Article
Behavioral Sciences
Emmanuel Peng Kiat Pua, Tarishi Desai, Cherie Green, Krysta Trevis, Natasha Brown, Martin Delatycki, Ingrid Scheffer, Sarah Wilson
Summary: Relatives of individuals with autism spectrum disorder may display milder social traits known as the broader autism phenotype, indicating potential genetic risk for ASD. This study found an inherited pattern of graded difficulties in social cognition in families with ASD and the BAP, with atypical faux pas detection being a potential endophenotype for ASD. Objective measures of social skills can help identify genetic risk for ASD and facilitate research on the genetic causes of ASD in this population.
Article
Behavioral Sciences
William J. Chopik, Jeewon Oh, Amy K. Nuttall, Katharine N. Thakkar, Brooke Ingersoll
Summary: Past research has focused on refining the broader autism phenotype (BAP) and its correlates, while neglecting how the BAP differs by socio-demographic characteristics, like age. This study found that total BAP scores were higher in younger adults and lower in older adults, particularly for pragmatic language difficulties. Aloofness also decreased with age, while rigidity did not show a significant association. These results suggest a decrease in BAP traits across the lifespan and have implications for clinical interventions.
Article
Medicine, Research & Experimental
T. A. Meridian McDonald
Summary: The paper discusses the increase in autism prevalence over the last 60 years with an unclear cause, proposing explanatory paradigms for autism and its increased prevalence in the general population. It introduces the concept of Broader Autism Phenotype Constellations (BAPCO) and suggests that assortative mating opportunities may have contributed to the increased frequency of these traits. The paper also introduces the BAPCO-Disability Matrix Paradigm (BAPCO-DMAP) to redefine autism in a way that includes constellations of BAPCO traits and co-occurring conditions.
MEDICAL HYPOTHESES
(2021)
Article
Psychology, Multidisciplinary
Seyed Mohammad Mahdi Moshirian Farahi, Craig Leth-Steensen
Summary: The current study used latent profile analysis to examine autism traits in a sample of university participants. The findings suggest that autism characteristics can be categorized into four latent profiles, with attention to detail being a unique facet. These results provide support for the fractional nature of the autism continuum.
CURRENT PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Kei Kanari, Moe Kikuchi-Ito
Summary: This study found that eye movement patterns exhibited by individuals with autism spectrum disorder (ASD) can serve as biomarkers for ASD diagnosis, and the gain of slow-phase OKN may predict individual differences in the degree of ASD.
Article
Family Studies
Elizabeth A. DeLucia, Olivia Semones, Kasey Stanton, Christina G. McDonnell
Summary: This study explored the relationship between caregivers' autistic or broader autism phenotype (BAP) traits and parenting practices. The results indicated that BAP traits were associated with parenting, with aloofness, pragmatic language difficulties, and rigidity showing differential associations with parenting outcomes.
JOURNAL OF CHILD AND FAMILY STUDIES
(2022)
Article
Behavioral Sciences
Yiqin Zhu, Wenting Mu, Marianne G. Chirica, Howard Berenbaum
Summary: This study aimed to develop a theory-driven factor structure of the Autism-Spectrum Quotient (AQ) that fit well across different samples. The researchers proposed a six-factor solution and tested it using exploratory and confirmatory factor analysis. The results showed that the theory-driven six-factor structure had a good fit across samples and could be used to measure different domains of autism spectrum features.
Article
Clinical Neurology
Richard H. Cole, Michael S. Elmalem, Panayiota Petrochilos
Summary: In a cohort of adults with Functional Neurological Disorder (FND), the prevalence of autistic traits and alexithymia is reported, along with the associated psychiatric comorbidity. Furthermore, it is explored whether alexithymia mediates the association between autistic traits and comorbidity.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Education, Special
Jing Meng, Chao Huo, Hengheng Tao, Zuoshan Li, Lin Shen
Summary: The study found that children with ASD have higher autistic traits compared to typically developing children, but there were no significant differences in autistic traits between parents in the two groups. Furthermore, the correlation in autistic traits between parents and children was only significant in the typically developing group. This suggests that the Autism-Spectrum Quotient may be useful as a screening tool for parents to identify children who should undergo further screening for autistic traits.
