Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph G. Woods, Eric C. Wong, Emma C. Boyd, Divya S. Bolar
Summary: In this study, a novel pulse sequence called VESPA ASL is introduced that combines velocity-selective and pseudo-continuous ASL to simultaneously label different pools of arterial blood for robust cerebral blood flow (CBF) and arterial transit time (ATT) measurement. The results show that VESPA ASL accurately measures CBF in the presence of long ATTs, and ATTs < TI can also be measured. VESPA ASL offers important advantages over existing methods for noninvasive perfusion and transit time imaging in vascular diseases with delayed arterial transit.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Review
Medicine, General & Internal
Efthymia Maria Kapasouri, Diomidis C. C. Ioannidis, Donnie Cameron, Vassilios S. S. Vassiliou, Michael Hornberger
Summary: This study aimed to systematically review and analyze the role of cerebral blood flow (CBF) in the medial temporal lobe (MTL) using arterial spin labeling magnetic resonance imaging (ASL-MRI) in patients with Alzheimer's disease (AD), individuals with mild cognitive impairment (MCI), and cognitively normal adults (CN). The results showed that CBF measured via ASL-MRI was impaired in AD compared to the CN group in subregions of the MTL, while there was no significant difference between MCI and CN participants in the MTL.
Article
Neurosciences
Eleonora Piccirilli, Antonio M. Chiarelli, Carlo Sestieri, Daniele Mascali, Darien Calvo Garcia, Adele Primavera, Rita Salomone, Richard G. Wise, Antonio Ferretti, Massimo Caulo
Summary: In preterm infants, disturbances in regional cerebral blood flow (CBF) can affect brain maturation and may not be associated with brain injury. This study aimed to investigate the spatial distribution of grey matter CBF in preterm and full-term newborns, as well as the relationship between CBF patterns, prematurity, and prematurity-related brain lesions. Using pCASL MRI, CBF measurements were obtained in 66 preterm and 38 full-term newborns. The findings showed that GM perfusion was associated with gestational age at birth and the presence of brain injury. The study also identified specific clusters of brain regions based on CBF patterns. These findings suggest that ASL MRI can be a valuable tool in assessing individuals at risk of domain-specific impairment.
HUMAN BRAIN MAPPING
(2023)
Article
Neuroimaging
Soudabeh Fazeli, Abraham Noorbakhsh, Steven G. Imbesi, Divya S. Bolar
Summary: This study evaluated cerebral perfusion changes in PRES patients using ASL technique, showing that the majority of patients had hyperperfusion in brain regions, supporting the hypothesis of autoregulatory failure.
NEUROIMAGE-CLINICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shota Ishida, Makoto Isozaki, Yasuhiro Fujiwara, Naoyuki Takei, Masayuki Kanamoto, Hirohiko Kimura, Tetsuya Tsujikawa
Summary: Using simulation-based supervised DNNs can reduce the effects of Rician noise on ASL parameter estimation and compute unbiased CBF and ATT values. The study found that DNN outperforms conventional methods in terms of accuracy, precision, and noise immunity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
James H. Holmes, Mu-Lan Jen, Laura B. Eisenmenger, Tilman Schubert, Patrick A. Turski, Kevin M. Johnson
Summary: This study introduces a mapping approach to investigate the relative tagging efficiency of VS-ASL, validated through numerical simulations and experiments. Unique efficiency patterns were observed in normal volunteers based on individual anatomy and physiology. While uniform tagging efficiency was generally seen in vivo, regions of high blood velocity and local susceptibility gradients showed reduced efficiency.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
M. A. G. Martens, F. A. Kennedy McConnell, N. Filippini, C. E. Mackay, P. J. Harrison, E. M. Tunbridge
Summary: Dopamine has complex effects on cerebral circulation, and its regulation by COMT can influence regional cerebral blood flow. This study found that COMT genotype and the COMT inhibitor tolcapone both affect cerebral perfusion, with different regions of the brain being influenced by each factor.
