Article
Psychiatry
Michael J. Spoelma, Katherine M. Ponte, Gordon Parker
Summary: This study aimed to identify common concerns of caregivers in the management of individuals with bipolar disorder. The results showed that concerns about work capacity and family impacts were almost ubiquitous, along with general feelings of ineffectiveness and irritation. Caregivers were more likely to fear suicide during depressive phases, while they were more likely to experience anger, concerns for their own safety, and take safety precautions during hypo/manic phases.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychiatry
A. S. J. Van der Watt, N. Dalvie, S. Seedat
Summary: Sleep disturbances and suicidality are common in mood and anxiety disorders. Telephone mood monitoring and sleep quality assessment may aid in early detection of relapse and relieve the burden on the mental healthcare system.
PSYCHIATRY RESEARCH
(2022)
Article
Health Care Sciences & Services
Lavinia De Chiara, Gloria Angeletti, Gaia Anibaldi, Chiara Chetoni, Flavia Gualtieri, Francesca Forcina, Paride Bargagna, Georgios Demetrios Kotzalidis, Tommaso Callovini, Marco Bonito, Alexia Emilia Koukopoulos, Alessio Simonetti
Summary: This study aimed to assess the impact of the COVID-19 pandemic on the mental health of pregnant women. The results showed that compared to a non-COVID sample, the COVID sample exhibited higher levels of mild depression and hypomania. However, there were no significant differences in terms of major depression and suicidal ideation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Daniel P. Moriarity, Corinne P. Bart, Allison Stumper, Payton Jones, Lauren B. Alloy
Summary: The study found that impulsive and interpersonal impairment were highly comorbid with mood symptoms, while suicidal ideation, sadness, decreased need for sleep, and guilt were most related to substance-related impairment. The components of these syndromes that confer cross-construct risk might not be the same as predicted by the other construct.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, Tomas Hajek, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Joseph F. Goldberg, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study used machine learning to identify highly discriminating symptoms between bipolar disorder and unipolar depression patients, assisting clinicians in distinguishing between the two conditions. Despite the unbalanced sample, the prediction rule ensembles showed potential in accuracy and may supersede traditional classificatory approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Alexandru I. Tiba, Simona Trip, Carmen H. Bora, Marius Drugas, Feliciana Borz, Daiana C. Miclaus, Laura Voss, Sorin C. Iova, Simona Pop
Summary: Primary irrational beliefs, especially those related to positive events, are found to be significantly associated with the risk of Bipolar Disorder. These findings highlight the importance of addressing positive primary irrational beliefs in the treatment of BPD.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Digby J. Quested, Jessica C. Gibson, Ann L. Sharpley, Julia H. Cordey, Alexis Economou, Franco De Crescenzo, Merryn Voysey, Jennifer Lawson, Jennifer M. Rendell, Hasanen Al-Taiar, Alison Lennox, Farooq Ahmad, John R. Geddes
Summary: The study compared the effectiveness and safety of adding melatonin in treating emergent episodes of hypomania or mania in bipolar disorder over a 3-week period. The results showed that melatonin did not effectively treat emerging hypomania or mania, as there was no significant difference between melatonin and placebo on the primary outcome.
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Manpreet K. Singh, Cynthia Siu, Michael Tocco, Andrei Pikalov, Antony Loebel
Summary: This study investigated the influence of mixed symptoms on treatment outcomes in pediatric bipolar depression and found that sleep disturbances and irritability are key symptoms that bridge between depressive and manic symptom clusters and influence treatment outcomes.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Julie Ramain, Lilith Abrahamyan Empson, Luis Alameda, Alessandra Solida, Julien Elowe, Nadir Mebdouhi, Philippe Conus, Philippe Golay
Summary: This study aims to investigate the impact of mood disturbances on the course and outcome of early psychosis. The results revealed that patients with co-occurring manic and depressive dimensions had poorer outcomes, highlighting the importance of accurate assessment and treatment of mood dimensions in early psychosis.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Uta Ouali, Yosra Zgueb, Lamia Jouini, Amina Aissa, Rabaa Jomli, Abdelhafidh Ouertani, Adel Omrani, Fethi Nacef, Mauro G. Carta, Antonio Preti
Summary: This study aimed to explore the reliability, factor structure, and criterion validity of the Arabic versions of the Hypomania Checklist (HCL-32) and the Mood Disorder Questionnaire (MDQ) in Tunisian patients diagnosed with mood disorders. The results showed that both tools had good reliability in all samples and were able to distinguish patients with BD from healthy controls as well as from patients with MDD.
