期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 224, 期 2, 页码 107-111出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2014.07.009
关键词
Tumor necrosis factor; Frustrative non-reward; Anterior cingulate gyrus; Amygdala; Prefrontal cortex; RNA-sequencing
资金
- Oxley Foundation
- Center of Clinical and Translational Science Training (CCTST) of University of Cincinnati College of Medicine
- National Institute of Health (NIH)
- NIH [NIMH R01 MH080973, NIMH R34 MH083924, NIMH R01 MH078043]
The mechanisms underlying aggression in adolescents with bipolar disorder have been poorly understood. The present study has investigated the associations among TNF gene expressions, functional brain activations under the Crush-alive non reward task, and aggression in adolescents with bipolar disorder. Baseline gene expressions and aggressive tendencies were measured with the RNA-sequencing and Brief Rating of Aggression by Children and Adolescents (BRACHA), respectively. Our results show that activity levels of left subgenual anterior cingulate gyrus (ACG), right amygdala, left Brodmann area 10 (orbitofrontal cortex), and right thalamus were inversely correlated with BRACHA scores and were activated with frustrative non-reward during the affective Posner Task. In addition, 11 TNF related gene expressions were significantly correlated with activation of amygdala or ACG during the affective Posner Task. Three TNF gene expressions were inversely correlated with BRACHA score while one TNF gene (TNFAIP3) expression was positively correlated with BRACHA score. Therefore, TNF-related inflammatory cytokine genes may play a role in neural activity associated with frustrative non-reward and aggressive behaviors in pediatric bipolar disorder. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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