RESEARCH IN AUTISM SPECTRUM DISORDERS
(2022)
Article
Psychiatry
Doha Bemmouna, Sebastien Weibel, Markus Kosel, Roland Hasler, Luisa Weiner, Nader Perroud
Summary: The co-occurrence of ADHD and ASD in adults is common. The utility of the AQ as a screening tool for ASD in the context of ADHD is limited, but the imagination subscale can be useful for distinguishing between individuals with ADHD and ASD.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Developmental
Fangyuan Liu, Anke M. Scheeren, Rachel Grove, Rosa A. Hoekstra, Ke Wang, Dehua Guo, Chongying Wang, Sander Begeer
Summary: The study evaluated the factor structure of the parent-reported Autism Spectrum Quotient Short Form in autistic children from China and the Netherlands, revealing culturally variant factor structures that may hinder cross-cultural comparisons. Substantial variation in parent-reported autistic traits between China and the Netherlands was observed, indicating potential challenges in cross-cultural assessments.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychology, Developmental
Elizabeth A. DeLucia, Madeline P. McKenna, Theresa M. Andrzejewski, Kristin Valentino, Christina G. McDonnell
Summary: Limited information is available on the development of self-regulation processes during the preschool period in children with Autism Spectrum Disorder (ASD). Parental characteristics, such as the broader autism phenotype (BAP), play a role in children's self-regulation, with mothers' BAP traits impacting self-regulation outcomes differently across groups. Emotion regulation was found to be a protective factor against internalizing behavioral concerns in children with ASD. Parental factors should be taken into consideration in emotion regulation interventions for young children with ASD.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychiatry
Christoph Klein, Teresa Miczuga, Marie Sophie Kost, Hannah Roering, Tomasz A. Jarczok, Nico Bast, Ulf Thiemann, Christian Fleischhaker, Ludger Tebartz Van Elst, Andreas Riedel, Monica Biscaldi
Summary: Sensory features in autism spectrum disorder (ASD) have gained attention in clinical work and research. The study introduces a self-rating scale, SPQ, to measure sensory hypersensitivity in adults with ASD. The researchers present the translation and validation of the SPQ in German, as well as its reliability and validity in autistic and neuro-typical samples.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Developmental
Wei Li, Hannah Rohde, Martin Corley
Summary: This study found that participants' evaluations of a speaker's meaning differed from the real-time comprehension processes. The way interpretation is achieved may vary across individuals due to individual differences.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2022)
Article
Psychiatry
Ekachaeryanti Zain, Naoki Fukui, Yuichiro Watanabe, Koyo Hashijiri, Takaharu Motegi, Maki Ogawa, Jun Egawa, Koji Nishijima, Toshiyuki Someya
Summary: This study aimed to clarify the optimal factor structure of the AQ for assessing autistic traits among perinatal women in Japan. Through exploratory and confirmatory factor analysis on a sample of Japanese women, a model consisting of 25 items distributed across three factors was identified. This three-factor model was found to be superior to previous models in assessing autistic traits.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Helin Yilmaz Kafali, Mireia Solerdelcoll, Lena Vujinovic, Dmytro Martsenkovskyi, Sewanu Awhangansi, Camille Noel, Emre Bora, Celso Arango
Summary: The study found that the diagnostic inter-rater reliability of the DSM-5-APS among child/adolescent mental health practitioners was consistent with the results from the DSM-5 field trials. Almost three in four practitioners endorsed psychopharmacological intervention as a treatment option for the DSM-5-APS case. Therefore, there is a need to raise awareness regarding the CHR-P paradigm and its treatment, as well as the development of solid guidelines for implementation in clinical practice.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Burcu Ozbaran, Sezen Kose, Ilayda Barankoglu, Nurhak Dogan
Summary: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that affects social interactions and behavior. Understanding the clinical and familial characteristics of hospitalized ASD patients is crucial. This study examined 253 Turkish children and adolescents with and without ASD, focusing on medical consultation areas, psychiatric management of mothers, and pharmacological treatment during hospitalization. The study found that patients with ASD were more likely to have relatives with a psychiatric disorder, and there were significant differences in age, sex, intellectual functioning, and suicide attempts between patients with and without ASD.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2022)
Article
Psychology, Clinical
Burcu Ozbaran, Furkan Turer, Hazal Y. Yilancioglu, Sezen Kose, Birsen Senturk Pilan, Ozge Guzel, Dilsah Baskol, Furkan Polat, Tezan Bildik, Saziye R. Sertoz, Bilgin Arda, Mustafa H. Ozhan
Summary: This study evaluated the depression and anxiety symptoms of children/grandchildren of COVID-19 patients and healthcare workers, as well as their perception of COVID-19-related stigma. The findings revealed that age and gender play a role in anxiety symptoms and stigma perceptions among children, with differences noted between different groups. The study highlights the need for further research to explore additional factors influencing perceptions of COVID-19-related stigma among children and parents.
CLINICAL CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Psychiatry
R. M. Murray, E. Bora, G. Modinos, A. Vernon
Summary: The onset of schizophrenia is influenced by biological and social risk factors during development, resulting in subtle changes in brain structure and cognitive function. Additionally, chronic medication effects, stress, drug use, and poor lifestyle choices can further impair brain health and cognition in patients with schizophrenia.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Medicine, General & Internal
Birsen Senturk Pilan, Ipek Inal Kaleli, Serpil Erermis, Ahsen Kaya, Sezen Kose, Burcu Ozbaran, Tezan Bildik
Summary: This study aimed to explore the impact of limited mental health services during the COVID-19 pandemic on forensic psychiatric evaluations. The results showed that conduct disorder and concomitant substance use were associated with missed appointments, while maternal employment was associated with completing the interviews. There were no significant differences in depression and anxiety scores between patients who missed or completed their assessments.
