Article
Neurosciences
Arcady A. Putilov, Olga G. Donskaya
Summary: The two-process conceptualization of sleep-wake regulation suggests that the biological differences between morning and evening types in sleep timing and duration might be related to the circadian process or the homeostatic process. This study tested whether morning and evening types have similar homeostatic processes to achieve adequate sleep on free days and simulated the sleep-wake patterns using a model of sleep-wake regulation. The results showed that the homeostatic components of sleep-wake regulation were identical in morning and evening types of the same age, and the observed differences in sleep timing and duration on weekdays and weekends can be attributed to differences in the circadian process between chronotypes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Renato de Filippis, Martina D'Angelo, Elvira Anna Carbone, Pasquale De Fazio, Luca Steardo
Summary: This study aimed to investigate the association between calcium imbalance and specific chronotype in bipolar disorder (BD) patients, as well as the mediating role of high parathyroid hormone (PTH) levels. The results showed significantly higher PTH levels in MEQ-E subjects compared to MEQ-M and MEQ-I, while no differences were found in calcium levels among the three chronotypes. In addition, the mediation analysis revealed that elevated PTH levels were directly influenced by the severity of depressive, anxiety, and manic symptoms.
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Luana Spano, Vincent Hennion, Cynthia Marie-Claire, Frank Bellivier, Jan Scott, Bruno Etain
Summary: This study found that circadian misalignment may partly explain the shorter telomere length in bipolar disorder patients and contribute to accelerated aging in these individuals.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2022)
Article
Clinical Neurology
Meyrel Manon, Scott Jan, Etain Bruno
Summary: The meta-analysis showed that patients with bipolar disorder have higher levels of sleep/activity rhythm disturbances compared to controls, including eveningness, decreased flexibility of rhythms, lower amplitude of rhythms, and disruptions in various activities, social interactions, sleep, and eating patterns. Further studies should investigate the effectiveness of individual assessment tools in clinical practice.
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: This study examined the relationships between impulsivity, sleep and circadian rhythm disturbance, and symptoms in individuals at high-risk for or with recent-onset bipolar spectrum disorders. The findings revealed that less total sleep time predicted increased next-day mood symptoms, and the relationship between impulsivity and mood symptoms was moderated by sleep time and circadian rhythm alterations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: Impulsivity, sleep disturbance, and circadian rhythm alterations are closely associated with bipolar spectrum disorders. Less total sleep time predicts increased mood symptoms, and individuals with less sleep and later circadian rhythms are more likely to exhibit a positive relationship between impulsivity and mood symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Frank Faltraco, Denise Palm, Andrew Coogan, Frederick Simon, Oliver Tucha, Johannes Thome
Summary: This review summarizes the current knowledge and literature on circadian rhythms in the context of mood disorders, with a focus on the role of circadian genes, hormones, and neurotransmitters. The study suggests a molecular link between disruptions in the circadian rhythm and mood disorders, often leading to clinical symptoms resembling depression.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Behavioral Sciences
Joanne S. Carpenter, Jacob J. Crouse, Elizabeth M. Scott, Sharon L. Naismith, Chloe Wilson, Jan Scott, Kathleen R. Merikangas, Ian B. Hickie
Summary: Major mood syndromes are common and disabling mental disorders, with a lack of clear delineation of underlying pathophysiological mechanisms hindering prevention and treatment. Dysfunction of the 24-h circadian system is a potential mechanism linked to mood syndromes. 'Circadian depression' is proposed as a new clinical phenotype with disrupted 24-h sleep-wake cycles, reduced motor activity, low subjective energy, and weight gain as key characteristics. Early onset, bipolarity features, poor response to traditional antidepressants, and concurrent cardiometabolic and inflammatory issues are part of the illness course associated with this phenotype. Identifying and targeting circadian disturbances in mood syndromes may offer valuable clinical insights for effective treatment strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Medicine, General & Internal
Andrea Aguglia, Antimo Natale, Benedetta Conio, Clio Franziska De Michiel, Alessio Lechiara, Fabrizio Pastorino, Laura Fusar-Poli, Alessandra Costanza, Andrea Amerio, Mario Amore, Gianluca Serafini
