Article
Immunology
Sara Francisco, Jean-Marc Billod, Javier Merino, Carmen Punzon, Alicia Gallego, Alicia Arranz, Sonsoles Martin-Santamaria, Manuel Fresno
Summary: This study reveals that Ochrobactrum intermedium LPS can activate both TLR4 and TLR2, indicating the occurrence of TLR4/TLR2 heterodimerization, and the core saccharide plays an important role in this interaction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wenxia Wang, Swarna Bale, Bharath Yalavarthi, Priyanka Verma, Pei-Suen Tsou, Ken M. Calderone, Dibyendu Bhattacharyya, Gary J. Fisher, John Varga, Swati Bhattacharyya
Summary: RP105 has been identified as a novel cell-intrinsic negative regulator of TLR4-MD2-driven sustained fibroblast activation, and its impaired function may contribute to the progression of systemic sclerosis.
Article
Medicine, General & Internal
Aleksandra Rajewska-Rager, Monika Dmitrzak-Weglarz, Natalia Lepczynska, Pawel Kapelski, Joanna Pawlak, Aleksandra Szczepankiewicz, Marcin Wilczynski, Maria Skibinska
Summary: This study aimed to establish dimensions of the Hamilton Depression Rating Scale (HDRS-17) in adolescents and young adults with major depression disorder (MDD) and correlate them with psychological variables. The study found that the core dimensions in young MDD patients were psychic depression/motor retardation, disturbed thinking, and sleep disturbances/anxiety. These dimensions were correlated with reward dependence, impulsivity, harm avoidance, and self-directedness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Katja Freundt, Christian Herzmann, Dominika Biedziak, Claudia Scheffzuek, Karoline Gaede, Cordula Stamme
Summary: Respiratory infections caused by Gram-negative bacteria are a major global health issue, and this study suggests that surfactant protein A may play a role in limiting the immune response to these infections by regulating Toll-like receptor 4 expression and localization in alveolar macrophages.
INFECTION AND IMMUNITY
(2022)
Article
Clinical Neurology
Jonathan Rabinowitz, Janet B. W. Williams, Ariana Anderson, Dong Jing Fu, Nanco Hefting, Bashkim Kadriu, Alan Kott, Atul Mahableshwarkar, Jan Sedway, David Williamson, Christian Yavorsky, Nina R. Schooler
Summary: This study explores the impact of measurement imprecisions on outcome assessment in the treatment of depression and proposes flags for logical and statistical consistency checks. The results show that nearly 30% of the depression treatments have inconsistent scoring and statistical outliers, which should be reviewed and addressed to improve the reliability and validity of clinical trial data.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Health Care Sciences & Services
Chan-Hyuk Lee, Su Hong Jeon, Min Ju Kim, Gyu Dam Ra, Yong-Hyun Lee, Seung Hyeon Hong, Byoung-Soo Shin, Hyun Goo Kang
Summary: Post-stroke depression (PSD) affects approximately one-third of stroke patients and has serious consequences. This study identified factors associated with PSD diagnosis and improvement in stroke patients. Overall, environmental factors like hospitalization period may play a role in managing PSD, and factors related to PSD improvement could help establish a strategy for recovery.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Melania Scarpa, Cesare Ruffolo, Andromachi Kotsafti, Fabio Canal, Francesca Erroi, Silvia Basato, Lucia Dall'Agnese, Alain Fiorot, Anna Pozza, Paola Brun, Nicolo Bassi, Angelo Dei Tos, Carlo Castoro, Ignazio Castagliuolo, Marco Scarpa
Summary: Research has shown that patients with MMR-deficient colorectal cancer have a more favorable prognosis, possibly due to the interplay between MMR genes and TLR4/MyD88 signaling, with TLR4 expression depending on MMR status and correlating directly with MLH1 expression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Lijing Su, Muhammad Athamna, Ying Wang, Junmei Wang, Marina Freudenberg, Tao Yue, Jianhui Wang, Eva Marie Y. Moresco, Haoming He, Tsaffrir Zor, Bruce Beutler
Summary: Sulfatides can activate mouse immune responses via the TLR4-MD-2 complex, but exhibit antagonistic effects in human cells. Their activity is related to the presence of the sulfate group and the length of the fatty acid chain, and their structure mimics the activation mechanism of molecules like LPS in receptors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Organic
Rachid Naitaleb, Agnes Denys, Fabrice Allain, Jerome Ausseil, Sylvestre Toumieux, Jose Kovensky
Summary: The study designed and synthesized sulfated compounds capable of crossing the blood-brain barrier, which were tested on HEK-TLR4 cells, demonstrating the potential of small oligosaccharides to modulate TLR4 activity with the 6-sulfate groups playing a key role in triggering TLR4 signalization.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Food Science & Technology
Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li
Summary: ZEA suppresses macrophage-mediated innate immunity activated by LPS, attenuating the production of proinflammatory mediators and cytokines, inhibiting inflammatory signaling pathways, and repressing inflammasome activation. This suggests that ZEA-contaminated food intake may decrease innate immunity and increase adverse effects during infection.
