Article
Psychiatry
Marit Schmid, Asa Hammar
Summary: Patients with first-episode MDD reported significantly lower executive functioning in everyday life compared to healthy controls one year after onset, regardless of symptom load. These residual cognitive symptoms appear to be associated with the risk of relapse and should be targeted in treatment and prevention of recurrence.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Penghong Liu, Mingxue Gao, Zhifen Liu, Yanyan Zhang, Hongwei Tu, Lei Lei, Peiyi Wu, Aixia Zhang, Chunxia Yang, Gaizhi Li, Ning Sun, Kerang Zhang
Summary: This study found that the gut microbiota composition in patients with major depressive disorder is associated with inflammatory factors and cognitive function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jin Liu, Yanjun Chen, Xinyu Xie, Bangshan Liu, Yumeng Ju, Mi Wang, Qiangli Dong, Xiaowen Lu, Jinrong Sun, Liang Zhang, Hua Guo, Futao Zhao, Weihui Li, Li Zhang, Zexuan Li, Mei Liao, Lingjiang Li, Yan Zhang
Summary: Cognitive impairment is prevalent in elderly patients with major depressive disorder (MDD), and there is a lack of longitudinal studies exploring the changes in cognitive impairment and the risk factors predicting residual cognitive impairment before and after long-term antidepressant treatment in elderly MDD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Zhou Wu, Chun Wang, Yingliang Dai, Chaoyong Xiao, Ning Zhang, Yuan Zhong
Summary: The study found that cognitive behavioral therapy plays a significant role in the treatment of major depressive disorder by improving brain connectivity between the dorsolateral prefrontal cortex (dlPFC) and hippocampus. Further research on the pathophysiology of the dlPFC is needed to better understand these abnormalities in patients with depressive symptoms and the effect of early CBT treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Tomiki Sumiyoshi, Tatsuya Hoshino, Izumi Mishiro, Lene Hammer-Helmich, Holly Ge, Yoshiya Moriguchi, Keita Fujikawa, Jovelle L. Fernandez
Summary: Early improvement in depressive symptoms predicts better cognitive outcomes in patients with Major Depressive Disorder (MDD). Grouping patients by mood and cognition status in early stages of antidepressant treatments may help improve long-term functional outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Peter Zhukovsky, Michael Wainberg, Milos Milic, Shreejoy J. Tripathy, Benoit H. Mulsant, Daniel Felsky, Aristotle N. Voineskos
Summary: This study compared the neural mechanisms underlying major depressive disorder (MDD), anxiety, and stress-related disorders. The results showed that MDD had the greatest differences in neural signatures, followed by anxiety and stress-related disorders. The neural signatures of MDD and anxiety disorders were highly similar, while stress-related disorders showed a distinct pattern. Controlling for genetic risk decreased the similarity between stress-related disorders and MDD/anxiety disorders. Cognitive impairment was associated with reduced within-network connectivity and increased between-network connectivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Betina Daniele Flesch, Ana Laura Sica Cruzeiro Szortyka, Gbenankpon Mathias Houvessou, Fabiane Neitzke Hoefs, Anaclaudia Gastal Fassa
Summary: MDE externalizing symptoms were present in 20% of university students, with females, individuals with a family history of depression, minority sexual orientation, and those experiencing conflicts with teachers or colleagues being more likely to exhibit these symptoms. It is important for educational institutions to train teachers to identify and handle students with externalizing symptoms of MDE, as well as to address conflicts between students and teachers.
Article
Clinical Neurology
Yongbo Hu, Jin Li, Youjin Zhao, Zaiquan Dong, Peiyuan Qiu, Shujuan Yang, Haizhen Xu, Weihong Kuang, Qiyong Gong
Summary: This study found that cognitive impairment is common in patients with major depressive disorder (MDD), especially in memory and processing speed. Age and educational attainment have a greater impact on cognitive function, while depression severity mainly affects processing speed.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Julia Maruani, Emilie Stern, Charlotte Boiret, Jeanne Leseur, Alix Romier, Michel Lejoyeux, Pierre A. Geoffroy
Summary: Cognitive behavioral therapy for insomnia (CBT-I) has positive effects on improving sleep quality in patients with insomnia and major depressive disorder (MDD). Treatment-resistant depression (TRD) predicts reduced insomnia severity with CBT-I. Patients with seasonal fluctuations in depressive symptoms and daytime dysfunction show enhanced CBT-I efficacy, especially for early awakenings insomnia. Shorter sleep duration predicts a less favorable response to CBT-I.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Yanling Zhou, Zhipei Zhang, ChengYu Wang, Xiaofeng Lan, Weicheng Li, Muqin Zhang, Guohui Lao, Kai Wu, Jun Chen, Guixiang Li, Yuping Ning
Summary: This study aimed to identify predictors of acute antidepressant efficacy in patients with first-episode Major Depressive Disorder (MDD). The study found that besides baseline clinical symptoms, cognitive function and global functioning could also be predictors of treatment outcome in first episode MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Guoshuai Luo, Yaxi Li, Cong Yao, Meijuan Li, Jie Li, Xiangyang Zhang
Summary: This study aimed to assess the relationship between duration of untreated illness (DUI) and clinical correlates in patients with major depressive disorder (MDD). The findings showed that older age, lower education level, and being married were associated with lower likelihood of seeking timely treatment. Prolonged DUI was associated with increased risk for various clinical conditions.
