Article
Pediatrics
Junjuan Yan, Yi Gu, Mengyu Wang, Yonghua Cui, Ying Li
Summary: This study examined the severity of obsessive-compulsive symptoms in pediatric patients with tic disorders in China and evaluated the psychometric properties of the CY-BOCS. The study found differences in the severity of symptoms among patients with tic disorders, and age and gender may be associated with the occurrence of obsessive-compulsive symptoms.
FRONTIERS IN PEDIATRICS
(2022)
Article
Psychology, Clinical
Mediha Alic, Aart de Leeuw, Jonathan Selier, Harold van Megen, Henny Visser
Summary: The present study examined the responsiveness and other psychometric properties of the revised Y-BOCS-II Severity Scale in a Dutch clinical sample. The results showed good internal consistency, test-retest reliability, and interrater reliability for the scale. The construct validity was also modest to good. The Y-BOCS-II was found to be more responsive over time compared to the original Y-BOCS-I, particularly in moderately to severely affected OCD patients.
CLINICAL PSYCHOLOGY & PSYCHOTHERAPY
(2022)
Article
Psychology, Clinical
Jennie M. Kuckertz, David W. Rhee, Meghan Schreck, Nathaniel Van Kirk, Devin Dattolico, Martha J. Falkenstein
Summary: This study investigated the psychometric properties of two commonly used measures of obsessive-compulsive symptoms and found that they are reliable and valid in capturing within-person changes as well as between-person changes. The analysis of per-person slopes using mixed-effects models confirmed the longitudinal concurrent validity of these measures. This research supports the continued use of these measures for longitudinal research purposes and provides a template for evaluating the psychometric properties of other commonly used measures in longitudinal investigations.
PSYCHOLOGICAL ASSESSMENT
(2021)
Article
Psychiatry
Vittoria Zaccari, Andrea Gragnani, Valerio Pellegrini, Tecla Caiazzo, Maria Chiara D'Arienzo, Antonella Magno, Giuseppe Femia, Francesco Mancini
Summary: This study aimed to monitor the symptomatic status of OCD patients during the COVID-19 emergency period and compare psychodiagnostic evaluations. The results showed a significant decrease in OCD symptoms among patients, indicating the effectiveness of CBT/ERP as a treatment for OCD. Therapists also observed improvements in symptoms, supporting the use of specific intervention procedures for OCD treatment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
G. R. E. G. O. R. Y. S. VOGT, M. I. C. H. E. L. L. E. AVENDANO-ORTEGA, S. O. P. H. I. E. C. SCHNEIDER, W. A. Y. N. E. K. GOODMAN, E. R. I. C. A. STORCH
Summary: The Yale-Brown Obsessive-Compulsive Scale-Second Edition (Y-BOCS-II) is a more comprehensive measure for assessing the severity of obsessive-compulsive disorder symptoms, especially in severely ill patients. It maintains strong consistency with the original scale when assessing patients with mild to moderate symptoms. By adding Y-BOCS item 4 and back-coding, both Y-BOCS and Y-BOCS-II scores can be obtained within one assessment, allowing for more robust data collection and comparability across studies.
JOURNAL OF PSYCHIATRIC PRACTICE
(2022)
Review
Clinical Neurology
Maral Melkonian, Sarah McDonald, Amelia Scott, Eyal Karin, Blake F. Dear, Bethany M. Wootton
Summary: Obsessive-compulsive disorder (OCD) is a chronic and unremitting condition with low rates of symptom improvement and spontaneous remission in the absence of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychology, Multidisciplinary
Basak Sahin, Yasir Safak, Kadir Ozdel
Summary: This study aimed to identify cognitive differences specific to symptom dimensions of OCD and investigate the relationship between these dimensions and cognitive features. The results showed that certain cognitive features were closely associated with specific symptom dimensions and could even predict these dimensions.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Esengul Ekici, Mustafa Ugurlu, Fatih Yigman, Yasir Safak, Kadir Ozdel
Summary: Obsessive-Compulsive Disorder (OCD) is a heterogeneous disorder, and the dimensions of contamination, harm, unwanted thoughts, and symmetry may vary in each patient. This study found that cognitive and emotional factors and their relations varied depending on the OCD dimensions. Identifying cognitive and emotional factors related to these differences is of significance for therapeutic interventions.