Review
Radiology, Nuclear Medicine & Medical Imaging
Sven Bambach, Mark Smith, P. Pearse Morris, Norbert G. Campeau, Mai-Lan Ho
Summary: Arterial spin labeling (ASL) is a noncontrast MRI technique used for quantitative evaluation of brain perfusion. This article discusses advanced applications of ASL across the lifespan, presenting case examples from children and adults with various pathologies. The article highlights the subtleties and pitfalls of ASL interpretation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Multidisciplinary Sciences
Hossein Rahimzadeh, Hadi Kamkar, Narges Hoseini-Tabatabaei, Neda Mohammadi Mobarakeh, Jafar Mehvari Habibabadi, Seyed-Sohrab Hashemi-Fesharaki, Mohammad-Reza Nazem-Zadeh
Summary: Summary in English: This study aimed to investigate the differences in perfusion pattern changes in right and left mesial temporal lobe epilepsy (mTLE). By using pulsed arterial spin labeling, 42 mTLE patients (22 left and 20 right mTLE) and 14 controls were surveyed. The results showed that cerebral blood flow decreased in the ipsilateral sides in both epilepsy subcohorts, with right mTLE showing significant differences in most regions of interest (ROIs), while left mTLE did not exhibit significant changes. Compared to controls, left mTLE displayed significant drops in cerebral blood flow in the left middle temporal and left intermediate posterior cerebral artery ROIs, as well as in the asymmetry index analysis in the parahippocampus, distal anterior cerebral artery, distal middle cerebral artery, and intermediate anterior cerebral artery. Cerebral blood flow hypoperfusion was observed in the left intermediate anterior cerebral artery, left middle temporal, right middle temporal, and left superior temporal in right mTLE patients compared to controls. Left mTLE also differed significantly from right mTLE in cerebral blood flow in the right distal middle cerebral artery ROI and the asymmetry index of the proximal middle cerebral artery.
Article
Neurosciences
Jin Fang, Kelei Hua, Feng Chen, Zhifang Wan, Yi Yin, Ping Liu, Tianyue Wang, Guihua Jiang
Summary: Patients with ankylosing spondylitis (AS) showed changes in cerebral blood flow (CBF), with increased CBF values in certain brain regions and decreased CBF values in others compared with healthy controls. However, there were no significant correlations between CBF values and specific clinical characteristics of AS.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rong Wang, Xueling Liu, Chong Sun, Bin Hu, Liqin Yang, Yiru Liu, Daoying Geng, Jie Lin, Yuxin Li
Summary: This study investigated neurovascular coupling changes and potential neural basis in patients with MELAS using rs-fMRI and ASL. The results showed dynamic alterations in neurovascular coupling from acute to chronic stage in MELAS patients, providing a novel insight into the pathogenesis of MELAS.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Endocrinology & Metabolism
Manuel Taso, Fanny Munsch, Li Zhao, David C. Alsop
Summary: High-resolution imaging methods using ASL and T-1 mapping highlight the importance of spatial resolution and tissue heterogeneity in measuring cortical cerebral blood flow. Regional analysis reveals significant differences across cortical regions, with depth-dependent T-1 variation complicating interpretation of ASL signal. This has implications for accurate CBF quantification, especially at lower resolutions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Ying Xiong, Rong-Sheng Chen, Xing-Yu Wang, Xiao Li, Lin-Qi Dai, Ren-Qiang Yu
Summary: The study aimed to investigate the neurobiological features of adolescent patients with MDD. Results showed differences in CBF in various brain regions between MDD patients and healthy controls, which can aid in early diagnosis and intervention.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Giannina R. Iannotti, Isaure Nadin, Vladimira Ivanova, Quentin Tourdot, Agustina M. Lascano, Shahan Momjian, Karl L. Schaller, Karl O. Lovblad, Frederic Grouiller
Summary: This study validates the use of functional arterial spin-labeling (ASL) as a noninvasive tool for presurgical functional brain mapping. The results show that functional ASL is more spatially accurate than blood oxygen level?dependent (BOLD) imaging when compared to transcranial magnetic stimulation, making it a valuable supplementary technique for presurgical mapping.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caiyu Zhuang, Julien Poublanc, Larissa Mcketton, Lakshmikumar Venkatraghavan, Olivia Sobczyk, James Duffin, Adrian P. Crawley, Joseph A. Fisher, Renhua Wu, David J. Mikulis
Summary: This study demonstrates that in both 1.5-s and 2.5-s PLD groups, the CVR values in the affected ROI were significantly lower than in the control ROI. Additionally, the CBF in the affected ROI was significantly lower compared to the control ROI in the 1.5-s PLD group, but not in the 2.5-s PLD group. In hemisphere-based analysis, CBF was significantly lower in the affected side compared to the control side in the 1.5-s PLD group, but not in the 2.5-s PLD group.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Review
Psychology, Multidisciplinary
Brandon Joa, Andrew B. Newberg
Summary: This review examines the role of guilt in the development of prolonged grief disorder (PGD) in bereaved individuals, using an integrative approach combining developmental psychology and neurophysiology. While the literature extensively mentions guilt and grief, there is limited understanding of the mechanisms linking guilt and PGD. This study suggests that targeting guilt may be a promising approach for the treatment of PGD, including considering the positive and prosocial aspects of guilt.