PSYCHIATRY RESEARCH
(2023)
Article
Neurosciences
Wei Sheng, Qian Cui, Kexing Jiang, Yuyan Chen, Qin Tang, Chong Wang, Yunshuang Fan, Jing Guo, Fengmei Lu, Zongling He, Huafu Chen
Summary: This study used a new data-driven analysis to examine the relationship between the course of illness and resting-state functional dysconnectivity in MDD. The results revealed the significance of the anterior cingulate cortex in the disease process of depression, and its links with network topography and pathological duration.
Review
Biochemistry & Molecular Biology
Masaki Kato, Hikaru Hori, Takeshi Inoue, Junichi Iga, Masaaki Iwata, Takahiko Inagaki, Kiyomi Shinohara, Hissei Imai, Atsunobu Murata, Kazuo Mishima, Aran Tajika
Summary: Continuing treatment with antidepressants after achieving remission is recommended to reduce the risk of relapse of depressive symptoms. Different classes of antidepressants have varying effectiveness in preventing relapse, with tricyclics showing the highest effect size. Maintenance therapy for at least 6 months is crucial for relapse prevention.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Qian Fang, Huanhuan Cai, Ping Jiang, Han Zhao, Yu Song, Wenming Zhao, Yongqiang Yu, Jiajia Zhu
Summary: Through comprehensive multi-modal neuroimaging meta-analyses, changes in brain structure and function were identified in drug-naive first-episode patients with major depressive disorder (DF-MDD). These changes were spatially associated with the expression of 1194 and 1733 genes, revealing common and distinct genetic modulations of brain structural and functional impairments in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemical Research Methods
Licia C. Silva-Costa, Bradley J. Smith, Victor Corasolla Carregari, Gustavo H. M. F. Souza, Erica M. Vieira, Ana Paula Mendes-Silva, Valeria de Almeida, Benilton S. Carvalho, Breno S. Diniz, Daniel Martins-de-Souza
Summary: Through mass spectrometry analysis of blood plasma samples, it was found that there are 96 differentially expressed proteins between late-life depression (LLD) patients and the control group, and a potential model of 75 proteins was established, suggesting that biological pathways related to vesicle-mediated transport and voltage-dependent calcium channels may be associated with LLD.
JOURNAL OF PROTEOMICS
(2022)
Article
Psychology, Clinical
Ondrej Bezdicek, Marketa Cervenkova, Hana Georgi, Ben Schmand, Adela Hladka, Aaron Rulseh, Miloslav Kopecek
Summary: The study aimed to investigate whether healthy older adults who show no cognitive decline over five years exhibit fewer age-related differences in instrumental activities of daily living. Results indicated that cognitive decline after four years, rather than age, predicted subtle impairment in IADL in healthy aging participants. Brain volumetric differences were found between SHA and Decliners based on two different classifications.
CLINICAL NEUROPSYCHOLOGIST
(2021)
Article
Environmental Sciences
Katerina Lukavska, Vaclav Burda, Jiri Lukavsky, Michaela Slussareff, Roman Gabrhelik
Summary: The study found that during the long-term, nation-wide distant schooling period in the Czech Republic, there were significant shortcomings in school-based prevention interventions related to screen-related risks, with a low proportion of schools conducting prevention interventions and a lack of awareness and recognition of the importance of certain screen-related risks.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Psychology, Multidisciplinary
Lucie Jicinska, Petra Sedlackova, Lukas Kolek, Tereza Tetourova, Kristina Volna, Jiri Lukavsky, Cyril Brom
Summary: This passage discusses the pros and cons of using instructional quizzes in educational games. Research findings suggest that both in-game quizzes and bare quizzes have their place in useful educational interventions, with bare quizzes being preferred in schooling contexts and game quizzes suitable for leisure time activities.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Daniel Riha, Marcela Sevcikova, Justyna Kvapilova, Marek Preiss
Summary: The study aimed to capture the narrative structure of expressive writing in patients with depressive disorder. Analysis revealed that themes of illness imprisonment, fears for the future, and relationships were most commonly covered, forming the basis for captured values and beliefs. The image of self in others was burdened with feelings of hopelessness, misfortune, and illness; while acting was not accentuated due to lack of strength and will, with an increase observed in acting for patients in remission in the 5th week post-hospitalization.
