Article
Clinical Neurology
Maria Faurholt-Jepsen, Jonas Busk, Maj Vinberg, Ellen Margrethe Christensen, Helgathorarinsdottir, Mads Frost, Jakob E. Bardram, Lars Vedel Kessing
Summary: The study found differences in location data between patients with bipolar disorder and healthy control individuals, as well as variations in location data between different affective states within bipolar disorder. Utilizing smartphone-based location data may be a promising measure to monitor illness and illness activity in patients with bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Developmental
Sigurd Arne Melbye, Sharleny Stanislaus, Maj Vinberg, Mads Frost, Jakob Eyvind Bardram, Kimie Sletved, Klara Coello, Hanne Lie Kjaerstad, Ellen Margrethe Christensen, Maria Faurholt-Jepsen, Lars Vedel Kessing
Summary: This study validated the associations between smartphone-based self-monitored mood, activity, and sleep with young patients with newly diagnosed BD, UR, and HC. The findings suggest that self-monitored mood and activity can serve as effective biomarkers for young patients with BD.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Psychiatry
Nan Lyu, Qian Zhao, Bingbing Fu, Jinhong Li, Han Wang, Fan Yang, Sitong Liu, Juan Huang, Xinwei Zhang, Ling Zhang, Rena Li
Summary: This study investigated the changes of peripheral hormones and inflammatory markers during different mood episodes in bipolar disorder (BD) and found that a combination of sex hormones, stress hormones, and CRP could be more effective in differentiating manic and depressive episodes. The biological markers of mood episodes in BD patients may be influenced by sex and age. These findings not only provide evidence for mood episode-related biological markers but also support targeted interventions in BD treatment.
Article
Clinical Neurology
Laura Pedrini, Clarissa Ferrari, Mariangela Lanfredi, Marcella Bellani, Stefano Porcelli, Elisabetta Caletti, Michela Sala, Maria Gloria Rossetti, Sara Piccin, Nicola Dusi, Matteo Balestrieri, Cinzia Perlini, Matteo Lazzaretti, Gian Mario Mandolini, Alessandro Pigoni, Andrea Boscutti, Carolina Bonivento, Alessandro Serretti, Roberta Rossi, Paolo Brambilla
Summary: This study found that the rate of reporting childhood trauma was higher in BD patients during euthymia compared to controls, with neglect being strongly related to BD. Childhood trauma was associated with higher scores on the SCL-90-R subscales, and it had a main effect on lifetime stressful events.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Ray Merrill, Kayla Slavik
Summary: The objective of this study was to assess the correlation between child sleep disorders and parental insomnia, hypersomnia, and sleep apnea, as well as the association between parental and child sleep disorders and parental stress. The results show that parents with insomnia and sleep apnea have a higher risk of stress, while there is no increased risk for those with hypersomnia. There is also a correlation between child sleep disorders and parental stress, insomnia, and sleep apnea.
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Katherine Gordon-Smith, Kate E. A. Saunders, Julia Savage, Nick Craddock, Ian Jones, Lisa Jones
Summary: The study found that individuals with bipolar disorder are interested in monitoring aspects such as physical activity, anxiety, sleep, and coping levels in addition to mood symptoms. Patients believe that besides mood symptoms, other aspects are equally important in longitudinal monitoring.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Brett D. M. Jones, Brisa S. Fernandes, M. Ishrat Husain, Abigail Ortiz, Tarek K. Rajji, Daniel M. Blumberger, Meryl A. Butters, Ariel G. Gildengers, Tatiana Shablinski, Aristotle Voineskos, Benoit H. Mulsant
Summary: This study aims to explore the relationships among clinical characteristics of bipolar disorder (BD), cognitive dysfunction, and aging. The results support both an early impairment model and an accelerated aging model, indicating that different cognitive domains are affected differently by BD and aging.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Dahlia Mukherjee, J. Dylan Weissenkampen, Emily Wasserman, Venkatesh Basappa Krishnamurthy, Caitlin E. Millett, Stephen Conway, Erika F. H. Saunders
Summary: In this study, diurnal cortisol patterns in individuals with BD and healthy controls were observed. Higher levels of nighttime cortisol in BD participants compared to healthy controls suggest impaired cortisol regulation in individuals with BD, potentially indicating a target for further study and treatment intervention.