Article
Cell Biology
Shuhua Luo, Chaoxiong Liao, Lina Zhang, Chunxiu Ling, Xuedi Zhang, Pengyun Xie, Guomei Su, Zhanghui Chen, Liangqing Zhang, Tianwen Lai, Jing Tang
Summary: N6-methyladenosine (m6A) modification is the most prevalent mRNA internal modification and serves as a widespread regulatory mechanism in various physiological processes. In this study, we found that methyltransferase-like protein 3 (METTL3) plays a crucial role in neutrophil activation. METTL3 controls the release of neutrophils from the bone marrow to circulation by regulating the surface expression of CXC chemokine receptor 2 (CXCR2) through Toll-like receptor 4 (TLR4) signaling in lipopolysaccharide (LPS)-induced endotoxemia. We discovered that the mRNA of TLR4 is modified by m6A, resulting in increased translation and decreased degradation, leading to elevated levels of TLR4 protein and subsequent activation of TLR4 signaling in neutrophils. The downregulation of TLR4 expression reduces cytokine secretion in METTL3-deleted neutrophils upon LPS stimulation through the TLR4/Myd88/nuclear factor KB (NF-KB) signaling pathway. Overall, these findings demonstrate that METTL3-mediated TLR4 expression is a critical determinant of neutrophil activation in endotoxemia.
Review
Immunology
Haidy A. Saleh, Mohamed H. Yousef, Anwar Abdelnaser
Summary: The innate immune response triggers inflammation and maintains immune homeostasis through epigenetic modifications. Studies have shown the significant impact of epigenetic changes in inflammatory diseases and tumor development, while also highlighting the potential of naturally-derived phytochemicals in regulating these processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pedro Paulo Carneiro, Andreza S. Dorea, Walker N. Oliveira, Luiz Henrique Guimaraes, Claudia Brodskyn, Edgar M. Carvalho, Olivia Bacellar
Summary: Research has shown that the use of TLR2 and TLR4 antagonists can reduce the number of infected cells and internalized parasites in monocytes of CL patients, as well as decrease oxidative burst, IL-1 beta, TNF, and CXCL9 production. Additionally, TNF production in cells from CL lesions also decreased after neutralization of TLR2 and TLR4.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Alicia Martinez-Lopez, Sylwia D. Tyrkalska, Francisca Alcaraz-Perez, Isabel Cabas, Sergio Candel, Francisco J. Martinez Morcillo, Maria P. Sepulcre, Diana Garcia-Moreno, Maria L. Cayuela, Victoriano Mulero
Summary: Fish, with their diverse and successful species, play an important role in studying the evolution of vertebrate immunity. There are significant differences in fish immunity compared to mammals, such as their reliance on ambient temperature, poor antibody response, and absence of antibody switching and lymph nodes. The high resistance of fish to the toxic effects of lipopolysaccharide (LPS) can be explained by the absence or inability of certain receptors to recognize LPS. This suggests that the receptor complex for LPS recognition developed after the divergence of fish and tetrapods.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Dermatology
Selami Aykut Temiz, Koray Durmaz, Recep Dursun, Arzu Ataseven, Begum Isik, Onur Karaagac, Ilkay ozer, Munise Daye
Summary: This study compared the emotional experiences of patients undergoing cosmetology procedures during the COVID-19 pandemic with a control group, revealing higher levels of depression and general anxiety in the cosmetology group. However, there was no significant difference in coronavirus anxiety scores between the two groups. It highlights the importance of considering the psychological impact of pandemic on patients undergoing cosmetological procedures.