CESKOSLOVENSKA PSYCHOLOGIE
(2021)
Article
Psychology, Clinical
Ondrej Bezdicek, Anna Marie Rosicka, Josef Mana, David J. Libon, Miloslav Kopecek, Hana Georgi
Summary: The study assessed the validity of a new, abbreviated Czech version of the Boston Naming Test (BNT) through advanced psychometric methods, aiming to help clinicians in the diagnosis of language disorders. Results showed that the Czech versions of BNT functioned similarly to the original version, with normative values provided for clinical use and future cross-cultural comparisons, adjusting for age, education, and sex influences.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2021)
Article
Psychology, Developmental
Tomas Nikolai, Filip Dechterenko, Beril Yaffe, Hana Georgi, Miloslav Kopecek, Marketa Cervenkova, Martin Vyhnalek, Ondrej Bezdicek
Summary: The current study used a psychometric approach and the Uniform data set Czech version to define and validate criteria for characterizing possible and probable cognitive deficits. The findings showed that the psychometrically derived criteria had low misclassification rates and could accurately classify possible and probable cognitive impairment, reducing the misdiagnosis rates compared to traditional criteria for MCI.
AGING NEUROPSYCHOLOGY AND COGNITION
(2023)
Article
Multidisciplinary Sciences
Filip Dechterenko, Daniela Jakubkova, Jiri Lukavsky, Christina J. Howard
Summary: Tracking real fish in an aquarium shares similarities with tracking simple objects in a typical laboratory MOT task, suggesting that the commonly used laboratory MOT task possesses a good level of ecological validity.
Article
Multidisciplinary Sciences
Filip Dechterenko, Jiri Lukavsky
Summary: This study finds that people can recognize parts of remembered photographs but struggle to reject distractors from unseen parts. Their memory representation is not detailed enough to rule out these distractors.
Article
Ophthalmology
Jana Nekolova, Jan Kremlacek, Jiri Lukavsky, Radovan Sikl, Martin Sin, Jana Langrova, Jana Szanyi, Nada Jiraskova
Summary: This study evaluated the effects of intraocular macular lens implantation and visual rehabilitation on the quality of life of patients with geographic atrophy secondary to age-related macular degeneration. The results showed that macular lens implantation followed by rehabilitation improved near vision and increased the quality of life of visually handicapped patients with macular degeneration.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Psychology, Biological
Jiri Lukavsky, Lauri Oksama, Filip Dechterenko
Summary: In everyday life, we often view objects through a limited aperture. In a series of multiple object tracking experiments, we found that longer and more frequent occlusions increased tracking errors, while a lower tracking load and memorizing identities improved performance under difficult occlusion conditions.
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Zuzana Ticha, Hana Georgi, Ben Schmand, Radek Heissler, Miloslav Kopecek
Summary: The study aimed to identify possible predictors of SuperAgers (SA). By conducting tests on 96 community-dwelling older persons aged 80-101 years, it was found that processing speed, sex, and age in 2012 could serve as predictors of SA in 2018.
Article
Psychology, Multidisciplinary
Radek Heissler, Hana Georgi, Jiri Kozeny, Miloslav Kopecek
Summary: This study investigates the factor structure and stability of the Czech comprehensive neuropsychological battery for SuperAgers (older people with excellent cognition). The results show that cognitive functioning in healthy older people can be categorized into four factors: verbal memory, attention/working memory, executive functions, and language. These four factors are the most stable and should be considered when identifying SuperAgers and comparing different models in future studies.
CESKOSLOVENSKA PSYCHOLOGIE
(2023)
Review
Public, Environmental & Occupational Health
Eva Dragomirecka, Hana Georgi, Hana Janeckova, Eva Jarolimova
Summary: Our study investigates the interest of caregivers in psychoeducational programs for relatives with dementia, the barriers preventing their usage, and their preferred program format. The results show a link between age and willingness to participate, with younger caregivers being more interested. Older caregivers, especially those providing partner care, faced difficulties due to the inability to leave the care recipient alone. Preferences for program format also varied, with younger participants preferring support groups and home consultations, while older caregivers preferred traditional education methods like consultations and courses.
KONTAKT-JOURNAL OF NURSING AND SOCIAL SCIENCES RELATED TO HEALTH AND ILLNESS
(2023)
Article
Multidisciplinary Sciences
Monika Fnaskova, Pavel Riha, Marketa Necasova, Marek Preiss, Ivan Rektor
Summary: This study examined the impact of stress experienced during prenatal and early postnatal development on Holocaust survivors. The results showed significant effects on the volume of the hippocampus and amygdala, as well as on psychological traits.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hana Malikova, Karin Kremenova, Petr Budera, Dalibor Herman, Jiri Weichet, Jiri Lukavsky, Pavel Osmancik
Summary: According to the study, periprocedural silent strokes were significantly more common after thoracoscopic epicardial ablation compared to catheter ablation in terms of both the number of affected patients and number of lesions. The majority of acute ischemic brain lesions were small, up to 5 mm in diameter, with roughly half of them being reversible. Reversibility of acute ischemic lesions decreased with size, although in 29.4% of affected patients, all lesions were fully reversible.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)