☆ 4.7 Article

Further development of YBOCS dimensions in the OCD Collaborative Genetics Study: Symptoms vs. categories

PSYCHIATRY RESEARCH (2008)

期刊

PSYCHIATRY RESEARCH

卷 160, 期 1, 页码 83-93

出版社

ELSEVIER IRELAND LTD

DOI: 10.1016/j.psychres.2007.07.010

关键词

obsessive compulsive disorder; symptoms; factors; familial; genetics

类别

Psychiatry

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Reagent

摘要

Despite progress in identifying homogeneous subphenotypes of obsessive-compulsive disorder (OCD) through factor analysis of the Yale Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC), prior solutions have been limited by a reliance on presupposed symptom categories rather than discrete symptoms. Furthermore, there have been few attempts to evaluate the familiality of OCD symptom dimensions. The purpose of this study was to extend prior work by this collaborative group in category-based dimensions by conducting the first-ever exploratory dichotomous factor analysis using individual OCD symptoms, comparing these results to a refined category-level solution, and testing the familiality of derived factors. Participants were 485 adults in the six-site OCD Collaborative Genetics Study, diagnosed with lifetime OCD using semi-structured interviews. YBOCS-SC data were factor analyzed at both the individual item and symptom category levels. Factor score intraclass correlations were calculated using a subsample of 145 independent affected sib pairs. The item- and category-level factor analyses yielded nearly identical 5-factor solutions. While significant sib-sib associations were found for four of the five factors, Hoarding and Taboo Thoughts were the most robustly familial (r(ICC) >= 0.2). This report presents considerable converging evidence for a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance. The results support investigation of this multidimensional model in OCD genetic linkage studies. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

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Validation of the Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) questionnaire for adults

Marco Solmi, Trevor Thompson, Andres Estrade, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Aschauer, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kaenel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana V. Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Andrlikova, Karolina Janku, Mark John Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winkel, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Farshad Sheybani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjoern Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll

Summary: The COH-FIT survey is a valid instrument to measure global mental health during the COVID-19 pandemic. The study confirmed the validity of COH-FIT items and the internal reliability of the co-primary outcome, the P-score. The survey has been translated into 30 languages and measures various mental health symptoms and factors.

JOURNAL OF AFFECTIVE DISORDERS (2023)

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Article Behavioral Sciences

Using simple economic games to assess social orienting and prosocial behavior in adolescents with autism spectrum disorder

Adrian Hase, Melanie Haynes, Gregor Hasler

Summary: This study utilized simple economic games to compare social-economic decision-making between adolescents with autism spectrum disorder (ASD) and neurotypical controls. The results showed that individuals with ASD exhibited reduced social orienting but displayed more prosocial behavior in certain conditions. These findings provide important insights into the conditions for prosocial behavior in ASD.

AUTISM RESEARCH (2023)

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Article Clinical Neurology

Can psychedelics enhance group psychotherapy? A discussion on the therapeutic factors

Polina Ponomarenko, Federico Seragnoli, Abigail Calder, Peter Oehen, Gregor Hasler

Summary: This article discusses the therapeutic potential, existing models and challenges of psychedelic-assisted group psychotherapy (PAGP). It argues that combining psychedelic substances and group therapy can enhance group connectedness and interpersonal learning, potentially leading to prosocial behavior and practice of newly acquired knowledge. Challenges include a more rigid therapy structure and potential loss of openness from patients, which can be addressed with adequate therapeutic training. The article aims to support clinical research on PAGP by providing a therapeutic framework and outlining its mechanisms and challenges.

JOURNAL OF PSYCHOPHARMACOLOGY (2023)

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Editorial Material Psychiatry

Extrapharmacological Safety Topics in Psychedelic-Assisted Psychotherapy

Abigail Calder, Gregor Hasler

Summary: This viewpoint suggests strategies to enhance safety for both patients and therapists in psychedelic-assisted psychotherapy.

JAMA PSYCHIATRY (2023)

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Review Clinical Neurology

Psychedelics in the treatment of eating disorders: Rationale and potential mechanisms

Abigail Calder, Seline Mock, Nicole Friedli, Patrick Pasi, Gregor Hasler

Summary: Eating disorders are serious illnesses with high mortality rates and comorbidity with other mental health problems. Psychedelic-assisted therapy has shown potential in treating comorbidities of eating disorders, such as mood disorders, PTSD, and substance use disorders. This review summarizes preliminary data on the efficacy of psychedelic-assisted therapy in anorexia nervosa, bulimia nervosa, and binge eating disorder, and discusses potential therapeutic mechanisms. It suggests that psychedelic-assisted therapy may be effective in treating anorexia nervosa and bulimia nervosa, while data on binge eating disorder is limited. The therapy may improve body image beliefs, normalize reward processing, promote cognitive flexibility, and facilitate trauma processing, as well as addressing common therapeutic factors. Safety concerns and future research recommendations are also discussed.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023)

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Article Neurosciences

Prefrontal Glutathione Levels in Major Depressive Disorder Are Linked to a Lack of Positive Affect

Ruth O'Gorman Tuura, Andreas Buchmann, Christopher Ritter, Adrian Hase, Melanie Haynes, Ralph Noeske, Gregor Hasler

Summary: This study found that elevated GSH levels in individuals with current major depressive disorder (MDD) may reflect a state rather than a trait neurobiological change, associated with a loss of positive affect.

BRAIN SCIENCES (2023)

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Meeting Abstract Neurosciences

Reduced Prefrontal.-Aminobutyric Acid and Glutamate Levels in Major Depression: Results of a Proton Magnetic Resonance Spectroscopy Study

Chris Ritter, Andreas Buchmann, Sabrina Muller, Martin Volle-Berg, Melanie Haynes, Carmen Ghisleni, Ralph Noeske, Ruth Tuura, Gregor Hasler

NEUROPSYCHOPHARMACOLOGY (2022)

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Meeting Abstract Neurosciences

Regional Grey Matter Volume Correlates With Anxiety, Apathy and Resilience in Geriatric Depression

Chris Ritter, Andreas Buchmann, Sabrina Muller, Martin Volle-Berg, Melanie Haynes, Carmen Ghisleni, Ralph Noeske, Ruth Tuura, Gregor Hasler

NEUROPSYCHOPHARMACOLOGY (2022)

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Article Education & Educational Research

Developing a Growth Learning Data Mindset: A Secondary School Approach to Creating a Culture of Data Driven Improvement

Lorenzo Vigentini, Brad Swibel, Garth Hasler

Summary: While Learning Analytics (LA) have gained traction in higher education, there are limited examples of its application in the school sector. This paper presents a case study from a comprehensive coeducational independent day school in Sydney, showcasing the added value of data-driven approaches to foster a culture of improvement among students and teachers. The authors reflect on their experience of developing LA dashboards over the past five years and discuss the impact on secondary school education.

JOURNAL OF LEARNING ANALYTICS (2022)

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