CURRENT PSYCHOLOGY
(2023)
Article
Psychiatry
Leonardo F. Fontenelle, Lucy Albertella, Mary-Ellen Brierley, Emma M. Thompson, Louise Destree, Sam R. Chamberlain, Murat Yucel
Summary: This study investigated the deterioration of symptoms of obsessive-compulsive and related disorders (OCRDs) during the COVID-19 pandemic, finding that factors such as being female, experiencing more COVID-19 related stressful events, and having higher compulsivity traits predicted worsened symptoms during the pandemic. Identifying a pre-pandemic profile of individuals most at risk of symptom deterioration may be valuable for future preventative initiatives related to COVID-19 or other communicable diseases. Future studies should follow up on these findings longitudinally.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Ghazal Jahanbakhsh, Seyed Alireza Haji Seyed Javadi, Mahnaz Majidi, Marzieh Khademi, Ramin Karimi
Summary: This study evaluated the effectiveness of using low-frequency rTMS over the left dorsolateral prefrontal cortex as an adjunctive treatment for OCD patients refractory to treatment. The results showed that after 15 sessions, adjunctive low-frequency rTMS significantly reduced the Y-BOCS scores and the reduction was durable even after three to six months. Additionally, using antipsychotic agents along with serotonergic agents as adjuvant therapy may predict a better response to adjunctive rTMS.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Ben Shofty, Ron Gadot, Ashwin Viswanathan, Nicole R. Provenza, Eric A. Storch, Sarah A. McKay, Matthew S. Meyers, Alyssa G. Hertz, Michelle Avendano-Ortega, Wayne K. Goodman, Sameer A. Sheth
Summary: Deep brain stimulation (DBS) is an accepted therapy for severe, treatment-refractory obsessive-compulsive disorder (trOCD). Various studies have suggested that the optimal target location within the anterior limb of the internal capsule may lie in the vicinity of the anterior commissure (AC), either just anterior to the AC above the ventral striatum (VS), or just posterior to the AC above the bed nucleus of the stria terminalis (BNST). In this study, the authors describe their practice of planning trajectories to both the VS and BNST and using awake intraoperative valence testing to individualize permanent target selection.
JOURNAL OF NEUROSURGERY
(2023)
Article
Psychology, Clinical
Gabriella T. Ponzini, Miranda Signorelli, Elizabeth A. Claydon, Christa Lilly, Shari A. Steinman
Summary: This study examined the stereotypes towards symptom presentations of obsessive compulsive disorder (OCD) and found that different types of symptoms are associated with different stereotypes, including anxiety-relevant stereotypes and stereotypes related to serious mental illness. The findings are important for reducing OCD stigma and provide intervention strategies for addressing these stereotypes.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Review
Psychology, Developmental
Luis C. Farhat, Edoardo F. Q. Vattimo, Divya Ramakrishnan, Jessica L. S. Levine, Jessica A. Johnson, Bekir B. Artukoglu, Angeli Landeros-Weisenberger, Fernando R. Asbahr, Sandra L. Cepeda, Jonathan S. Comer, Daniel Fatori, Martin E. Franklin, Jennifer B. Freeman, Daniel A. Geller, Paul J. Grant, Wayne K. Goodman, Isobel Heyman, Tord Ivarsson, Fabian Lenhard, Adam B. Lewin, Fenghua Li, Lisa J. Merlo, Hamid Mohsenabadi, Tara S. Peris, John Piacentini, Ana Rosa-Alcazar, Angel Rosa-Alcazar, Michelle Rozenman, Jeffrey J. Sapyta, Eva Serlachius, Mohammad J. Shabani, Roseli G. Shavitt, Brent J. Small, Gudmundur Skarphedinsson, Susan E. Swedo, Per Hove Thomsen, Cynthia Turner, Bernhard Weidle, Euripedes C. Miguel, Eric A. Storch, David Mataix-Cols, Michael H. Bloch
Summary: This study conducted a meta-analysis to determine the discriminative ability of the CY-BOCS in pediatric OCD and to establish optimal cutoffs. The results showed that the CY-BOCS had sufficient discriminative ability to determine response and remission, and identified optimal cutoff values for these outcomes. Standardized operational definitions for response and remission in clinical trials will improve comparability.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Mathematical & Computational Biology
Maria Tubio-Fungueirino, Eva Cernadas, Oscar F. Goncalves, Cinto Segalas, Sara Bertolin, Lorea Mar-Barrutia, Eva Real, Manuel Fernandez-Delgado, Jose M. Menchon, Sandra Carvalho, Pino Alonso, Angel Carracedo, Montse Fernandez-Prieto
Summary: The study reveals that machine learning can be used to predict changes in symptoms of OCD by analyzing sociodemographic and clinical data. This could be valuable for clinicians to quickly identify patients at higher risk and provide optimized care, especially during future pandemics.