JOURNAL OF DR BEHCET UZ CHILDRENS HOSPITAL
(2022)
Article
Clinical Neurology
Adem Bayrakci, Nabi Zorlu, Merve Karakilic, Funda Gulyuksel, Berna Yalincetin, Elif Oral, Fazil Gelal, Emre Bora
Summary: Negative symptoms in schizophrenia are associated with poor long-term outcome and functioning. This study examined the neurobiological mechanisms underlying negative symptoms by analyzing brain scans of schizophrenia patients and controls. The findings revealed abnormal network connectivity and modularity in the brains of schizophrenia patients, indicating a specific alteration in overall negative symptoms. The study also identified specific brain regions associated with negative and cognitive symptoms.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Seyma Kar, Eren Er, Aysun Ata, Ipek Inal-Kaleli, Tugce Ozcan, Sezen Kose, Burcu Ozbaran, Gunay Demir, Samim Ozen, Sukran Darcan, Damla Goksen
Summary: This study investigated the neurocognitive functions of children with type 1 diabetes and analyzed the effects of age of onset, metabolic control, and insulin regimen on these functions. The results showed that children with diabetes had lower intelligence levels compared to healthy controls, and poor metabolic control and a history of diabetic ketoacidosis had a negative impact on neurocognitive functions.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Article
Pediatrics
Birsen Senturk Pilan, Ipek Inal Kaleli, Didem Cek, Tugce Ozcan, Faig Azizov, Samira Huseynova, Gizem Cengiz, Sezen Kose, Burcu Ozbaran, Zeki Yuncu, Serpil Erermis, Tezan Bildik
Summary: This study aimed to investigate how the pandemic has impacted the mental health of adolescents previously diagnosed with psychiatric disorders. Telephone interviews were conducted with 59 patients aged 12-18 years, and their socio-demographic data, psychiatric diagnoses, and previous clinical impression scores were collected. The findings revealed that participants with multiple psychiatric conditions had higher clinical impression scores prior to the pandemic, and there was a significant difference in impression scores between before and during the early stages of the pandemic for those with multiple psychiatric conditions. The satisfaction scores for telepsychiatry services were higher among participants with a single psychiatric disorder. This study highlights the importance and challenges of delivering healthcare to youth with mental health problems during lockdown.
JOURNAL OF PEDIATRIC RESEARCH
(2023)
Article
Psychiatry
Sezen Kose, Ipek Inal-Kaleli, Ecem Boru, Oyku Yavuz-Kan, Gulden Hakverdi, Buket Ucuncu, Hilal Nur Calik, Sevil Savran-Yorulmaz, Birsen Senturk-Pilan, Burcu Ozbaran, Halit Isik, Eylem Ulas Saz, Tezan Bildik
Summary: This study analyzed the changes in child and adolescent psychiatric (CAP) emergency admissions over a four-year period (2018-2021), including the pandemic period. The results showed that during the first month of the COVID-19 pandemic, suicide attempts, manic symptoms, and total CAP emergency admissions decreased. However, during the subsequent pandemic period, there was an increase in total CAP emergency admissions, especially in cases presenting with psychiatric symptoms related to general medical conditions. This study highlights the importance of considering underlying medical conditions in patients presenting with psychiatric complaints in the emergency department.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Pediatrics
Ipek Dokurel Cetin, Birsen Senturk, Sezen Kose, Gul Aktan, Hasan Tekgul, Seda Kanmaz, Mine Serin, Sanem Yilmaz, Sarenur Gokben
Summary: This study aimed to investigate the frequency of sleep problems and behavioral difficulties in adolescents with epilepsy and their caregivers. The results showed that adolescents with epilepsy had higher sleep problem scores and psychopathological symptoms compared with healthy controls. Caregivers of adolescents with epilepsy were also more vulnerable to sleep problems.
TURKISH JOURNAL OF PEDIATRICS
(2023)
Article
Psychiatry
Reyhan Calisan Kinter, Burcu Ozbaran, Ipek Inal Kaleli, Sezen Kose, Tezan Bildik, Mohammad Ghaziuddin
Summary: Autistic children with ARFID show differences in eating attitudes, social functioning, sensory processing, and quality of life compared to autistic and typically developing children.
PSYCHIATRIC QUARTERLY
(2023)
Meeting Abstract
Clinical Neurology
Emre Bora
Article
Psychiatry
Sezen Kose, Burcu Ozbaran, Nurhak Dogan, Ilayda Barankoglu, Tezan Bildik
Summary: The study compared patients hospitalized in child psychiatry inpatient service during the pandemic and normal period in terms of clinical profile, illness severity, and length of hospitalization. Results showed that patients in the pandemic period had higher clinical severity, with significantly higher CGI-S scores during hospitalization.
KLINIK PSIKIYATRI DERGISI-TURKISH JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Nurhak Dogan, Hilal Subasi, Zeynep Irem Erbasan, Akin Tahillioglu, Seda Kanmaz, Sezen Kose, Burcu Ozbaran, Hepsen Mine Serin
Summary: Anti-NMDAR encephalitis is a rare autoimmune disease characterized by the attack of antibodies on glutamate receptors in the brain. It presents with both neurological and psychiatric symptoms, with a wide range of psychiatric manifestations.