Article
Psychiatry
Darryl Bassett, Philip Boyce, Bill Lyndon, Roger Mulder, Gordon Parker, Richard Porter, Ajeet Singh, Erica Bell, Amber Hamilton, Grace Morris, Gin S. Malhi
Summary: Psychotic episodes occur in a significant proportion of patients with major mood disorders, and their nature and management are less understood compared to non-psychotic periods of illness. This is concerning due to the higher risk of suicide and comorbidity in this subtype of mood disorder. The relationship between psychotic mood and other forms of psychosis, particularly schizophrenia, remains poorly understood. Therefore, our targeted review aims to provide clinical context and a framework for managing these disorders in real-world practice, considering both biological and psychological interventions.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Christoph Born, Heinz Grunze, Robert M. Post, Lori L. Altshuler, Ralph Kupka, Susan L. McElroy, Mark A. Frye, Trisha Suppes, Paul E. Keck, Willem A. Nolen, Lars Schaerer
Summary: This study analyzed the presence of depressive symptoms in bipolar disorder patients and found that (hypo)manic states are associated with a higher burden of depression compared to non-(hypo)manic states. Female patients were more likely to exhibit depressive symptoms, and mania and depression were shown to complement each other rather than being opposing poles.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2021)
Article
Psychiatry
HyunChul Youn, Moon-Soo Lee, Hyun-Ghang Jeong, Seung-Hyun Kim
Summary: This study used the Medication Event Monitoring System (MEMS) to assess medication adherence in patients with bipolar disorder (BD) and found that MEMS-measured adherence was more closely correlated with pill counts. Medication adherence was negatively associated with prescription duration and the Brief Psychiatric Rating Scale-Affect Subscale Score. Additionally, the study suggests caution when using self-reporting and clinician rating methods to assess medication adherence in patients with BD.
ANNALS OF GENERAL PSYCHIATRY
(2022)
Article
Psychiatry
Gordon Parker, Minas Coroneo
Summary: This study presents exemplars of pseudo-hallucinations experienced by individuals with bipolar disorder, suggesting their overrepresentation in this condition and arguing that their presence does not indicate psychosis. The historical definitions of pseudo-hallucinations are reviewed, and six profiles are presented, considering manifestations, sequencing, and response to medication in bipolar disorder patients. The findings indicate the richness of expression, variable time course, and response to medication of pseudo-hallucinations in individuals with bipolar disorder.
AUSTRALASIAN PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Gordon Parker
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker
Summary: If attention-deficit hyperactivity disorder and bipolar disorder are independent conditions, the rate of comorbidity between the two is much higher than chance. This article explores the explanations for such a high comorbid prevalence and its management implications.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Imogen H. Bell, Jennifer Nicholas, Amy Broomhall, Eleanor Bailey, Sarah Bendall, Alexandra Boland, Jo Robinson, Sophie Adams, Patrick McGorry, Andrew Thompson
Summary: The COVID-19 pandemic has had both positive and negative impacts on the mental health and wellbeing of young people. The survey found that a high percentage of young people experienced clinical depression, anxiety, and loneliness. The majority of them also reported negative impacts on their work, non-work activities, and mental health. However, some respondents mentioned positive impacts such as increased self-care and reflection due to reduced pressures in daily life.