FRONTIERS IN NEUROINFORMATICS
(2022)
Article
Psychology, Clinical
Alan E. Kazdin, Chi-Shin Wu, Irving Hwang, Victor Puac-Polanco, Nancy A. Sampson, Ali Al-Hamzawi, Jordi Alonso, Laura Helena Andrade, Corina Benjet, Jose-Miguel Caldas-de-Almeida, Giovanni de Girolamo, Peter de Jonge, Silvia Florescu, Oye Gureje, Josep M. Haro, Meredith G. Harris, Elie G. Karam, Georges Karam, Viviane Kovess-Masfety, Sing Lee, John J. McGrath, Fernando Navarro-Mateu, Daisuke Nishi, Bibilola D. Oladeji, Jose Posada-Villa, Dan J. Stein, T. Bedirhan Ustun, Daniel V. Vigo, Zahari Zarkov, Alan M. Zaslavsky, Ronald C. Kessler
Summary: Antidepressant medications (ADMs) are widely used for a variety of conditions, not only depression and anxiety. The usage rate of ADMs is higher in high-income countries compared to low- and middle-income countries, and newer ADMs are more frequently used in high-income countries. Among users, 58.8% perceive ADMs to be very effective and 28.3% perceive them to be somewhat effective, with these proportions being higher in low- and middle-income countries than in high-income countries.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Jason Bantjes, Molly Kessler, Christine Lochner, Elsie Breet, Ahmed Bawa, Janine Roos, Charl Davids, Memory Muturiki, Ronald C. Kessler, Dan J. Stein
Summary: This study estimated the 30-day prevalence of 11 common mental disorders among university students in South Africa and found disparities in student mental health across historically segregated institutions and marginalized groups. Anxiety disorders and disruptive behavior disorders had the highest prevalence rates. Sociodemographic factors such as age, gender, gender non-conforming identity, and race significantly influenced the risk of mental disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Substance Abuse
Antonio Verdejo-Garcia, Tara Rezapour, Emily Giddens, Arash Khojasteh Zonoozi, Parnian Rafei, Jamie Berry, Alfonso Caracuel, Marc L. Copersino, Matt Field, Eric L. Garland, Valentina Lorenzetti, Leandro Malloy-Diniz, Victoria Manning, Ely M. Marceau, David L. Pennington, Justin C. Strickland, Reinout Wiers, Rahia Fairhead, Alexandra Anderson, Morris Bell, Wouter J. Boendermaker, Samantha Brooks, Raimondo Bruno, Salvatore Campanella, Janna Cousijn, W. Miles Cox, Andrew C. Dean, Karen D. Ersche, Ingmar Franken, Brett Froeliger, Pedro Gamito, Thomas E. Gladwin, Priscila D. Goncalves, Katrijn Houben, Joanna Jacobus, Andrew Jones, Anne M. Kaag, Johannes Lindenmeyer, Elly McGrath, Talia Nardo, Jorge Oliveira, Charlotte R. Pennington, Kelsey Perrykkad, Hugh Piercy, Claudia Rupp, Mieke H. J. Schulte, Lindsay M. Squeglia, Petra Staiger, Dan J. Stein, Jeff Stein, Maria Stein, William W. Stoops, Mary Sweeney, Katie Witkiewitz, Steven P. Woods, Richard Yi, Min Zhao, Hamed Ekhtiari
Summary: This study used a Delphi approach to reach consensus on recommendations for developing and applying cognitive training and remediation interventions for substance use disorders. Through two rounds of surveys, experts reached consensus on the targets, approaches, active ingredients, and modes of delivery for these interventions. The study indicates that intervention measures based on validated techniques and flexible delivery methods can effectively improve cognitive deficits in the treatment of substance use disorders.
