Article
Environmental Sciences
Wafaa H. Mohamed, Marwa F. Ali, Doha Yahia, Hassan A. Hussein
Summary: This study evaluated the potential reproductive toxicity of sulfoxaflor (SFX) insecticide in male Sprague Dawley rats. The results showed that SFX exposure led to abnormal sperm morphology, sperm DNA damage, and significant pathological changes in the testes, epididymis, and seminal vesicles of the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Weili Mao, Lingling Mao, Nan Zhao, Yingying Zhang, Meirong Zhao, Hangbiao Jin
Summary: This study investigated the occurrence of free Bisphenol S (BPS) and its conjugated metabolites in rat internal tissues, blood, and excreta after continuous BPS dosage. The results showed that concentrations of free BPS and its metabolites reached steady state after 9 days of continuous dosage. The study also found that analyzing human blood and urine may not accurately reflect the contamination of BPS metabolites in human internal tissues.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Zrinka Mihaljevic, Toni Kujundzic, Vladimir Jukic, Ana Stupin, Mato Drenjancevic, Ines Drenjancevic
Summary: White wine has lower vasodilatory activity and polyphenolic content compared to red wine. Different fermentation processes result in white wines with varying levels of antioxidant capacity and vasodilator potential, with standard procedure and must cooling procedure producing wines with lower phenolic content and vasodilatory potential.
Article
Veterinary Sciences
Hiroto Kobayashi, Nobuyuki Shirasawa, Akira Naito
Summary: Although there may be differences in steroid hormone synthesis between SD and Wistar rats, results indicate that SD rats are equally useful for conducting experiments on gastric estrogen synthesis compared to Wistar rats.
EXPERIMENTAL ANIMALS
(2021)
Article
Food Science & Technology
K. A. Woodling, P. Chitranshi, C. C. Jacob, L. Loukotkova, L. S. Von Tungeln, G. R. Olson, R. E. Patton, S. Francke, S. R. Mog, R. P. Felton, F. A. Beland, Y. Zang, G. Gamboa da Costa
Summary: This study found that long-term consumption of BVO may lead to thyroid follicular cell hypertrophy and changes in serum thyroid-related hormone levels. Additionally, a continuous accumulation of bromide was observed in the heart, liver, and inguinal fat, indicating potential toxic reactions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaoli Fan, Hengzhi Song, Xiaotian Xu, Xi Lu, Yuhui Wang, Xiaoqun Duan
Summary: The toxicity of sodium p-hydroxybenzoate was evaluated in rats through 90-day repeated oral toxicity experiments according to OECD guidelines. The results showed no adverse effects were observed below a dose of 250 mg/kg body weight per day.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Brianna J. Stubbs, Andrey Nikiforov, Marisa O. Rihner, Sari L. Weston, Nancy Higley, Donald G. Stump, Gregory A. Krane, Gopi Gadupudi, Eric Verdin, John C. Newman
Summary: The study revealed dose-dependent acute adverse reactions of Bis-hexanoyl (R)-1,3-butanediol in rats, but these reactions disappeared after the recovery period, with a determined NOAEL of 12000 mg/kg/day.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Nan Zhao, Meirong Zhao, Hangbiao Jin
Summary: The toxic effects of exposure to microplastics (MPs) on living organisms and humans are a global concern. However, previous studies mainly focused on the health risks of a single type of MP (such as polystyrene) for animals. In this study, rats were exposed to a mixture of 10 types of MPs to assess the potential health risks in mammals from co-exposure to various MPs. The results showed significant perturbations in gut microbes and serum metabolites in rats after MP exposure, providing insights into the toxicity mechanism of MPs.
ENVIRONMENTAL POLLUTION
(2023)
Article
Agriculture, Multidisciplinary
Ye Zhang, Chizumi Abe, Koji Ochiai, Toshiro Matsui
Summary: This study clarified the distribution of glyceollins in rat organs, finding that they accumulated in circulatory organs in intact and conjugated forms with a specific preference order. Glyceollin I showed higher accumulation compared to III, while daidzein and hydroxy equol were detected only in the liver and kidneys at lower concentrations.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Andrea N. Wang, Joselia Carlos, Krishna K. Singh, Graham M. Fraser, John J. McGuire
Summary: In this study, endothelial dysfunction and altered expression of endothelial genes in type 2 diabetes were examined using ZDSD rats as a model. The results showed that ZDSD rats exhibited endothelial dysfunction and increased sensitivity to PAR2 agonist-induced vasodilation. Additionally, altered expression of multiple endothelial genes, including PAR2, suggested the involvement of inflammatory and angiogenesis signaling pathways in the endothelium of ZDSD rats.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mi Seong Jo, Boo Wook Kim, Young Hun Kim, Jin Kwon Kim, Hoi Pin Kim, Jae Hoon Shin, Gun Ho Lee, Kangho Ahn, Mary Gulumian, Il Je Yu
Summary: The inhalation toxicity of carbon nanofibers (CNFs) is not well understood due to limited studies. This study examined the acute and short-term inhalation effects of CNFs on rats and found no noticeable toxicological responses. The findings suggest that CNFs do not pose significant risks in terms of inhalation toxicity.
Article
Pharmacology & Pharmacy
Xia Li, Miao Zhang, Hock Eng Khoo, Tiemin Jiang, Yuan Guan, Peijun Li
Summary: This study observed the effect of polysaccharides extracted from Enteromorpha intestinalis on the intestinal function of rats. The results showed that WPEI improved intestinal peristalsis and other intestinal functions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Alessandro Virtuoso, Pernille Tveden-Nyborg, Anne Marie Voigt Schou-Pedersen, Jens Lykkesfeldt, Heidi Kaastrup Mueller, Betina Elfving, Dorte Bratbo Sorensen
Summary: The effect of high-fat feeding on brain-derived neurotrophic factor (BDNF) is conflicting. This study found that chronic, restricted access to Cafeteria Diets (CAF) increased BDNF levels in the prefrontal cortex (PFC) of rats, suggesting that this may be a suboptimal feeding regime.
Article
Pharmacology & Pharmacy
Christine M. Madla, Yujia Qin, Francesca K. H. Gavins, Jing Liu, Liu Dou, Mine Orlu, Sudaxshina Murdan, Yang Mai, Abdul W. Basit
Summary: The study demonstrates that Wistar and Sprague Dawley rats have differences in gastrointestinal factors that influence oral drug absorption, particularly in relation to the expression of P-glycoprotein (P-gp). Significant sex differences in P-gp expression were observed in Wistar rats, while Sprague Dawley rats showed no sex differences. In light of these findings, Wistar rats may be a better pre-clinical animal model for studying oral drug absorption of P-gp substrates in both male and female subjects.
Article
Plant Sciences
Soo Im Chang, Doug-Young Ryu
Summary: The study evaluated the subchronic toxicity and toxicokinetic characteristics of AG NPP709 in laboratory rats. The results showed that AG NPP709 did not have any harmful effects on the rats under experimental conditions. The no observed adverse effect level of AG NPP709 in rats was estimated to be 2.0 g/kg/day.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)