OMEGA-JOURNAL OF DEATH AND DYING
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Danny J. J. Wang
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Peripheral Vascular Disease
Isabel J. Sible, Jung Yun Jang, Shubir Dutt, Belinda Yew, John Paul M. Alitin, Yanrong Li, Anna E. Blanken, Jean K. Ho, Anisa J. Marshall, Arunima Kapoor, Fatemah Shenasa, Aimee Gaubert, Amy Nguyen, Virginia E. Sturm, Mara Mather, Kathleen E. Rodgers, Xingfeng Shao, Danny J. Wang, Daniel A. Nation
Summary: Elevated blood pressure variability is associated with decreased cerebrovascular reactivity, indicating potential early markers of cerebrovascular dysfunction and disease.
AMERICAN JOURNAL OF HYPERTENSION
(2023)
Article
Clinical Neurology
Yingying Li, Yunqing Ying, Tingyan Yao, Xuejia Jia, Huilou Liang, Weijun Tang, Xiuqin Jia, Haiqing Song, Xingfeng Shao, Danny J. J. Wang, Chaodong Wang, Xin Cheng, Qi Yang
Summary: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and heterozygous HTRA1 mutation-related cerebral small vessel disease (CSVD) are two types of dominant hereditary CSVD, and this study found that the water exchange rate across the blood-brain barrier (BBB) was decreased in both types, suggesting a common pathophysiological mechanism. These findings highlight the potential use of measuring BBB permeability for monitoring the course of CADASIL and heterozygous HTRA1 mutation-related CSVD.
Review
Pharmacology & Pharmacy
Xue Wang, Courtney Bishop, James O'Callaghan, Ali Gayhoor, Justin Albani, Wendy Theriault, Michael Chappell, Xavier Golay, Danny Wang, Lino Becerra
Summary: Neurodegenerative mechanisms affect the brain through changes in structure and physiology. Cerebral blood flow (CBF) is a challenging biomarker to harmonize for clinical trials. Arterial spin labeling (ASL) perfusion MRI is a promising method for quantifying CBF without contrast agents and has been increasingly applied in clinical trials. This review presents ASL MRI techniques, implementation strategies, confidence levels in assessing disease progression and treatment effects, and image analysis details.
DRUG DISCOVERY TODAY
(2023)
Editorial Material
Neurosciences
Long-Biao Cui, Danny J. J. Wang, Guolin Ma
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neuroimaging
Xiuqin Jia, Chen Ling, Yingying Li, Jinyuan Zhang, Zhixin Li, Xuejia Jia, Danny J. J. Wang, Zihao Zhang, Yun Yuan, Qi Yang
Summary: Brain damage caused by small vessel disease (SVD) differs between males and females. This study aimed to investigate the sex-specific neuroanatomical mechanisms of SVD by adjusting for the effects of age and sex on healthy brain volume. Male CADASIL patients showed significant cognitive declines and greater gray matter atrophy compared to female patients, specifically in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), entorhinal cortex (EC), and temporooccipital cortex. Working memory was associated with volumes in the right OFC in female CADASIL patients, while visuospatial ability was associated with the right hOcl volume in males. These findings highlight the importance of considering sex differences in the pathogenesis and treatment of CADASIL and SVD.
