Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Clinical Neurology
Matthew J. King, Kesia Courtenay, Bruce K. Christensen, Aaron S. Benjamin, Todd A. Girard
Summary: Depression is associated with lower specificity in autobiographical memories, which may not only be due to difficulties in focusing on event details, but also to broader memory deficits and weakened memory traces with the passage of time. These findings have important implications for memory interventions and treatments in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Behavioral Sciences
Matilde Conti, Alice Teghil, Antonella Di Vita, Maddalena Boccia
Summary: This article describes the case of a 53-year-old woman, DR, who complains of a specific and lifelong deficit in recalling autobiographical episodes. Through neuropsychological assessment and MRI examination, it was found that she has a deficit in episodic re-experiencing of personal life events and shows structural and functional abnormalities in certain brain regions. The study provides further evidence of a severely deficient autobiographical memory condition and offers important insights into the underlying neurocognitive mechanisms.
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Laurie Compere, Sylvain Charron, Thierry Gallarda, Eirini Rari, Stephanie Lion, Marion Nys, Adele Anssens, Sandrine Coussinoux, Sebastien Machefaux, Catherine Oppenheim, Pascale Piolino
Summary: Recent literature on sex-related differences in autobiographical memory emphasizes the importance of psychosocial factors like gender identity over biological sex. This fMRI study found gender identity to have a stronger impact on autobiographical memory than biological sex, highlighting the need to consider hormonal factors in future research. The results suggest an interaction between biological sex and gender identity in explaining variations in autobiographical memory.
Article
Neurosciences
Chunlian Chen, Bo Li, Shufen Zhang, Zhe Liu, Yu Wang, Minghe Xu, Yuqing Ji, Shuang Wang, Gang Sun, Kai Liu
Summary: In this study, brain structural alterations and relevant functional changes in patients with postpartum depression (PPD) were investigated. The findings revealed increased gray matter volume in the left dorsolateral prefrontal cortex, right precentral gyrus, and orbitofrontal cortex of PPD patients compared to healthy postnatal women. The functional connectivity between these regions also showed enhancement. Additionally, the increased gray matter volume in the left dorsolateral prefrontal cortex and the functional connectivity between the right precentral gyrus and right median cingulate gyrus were positively correlated with the severity of depression symptoms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Jin Hua Zheng, Wen Hua Sun, Jian Jun Ma, Zhi Dong Wang, Qing Qing Chang, Lin Rui Dong, Xiao Xue Shi, Ming Jian Li, Qi Gu, Si Yuan Chen
Summary: This study found smaller overall gray matter volume in patients with Parkinson's disease, particularly in the right superior temporal gyrus and left frontotemporal region. This structural abnormality may be correlated with patients' age and severity of movement disorder, and enhanced brain activity was also observed.
