期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 162, 期 3, 页码 230-235出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2007.08.008
关键词
striatal D-2/D-3 receptor; dopamine transporter; major depression; SPECT; healthy volunteer; antidepressant
In order to explore the neuropathology of the pre- and post-synaptic dopamine neurons of patients with major depression, we examined striatal D-2/D-3 receptor uptake and dopamine transporter (DAT) availability simultaneously in drug-free depressed patients using a dual-isotope single photon emission computed tomography (SPECT) imaging technique. Ten-unmedicated patients with unmediated depression and ten healthy controls were recruited. The striatal dopamine D2/D3 receptor availability was measured using SPECT and [I-123] IBZM, while DAT was measured using SPECT and [Tc-99m] TRODAT-1. The symptom changes of the drug-free patients were reassessed after a 4-week antidepressant treatment. DAT binding in the patient group were significantly higher than in control group. That was not the case, however, for striatal D2/D3 receptor availability. Pre-treatment striatal DAT availability correlated only marginally with changes in the Hamilton Depression Rating Scale after 4 weeks of treatment. Central dopamine functions may be altered in patients with major depression, particularly in the pre-synaptic sites. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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