DERMATOLOGIC THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tsang-Hsiung Lin, Hsing-Hao Su, Hong-Yo Kang, Tsung-Hsien Chang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Hung-Chun Fu, I-Chieh Chuang, Yi-Chien Yang, Pei-Chin Chuang, Hao Lin, Yu-Che Ou, Chan-Chao Chang Chien, Hui-Shan Huang, Hong-Yo Kang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Genetics & Heredity
Kuo-Chung Lan, Yi-Chi Lin, Yung-Chiao Chang, Hsin-Jung Lin, Yi-Ru Tsai, Hong-Yo Kang
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Cell Biology
Yi-Yung Hung, Ming-Kung Wu, Meng-Chang Tsai, Ya-Ling Huang, Hong-Yo Kang
Article
Cell Biology
Yi-Yung Hung, Ya-Ling Huang, Chawnshang Chang, Hong-Yo Kang
Review
Cell Biology
Jia-Feng Chen, Pei-Wen Lin, Yi-Ru Tsai, Yi-Chien Yang, Hong-Yo Kang
Article
Biochemistry & Molecular Biology
Kuo-Chung Lan, Pin-Yao Lin, Yung-Chiao Chang, Yun-Ju Chen, Yi-Ru Tsai, Ismaeil Salim Ismaeil Mohamed, Hong-Yo Kang
BIOMEDICAL JOURNAL
(2019)
Article
Oncology
Chen-Kai Chou, Shun-Yu Chi, Fong-Fu Chou, Shun-Chen Huang, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Article
Immunology
Ting- Chiang, Yi-Yung Hung, Ming-Kung Wu, Ya-Ling Huang, Hong-Yo Kang
Summary: This study identified the abnormal expression of the GRβ/TNIP2/TNF-α axis in patients with MDD, which may lead to inflammation in depression. Inhibiting TNIP2 could potentially reduce the promoting effect of GRβ on TNF-α levels.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Ya-Ting Chang, Yung-Lung Chen, Hong-Yo Kang
Summary: Sex differences play a significant role in cardiovascular and cognitive function, impacting various aspects including pathophysiology, disease onset, symptoms, and severity. Atrial fibrillation (AF) may contribute to vascular cognitive impairment (VCI), with sex hormones potentially serving as therapeutic targets for early intervention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The present study aimed to determine the association of ER mRNA expression levels with clinicopathologic features in PTC. The expression of ER alpha 66, ER alpha 36, ER beta, and GPER1 was lower in PTC specimens than in adjacent normal thyroid tissues. Low GPER1 expression was associated with extrathyroidal extension. There was no obvious difference in expression of ERs between PTC specimens from male and female patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kuo-Chung Lan, Kuo-Ting Wei, Pei-Wen Lin, Ching-Chen Lin, Pei-Ling Won, Ya-Fen Liu, Yun-Ju Chen, Bi-Hua Cheng, Tien-Min G. Chu, Jia-Feng Chen, Ko-En Huang, Chawnshang Chang, Hong-Yo Kang
Summary: The study found that androgen receptor (AR) is highly expressed in periosteum cells during bone fracture repair and is co-localized with a mesenchymal progenitor cell marker, Prrx1. Mice lacking AR in periosteum showed reduced callus size and new bone volume. Targeting the androgen/AR axis in periosteum may provide a novel therapy approach to improve fracture healing.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Hao Lin, Kuo-Chung Lan, Yu-Che Ou, Chen-Hsuan Wu, Hong-Yo Kang, I-Chieh Chuang, Hung-Chun Fu
Summary: The study found that strong progesterone receptor-B expression was associated with better platinum sensitivity and survival in patients with high-grade serous ovarian cancer. Clinical data indicated that high expression of progesterone receptor-B and optimal debulking were independent factors predicting better platinum sensitivity. In cell models, enhancing progesterone receptor-B expression and progesterone treatment increased platinum sensitivity and apoptosis of ovarian cancer cells, suggesting potential therapeutic targets for high-grade serous ovarian carcinoma.
Article
Biochemistry & Molecular Biology
Yi-Yung Hung, Chen-Kai Chou, Yi-Chien Yang, Hung-Chun Fu, El-Wui Loh, Hong-Yo Kang
Summary: This study found that in patients with major depressive disorder, the expression levels of miR-146a in exosomes were higher, and patients who achieved remission showed lower levels of various microRNAs before treatment and increased levels after treatment. Let-7e, miR-145, and miR-146a showed acceptable discrimination between the remission and non-remission groups.
Article
Endocrinology & Metabolism
Chen-Kai Chou, Shun-Yu Chi, Yi-Yung Hung, Yi-Chien Yang, Hung-Chun Fu, Jia-He Wang, Chueh-Chen Chen, Hong-Yo Kang
Summary: The study revealed that dysregulated expression of miR-146b and androgen receptor (AR) played critical roles in the tumorigenesis of papillary thyroid carcinoma (PTC). It was confirmed that miR-146b expression was significantly inversely correlated with AR expression. Further experiments showed that AR might bind to the androgen receptor element on the promoter region of miR-146b, leading to repression of miR-146b expression and reduction of PTC tumor aggressiveness. PTC patients with low AR/high miR-146b expression were associated with advanced tumor characteristics.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)