Review
Neurosciences
Ann M. Alex, Claudia Buss, Elysia Poggi Davis, Gustavo de los Campos, Kirsten A. Donald, Damien A. Fair, Nadine Gaab, Wei Gao, John H. Gilmore, Jessica B. Girault, Karen Grewen, Nynke A. Groenewold, Benjamin L. Hankin, Jonathan Ipser, Shreya Kapoor, Pilyoung Kim, Weili Lin, Shan Luo, Elizabeth S. Norton, Thomas G. O'Connor, Joseph Piven, Anqi Qiu, Jerod M. Rasmussen, Michael A. Skeide, Dan J. Stein, Martin A. Styner, Paul M. Thompson, Laurie Wakschlag, Rebecca Knickmeyer
Summary: Imaging genetics studies have primarily focused on adults and adolescents, with very few studies examining brain development in infancy and early childhood. However, understanding the genetic influences on early brain development is crucial for predicting risk of psychiatric illness and neurodevelopmental disabilities. This review summarizes findings from imaging genetics studies in infants and young children, and introduces a working group established to facilitate large-scale studies in this population.
BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychiatry
Kimberly Blake, Ziphozihle Ntwatwa, Tobias Kaufmann, Dan J. Stein, Jonathan C. Ipser, Nynke A. Groenewold
Summary: The study suggests that psychopathology is related to an advanced brain aging process, and machine learning models can predict an individual's age based on brain imaging data. The meta-analysis found that there is a larger brain age difference in psychotic disorders and a smaller difference in mood disorders. Clinical factors, such as symptom severity, may be associated with a larger brain age difference in psychopathology.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Developmental
Sara Bertolin, Pino Alonso, Ignacio Martinez-Zalacain, Jose M. Menchon, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargallo, Marcelo Camargo Batistuzzo, Premika S. W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O'Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Pico-Perez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas
Summary: The results of the study suggest that higher cortical thickness in specific right prefrontal cortex regions may play an important role in the response to cognitive-behavioral therapy in children with OCD.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Review
Neurosciences
A. Prag, K. A. Donald, E. Weldon, S. L. Halligan, D. J. Stein, S. Malcolm-Smith
Summary: Child development is influenced by maternal characteristics, but there is limited research on this topic in Sub-Saharan Africa. This scoping review aims to assess the nature and extent of observational assessments of dyadic interactions and explore the risks and outcomes associated with maternal sensitivity in this context. The research findings highlight the need for more culturally sensitive and rigorous studies in this field.
ACTA NEUROPSYCHIATRICA
(2023)
Article
Biochemistry & Molecular Biology
Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortes Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A. M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Haberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke Huls, Nastassja Koen, Stephanie J. London, Maria C. Magnus, Giulia Mancano, Rosa H. Mulder, Christian M. Page, Katri Raikkonen, Stefan Roeder, Rebecca J. Schmidt, Tabea S. Send, Gemma Sharp, Dan J. Stein, Fabian Streit, Johanna Tuhkanen, Stephanie H. Witt, Heather J. Zar, Ana C. Zenclussen, Yining Zhang, Lea Zillich, Rosalind Wright, Jari Lahti, Kelly J. Brunst
Summary: Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. This meta-analysis examined the association between maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of specific genes implicated in neurodevelopment, neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. These findings provide novel insights into potential mechanisms of neurodevelopment in offspring.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Clinical Neurology
Dan J. Stein
Summary: Patients with depression require thorough clinical assessment for symptom profile, severity, comorbidity, and other factors. Co-existing anxiety symptoms in depressed patients are associated with more severe depression and worse outcomes. Agomelatine is an effective antidepressant that relieves depressive symptoms and supports recovery, and it is well tolerated in patients with depression and concomitant anxiety symptoms. Combining pharmacotherapy with psychotherapy is more effective than either alone. Persistence with treatment is important for patients.
