Review
Biochemistry & Molecular Biology
Carmen Concerto, Alessandro Rodolico, Valeria Meo, Donatella Chiappetta, Marina Bonelli, Ludovico Mineo, Giulia Saitta, Sebastiano Stuto, Maria Salvina Signorelli, Antonino Petralia, Giuseppe Lanza, Eugenio Aguglia
Summary: This study found that high doses of Maca Root, SAMe, or Saffron may improve antidepressant-induced sexual dysfunctions. Additionally, Rosa Damascena was more effective in men, while no evidence of effects was observed for Gingko Biloba and Yohimbine. Future research should consider larger sample sizes and confounding factors, such as depressive status and individual vulnerability.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Immunology
Cecilie V. Vollmond, Malte M. Tetens, Fie W. Paulsen, Jan Gerstoft, Gitte Kronborg, Isik S. Johansen, Carsten S. Larsen, Lothar Wiese, Michael Dalager-Pedersen, Steffen Leth, Preben B. Mortensen, Anne-Mette Lebech, Niels Obel, Lars H. Omland
Summary: In this nationwide, population-based, matched cohort study in Denmark, we found that people with HIV have an increased risk of depression, receipt of antidepressants, treatment with electroconvulsive therapy, and suicide compared to the general population. This risk decreases after 2 years but remains higher than the general population. Familial factors are unlikely to explain this risk.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Clinical Neurology
Hesan Jelodari Mamaghani, Zohreh Erfani, Farbod Torkamand, Seyed Mohammad Vahabi, Narges Erfani, Fahimeh Vahabizad, Abdorreza Naser Moghadasi
Summary: This study investigated the prevalence of sexual dysfunction and depression in neuromyelitis optica (NMO) patients. It found a high proportion of patients with sexual dysfunction in NMO, and this dysfunction was correlated with the severity and duration of the disease. The findings highlight the importance of addressing sexual dysfunction and depression in the management of NMO, as they have a negative impact on quality of life.
NEUROLOGICAL SCIENCES
(2023)
Review
Medicine, Research & Experimental
Samantha Klaas, Jessica Barbut Siva, Maarten Bak, Mark Govers, Rudy Schreiber
Summary: Although PSSD has been recognized as a medical condition, it is still largely unknown and under-diagnosed. This study aims to understand the symptomatology, mechanisms, and treatment options of PSSD through a design thinking approach. Insights from a targeted patient's needs and pains were used to generate new ideas, which informed a literature search on potential pathophysiological mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Geriatrics & Gerontology
Bret R. Rutherford, C. Jean Choi, Jongwoo Choi, Ben Mass, Xiaofu He, Kaleigh O'Boyle, Joel Sneed, Patrick J. Brown, Adam Brickman, Melanie M. Wall, Steven P. Roose
Summary: This study investigated the impact of slowed processing speed and executive dysfunction on the development of positive treatment expectancies in late-life depression (LLD) patients. The results suggest that slowed processing speed impairs the development of expectancies in antidepressant trials for LLD, which may explain lower antidepressant response among older adults.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Lars Vedel Kessing, Simon Christoffer Ziersen, Esben Budtz-Jorgensen, Thomas Gerds
Summary: The study confirmed a decreased response to antidepressants in patients with depression and comorbid epilepsy, especially among younger and unemployed patients. This emphasizes the importance of close monitoring and psychological support for these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Philip Boyce, Rebecca Anglin, Elizabeth McKinnon, Andrew J. Lewis
Summary: The study found that women with untreated depression during pregnancy had higher intake of unhealthy takeaway food throughout the postpartum period, while higher depressive symptoms in the postpartum were also associated with higher takeaway intake. However, there was no difference in fruit and vegetable intake among the three groups, and intake was highest for all women late in pregnancy and declined in the postpartum period.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Public, Environmental & Occupational Health
Livio Tarchi, Giuseppe Pierpaolo Merola, Ottone Baccaredda-Boy, Francesca Arganini, Emanuele Cassioli, Eleonora Rossi, Mario Maggi, David S. Baldwin, Valdo Ricca, Giovanni Castellini
Summary: The purpose of this systematic review was to investigate the adverse effects of SSRIs on sexual function and determine if these effects persist after discontinuation. The review found limited evidence of sexual dysfunction following SSRI discontinuation and was unable to establish a cause-effect relationship. However, it highlighted the need for further research to explore the relationship between SSRI exposure and persistent sexual dysfunction and to develop new treatment options.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Andrology
Mehmet Serkan Ozkent, Mustafa Bilal Hamarat, Hakan Hakki Taskapu, Muzaffer Tansel Kilinc, Yunus Emre Goger, Mehmet Giray Sonmez
Summary: This study aimed to evaluate the relationship of erectile dysfunction (ED) with self-esteem, symptom severity, and depression. Significant differences were found between ED patients and healthy controls in terms of self-esteem, symptom severity, and depression. Sexual satisfaction significantly impacts men's social lives.
