Article
Food Science & Technology
Lin Ding, Jinyue Yang, Haoran Guo, Peixu Cong, Jie Xu, Changhu Xue, Xiangzhao Mao, Tiantian Zhang, Yuming Wang
Summary: Dietary supplementation of docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) in the form of phosphoethanolamine plasmalogens (PlsEtn) has been shown to remodel lipidome and regulate fatty acid metabolic process in white adipose tissue (WAT), suggesting it as a potential strategy for obesity treatment in the future.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemical Research Methods
Andrew Gold, Li Chen, Jiangjiang Zhu
Summary: This paper conducts a comprehensive study on the metabolic and lipidomic characteristics of Escherichia coli's adaptation to acid stress. The results show significant differences in the extracellular metabolome and lipidome induced by amino acid supplementation, as well as alterations in metabolic pathways and phospholipid synthetic pathways. The findings suggest that acid resistance mechanisms may have a coordinated metabolic phenotype.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Moritz Warmbrunn, Annefleur M. Koopen, Nicolien C. de Clercq, Pieter F. de Groot, Ruud S. Kootte, Kristien E. C. Bouter, Kasper W. ter Horst, Annick Hartstra, Mireille J. Serlie, Mariette T. Ackermans, Maarten R. Soeters, Daniel H. van Raalte, Mark Davids, Max Nieuwdorp, Albert K. Groen
Summary: The study identified distinct plasma metabolite profiles between insulin-resistant and non-insulin resistant subjects with metabolic syndrome. Despite insulin resistance being considered a risk factor for cardiovascular diseases, there was little correspondence between metabolites associated with insulin resistance and those associated with cardiovascular disease risk. Insulin resistance was related to fatty acid metabolism and glycerolphosphorylcholine.
Article
Chemistry, Analytical
Ching-Hua Lee, Sung-Chun Tang, Ching-Hua Kuo
Summary: The study developed a sensitive and specific LC-MS/MS-MRM method to accurately identify PC(O-) and PC(P-), and applied it to investigate the regulation of etherPCs in primary neuronal cultures under hypoxic stress. Results revealed that the regulation of etherPCs was related to sn-1 chain length, while concentration changes of diacyl-PCs depended heavily on the degree of unsaturation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Nutrition & Dietetics
Christine Dawczynski, Johannes Plagge, Gerhard Jahreis, Gerhard Liebisch, Marcus Hoering, Claudine Seeliger, Josef Ecker
Summary: The content of polyunsaturated fatty acids in complex lipids affects their properties and has implications for health and disease. A study investigating the incorporation of dietary PUFA in the human plasma lipidome found that certain types of PUFA significantly impact the composition of ethanolamine-containing glycerophospholipids (GPL). These findings suggest that diets enriched with highly unsaturated fatty acids more effectively alter plasma GPL acyl chain composition compared to diets with primarily di- and tri-unsaturated fatty acids.
Article
Chemistry, Analytical
Leicheng Zhang, Tengfei Xu, Jingtao Zhang, Stephen Choong Chee Wong, Mark Ritchie, Han Wei Hou, Yulan Wang
Summary: The study proposes a novel strategy integrating spiral inertial microfluidics and ion mobility mass spectrometry for single-cell metabolite detection and identification. The technology successfully screened the metabolic profiles of different types of cancer cells, improving confidence in metabolite identification. This approach offers a simple and efficient method for single-cell lipid profiling, with additional ion mobility separation significantly enhancing the confidence toward identification of metabolites.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jiangang Zhang, Yu Zhou, Juan Lei, Xudong Liu, Nan Zhang, Lei Wu, Yongsheng Li
Summary: Dysfunctional lipid metabolism is crucial in the development and progression of various diseases. Accurate measurement of lipidomes can uncover complex interactions between genes, proteins, and lipids. This study proposes a simplified workflow for predicting retention time in phospholipidomics and reveals the abundance of unsaturated fatty acyl phospholipids in hepatocellular carcinoma cell lines with drug resistance. It highlights the importance of lipidomics in understanding disease development.
Article
Neurosciences
Tian-Xin Yang, Yun-Fang Zhu, Cheng-Cheng Wang, Jin-Yue Yang, Chang-Hu Xue, Qing-Rong Huang, Yu-Ming Wang, Tian-Tian Zhang
Summary: The study provides evidence for the positive effect of PlsEtn on neuroprotection and neuroinflammation inhibition, and PlsEtn may be explored as a potential functional ingredient.
BRAIN RESEARCH BULLETIN
(2022)
Article
Medicine, Legal
Maika Nariai, Hiroko Abe, Yumi Hoshioka, Yohsuke Makino, Hirotaro Iwase
Summary: This study used metabolomics analysis to identify a set of potential metabolites that could be used for forensic diagnosis of diabetes mellitus in postmortem blood samples. The findings suggest that further metabolomics research using postmortem samples is necessary to identify markers for forensic diagnosis.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yoshihiro Kita, Suzumi M. Tokuoka, Yoshiya Oda, Takao Shimizu
Summary: This article reports the development of a lightweight chromatogram browser software called TRACES for MRM-based targeted LC-MS analysis. TRACES provides rapid access to MRM chromatograms and has a chromatogram-level deisotoping function, helping users with data browsing and identification of regions potentially affected by isotopic signals.
