期刊
PSYCHIATRY INVESTIGATION
卷 6, 期 4, 页码 306-312出版社
KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.4306/pi.2009.6.4.306
关键词
Borna disease virus; Psychiatric disorders; Peripheral blood mononuclear cell; Real-time reverse transcriptase polymerase chain reaction
类别
资金
- Ministry of Health and Welfare, Republic of Korea [A040042]
Objective Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been Suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea. Methods We recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs). Results Neither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups. Conclusion Our results suggest that BDV might not be associated with psychiatric patients in Korea. Psychiatry Invest 2009;6:306-312
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