NEUROIMAGE-CLINICAL
(2023)
Article
Psychiatry
Eric L. Goldwaser, Danny J. J. Wang, Bhim M. Adhikari, Joshua Chiappelli, Xingfeng Shao, Jiaao Yu, Tong Lu, Shuo Chen, Wyatt Marshall, Alexa Yuen, Mark Kvarta, Yizhou Ma, Xiaoming Du, Si Gao, Osamah Saeedi, Heather Bruce, Patrick Donnelly, Hugh O'Neill, Alan R. Shuldiner, Braxton D. Mitchell, Peter Kochunov, L. Elliot Hong
Summary: This study provides initial evidence of neurovascular water exchange abnormalities, particularly associated with negative symptoms, in schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Farzan Abdolahi, Victoria Yu, Rohit Varma, Xiao Zhou, Ruikang K. Wang, Lina M. D'Orazio, Chenyang Zhao, Kay Jann, Danny J. Wang, Amir H. Kashani, Xuejuan Jiang
Summary: This study found that lower retinal capillary perfusion is associated with worse information processing, fluid cognition, and MRI biomarkers of cerebral small vessel disease among Black Americans, but is not related to crystallized cognition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Kay Jann, Julia Boudreau, Daniel Albrecht, Steven Y. Cen, Ryan P. Cabeen, John M. Ringman, Danny J. J. Wang
Summary: This study found that rs-fMRI complexity is closely related to tau-PET detected neurodegeneration and cognitive decline in Alzheimer's disease. The reduction in complexity indicates tau-related neuropathology and cognitive decline in AD processes.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sayim Gokyar, Chenyang Zhao, Samantha J. Ma, Danny J. J. Wang
Summary: The purpose of this study is to predict subject-specific local specific absorption rate (SAR) distributions of the human head for parallel transmission (pTx) systems at 7 T. A multichannel 3D convolutional neural network (CNN) architecture was proposed, designed, and demonstrated to predict local SAR maps as well as peak-spatial SAR (ps-SAR) levels. The results showed that the proposed method had smaller prediction errors and could make predictions within a second, making it clinically useful.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinyang Shou, Chenyang Zhao, Xingfeng Shao, Kay Jann, Hosung Kim, Karl G. Helmer, Hanzhang Lu, Danny J. J. Wang
Summary: This study presents a Swin Transformer-based DL model, SwinIR, for denoising single-delay and multi-delay 3D ASL data and compares its performance with CNN and other Transformer-based methods. The results show that SwinIR outperforms CNN and other Transformer-based networks in denoising effectiveness.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Geriatrics & Gerontology
Cecily G. Swinford, Shannon L. Risacher, Aaron Vosmeier, Rachael Deardorff, Evgeny J. Chumin, Mario Dzemidzic, Yu-Chien Wu, Sujuan Gao, Brenna C. McDonald, Karmen K. Yoder, Frederick W. Unverzagt, Sophia Wang, Martin R. Farlow, Jared R. Brosch, David G. Clark, Liana G. Apostolova, Justin Sims, Danny J. Wang, Andrew J. Saykin
Summary: Identifying biomarkers for early detection of Alzheimer's disease (AD) is crucial for developing effective treatments. Cerebral blood flow (CBF) has potential as an early biomarker, as individuals with AD typically have decreased CBF compared to normal aging peers. Further research is needed to understand the relationships between CBF, AD risk factors, and pathologies.
NEUROBIOLOGY OF AGING
(2023)
Article
Neurosciences
Chenyang Zhao, Xingfeng Shao, Qinyang Shou, Samantha J. Ma, Sayim Gokyar, Christina Graf, Rudolf Stollberger, Danny J. J. Wang
Summary: This study presents a distortion-free three-dimensional pCASL sequence at 7T by optimizing labeling parameters, background suppression pulses, and readout sequence. In-vivo experiments demonstrate that this technique achieves whole-cerebrum coverage, high labeling efficiency, and high-resolution imaging without distortion.
Article
Neuroimaging
Xiuqin Jia, Yingying Li, Yunqing Ying, Xuejia Jia, Weijun Tang, Yueyan Bian, Jiajia Zhang, Danny J. J. Wang, Xin Cheng, Qi Yang
Summary: Excessive iron deposition in CADASIL may lead to cognitive decline, particularly affecting memory and executive function. White matter microstructural changes may mediate this process.
NEUROIMAGE-CLINICAL
(2023)
