期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 182, 期 1, 页码 53-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2009.11.002
关键词
Gamma-aminobutyric acid; Magnetic resonance spectroscopy; Personality; NEO-FFI
We hypothesized that brain gamma-aminobutyric acid (GABA) levels are associated with neuroticism, a trait associated with depression and anxiety disorders. We examined the correlation between brain GABA concentrations and the five factors included in the NEO Five-Factor Inventory (NEO-FFI) in healthy volunteers using magnetic resonance spectroscopy (MRS) at 3 T. Forty-one healthy subjects (21 males, 20 females; age: 35 +/- 7 years) were enrolled in this study. Each subject underwent a 3 T 1H-MRS study with a MEGA-PRESS sequence. Spectroscopy voxels (3 cm x 3 cm x 3 cm) were placed in the frontal lobe and the parieto-occipital lobe. A negative correlation was found between the GABA/creatine ratios in the frontal lobe and scores of extroversion on the NEO-FFI. These results suggest that GABAergic neurons are related to personality traits of healthy subjects. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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