraborty, Jean Yi, Lisa Rybicki, Jaime Preussler, Abhinav Deol, Alison Loren, Bipin Savani, Heather S. L. Jim, Jan Cerny, Jana Reynolds, Jennifer Whitten, John R. Wingard, Joseph P. McGuirk, Joseph Uberti, Nandita Khera, Patrick Stiff, Samantha M. Jaglowski, Shahrukh Hashmi, Shernan G. Holtan, Steven Devine, Theresa Hahn, Victoria L. Whalen, Wael Saber, William Wood, K. Scott Baker, Karen Syrjala, Navneet S. Majhail
Summary: Survivors of autologous hematopoietic cell transplantation (AHCT) for multiple myeloma in stable remission do not have clinically meaningful worsening in physical functioning compared to the general population. However, they may experience distress related to health burden, uncertainty, and finances. Adherence to preventive care guidelines is high, but adherence to exercise and diet guidelines is relatively low.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
