期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 183, 期 1, 页码 85-88出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2010.04.004
关键词
Dopamine; Obsessive-compulsive disorder; Positron emission tomography; Anterior cingulate cortex
Functional neuroimaging studies in patients with obsessive-compulsive disorder (OCD) suggest there is a hyperactivation of the anterior cingulate cortex (ACC) during provocation of symptoms and conflict-inhibition tasks. Since dopamine, acting through D-1 receptors is suggested to modulate ACC activity, we hypothesised that there would be an altered D-1 binding potential (BP) in the ACC of OCD patients. Using [C-11]-SCH23390 and positron emission tomography, we report significantly reduced D-1 BP in seven drug-free OCD patients compared with matched healthy controls. These findings suggest mesocortical dopamine inputs via D-1 receptors may play a role in the aetiology of OCD. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.
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