NEUROSCIENCE LETTERS
(2022)
Article
Behavioral Sciences
Stephanie Matijevic, Jessica R. Andrews-Hanna, Aubrey A. Wank, Lee Ryan, Matthew D. Grilli
Summary: This study aims to investigate the role of age in individual differences and the functional connectivity of the posterior medial network (PMN) in episodic detail generation. The results show that compared to younger adults, older adults produce memory narratives with lower episodic specificity and more semantic detail. The study also found that stronger anterior PMN functional connectivity is related to lower episodic detail in older adults, while increased posterior PMN functional connectivity is related to increased semantic detail. These brain-behavior relationships appear to be age-specific.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongyu Wu, Ban Luo, Qiuxia Wang, Yali Zhao, Gang Yuan, Ping Liu, Linhan Zhai, Wenzhi Lv, Jing Zhang
Summary: This study explored the brain characteristics and their relationship with ophthalmologic performance in patients with dysthyroid optic neuropathy (DON). The results showed significant morphological and functional alterations in the visual cortex of DON patients, which may provide insights into the mechanism of vision loss and facilitate the diagnosis and treatment of DON.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Anne Assmann, Anni Richter, Hartmut Schuetze, Joram Soch, Adriana Barman, Gusalija Behnisch, Lea Knopf, Matthias Raschick, Annika Schult, Torsten Wuestenberg, Joachim Behr, Emrah Duezel, Constanze Seidenbecher, Bjoern H. Schott
Summary: This study found that the NCAN gene rs1064395 A allele is associated with decreased memory function, variations in prefrontal cortex structure, and ECM composition; risk allele carriers exhibited higher false alarm rates and inefficiently increased left hippocampal activation; the results may reflect an intermediate phenotype of NCAN rs1064395 contributing to the risk of bipolar disorder and schizophrenia.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jin Hua Zheng, Wen Hua Sun, Jian Jun Ma, Zhi Dong Wang, Qing Qing Chang, Lin Rui Dong, Xiao Xue Shi, Ming Jian Li, Qi Gu, Si Yuan Chen, Dong Sheng Li
Summary: The PIGD and TD motor subtypes of Parkinson's disease have different clinical manifestations. This study found that PIGD patients had smaller gray matter volume in the medial frontal gyrus, which was negatively correlated with the severity of PIGD symptoms. Additionally, PIGD patients showed stronger functional connectivity between the right superior frontal gyrus and other brain regions. These findings help explain the clinical differences between the two motor subtypes of PD.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Psychiatry
Miaomiao Yu, Xinyu Gao, Xiaoyu Niu, Mengzhe Zhang, Zhengui Yang, Shaoqiang Han, Jingliang Cheng, Yong Zhang
Summary: This article aimed to investigate the common and certain neural alterations in the structure and function of the brain in patients with ADHD through a comprehensive analysis of multiple neuroimaging studies. The study found abnormal changes in the structure and function of the brain in ADHD patients, which may be associated with the left superior frontal gyrus and the corpus callosum, serving as imaging metrics for ADHD patients in the future.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Sandra Manninen, Tomi Karjalainen, Lauri J. Tuominen, Jarmo Hietala, Valtteri Kaasinen, Juho Joutsa, Juha Rinne, Lauri Nummenmaa
Summary: In a retrospective analysis of brain scans from 328 subjects, grey matter density was found to be correlated with availability of mu-opioid and dopamine D2 receptors, as well as serotonin transporters measured through PET scans. The study suggests that future research should consider the interactive effects of grey matter density and PET outcome measures when comparing different groups such as patients and controls.
Article
Behavioral Sciences
Emily C. Gibson, Lucy Ford, Gail A. Robinson
Summary: Highly superior autobiographical memory (HSAM) is characterized by the ability to recall personal experiences with high detail and accuracy. This study investigated autobiographical memory and future thinking in a case of HSAM, finding that while recall of past events was stronger, there was no significant advantage in constructing future-oriented narrative scenes.
Article
Critical Care Medicine
Eun Namgung, Woo-Jung Song, Yong-Hwan Kim, Jin An, You Sook Cho, Dong-Wha Kang
Summary: The study found that patients with chronic refractory cough exhibited structural and functional alterations in the left frontal brain regions, which were associated with cough duration, severity, and psychological/social impact.