Summary: This study investigated the relationship between chronotype and cardiometabolic parameters in patients with bipolar disorder. The results showed that patients with an eveningness chronotype had higher body mass index, total and low-density lipoprotein cholesterol compared to those with an intermediate or morning chronotype. Furthermore, the atherogenic coefficient and Castelli risk index were found to be higher in bipolar patients with an evening chronotype. Investigating the relationship between chronotype and obesity and cardiovascular risk is important for improving clinical and therapeutic approaches and reducing mortality in bipolar disorder.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark A. Frye, Fred H. Gage, Elliot S. Gershon, Melvin G. McInnis, Caroline M. Nievergelt, John I. Nurnberger, Paul D. Shilling, Ketil J. Oedegaard, Peter P. Zandi, R. Kelsoe John, David K. Welsh, Michael J. McCarthy
Summary: Neuronal circadian rhythm abnormalities are present in patients with bipolar disorder, with the most pronounced deficits observed in individuals who do not respond to lithium treatment. Stimulation of entrainment pathways may partly reverse these rhythm deficits.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Stephen P. Becker, Aaron M. Luebbe, Michael J. Kofler, G. Leonard Burns, Matthew A. Jarrett
Summary: This study found that college students with attention-deficit/hyperactivity disorder (ADHD) symptoms are more likely to have an evening chronotype. In particular, symptoms of inattention are strongly associated with a preference for later circadian rhythms.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychiatry
Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kursat Altinbas, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P. Behere, Prakash B. Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H. Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Sule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y. W. Cheung, Silvia Chiesa, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Maria Del Zompo, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T. Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G. Fiedorowicz, Kostas N. Fountoulakis, Mark A. Frye, Pierre A. Geoffroy, Ana Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Bartholomeus C. M. Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T. Isometsa, Maja Ivkovic, Sven Janno, Simon Johnsen, Flavio Kapczinski, Gregory N. Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara Koenig, Timur L. Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landen, Erik R. Larsen, Melanie Lenger, Ute Lewitzka, Rasmus W. Licht, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Ostergaard Madsen, Simone Alberte Kongstad A. Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Klaus Martiny, Yuki Mashima, Declan M. McLoughlin, Ybe Meesters, Ingrid Melle, Fatima Meza-Urzua, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorov, Rodrigo Munoz, Starlin Mythri, Fethi Nacef, Ravi K. Nadella, Takako Nakanotani, Rene Ernst Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Andrea Pfennig, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-apha, Michaela Ratzenhofer, Maria Redahan, M. S. Reddy, Andreas Reif, Eva Z. Reininghaus, Jenny Gringer Richards, Philipp Ritter, Janusz K. Rybakowski, Leela Sathyaputri, Angela M. Scippa, Christian Simhandl, Daniel Smith, Jose Smith, Paul W. Stackhouse, Dan J. Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J. Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E. Vaaler, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H. Young, Yosra Zgueb, Peter C. Whybrow
Summary: This study investigated the relationship between solar insolation and the polarity of the first episode of BD I. The results showed that the greater the change in solar insolation throughout the year, the more likely the first episode polarity was depression. Other associated variables included being female and increasing percentage of gross domestic product spent on country health expenditures. This study highlights the need for increased awareness and research into circadian dysfunction throughout the course of BD.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Psychiatry
Kounseok Lee, Hye-Kyung Lee, Sunhae Kim, Seok Hyeon Kim
Summary: The study found that evening-type university students were more likely to experience hypomanic symptoms, while there was no significant difference between intermediate-type and morning-type groups among male students. The evening-type group had a higher positive response rate for most items in the MDQ.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Ilona Merikanto, Laura Kortesoja, Christian Benedict, Frances Chung, Jonathan Cedernaes, Colin A. Espie, Charles M. Morin, Yves Dauvilliers, Markku Partinen, Luigi De Gennaro, Yun Kwok Wing, Ngan Yin Chan, Yuichi Inoue, Kentaro Matsui, Brigitte Holzinger, Giuseppe Plazzi, Sergio Arthuro Mota-Rolim, Damien Leger, Thomas Penzel, Bjorn Bjorvatn
Summary: During the COVID-19 pandemic, evening-types experienced poorer mental health, well-being, and quality of life compared to other circadian types. They also reported delayed sleep-wake schedules, increased sleep duration, and more severe sleep problems. Meanwhile, morning-types were less vulnerable to sleep changes and experienced protection from most sleep problems.