Review
Psychology, Clinical
Harry Costello, Jonathan P. Roiser, Robert Howard
Summary: Depression in dementia is common and has negative effects on patients and carers. Antidepressants are widely used but lack evidence of efficacy, and may be harmful. More research is needed to understand why antidepressants are ineffective in dementia and to find new treatment targets. Clinicians continue to prescribe antidepressants, but novel approaches are needed to identify effective treatments for depression in dementia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jessica M. de Klerk-Sluis, Marloes J. Huijbers, Stephan Locke, Jan Spijker, Philip Spinhoven, Anne E. M. Speckens, Henricus G. Ruhe
Summary: The study found that cognitive reactivity (CR) and mindfulness were associated with relapse in remitted major depressive disorder (MDD) patients before the initiation of Mindfulness-based cognitive therapy (MBCT). Higher CR and lower mindfulness were found to increase the risk of relapse, while self-compassion and rumination were not associated with relapse. Particularly, for rumination, there was a significant interaction with the use of maintenance antidepressant medication, impacting its relationship with relapse.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Jeffrey A. Keelan, Olav Spigset, Andrew Lewis
Summary: This study examined the relationship between antidepressant use during the perinatal period and oxytocin levels. While concurrent oxytocin blood concentrations were not associated with antidepressant use, women taking antidepressants during pregnancy showed larger increases in oxytocin over the perinatal period compared to control women. Future research could investigate specific antidepressant agents and their impact on parenting.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Farhana Islam, Leen Magarbeh, Samar S. M. Elsheikh, Stefan Kloiber, Caroline W. Espinola, Venkat Bhat, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar V. Parikh, Franca Placenza, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Treatment-emergent sexual dysfunction is a common issue in individuals with major depressive disorder on antidepressants. This study found that polymorphisms in genes encoding drug-metabolizing enzymes and the transmembrane efflux pump were associated with changes in sexual function and satisfaction. Specifically, CYP2C19 metabolizer phenotypes were linked to changes in sexual arousal, and higher concentrations of the escitalopram metabolite, S-desmethylcitalopram, were associated with a decline in sexual function and satisfaction in females.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Pharmacology & Pharmacy
Joan Winter, Kimberly Curtis, Bo Hu, Anita H. Clayton
Summary: Sexual dysfunction is a common symptom in approximately 70% of patients with major depressive disorder. Antidepressant medications and adjunctive treatments can contribute to sexual dysfunction, making evaluation and treatment complex.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Psychiatry
Jian-An Su, Chih-Cheng Chang, Yao-Hsu Yang, Chuan-pin Lee, Ko-Jung Chen, Chung-Ying Lin
Summary: In this study, the effects of antidepressant use and underlying depression on pregnancy and neonatal complications were evaluated separately, considering confounding factors. The results showed that mothers with depression but no antidepressant use had increased risks of intrauterine growth restriction and preterm delivery compared to those without depression. Antidepressant use during pregnancy increased the risks of gestational diabetes, malpresentation, preterm delivery, cardiovascular anomalies, anemia, low Apgar score, preterm delivery, and genitourinary defects. However, the use of antidepressants before and during pregnancy did not increase the risk of stillbirth. Therefore, physicians should consider the risks and benefits to both the mother and fetus when treating depression during pregnancy with antidepressants.
ASIAN JOURNAL OF PSYCHIATRY
(2023)