Article
Neurosciences
Yan Sun, Tianye Jia, Edward D. Barker, Di Chen, Zuo Zhang, Jiayuan Xu, Suhua Chang, Guangdong Zhou, Yun Liu, Nicole Tay, Qiang Luo, Xiao Chang, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Michael N. Smolka, Henrik Walter, Robert Whelan, Lin Lu, Jie Shi, Gunter Schumann, Sylvane Desrivieres
Summary: Negative life events (NLEs) increase the risk for externalizing behaviors (EBs) and internalizing behaviors (IBs). DNA methylation associated with behavioral problems may reflect this risk and long-lasting effects of NLEs.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Helene Vulser, Herve S. Lemaitre, Stella Guldner, Pauline Bezivin-Frere, Martin Loffler, Anna S. Sarvasmaa, Jessica Massicotte-Marquez, Eric Artiges, Marie-Laure Paillere Martinot, Irina Filippi, Ruben Miranda, Argyris Stringaris, Betteke Maria van Noort, Jani Penttila, Yvonne Grimmer, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Juliane H. Frohner, Hugh Garavan, Antoine Grigis, Penny A. Gowland, Andreas Heinz, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Philip A. Spechler, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Jean-Luc Martinot, Frauke Nees
Summary: Adolescence is a critical period for circadian rhythm, with a shift toward eveningness. Eveningness in adolescence predicts later onset of depressive symptoms. This study investigates the structural variations associated with chronotype in early adolescence and its contribution to the development of depressive symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Raka Maitra, Charlotte M. Horne, Owen O'Daly, Evangelos Papanastasiou, Christian Gaser, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Froehner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne M. Winterer, Robert Whelan, Erin Burke Quinlan, Alex Ing, Gunter Schumann, Sukhi Shergill
Summary: The study found that Psychotic Like Experiences (PLEs) in adolescents are associated with changes in cortical gyrification, indicating abnormal neurodevelopment. Adolescents with higher PLEs had lower cortical gyrification in the fronto-temporal regions in the left hemisphere, and higher cortical gyrification in the right parietal cortex during late adolescence. The study also revealed that adolescents with high PLEs were 5.6 times more likely to develop psychosis by age 23.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Kristina Meyer, Catherine Hindi Attar, Jana Fiebig, Thomas Stamm, Tyler R. Bassett, Michael Bauer, Udo Dannlowski, Thomas Ethofer, Irina Falkenberg, Andreas Jansen, Georg Juckel, Tilo Kircher, Christoph Mulert, Gregor Leicht, Anne Rau, Dirk Ritter, Philipp Ritter, Sarah Trost, Christoph Vogelbacher, Henrik Walter, Sarah Wolter, Martin Hautzinger, Felix Bermpohl
Summary: This study investigates the impact of psychotherapy on neural correlates of affective theory of mind (aToM) in bipolar disorder patients. The results show that a cognitive behavioral intervention (SEKT) increases ToM network activation, while an emotion-focused intervention (FEST) does not.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Corinna Haenschel, Dino Krupic, Antonia Hoff, Philip J. Corr, Sebastian Gaigg, Anne-Kathrin Fett
Summary: This study investigated the association between two different measures of schizotypy and symptoms of depression and anxiety in a sample of university students. The results indicated that persecutory ideation was a strong predictor of anxiety, depression, and stress sensitivity, while the dimensions of no close friends and social anxiety predicted psychological distress and stress.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Computer Science, Interdisciplinary Applications
Harshvardhan Gazula, Kelly Rootes-Murdy, Bharath Holla, Sunitha Basodi, Zuo Zhang, Eric Verner, Ross Kelly, Pratima Murthy, Amit Chakrabarti, Debasish Basu, Subodh Bhagyalakshmi Nanjayya, Rajkumar Lenin Singh, Roshan Lourembam Singh, Kartik Kalyanram, Kamakshi Kartik, Kumaran Kalyanaraman, Krishnaveni Ghattu, Rebecca Kuriyan, Sunita Simon Kurpad, Gareth J. Barker, Rose Dawn Bharath, Sylvane Desrivieres, Meera Purushottam, Dimitri Papadopoulos Orfanos, Eesha Sharma, Matthew Hickman, Mireille Toledano, Nilakshi Vaidya, Tobias Banaschewski, Arun L. W. Bokde, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rudiger Bruhl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Juliane H. Frohner, Lauren Robinson, Michael N. Smolka, Henrik Walter, Jeanne Winterer, Robert Whelan, Jessica A. Turner, Anand D. Sarwate, Sergey M. Plis, Vivek Benegal, Gunter Schumann, Vince D. Calhoun
Summary: With the growth of decentralized/federated analysis approaches in neuroimaging, the opportunities to study brain disorders using data from multiple sites has grown multi-fold. One such initiative is the Neuromark, a fully automated spatially constrained independent component analysis (ICA) that is used to link brain network abnormalities among different datasets, studies, and disorders while leveraging subject-specific networks.