NEUROPSYCHOBIOLOGY
(2022)
Review
Neurosciences
Mahmoud Suliman, Michael W. Schmidtke, Miriam L. Greenberg
Summary: The current drugs used to treat bipolar disorder are not always effective and have serious side effects. The main barrier to developing new drugs is the lack of understanding of the therapeutic mechanisms of currently available drugs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Psychiatry
Mai Uchida, Qasim Bukhari, Maura DiSalvo, Allison Green, Giulia Serra, Chloe Hutt Vater, Satrajit S. Ghosh, Stephen V. Faraone, John D. E. Gabrieli, Joseph Biederman
Summary: This study developed a quantitative predictive model for bipolar disorder using machine learning algorithms and clinical data. The predictors included behavioral problems, school functioning, and anxiety/depression and aggression scales. The results have important clinical and scientific implications for assessing the risk of bipolar disorder in children.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Laura Palagini, Mario Miniati, Donatella Marazziti, Cristian Franceschini, Luigi Zerbinati, Luigi Grassi, Verinder Sharma, Dieter Riemann
Summary: The study found that insomnia symptoms play a mediating role in the association between severity of depressive symptoms, suicidal risk, early life stressors, and level of resilience among patients with bipolar disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Psychiatry
Gin S. Malhi, Erica Bell, Kamaldeep Bhui
Summary: The 11th revision of the ICD brings significant advancements but also compromises that may negatively affect clinical practice, as illustrated in this editorial focusing on mood disorders and bipolar disorder subtyping.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Thomas Vaessen, Ulrich Reininghaus, Evelyne van Aubel, Annelie Beijer-Klippel, Henrietta Steinhart, Inez Myin-Germeys, James Waltz
Summary: Affective reactivity to daily stressors is increased in individuals in the early stages of psychosis. Studies have shown altered neural reactivity to stress in limbic, prelimbic, and salience areas in psychosis patients and individuals at increased psychosis risk. This study investigates if a similar pattern of neural reactivity is present in early psychosis individuals and if brain activity in these regions is associated with daily-life stress reactivity.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Immunology
Joske Hoes, Audrey J. King, Tessa M. Schurink-van 't Klooster, Johannes Berkhof, Johannes A. Bogaards, Hester E. de Melker
Summary: The bivalent HPV vaccine administered in a 2-dose schedule has proven to be highly effective in preventing HPV infections among preadolescent girls in the Netherlands, with a 4-year postvaccination effectiveness rate of 84.0% against HPV-16/18 and 86.5% against cross-protective types HPV-31/33/45.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Biotechnology & Applied Microbiology
J. Hoes, H. Pasmans, T. M. Schurink-van 't Klooster, F. R. M. van der Klis, R. Donken, J. Berkhof, H. E. de Melker
Summary: Licensed HPV vaccines are highly effective in inducing high levels of neutralizing antibodies, but the correlation of protection against HPV is lacking and evidence for long-term antibody persistence is limited. The World Health Organization recommends immunization of young girls to eliminate cervical cancer, highlighting the need for long-lasting protection.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Oncology
Stefanie Dick, Frederique J. Vink, Danielle A. M. Heideman, Birgit Lissenberg-Witte, Chris J. L. M. Meijer, Johannes Berkhof
Summary: The use of FAM19A4/miR124-2 methylation and/or HPV genotyping in HPV-positive women with BMD can significantly reduce the number of direct colposcopy referrals. Methylation analysis showed good discrimination, with a CIN3+ risk of 33.1% after a positive result and 9.8% after a negative result. HPV genotyping also provided valuable risk stratification information.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Chris J. L. M. Meijer, Willem J. G. Melchers, Ruud L. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert J. van Kemenade, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study validated individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 for the detection of CIN3+ in high-risk HPV-positive women invited for routine screening, showing promising clinical utility.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Wieke W. Kremer, Stefanie Dick, Danielle A. M. Heideman, Renske D. M. Steenbergen, Maaike C. G. Bleeker, Harold R. Verhoeve, W. Marchien van Baal, Nienke van Trommel, Gemma G. Kenter, Chris J. L. M. Meijer, Johannes Berkhof
