Article
Clinical Neurology
Shen Li, Bin Yu, Dongmei Wang, Luyao Xia, Li Wang, Dachun Chen, Meihong Xiu, Xiang Yang Zhang
Summary: This study found that SG-P50 deficit may be an informational biomarker for depressive symptoms and neurocognitive impairments in FEAN-SCZ patients. For depressive FEAN-SCZ patients, the S2 amplitude of SG-P50 may serve as an independent predictor of MCCB-Mazes (NAB).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Engineering, Biomedical
Qi Chang, Cancheng Li, Jicong Zhang, Chuanyue Wang
Summary: This study discovered and characterized P50 dynamic brain connections using microstate analysis. The results suggest that deficits in P50 suppression in schizophrenia may be attributed to abnormal baseline sensory perception and adaptation. This finding provides new insights into the mechanisms of P50 suppression in the early stage of schizophrenia.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Psychology, Biological
Tzvetan Popov, Brigitte Rockstroh, Gregory A. Miller
Summary: This study found that individuals with schizophrenia exhibit poorer sensory gating, particularly in the A1 region, as well as in adjacent brain regions. In addition, the study suggests that endogenous connectivity evident in a sequence of activity from angular gyrus to portions of superior temporal gyrus may contribute to both normal and abnormal gating in schizophrenia.
Article
Psychiatry
Leilei Wang, Wanjun Zeng, Yi Yin, Yanfang Zhou, Junchao Huang, Ping Zhang, Song Chen, Hongzhen Fan, Xingguang Luo, Shuping Tan, Zhiren Wang, Chiang-Shan R. Li, Baopeng Tian, Li Tian, Chuanlian Ma, Yanli Li, Yunlong Tan
Summary: The study investigates the relationship between sensory gating deficits, childhood trauma, and schizophrenia onset. It is found that patients with first-episode schizophrenia have more severe childhood trauma experiences and sensory gating deficits. Sensory gating deficits might mediate the effects of childhood trauma on the onset of schizophrenia.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Yushen Ding, Qing Tian, Wenpeng Hou, Zhenzhu Chen, Zhen Mao, Qijing Bo, Fang Dong, Chuanyue Wang
Summary: This study investigated the relationship between sensory gating and cognitive function in schizophrenia patients. It found impairments in both sensory gating and cognitive function, with the PSSPPI measure at 60 ms showing significant associations with clinical symptoms and cognitive performance.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Shuai Wang, Zijie Li, Xuejiao Wang, Jinhong Li, Xueru Wang, Jingyu Chen, Yingna Li, Changming Wang, Ling Qin
Summary: Auditory gating (AG) is an adaptive mechanism for filtering out redundant acoustic stimuli to protect the brain against information overload. The posterior parietal cortex (PPC) shows an intermediate level of AG in auditory thalamocortical circuits, with the strongest AG in the granular layer. AG in the PPC is determined by the integrated signal streams from the medial dorsal thalamic nucleus (MD) and auditory cortex (AC) in a bottom-up manner. A mouse model of schizophrenia (SZ) presents an AG deficit in the PPC, possibly inherited from the dysfunction of MD.
Article
Psychiatry
Qingyan Yang, Yong Zhang, Kebing Yang, Yajuan Niu, Fengmei Fan, Song Chen, Xingguang Luo, Shuping Tan, Zhiren Wang, Jinghui Tong, Fude Yang, Chiang-Shan R. Li, Yunlong Tan
Summary: This study aimed to investigate the relationship between serum level of kynurenine pathway (KP) metabolites and P50 auditory gating in patients with first-episode schizophrenia. The results showed significant associations between metabolite levels and auditory gating, suggesting that the KP might play an important role in sensory gating deficit in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Nursing
Hsiao-Chi Tsai, Li-Hui Wu, Shu-Fang Chang
Summary: The study examined how demographic characteristics, physiological state, cognitive function, sensory function, and biomarkers can be used as predictors of frailty in patients with schizophrenia. A cross-sectional study design was used to collect data on these factors in patients and analyze them using various statistical methods. The results showed that patients with lower education, longer hospital stays, higher muscle mass, higher metabolic rate, lower cognitive function, use of tranquillisers and sleeping pills, and use of assistive equipment were more likely to be frail. Additionally, cognitive function, use of a wheelchair, and use of an assistive walker were predictive of frailty in schizophrenia patients.
Article
Biology
Bochuan Teng, Joshua P. Kaplan, Ziyu Liang, Zachary Krieger, Yu-Hsiang Tu, Batuujin Burendei, Andrew B. Ward, Emily R. Liman
Summary: This study found that OTOP1 and OTOP3 channels are activated by extracellular protons, while OTOP2 channels are active over a broad range of pH values and respond to extracellular alkalization. By swapping extracellular linkers, the pH-sensitive gating of OTOP2 and OTOP3 channels can be changed. These findings indicate that members of the OTOP channel family are proton-gated channels, and the gating apparatus is distributed across different extracellular regions of the channels.