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Michael J. Spoelma, Anastasia Serafimovska, Gordon Parker
Summary: The objective of this paper was to review potential biomarkers of melancholia in order to improve differential diagnosis, clinical response, and treatment outcomes. By comparing melancholic with non-melancholic depression, we emphasized the importance of distinguishing melancholia as its own condition.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Michael J. Spoelma, Katherine M. Ponte, Gordon Parker
Summary: This study aimed to identify common concerns of caregivers in the management of individuals with bipolar disorder. The results showed that concerns about work capacity and family impacts were almost ubiquitous, along with general feelings of ineffectiveness and irritation. Caregivers were more likely to fear suicide during depressive phases, while they were more likely to experience anger, concerns for their own safety, and take safety precautions during hypo/manic phases.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychology, Applied
Gabriela Tavella, Michael Spoelma, Gordon Parker
Summary: Individuals often self-diagnose burnout, but there is ongoing debate among researchers and practitioners on how to define and measure this syndrome. This study aimed to determine if a new 34-item burnout measure could distinguish between those who identified as burnt out and those who didn't, and identify the most distinguishing symptoms. The measure successfully differentiated individuals with self-reported burnout, with exhaustion, cognitive dysfunction, lack of pleasure in work, and self-criticism being the most indicative symptoms.
INTERNATIONAL JOURNAL OF STRESS MANAGEMENT
(2023)
Article
Psychiatry
Gordon Parker
Summary: This article hypothesizes that the increased prevalence of adult-onset attention-deficit disorder (ADD) and attention-deficit hyperactivity disorder (ADHD) may be attributed to the use of mobile technology and digital media. The data and clinical observations support this hypothesis, though it has not been proven.
AUSTRALASIAN PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker
Summary: This study examines the impact of mood stabilizers on the creativity of patients. The results indicate a distinct gradient in the cognitive effects of different mood stabilizers, with lithium posing the highest risk and lamotrigine seemingly without impact. Clinicians are advised to closely monitor cognitive side effects when using lithium.
AUSTRALASIAN PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Gordon Parker, Minas T. Coroneo, Michael J. Spoelma
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker, Michael J. Spoelma, Samuel J. Skidmore, Amelia Reid, Samuel Morris, Greta Ferguson, Michael H. Connors
Summary: This study describes the development of an observational measure for differentiating schizophrenia from mania. The researchers identified two sets of 10 items that best differentiated the two conditions. They also found that a difference score of +1 showed optimal differentiation between schizophrenia and mania.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma
Summary: ChatGPT has shown the capability of providing basic and informative content related to bipolar disorders, including descriptions of symptoms, classification types, causes, and treatment options. It has also demonstrated creativity in generating songs that capture the nuances of bipolar symptoms.
Article
Psychiatry
Gordon Parker, Gabriela Tavella, Matthew Hopcraft
Summary: This study aimed to examine the convergent validity of the Sydney Burnout Measure (SBM) by comparing it with the Maslach Burnout Inventory (MBI). It also explored the relationship between burnout and psychological distress. The results showed a high correlation between the two measures, supporting the convergent validity of the SBM. The study also found a significant correlation between the burnout measures and the measures of psychological distress.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Michael J. Spoelma, Joanne Leidreiter, Adam Bayes, Artin Jebejian, Gordon Parker
Summary: This study provides an alternative perspective on the effectiveness of common bipolar disorder maintenance treatments by considering naturalistic data. The findings suggest a preference for lamotrigine in the maintenance treatment of bipolar II disorder, while the side effect profile of lithium remains a concern.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Substance Abuse
Jacqueline K. Gollan, Gabrielle Liverant, Nancy C. Jao, Kayla A. Lord, Alexis E. Whitton, Lee Hogarth, Erica Fox, Anna-Marika Bauer, Mackenzie Hosie Quinn, Diego A. Pizzagalli, Frank T. Leone, George D. Papandonatos, Robert A. Schnoll, Brian Hitsman
Summary: This study investigated how adult daily smokers learned to seek reward during a 12-week treatment combining behavioral activation and varenicline. The results showed that smokers with more severe depressive symptoms experienced a decline in reward learning during smoking cessation treatment, posing challenges for standard smoking cessation approaches.
NICOTINE & TOBACCO RESEARCH
(2023)