Article
Biochemistry & Molecular Biology
Paula A. Gonzalez, Judith Simcox, Hershel Raff, Gina Wade, Helaina Von Bank, Steven Weisman, Keri Hainsworth
Summary: The study showed that there is a distinct lipid signature associated with chronic pain and its co-occurrence with obesity in adolescents, indicating that specific lipid metabolites may play a role in the inflammation mechanism related to chronic pain and obesity.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Cell Biology
David Balgoma, Fredrik Kullenberg, Carlemi Calitz, Maria Kopsida, Femke Heindryckx, Hans Lennernas, Mikael Hedeland
Summary: The study indicates that supplementation with PUFAs and/or etherPEs with PUFAs may serve as a potential general adjuvant of anthracyclins, while modulation of cholesterol metabolism could be considered a specific adjuvant depending on the type of tumor and individual. Additionally, the imbalance between PUFAs and cholesterol and saturated lipids partially explains the sensitivity to anthracyclins in different cells. Overall, the modulation of different lipid metabolic pathways may be considered for generalized and personalized metabochemotherapies.
Article
Cell Biology
Daniel P. Pike, Reagan M. McGuffee, Elizabeth Geerling, Carolyn J. Albert, Daniel F. Hoft, Michael G. S. Shashaty, Nuala J. Meyer, Amelia K. Pinto, David A. Ford
Summary: This study reveals the loss of plasmalogens during sepsis and SARS-CoV-2 infection. Plasma plasmalogens should be considered as biomarkers of infection and prognostic indicators for sepsis and COVID-19 outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Hyemin Lee, Li Zhuang, Boyi Gan
Summary: Recent studies have highlighted the critical role of ether-linked phospholipids in providing polyunsaturated fatty acid-containing phospholipids in ferroptosis, as well as the context-dependent role of TMEM189-mediated vinyl-ether phospholipid synthesis in ferroptosis.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Biochemistry & Molecular Biology
Majd B. B. Protty, P. Vince Jenkins, Peter W. W. Collins, Valerie B. B. O'Donnell
Summary: Phospholipids are vital for cell structure and cell activation signalling pathways. They play a key role in supporting blood clotting by rapidly externalizing upon platelet activation. Enzymatically oxidized phospholipids have also been found to facilitate blood clotting. However, the exact role of phospholipids in thrombo-inflammatory conditions is not fully understood.
Article
Multidisciplinary Sciences
Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Blach, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmueller
NATURE COMMUNICATIONS
(2020)
Article
Clinical Neurology
Megan M. Bernath, Sudeepa Bhattacharyya, Kwangsik Nho, Dinesh Kumar Barupal, Oliver Fiehn, Rebecca Baillie, Shannon L. Risacher, Matthias Arnold, Tanner Jacobson, John Q. Trojanowski, Leslie M. Shaw, Michael W. Weiner, P. Murali Doraiswamy, Rima Kaddurah-Daouk, Andrew J. Saykin
Article
Clinical Neurology
Mitchel A. Kling, Dayan B. Goodenowe, Vijitha Senanayake, Siamak MahmoudianDehkordi, Matthias Arnold, Tyler J. Massaro, Rebecca Baillie, Xianlin Han, Yuk-Yee Leung, Andrew J. Saykin, Kwangsik Nho, Alexandra Kueider-Paisley, Jessica D. Tenenbaum, Li-San Wang, Leslie M. Shaw, John Q. Trojanowski, Rima F. Kaddurah-Daouk
ALZHEIMERS & DEMENTIA
(2020)
Article
Multidisciplinary Sciences
Ronald B. Moss, Meghan McCabe Pryor, Rebecca Baillie, Katherine Kudrycki, Christina Friedrich, Mike Reed, Dennis J. Carlo
Article
Multidisciplinary Sciences
Jingye Wang, Runmin Wei, Guoxiang Xie, Matthias Arnold, Alexandra Kueider-Paisley, Gregory Louie, Siamak Mahmoudian Dehkordi, Colette Blach, Rebecca Baillie, Xianlin Han, Philip L. De Jager, David A. Bennett, Rima Kaddurah-Daouk, Wei Jia
SCIENTIFIC REPORTS
(2020)
Article
Psychiatry
Siamak MahmoudianDehkordi, Ahmed T. Ahmed, Sudeepa Bhattacharyya, Xianlin Han, Rebecca A. Baillie, Matthias Arnold, Michelle K. Skime, Lisa St. John-Williams, M. Arthur Moseley, J. Will Thompson, Gregory Louie, Patricio Riva-Posse, W. Edward Craighead, William McDonald, Ranga Krishnan, A. John Rush, Mark A. Frye, Boadie W. Dunlop, Richard M. Weinshilboum, Rima Kaddurah-Daouk
Summary: SSRIs have effects on amino acid metabolism and lipid membrane remodeling, which may play roles in treatment response and are linked to mitochondrial energetics.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A. Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex A. T. Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F. Watts, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Vincent Dore, Juergen Fripp, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Ralph N. Martins, Eric K. Moses, Rima Kaddurah-Daouk, Peter J. Meikle