Review
Behavioral Sciences
Andrey T. Proshin
Summary: This article presents a comparative analysis of the characteristics of cholinergic and dopaminergic mechanisms associated with gating decline in healthy individuals and patients with schizophrenia, and discusses the differences in gating mechanisms between the two cohorts.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Jun-Rui Jian, Yen-Yun Lin, Lisa Tabor Connor, Chia-Hsiung Cheng
Summary: This study found a specific relationship between an individual's perceptual experience and the electrophysiological SG function of the right IFG.
NEUROSCIENCE LETTERS
(2022)
Article
Behavioral Sciences
Peter J. Hills, Martin R. Vasilev, Panarai Ford, Lucy Snell, Emma Whitworth, Tessa Parsons, Rebecca Morisson, Abigail Silveira, Bernhard Angele
Summary: The study found that sensory gating was related to positive and disorganized dimensions, smooth pursuit eye movement error was related to negative dimensions, while latent inhibition and prepulse inhibition were not related to any dimensions of schizotypy. These results suggest that the symptom clusters associated with different endophenotypes are largely independent of each other.
Article
Neurosciences
Stefanie Linnhoff, Aiden Haghikia, Tino Zaehle
Summary: This study investigated the potential of P50 sensory gating and prepulse inhibition ratios as surrogate markers for cognitive fatigue in people with multiple sclerosis (pwMS). The results showed that P50 sensory gating was correlated with subjective fatigue ratings. This study is the first to demonstrate fatigue-related disruption of sensory gating in pwMS.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Saeka Tomatsu, Geehee Kim, Shinji Kubota, Kazuhiko Seki
Summary: This article investigates the role of presynaptic inhibition in proprioceptive signals and finds that it can modulate proprioceptive input based on muscle length. This presynaptic inhibition may be initiated by cortical signals and has an impact on stable motor output.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Sara de la Salle, Joelle Choueiry, Judy McIntosh, Hayley Bowers, Vadim Ilivitsky, Verner Knott
Summary: This study found that a subanesthetic dose of the NMDAR antagonist ketamine impaired auditory sensory gating, providing further evidence for the role of NMDAR hypofunction in schizophrenia.
PSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Shahrzad Mazhari, Yousef Moghadas Tabrizi, Alireza Ghaffari Nejad
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
(2015)
Article
Neurosciences
M. Nozari, M. Shabani, A. M. Farhangi, S. Mazhari, N. Atapour
Article
Psychology, Biological
Masoud Nazeri, Mohammad Shabani, Samaneh Ghotbi Ravandi, Iraj Aghaei, Masoumeh Nozari, Shahrzad Mazhari
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Psychology, Biological
Hakimeh Saadati, Saeed Esmaeili-Mahani, Khadije Esmaeilpour, Masoud Nazeri, Shahrzad Mazhari, Vahid Sheibani
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Neurosciences
Ali Mohammad Pourrahimi, Shahrzad Mazhari, Mohammad Shabani, Yousef Moghadas Tabrizi, Vahid Sheibani
NEUROSCIENCE LETTERS
(2016)
Article
Neurosciences
Shokouh Arjmand, Mina Behzadi, Kristi A. Kohlmeier, Shahrzad Mazhari, Abdolreza Sabahi, Mohammad Shabani
ACTA NEUROPSYCHIATRICA
(2019)
Article
Multidisciplinary Sciences
Sara Sardari, Ali Mohammad Pourrahimi, Hossein Talebi, Shahrzad Mazhari
SCIENTIFIC REPORTS
(2019)
Article
Psychiatry
Shahrzad Mazhari, Mahin Eslami Shahrbabaki, Ali Mohammad Pourrahimi, Hoda Faezi, Mohammad Reza Baneshi
IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES
(2019)
Article
Entomology
Seyed Ahmad Hosseinzadeh, Shahrzad Mazhari, Kiomars Najafi, Meysam Ahmadi, Iraj Aghaei, Masuumeh Niazi, Mohammad Shabani
ENTOMOLOGY AND APPLIED SCIENCE LETTERS
(2018)
Article
Psychiatry
Pegah Vafaii, Ali Mohammad Pourrahimi, Nouzar Nakhaee, Shahrzad Mazhari
IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES
(2018)
Review
Medicine, General & Internal
Shahrzad Mazhari, Saeed Esmailian, Armita Shah-Esmaeili, Ali S. Goughari, Azam Bazrafshan, Morteza Zare
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2017)
Article
Psychiatry
Shahrzad Mazhari, Nooshin Parvaresh, Ali Mohammad Pourrahimi, Ghodratollah Rajabizadeh, Kianoosh Abasabadi
IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES
(2017)
Article
Psychiatry
Shahrzad Mazhari, Ali R. Ghafaree-Nejad, Somayeh Soleymani-Zade, Richard S. E. Keefe
ASIAN JOURNAL OF PSYCHIATRY
(2017)
Article
Psychiatry
Ali S. Goughari, Shahrzad Mazhari, Ali M. Pourrahimi, Mohammad M. Sadeghi, Nouzar Nakhaee
JOURNAL OF PSYCHIATRIC PRACTICE
(2015)
Article
Psychiatry
Yousef Moghadas Tabrizi, Shahrzad Mazhari
IRANIAN JOURNAL OF PSYCHIATRY AND BEHAVIORAL SCIENCES
(2018)