Summary: This study evaluated the prognostic value of FAM19A4/miR124-2 methylation in untreated CIN2/3 patients for clinical regression. The results showed that most untreated CIN2/3 patients with negative baseline FAM19A4/miR124-2 methylation showed clinical regression, indicating that methylation, combined with cytology or HPV genotyping, can support a wait-and-see policy for CIN2/3 patients.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Clare A. Aitken, Federica Inturrisi, Sylvia Kaljouw, Daan Nieboer, Albert G. Siebers, Willem J. G. Melchers, Adriaan J. C. van den Brule, Anco Molijn, John W. J. Hinrichs, Hubert G. M. Niesters, Folkert J. van Kemenade, Johannes Berkhof, Inge M. C. M. de Kok
Summary: In the Netherlands, self-collected samples have lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection compared to clinician-collected samples. The differences between the two sampling methods are likely related to sociodemographic factors as well as differences in screening test accuracy and background risk. Self-sampling can be used as a more convenient screening tool for underscreened women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Letter
Oncology
Johannes Berkhof, Stefanie Dick, Wieke Kremer, Maaike Bleeker, Chris Meijer
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Irene Man, Damien Georges, Tiago M. de Carvalho, Lopamudra Ray Saraswati, Prince Bhandari, Ishu Kataria, Mariam Siddiqui, Richard Muwonge, Eric Lucas, Johannes Berkhof, Rengaswamy Sankaranarayanan, Johannes A. Bogaards, Partha Basu, Iacopo Baussano
Summary: The use of single-dose HPV vaccination could significantly reduce the burden of cervical cancer in India.
Article
Clinical Neurology
Arenda Mank, Judith J. M. Rijnhart, Ingrid S. van Maurik, Linus Jonsson, Ron Handels, Els D. Bakker, Charlotte E. Teunissen, Bart N. M. van Berckel, Argonde C. van Harten, Johannes Berkhof, Wiesje M. van der Flier
Summary: This study compared the trajectories of quality of life (QoL) between amyloid-positive and amyloid-negative patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI). The results showed that amyloid-positive patients had a faster decline in QoL over time compared to amyloid-negative patients. QoL decreased along the Alzheimer's disease continuum, with the steepest decrease in dementia patients.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Federica Inturrisi, Lawrence Rozendaal, Nienke J. Veldhuijzen, Danielle A. M. Heideman, Chris J. L. M. Meijer, Johannes Berkhof
Summary: This study explores the association between previous screening results and the risk of cervical intraepithelial neoplasia grade 3 or cancer (CIN3+). The findings suggest that HPV-negative women with a previous positive HPV test have an increased long-term risk of CIN3+. The results support the implementation of risk-based intervals in HPV-based screening programs.
Article
Immunology
Joske Hoes, Audrey J. King, Johannes Berkhof, Hester E. de Melker
Summary: The long-term effectiveness of three-dose HPV16/18 vaccination among Dutch women who were eligible for vaccination during a catch-up campaign was evaluated. The vaccine showed high effectiveness of 95.8% against persistent infections with HPV16/18 and 64.6% against cross protective type persistent infections (HPV31/33/45). There was no evidence of waning of protection over time, indicating promising long-term protection and future clinical impact.
Article
Oncology
Feline O. Voss, Nikki B. Thuijs, Sylvia Duin, Mujde Ozer, Marc van Beurden, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study aimed to validate the accuracy of previously identified DNA methylation markers for detection of high-grade vulvar intraepithelial neoplasia (VIN). The best-performing individual marker was found to be SST, detecting 80% of high-grade VIN cases, with excellent detection of HPV-independent VIN, known to have the highest cancer risk. Selection of a marker panel including ZNF582, SST, and miR124-2 also yielded high accuracy for detection of high-grade VIN.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Clinical Neurology
Arenda Mank, Ingrid S. van Maurik, Argonde C. van Harten, Hanneke F. M. Rhodius-Meester, Charlotte E. Teunissen, Bart N. M. van Berckel, Johannes Berkhof, Wiesje M. van der Flier, Judith J. M. Rijnhart
Summary: This study investigates life satisfaction across different stages of Alzheimer's disease and found that participation in meaningful activities is crucial for maintaining life satisfaction. The impact on life satisfaction is mainly explained by reduced transportation use.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Letter
Oncology
Marc Arbyn, Karen Canfell, Mario Poljak, Johannes Berkhof, Silvia de Sanjose, Nicolas Wentzensen
