期刊
PSYCHIATRY RESEARCH
卷 169, 期 2, 页码 173-175出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2008.10.003
关键词
Endophenotype; Dopamine; Schizophrenia
类别
资金
- Icelandic Research Fund (RANNIS)
- European Union [037761]
The association between the catechol-O-methyltransferase (COMT) val(158)met polymorphism (rs4680) and smooth pursuit eye movements (SPEM) was investigated in 110 schizophrenia patients and 96 controls. Patients had lower steady-state pursuit gain and made more frequent saccades than controls. Genotype was not associated with schizophrenia or SPEM, in either group or the combined sample. SPEM deficits in schizophrenia appear to be determined by genotypes other than rs4680, although the study may have lacked power to detect small effects. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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