Summary: The APOE genotype is strongly associated with late-onset Alzheimer's disease, with specific lipid species mediating up to 30% and 10% of the treatment effect of APOE epsilon 2 and epsilon 4, respectively. Plasma lipid species represent a potential therapeutic target for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Emrin Horgusluoglu, Ryan Neff, Won-Min Song, Minghui Wang, Qian Wang, Matthias Arnold, Jan Krumsiek, Beatriz Galindo-Prieto, Chen Ming, Kwangsik Nho, Gabi Kastenmueller, Xianlin Han, Rebecca Baillie, Qi Zeng, Shea Andrews, Haoxiang Cheng, Ke Hao, Alison Goate, David A. Bennett, Andrew J. Saykin, Rima Kaddurah-Daouk, Bin Zhang
Summary: This study aims to identify AD-specific metabolomic changes and their potential upstream genetic and transcriptional regulators through an integrative systems biology framework. The findings suggest that short-chain acylcarnitines/amino acids and medium/long-chain acylcarnitines are most associated with AD clinical outcomes. Integration of gene expression data reveals ABCA1 and CPT1A are involved in regulating acylcarnitines and amino acids in AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Multidisciplinary Sciences
Christopher R. Brydges, Oliver Fiehn, Helen S. Mayberg, Henry Schreiber, Siamak Mahmoudian Dehkordi, Sudeepa Bhattacharyya, Jungho Cha, Ki Sueng Choi, W. Edward Craighead, Ranga R. Krishnan, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk
Summary: The study found that indole sulfate, a metabolite of gut microbiota, was closely associated with anxiety symptoms but not related to post-treatment outcomes. This suggests that cognitive behavioral therapy and antidepressant medications relieve anxiety through mechanisms unrelated to modulation of gut-derived indoles.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Priyanka Baloni, Matthias Arnold, Luna Buitrago, Kwangsik Nho, Herman Moreno, Kevin Huynh, Barbara Brauner, Gregory Louie, Alexandra Kueider-Paisley, Karsten Suhre, Andrew J. Saykin, Kim Ekroos, Peter J. Meikle, Leroy Hood, Nathan D. Price, P. Murali Doraiswamy, Cory C. Funk, A. Ivan Hernandez, Gabi Kastenmueller, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk
Summary: This study investigates the role of sphingomyelin and ceramide metabolism in Alzheimer's disease through multi-omics analyses and imaging features. The findings suggest potential therapeutic targets in the sphingomyelin pathway and demonstrate the efficacy of modulators of S1P metabolism in treating Alzheimer's disease, as validated in mouse models.
COMMUNICATIONS BIOLOGY
(2022)
Article
Clinical Neurology
Kwangsik Nho, Alexandra Kueider-Paisley, Matthias Arnold, Siamak MahmoudianDehkordi, Shannon L. Risacher, Gregory Louie, Colette Blach, Rebecca Baillie, Xianlin Han, Gabi Kastenmueller, P. Murali Doraiswamy, Rima Kaddurah-Daouk, Andrew J. Saykin
Summary: Metabolomics in the Alzheimer's Disease Neuroimaging Initiative cohort revealed associations between specific circulating blood metabolites and brain amyloid-beta deposition, memory scores, cognitive function changes, and disease progression in Alzheimer's disease.
BRAIN COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Kevin Huynh, Wei Ling Florence Lim, Corey Giles, Kaushala S. Jayawardana, Agus Salim, Natalie A. Mellett, Adam Alexander T. Smith, Gavriel Olshansky, Brian G. Drew, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley I. Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Matthias Arnold, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk, Ralph N. Martins, Peter J. Meikle
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Priyanka Baloni, Cory C. Funk, Jingwen Yan, James T. Yurkovich, Alexandra Kueider-Paisley, Kwangsik Nho, Almut Heinken, Wei Jia, Siamak Mahmoudiandehkordi, Gregory Louie, Andrew J. Saykin, Matthias Arnold, Gabi Kastenmueller, William J. Griffiths, Ines Thiele, Rima Kaddurah-Daouk, Nathan D. Price
CELL REPORTS MEDICINE
(2020)
Meeting Abstract
Pharmacology & Pharmacy
C. Friedrich, R. Baillie, M. Weis, M. Pryor, V. Hurez, K. Kudrycki, M. Reed
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Meeting Abstract
Pharmacology & Pharmacy
C. Friedrich, R. Baillie, M. Weis, M. Pryor, V. Hurez, K. Kudrycki, M. Reed
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)