Article
Substance Abuse
Rene Freichel, Janine Pfirrmann, Janna Cousjin, Peter de Jong, Ingmar Franken, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Herta Flor, Antoine Grigis, Hugh Garavan, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah H. Hohmann, Juliane N. Froehner, Michael Smolka, Nilakshi Vaidya, Robert Whelan, Gunter Schumann, Henrik M. Walter, Ilya W. Veer, Reinout Wiers
Summary: This study aims to examine the dynamic associations between distal and proximal risk factors (personality traits, life stressors, and drinking motives) and their relationship with alcohol use in adolescence and early adulthood. The findings suggest that heavy and frequent alcohol use, along with social drinking motives, are key targets for preventing alcohol-related problems during late adolescence. However, there was no evidence found for personality traits and life stressors predisposing towards distinct drinking motives over time.
Article
Public, Environmental & Occupational Health
Astrid Juhl Andersen, Irwin Hecker, Solene Wallez, Anke Witteveen, Antonio Lora, Ellenor Mittendorfer-Rutz, Giovanni Corrao, Henrik Walter, Josep Maria Haro, Marit Sijbrandij, Matteo Monzio Compagnoni, Mireia Felez-Nobrega, Raffael Kalisch, Richard Bryant, Maria Melchior, Murielle Mary-Krause
Summary: The COVID-19 pandemic has widened the social inequality gap in smoking rates, with a higher prevalence among those with low education. From 2020 to 2021, the difference in smoking rates between low and high education groups increased. Smokers with higher education were more likely to decrease their tobacco consumption compared to those with lower education.
Article
Psychology, Developmental
Tochukwu Nweze, Tobias Banaschewski, Cyracius Ajaelu, Chukwuemeka Okoye, Michael Ezenwa, Robert Whelan, Dimitri Papadopoulos Orfanos, Arun L. W. Bokde, Sylvane Desrivieres, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Tomas Paus, Luise Poustka, Sarah Hohmann, Sabina H. Millenet, Juliane N. Froehner, Michael Smolka, Henrik Walter, Gunter L. Schumann, Jamie Hanson
Summary: This study examines the relationship between stress exposure in childhood and adolescence and cortical structures and cognitive functioning. Longitudinal analysis shows that adolescent stress exposure is related to small changes in cortical structures, particularly in the prefrontal cortex. These findings provide important insights into the impact of stress on brain development.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Selene Gallo, Ahmed El-Gazzar, Paul Zhutovsky, Rajat M. Thomas, Nooshin Javaheripour, Meng Li, Lucie Bartova, Deepti Bathula, Udo Dannlowski, Christopher Davey, Thomas Frodl, Ian Gotlib, Simone Grimm, Dominik Grotegerd, Tim Hahn, Paul J. Hamilton, Ben J. Harrison, Andreas Jansen, Tilo Kircher, Bernhard Meyer, Igor Nenadic, Sebastian Olbrich, Elisabeth Paul, Lukas Pezawas, Matthew D. Sacchet, Philipp Saemann, Gerd Wagner, Henrik Walter, Martin Walter, Guido van Wingen
Summary: The promise of machine learning in psychiatric diagnostic tools has been hindered by the absence of large datasets. This study used machine learning and deep learning algorithms to differentiate patients with major depressive disorder (MDD) and identify neurophysiological signatures of depression. The results showed that whole brain resting-state connectivity is a reliable but poor biomarker for MDD.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Narges Chinichian, Johann D. Kruschwitz, Pablo Reinhardt, Maximilian Palm, Sarah A. Wellan, Susanne Erk, Andreas Heinz, Henrik Walter, Ilya M. Veer