NEUROLOGY AND THERAPY
(2023)
Article
Anthropology
Olivia P. Matshabane, Paul S. Appelbaum, Marlyn C. Faure, Patricia A. Marshall, Dan J. Stein, Jantina de Vries, Megan M. Campbell
Summary: Internalised stigma among people with mental illness is common and has negative consequences. However, there is no validated tool to measure internalised stigma in the Xhosa language. This study aimed to translate and validate the ISMI scale in isiXhosa. The results showed that the ISMI-X scale demonstrated good psychometric utility and validity, providing valuable insights into the translation design.
TRANSCULTURAL PSYCHIATRY
(2023)
Article
Psychiatry
Zsolt Horvath, Lena Nagy, Monika Koos, Shane W. Kraus, Zsolt Demetrovics, Marc N. Potenza, Rafael Ballester-Arnal, Dominik Batthyany, Sophie Bergeron, Joel Billieux, Peer Briken, Julius Burkauskas, Georgina Cardenas-Lopez, Joana Carvalho, Jesus Castro-Calvo, Lijun Chen, Giacomo Ciocca, Ornella Corazza, Rita Csako, David P. Fernandez, Hironobu Fujiwara, Elaine F. Fernandez, Johannes Fuss, Roman Gabrhelik, Ateret Gewirtz-Meydan, Biljana Gjoneska, Mateusz Gola, Joshua B. Grubbs, Hashim T. Hashim, Md. Saiful Islam, Mustafa Ismail, C. Martha Jimenez-Martinez, Tanja Jurin, Ondrej Kalina, Verena Klein, Andras Kolto, Sang-Kyu Lee, Karol Lewczuk, Chung-Ying Lin, Christine Lochner, Silvia Lopez-Alvarado, Katerina Lukavska, Percy Mayta-Tristan, Dan J. Miller, Olga Orosova, Gabor Orosz, Mami Sungkyunkwan Univ res team, Fernando P. Ponce, Gonzalo R. Quintana, Gabriel C. Quintero Garzola, Jano Ramos-Diaz, Kevin Rigaud, Ann Rousseau, Marco De Tubino Scanavino, Marion K. Schulmeyer, Pratap Sharan, Mami Shibata, Sheikh Shoib, Vera Sigre-Leiros, Luke Sniewski, Ognen Spasovski, Vesta Steibliene, Dan J. Stein, Julian Strizek, Meng-Che Tsai, Berk C. Unsal, Marie-Pier Vaillancourt-Morel, Marie Claire Van Hout, Beata Bothej
Summary: This study examined different measurement models for the Alcohol Use Disorders Identification Test (AUDIT) and its measurement invariance across various subgroups. The results showed that a two-factor model with factors of 'alcohol use' and 'alcohol problems' had the best fit across countries, languages, genders, and sexual orientations. The study also found high levels of measurement invariance for the AUDIT, supporting its use in cross-cultural research and comparisons among genders and sexual orientations.
COMPREHENSIVE PSYCHIATRY
(2023)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Obstetrics & Gynecology
Deborah Jonker, Brigitte Melly, Lucy T. Brink, Hein J. Odendaal, Dan J. Stein, Kirsten A. Donald
Summary: This study found that there is a correlation between the quantity, frequency, and timing of prenatal alcohol and tobacco exposure and blood flow velocities in the fetal-placental-maternal circulation. It also revealed that these factors, along with Doppler flow velocity waveforms, can predict infant birth weight.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Psychiatry
Yanga Thungana, Zukiswa Zingela, Stefan van Wyk, Hannah H. Kim, Amantia Ametaj, Anne Stevenson, Rocky E. Stroud, Dan J. Stein, Bizu Gelaye
Summary: This study aimed to assess the construct validity and psychometric properties of the psychosis screening questionnaire (PSQ) in South Africa. The study found that the PSQ demonstrated a unidimensional factor structure among South Africans. The research suggests the potential for using PSQ to screen for early psychosis.
SOUTH AFRICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Jason Bantjes, Molly J. Kessler, Xanthe Hunt, Dan J. Stein, Ronald C. Kessler
Summary: Mental health problems are common among South African university students, yet treatment rates are low. Identifying barriers to treatment is crucial for increasing the treatment rates.
INTERNATIONAL JOURNAL OF MENTAL HEALTH SYSTEMS
(2023)