Summary: We propose an intuitive and computationally efficient method to measure dynamic reconfiguration of brain regions, termed flexibility. Our method is based on a pre-defined set of biologically plausible brain modules and does not rely on data-driven module estimation, reducing computational burden. By measuring the change of affiliation of brain regions over time, we can assess the flexibility of brain networks. Our results demonstrate that our method produces similar patterns of whole-brain network reconfiguration compared to a more computationally expensive data-driven method, indicating its validity and efficiency in estimating whole-brain flexibility and analyzing biologically plausible brain networks at a finer scale.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Kristina Meyer, Catherine Hindi Attar, Jana Fiebig, Thomas Stamm, Tyler R. Bassett, Michael Bauer, Udo Dannlowski, Thomas Ethofer, Irina Falkenberg, Andreas Jansen, Georg Juckel, Tilo Kircher, Christoph Mulert, Gregor Leicht, Anne Rau, Jonas Rauh, Dirk Ritter, Philipp Ritter, Sarah Trost, Christoph Vogelbacher, Henrik Walter, Sarah Wolter, Martin Hautzinger, Felix Bermpohl
Summary: In this study, an emotion-centered psychotherapeutic intervention (FEST) was found to enhance amygdala activation and connectivity in patients with bipolar disorder (BD), and this increase was associated with a reduction in depressive symptoms.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Medicine, General & Internal
Nilakshi Vaidya, Bharath Holla, Jon Heron, Eesha Sharma, Yuning Zhang, Gwen Fernandes, Udita Iyengar, Alex Spiers, Anupa Yadav, Surajit Das, Sanjit Roy, Chirag K. Ahuja, Gareth J. Barker, Debasish Basu, Rose Dawn Bharath, Matthew Hickman, Sanjeev Jain, Kartik Kalyanram, Kamakshi Kartik, Murali Krishna, Ghattu Krishnaveni, Kalyanaraman Kumaran, Rebecca Kuriyan, Pratima Murthy, Dimitri Papadopoulos Orfanos, Meera Purushottam, Sunita Simon Kurpad, Lenin Singh, Roshan Singh, B. N. Subodh, Mireille Toledano, Henrik Walter, Sylvane Desrivieres, Amit Chakrabarti, Vivek Benegal, Gunter Schumann
Summary: This cohort study shows that low-level arsenic exposure is associated with impairments in executive function and has characterized the underlying brain mechanisms. These impairments are exacerbated by risk factors such as poor nutrition and poverty. The study calls for reexamination of safe levels of arsenic exposure and suggests improvements in nutrition and socioeconomic conditions as potential ways to mitigate the harmful consequences.
Article
Psychiatry
Yoki L. Mertens, Antje Manthey, Anika Sierk, Peter de Jong, Henrik Walter, Judith K. Daniels
Summary: This study aimed to investigate the neurobiological changes involved in acute post-traumatic dissociation. The results showed that self-reported acute dissociation significantly increased during trauma recall, but the pharmacological manipulation failed to increase amygdala activation. These findings cast doubt on the suggested role of the amygdala in subserving dissociative processing of trauma memories.
Article
Psychology, Multidisciplinary
Caitlin Duncan, Ulf Toelch, Henrik Walter, Isabel Dziobek
Summary: Discrimination towards ethnic minorities is a persistent societal problem, partly due to a bias in trust. This study investigated how people change their explicit trust bias towards ethnicity based on behavioral interactions with ingroup and outgroup members in a modified Trust Game. The results showed that participants' initial trust bias disappeared after the game, with the largest change observed for unfair ingroup members. The reduction of trust bias also generalized to new in- and outgroup members, and participants' learning was best explained by a model with one learning rate.
FRONTIERS IN PSYCHOLOGY
(2023)
